August 9, 2024

Ameet Mallik
Chief Executive Officer
ADC Therapeutics SA
Biop  le
Route de la Corniche 3B
1066 Epalinges
Switzerland

       Re: ADC Therapeutics SA
           Registration Statement on Form S-3
           Filed August 6, 2024
           File No. 333-281288
Dear Ameet Mallik:

       This is to advise you that we have not reviewed and will not review your 
registration
statement.

       Please refer to Rules 460 and 461 regarding requests for acceleration. 
We remind you that
the company and its management are responsible for the accuracy and adequacy of 
their
disclosures, notwithstanding any review, comments, action or absence of action 
by the staff.

       Please contact Joshua Gorsky at 202-551-7836 with any questions.



                                                           Sincerely,

                                                           Division of 
Corporation Finance
                                                           Office of Life 
Sciences
cc:   David Li