FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Avalon Ventures XI, L.P.
  2. Issuer Name and Ticker or Trading Symbol
Janux Therapeutics, Inc. [JANX]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
1134 KLINE STREET
3. Date of Earliest Transaction (Month/Day/Year)
10/16/2024
(Street)

LA JOLLA, CA 92037
4. If Amendment, Date Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 10/16/2024   S   60,179 D $ 49.69 (1) 2,761,291 D (2)  
Common Stock 10/16/2024   S   11,657 D $ 49.69 (1) 534,883 I By Avalon BioVentures I, LP (3)
Common Stock 10/16/2024   S   61,445 D $ 49.69 (1) 2,819,366 I By Avalon BioVentures SPV I, L.P. (4)
Common Stock 10/16/2024   S   29,474 D $ 50.61 (5) 2,731,817 D (2)  
Common Stock 10/16/2024   S   5,710 D $ 50.61 (5) 529,173 I By Avalon BioVentures I, LP (3)
Common Stock 10/16/2024   S   30,094 D $ 50.61 (5) 2,789,272 I By Avalon BioVentures SPV I, LP (4)
Common Stock 10/16/2024   M   4,968 A $ 17 11,855 D (6)  
Common Stock 10/16/2024   M   2,070 A $ 10.73 13,925 D (6)  
Common Stock 10/16/2024   M   2,070 A $ 13.22 15,995 D (6)  
Common Stock 10/16/2024   M   1,407 A $ 39.8 17,402 D (6)  
Common Stock 10/16/2024   S   10,957 D $ 50.8 (7) 6,445 D (6)  
Common Stock 10/17/2024   M   836 A $ 17 7,281 D (6)  
Common Stock 10/17/2024   M   348 A $ 10.73 7,629 D (6)  
Common Stock 10/17/2024   M   348 A $ 13.22 7,977 D (6)  
Common Stock 10/17/2024   M   237 A $ 39.8 8,214 D (6)  
Common Stock 10/17/2024   S   1,843 D $ 50.02 (8) 6,371 D (6)  
Common Stock 10/18/2024   S   102,732 D $ 50.3 (9) 2,629,085 D (2)  
Common Stock 10/18/2024   S   19,900 D $ 50.3 (9) 509,273 I By Avalon BioVentures I, LP (3)
Common Stock 10/18/2024   S   104,892 D $ 50.3 (9) 2,684,380 I By Avalon BioVentures SPV I, L.P. (4)
Common Stock 10/18/2024   S   15,462 D $ 51.18 (10) 2,613,623 D (2)  
Common Stock 10/18/2024   S   2,995 D $ 51.18 (10) 506,278 I By Avalon BioVentures I, LP (3)
Common Stock 10/18/2024   S   15,788 D $ 51.18 (10) 2,668,592 I By Avalon BioVentures SPV I, L.P. (4)
Common Stock 10/18/2024   S(11)   541,824 D $ 44.75 2,071,799 D (2)  
Common Stock 10/18/2024   S(11)   104,957 D $ 44.75 401,321 I By Avalon BioVentures I, LP (3)
Common Stock 10/18/2024   S(11)   553,219 D $ 44.75 2,115,373 I By Avalon BioVentures SPV I, L.P. (4)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (right to buy) $ 17 10/16/2024   M     4,968   (12) 07/19/2027 Common Stock 4,968 $ 0 22,776 D (6)  
Stock Option (right to buy) $ 10.73 10/16/2024   M     2,070   (12) 07/19/2027 Common Stock 2,070 $ 0 9,490 D (6)  
Stock Option (right to buy) $ 13.22 10/16/2024   M     2,070   (12) 07/19/2027 Common Stock 2,070 $ 0 9,490 D (6)  
Stock Option (right to buy) $ 39.8 10/16/2024   M     1,407   (12) 07/19/2027 Common Stock 1,407 $ 0 6,309 D (6)  
Stock Option (right to buy) $ 17 10/17/2024   M     836   (12) 07/19/2027 Common Stock 836 $ 0 21,940 D (6)  
Stock Option (right to buy) $ 10.73 10/17/2024   M     348   (12) 07/19/2027 Common Stock 348 $ 0 9,142 D (6)  
Stock Option (right to buy) $ 13.22 10/17/2024   M     348   (12) 07/19/2027 Common Stock 348 $ 0 9,142 D (6)  
Stock Option (right to buy) $ 39.8 10/17/2024   M     237   (12) 07/19/2027 Common Stock 237 $ 0 6,072 D (6)  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Avalon Ventures XI, L.P.
1134 KLINE STREET
LA JOLLA, CA 92037
    X    
Avalon BioVentures I, LP
11099 N TORREY PINES ROAD, SUITE 290
LA JOLLA, CA 92037
    X    
Avalon BioVentures SPV I, L.P.
11099 N TORREY PINES ROAD, SUITE 290
LA JOLLA, CA 92037
    X    
Lichter Jay
11099 N TORREY PINES ROAD, SUITE 290
LA JOLLA, CA 92037
    X    

