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                               May 8, 2024

       Christopher Fenimore
       Chief Financial Officer
       Regeneron Pharmaceuticals, Inc.
       777 Old Saw Mill River Road
       Tarrytown, New York 10591-6707

                                                        Re: Regeneron 
Pharmaceuticals, Inc.
                                                            Form 10-K for the 
Fiscal Year Ended December 31, 2023
                                                            Filed February 5, 
2024
                                                            File No. 000-19034

       Dear Christopher Fenimore:

              We have limited our review of your filing to the financial 
statements and related
       disclosures and have the following comments.

              Please respond to this letter within ten business days by 
providing the requested
       information or advise us as soon as possible when you will respond. If 
you do not believe a
       comment applies to your facts and circumstances, please tell us why in 
your response.

                                                        After reviewing your 
response to this letter, we may have additional comments.

       Form 10-K for the Fiscal Year Ended December 31, 2023

       Item 1. Business
       Products, page 3

   1.                                                   Please address the 
following as it relates to your presentation of net product sales of
                                                        Regeneron-discovered 
products on page 5:

                                                              Explain the 
purpose of this disclosure and its usefulness to investors.
                                                              Disclose more 
prominently that not all of the net product sales presented on page 5
                                                            are recognized as 
revenue in your Statements of Operations.
                                                              For those net 
product sales recorded by a collaboration partner and for which you
                                                            record your share 
of profits in connection with the collaboration, quantify the
                                                            amounts recorded 
and specify where such amounts are recorded on your Statements
                                                            of Operations 
(i.e., collaboration revenue).
                                                              Provide 
cross-references to your revenue disclosure for each collaboration in MD&A.
 Christopher Fenimore
FirstName
Regeneron LastNameChristopher
           Pharmaceuticals, Inc. Fenimore
Comapany
May  8, 2024NameRegeneron Pharmaceuticals, Inc.
May 8,
Page 2 2024 Page 2
FirstName LastName
Notes to the Consolidated Financial Statements
3. Collaboration, License and Other Agreements
a. Sanofi, page F-17

2.       We note your disclosure on page 89 that under your collaboration 
agreements with Bayer
         and Sanofi, you have contingent contractual obligations to reimburse 
Bayer and Sanofi for
         a defined percentage of agreed-upon development expenses funded by 
Bayer and Sanofi
         (i.e., "development balance") if the applicable collaboration is 
profitable. You also
         disclose that these reimbursements are deducted each quarter, in 
accordance with a
         formula, from your share of the collaboration profits otherwise 
payable to you. Please
         address the following specifically as it relates to your contingent 
reimbursement
         obligation under the Sanofi Antibody License and Collaboration 
Agreement ("LCA"):

                Describe and quantify the contractual terms governing your 
contingent
              reimbursement obligation under the LCA and the methods and key 
assumptions used
              to determine the associated $2.33 billion contingent obligation 
as of December 31,
              2023.
                Clarify why the $2.33 billion contingent repayment obligation 
does not appear to be
              recorded as a liability on your balance sheet. In particular, 
explain your basis for
              deeming the obligation to be contingent given the likelihood of 
continued profits
              under the Antibody LCA.
                Clarify your basis for reporting certain reimbursements of 
Sanofi development
              expenses as R&D expense, while reporting other such 
reimbursements as a reduction
              of collaboration profits. For example, if true, confirm that the 
$83.7 million in R&D
              expenses classified as "Regeneron's obligation for its share of 
Sanofi R&D expenses,
              net of reimbursement of R&D expenses" on page F-17 represents 
your share of
              current period R&D expenses incurred by Sanofi based on the 
original expense
              sharing percentage in the LCA, while the $459.8 million reported 
on page 80 as
              "Reimbursement of development expenses incurred by Sanofi in 
accordance with
              Regeneron's payment obligation" represents reimbursements of 
amounts due under
              your contingent repayment obligation which relates to cumulative 
development costs.
                Clarify your disclosure on page F-17 that a portion of the 
value associated with the
              increase in reimbursement percentage (from 10% to 20%) was deemed 
to be
              contingent consideration attributable to your acquisition of the 
Libtayo (cemiplimab)
              rights under the IO LCA, which will be recorded as an increase to 
the Libtayo
              intangible asset over time as you repay such development costs to 
Sanofi. Cite the
              relevant accounting guidance supporting this accounting 
treatment.
                Revise your disclosure accordingly.

       In closing, we remind you that the company and its management are 
responsible for the
accuracy and adequacy of their disclosures, notwithstanding any review, 
comments, action or
absence of action by the staff.
 Christopher Fenimore
Regeneron Pharmaceuticals, Inc.
May 8, 2024
Page 3

       Please contact Franklin Wyman at 202-551-3660 or Angela Connell at 
202-551-3426
with any questions.



FirstName LastNameChristopher Fenimore                 Sincerely,
Comapany NameRegeneron Pharmaceuticals, Inc.
                                                       Division of Corporation 
Finance
May 8, 2024 Page 3                                     Office of Life Sciences
FirstName LastName