FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
MAETZOLD DEREK J
  2. Issuer Name and Ticker or Trading Symbol
CASTLE BIOSCIENCES INC [CSTL] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Pres. & Chief Exec. Officer
(Last)
(First)
(Middle)
C/O CASTLE BIOSCIENCES, INC., 505 S. FRIENDSWOOD DRIVE, SUITE 401		 3. Date of Earliest Transaction (Month/Day/Year)
08/09/2024
(Street)

FRIENDSWOOD, TX 77546		 4. If Amendment, Date Original Filed (Month/Day/Year)
 6. Individual or Joint/Group Filing (Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3) 		2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8) 		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4) 		6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4) 		7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 08/09/2024   A   66,991 (1) A $ 0 124,884 D  
Common Stock 08/09/2024   F   21,828 D $ 26.83 103,056 D  
Common Stock               82,482 I By The Maetzold Descendants 2020 Trust (2)
Common Stock               71,379 I By Derek Maetzold 2020 Irrevocable Trust (3)
Common Stock               8,527 I By The Maetzold 2018 Remainder Trust FBO Emily Carol Kirk (4)
Common Stock               8,525 I By The Maetzold 2018 Remainder Trust FBO Hannah Elizabeth Maetzold (5)
Common Stock               8,525 I By The Maetzold 2018 Remainder Trust FBO John Derek Maetzold (6)
Common Stock               8,525 I By The Maetzold 2018 Remainder Trust FBO Peter Douglas Maetzold (7)
Common Stock               122,866 I By DJM Grantor Retained Annuity Trust No. 5 (8)
Common Stock               26,134 I By DJM Grantor Retained Annuity Trust No. 6 (9)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3) 		2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8) 		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5) 		6. Date Exercisable and Expiration Date
(Month/Day/Year) 		7. Title and Amount of Underlying Securities
(Instr. 3 and 4) 		8. Price of Derivative Security
(Instr. 5) 		9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4) 		10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4) 		11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Performance-Based Stock Unit (10) 08/09/2024   A   66,991     (10)   (10) Common Stock 66,991 $ 0 66,991 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
MAETZOLD DEREK J
C/O CASTLE BIOSCIENCES, INC.
505 S. FRIENDSWOOD DRIVE, SUITE 401
FRIENDSWOOD, TX 77546		   X     Pres. & Chief Exec. Officer  

Signatures

 /s/ Frank Stokes, Attorney-in-fact   08/13/2024
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Represents 50% of the Performance-Based Stock Units ("PSUs") granted on December 23, 2022 ("2022 PSUs") that vested based on the satisfaction of certain performance criteria as certified by the board of directors of the Issuer on August 9, 2024 (the "Initial Vesting Date").
(2) Held by The Maetzold Descendants 2020 Trust of which the Reporting Person's spouse is the trustee and the Reporting Person's spouse and their children are beneficiaries.
(3) Held by Derek Maetzold 2020 Irrevocable Trust of which the Reporting Person is the trustee and his children are beneficiaries.
(4) Held by The Maetzold 2018 Remainder Trust FBO Emily Carol Kirk of which the Reporting Person is the trustee and his child is the beneficiary.
(5) Held by The Maetzold 2018 Remainder Trust FBO Hannah Elizabeth Maetzold of which the Reporting Person is the trustee and his child is the beneficiary.
(6) Held by The Maetzold 2018 Remainder Trust FBO John Derek Maetzold of which the Reporting Person is the trustee and his child is the beneficiary.
(7) Held by The Maetzold 2018 Remainder Trust FBO Peter Douglas Maetzold of which the Reporting Person is the trustee and his child is the beneficiary.
(8) Held by DJM Grantor Retained Annuity Trust No. 5 of which the Reporting Person is the trustee and beneficiary. Reflects the transfer on July 5, 2024 of 26,134 shares of common stock from the DJM Grantor Retained Annuity Trust No. 5 to DJM Grantor Retained Annuity Trust No. 6.
(9) Held by DJM Grantor Retained Annuity Trust No. 6 of which the Reporting Person is the trustee and the beneficiaries are The Maetzold 2018 Remainder Trust FBO John Derek Maetzold, The Maetzold 2018 Remainder Trust FBO Emily Carol Kirk, The Maetzold 2018 Remainder Trust FBO Peter Douglas Maetzold and The Maetzold 2018 Remainder Trust FBO Hannah Elizabeth Maetzold. Reflects the transfer on July 5, 2024 of 26,134 shares of common stock from the DJM Grantor Retained Annuity Trust No. 5 to DJM Grantor Retained Annuity Trust No. 6.
(10) Each PSU represents the right to receive one share of the Issuer's Common Stock. These PSUs represent the remaining 50% of the 2022 PSUs which are all subject to time-based vesting and will vest in full on the one-year anniversary of the Initial Vesting Date.

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