Signatures

 Avalon Ventures XI, L.P., By: Avalon Ventures XI GP, LLC, its general partner, By /s/ Jay B. Lichter, Authorized Signatory   10/18/2024
**Signature of Reporting Person Date

 Avalon BioVentures I, LP, By: Avalon BioVentures GP, LLC, its general partner, By /s/ Jay B. Lichter, Authorized Signatory   10/18/2024
**Signature of Reporting Person Date

 Avalon BioVentures SPV I, LP, By: ABV SPV I GP, LLC, its general partner, By /s/ Jay B. Lichter, Authorized Signatory   10/18/2024
**Signature of Reporting Person Date

 /s/ Jay B. Lichter   10/18/2024
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $49.50 to $50.45 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.
(2) The securities are directly held by Avalon Ventures XI, L.P. ("Avalon Ventures"). Avalon Ventures XI GP, LLC ("Avalon XI GP") is the general partner of Avalon Ventures and may be deemed to beneficially own the securities held by Avalon Ventures. Mr. Lichter is a managing member of Avalon XI GP and shares voting and investment power with respect to the securities held by Avalon Ventures. Each of the Reporting Persons disclaims beneficial ownership of these securities except to the extent of his or its respective pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purpose.
(3) The securities are directly held by Avalon BioVentures I, LP ("ABV I"). Avalon BioVentures GP LLC ("ABV GP") is the general partner of ABV I and may be deemed to beneficially own the securities held by ABV I. Mr. Lichter is a managing member of ABV GP and shares voting and investment power with respect to the securities held by ABV I. Each of the Reporting Persons disclaims beneficial ownership of these securities except to the extent of his or its respective pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purpose.
(4) The securities are directly held by Avalon BioVentures SPV I, LP ("ABV SPV"). ABV SPV I GP LLC ("ABV SPV GP") is the general partner of ABV SPV and may be deemed to beneficially own the securities held by ABV SPV. Mr. Lichter is a managing member of ABV SPV GP and shares voting and investment power with respect to the securities held by ABV SPV. Each of the Reporting Persons disclaims beneficial ownership of these securities except to the extent of his or its respective pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purpose.
(5) The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $50.46 to $51.25 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.
(6) The securities are directly held by Mr. Lichter.
(7) The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $50.76 to $51.05 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
(8) The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $49.97 to $50.18 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
(9) The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $50.00 to $50.86 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
(10) The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $51.00 to $51.97 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
(11) Shares sold in a private transaction pursuant to a stock purchase agreement dated September 12, 2024. The closing of the transaction was subject to certain customary conditions to closing, including the expiration or earlier termination of the applicable waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended. The closing conditions were satisfied, and the transaction closed, on October 18, 2024.
(12) Immediately exercisable.

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