United States securities and exchange commission logo




                                                                                
                              March 12, 2024

       Adam Stone
       Chief Executive Officer
       Aja Holdco, Inc.
       51 Astor Place, 10th Floor
       New York, New York 10003

                                                        Re: Aja Holdco, Inc.
                                                            Draft Registration 
Statement on Form S-4
                                                            Submitted February 
14, 2024
                                                            CIK No. 0002006986

       Dear Adam Stone:

                                                        We have reviewed your 
draft registration statement and have the following comments.

              Please respond to this letter by providing the requested 
information and either submitting
       an amended draft registration statement or publicly filing your 
registration statement on
       EDGAR. If you do not believe a comment applies to your facts and 
circumstances or do not
       believe an amendment is appropriate, please tell us why in your 
response.

               After reviewing the information you provide in response to this 
letter and your amended
       draft registration statement or filed registration statement, we may 
have additional comments.

       Draft Registration Statement on Form S-4

       Notice of Extraordinary General Meeting, page i

   1.                                                   We note that the Dear 
Shareholders letter contains long sections of what appears to be
                                                        entire clauses copied 
and pasted from legal agreements. Please revise to summarize the
                                                        transactions and 
agreements described in the letter in plain English. Similarly, revise the
                                                        entire section on pages 
104 through 118.
       Market and Industry Data, page iii

   2.                                                   Your statements that 
(i) "you are cautioned not to give undue weight to these estimates,"
                                                        (ii) "the accuracy and 
completeness of such information is not guaranteed," and (iii)
                                                        "Adagio has not 
independently verified any third-party information" may imply an
                                                        inappropriate 
disclaimer of responsibility with respect to the third party information and
                                                        internal research. 
Please revise to clarify that, notwithstanding the foregoing, you believe
                                                        that this information 
is reliable.
 Adam Stone
FirstName
Aja Holdco,LastNameAdam Stone
             Inc.
Comapany
March      NameAja Holdco, Inc.
       12, 2024
March2 12, 2024 Page 2
Page
FirstName LastName
3.       Please revise here and in the business section to explain what you 
mean by your disclosure
         on page iv relating to "the novelty of the markets for Adagio's 
products" or remove this
         disclosure.
Questions and Answers for Shareholders of Arya
Q. What proposals are shareholders of ARYA being asked to vote upon, page xiv

4.       We note that The Adjournment Proposal permits adjournment "if the 
holders of the Public
         Shares have elected to redeem such number of shares such that the New 
Adagio Common
         Stock would not be approved for listing on a U.S. stock exchange." 
Here or elsewhere in
         the Prospectus, please briefly describe the specific listing rules 
that could be implicated
         by redemptions and to provide additional detail regarding the level of 
redemptions that
         could cause the New Adagio Common Stock to fail to qualify for listing 
on a U.S. stock
         exchange. Include risk factor disclosure to describe material risks to 
public shareholders
         seeking to exercise their redemption rights.
Summary
Adagio Business Summary, page 1

5.       Please balance your disclosure regarding Adagio in the Summary section 
to include
         equally prominent disclosure of the limitations you face in 
implementing your business
         strategy, including, but not limited to, the fact that Adagio has 
incurred net losses in each
         quarterly and annual period since inception and that it has not yet 
generated any
         meaningful revenue.
6.       We note your statement that the preliminary data from your clinical 
trials is "suggestive of
         outcomes favorable to the current standard of care." Please expand on 
this statement to
         briefly describe the current standard of care and the way or ways in 
which the preliminary
         data from your clinical trials suggests more favorable outcomes 
compared to the current
         standard.
7.       Please disclose that Adagio's audit report includes a paragraph 
related to substantial doubt
         about the ability of Adagio to continue as a going concern.
8.       We note your statement here that "[s]ome of Adagio   s products have 
obtained regulatory
         approvals in the EU for commercialization" and on page 31 that "Adagio 
only has one
         product, iCLAS ULTC catheter and system, which is authorized for 
commercialization
         only in the European Union." If true, please revise your Summary 
section to state that you
         only have one product that has obtained regulatory approval or 
otherwise clarify this
         description.
The ARYA Board's Reasons for the Business Combination, page 5

9.       We note your statement here and on page 133 regarding "the support for 
the implied
         valuation of Adagio indicated by the commitments obtained from the 
PIPE Investors."
         Please clarify what you mean by "the implied valuation indicated by 
such commitments."
 Adam Stone
FirstName
Aja Holdco,LastNameAdam Stone
             Inc.
Comapany
March      NameAja Holdco, Inc.
       12, 2024
March3 12, 2024 Page 3
Page
FirstName LastName
Sponsor Letter Agreement, page 9

10.      We note your disclosure that pursuant to the Sponsor Letter Agreement 
"each of the
         Insiders and ARYA agreed to terminate certain existing agreements or 
arrangements."
         Please clarify what existing agreements or arrangements will be 
terminated.
Organizational Structure, page 10

11.      We note that you included your organizational structures before and 
after the merger.
         Please revise the post business combination structure to show what 
percentages of the
         combined company will be owned by the current officers, directors and 
shareholders of
         both ARYA and Adagio, as well as PIPE investors.
Risk Factors
Risks Related to Adagio's Business
Adagio is dependent on limited third-party suppliers and manufacturers, page 40

12.      We note your disclosure that "Adagio relies on third-party suppliers 
to provide it with
         certain components of its products, some of which are single-source 
suppliers." Please
         identify specific third-party suppliers and briefly describe any 
contracts with such third-
         party suppliers, upon which Adagio's business is substantially 
dependent.
Unfavorable U.S. or global economic conditions as a result of the COVID-19 
pandemic, page 46

13.      We note your reference to the potential impact on Adagio's "proteomics 
product
         platform." Please revise here and in the Business section to describe 
this product platform
         or advise.
Subscription Agreements, page 119

14.      We note that in several sections of your prospectus you refer to the   
 commitments by
         certain investors to subscribe for and purchase Class A Ordinary 
Shares in the open
         market and not to redeem such shares prior to the Closing Date.    
Please disclose here and
         in other appropriate sections of the filing how you will determine the 
number of shares,
         also referred to as the    New Adagio Common Stock,    to be issued 
pursuant to the
         subscription agreements.
Background of the Business Combination, page 123

15.      We note your disclosure that on January 25, 2023, representatives of 
ARYA provided
         representatives of Adagio with a draft, non-binding term sheet with 
respect to the potential
         business combination, which provided for a $75 million pre-transaction 
equity value of
         Adagio. Please expand on this disclosure to explain how the parties 
arrived at the $75
         million pre-transaction equity valuation, including the methodology 
employed in reaching
         the valuation. Please provide corresponding disclosure for the other 
valuations noted in
         the background section or explain what led to the changes in valuation 
during the course
 Adam Stone
FirstName
Aja Holdco,LastNameAdam Stone
             Inc.
Comapany
March      NameAja Holdco, Inc.
       12, 2024
March4 12, 2024 Page 4
Page
FirstName LastName
         of the negotiations. In this regard, we note that between October 18, 
2023 and November
         28, 2023 it appears the equity value was reduced to $24 million. 
Finally, please expand on
         your discussion of the drafts of the business combination agreement to 
note the equity
         valuation included in such drafts or that the terms were consistent 
with the non-binding
         term sheet.
16.      We note your disclosure that during the November 28, 2023 meeting, 
"ARYA   s
         management and representatives of the Sponsor provided the ARYA 
directors with an
         update on Adagio   s business, including updates to Adagio   s 
financial projections and
         refinements to Adagio   s go-to-market strategy." Please expand on 
this disclosure to
         describe Adagio's original financial projections and go-to-market 
strategy as well as the
         changes to such items.
17.      We note your discussion relating to three potential business 
combination targets and seven
         potential business combination targets on page 122. You identify only 
Adagio and
         Amucus as potential acquisition targets in this section. Please 
identify each potential target
         and describe any letters of intent or confidentially agreements 
entered into with
         these target companies.
18.      We note your discussion of the PIPE financing in this section. Please 
revise your
         disclosure to discuss whether there were any valuations or other 
material information
         about the SPAC, the target, or the de-SPAC transaction provided to 
potential PIPE
         investors that have not been disclosed publicly.
Opinion of ARYA's Financial Advisor, page 136

19.      We note your disclosure that in arriving at its opinion, Scalar 
reviewed certain internal
         estimates, and other data relating to the business and financial 
prospects of Adagio that
         were provided to Scalar by the management of ARYA. We also note your 
statement that
         "Scalar also was advised by ARYA   s senior management, and Scalar 
assumed, that the
         financial projections and other prospective information, including, 
but not limited to,
         projections for the timely receipt of governmental, regulatory and 
other third-party
         approvals, represented a reasonable basis upon which to evaluate the 
future business and
         financial prospects of Adagio." Please clarify if Scalar received and 
reviewed financial
         projections in connection with arriving at its opinion. If so, please 
disclose such
         projections and qualitatively and quantitatively describe all material 
assumptions
         underlying such projections.
Opinion of ARYA's Financial Advisor
Selected Precedent Financings and M&A Transactions Analysis, page 141

20.      We note your statement that "Scalar selected these financings and M&A 
transactions
         based on information obtained by searching SEC filings, public company 
disclosures,
         press releases, equity research reports, industry and popular press 
reports, databases and
         other sources." Please revise to clarify the specific selection 
criteria used to create the list
 Adam Stone
Aja Holdco, Inc.
March 12, 2024
Page 5
         of precedent financing and M&A transactions. Additionally, please note 
whether there
         were any financing or M&A transactions that met the selection criteria 
but were excluded
         from the list of precedent transactions.
Unaudited Pro Forma Condensed Combined Financial Information, page 166

21.      Please expand your disclosures here or within Note 1 to provide a 
clear description of all
         material components of Business Combination Agreement in addition to 
the Subscription
         Agreements and any other material agreements as required by Article 
11-02(a)(2) of
         Regulation S-X. In this regard, also particularly provide discussions 
about the conversion
         of both entity   s equity outstanding prior to the closing.
Note 2. Basis of Pro Forma Presentation, page 172

22.      We note your conclusion that ARYA will be the accounting acquirer and 
Adagio will be
         the accounting acquiree resulting in the use of the accounting method 
of accounting in
         accordance with ASC 805. We further note that this conclusion is 
based, in part, on your
         assessment that Adagio is considered a Variable Interest Entity (VIE) 
upon consummation
         of the business combination due to the amount of    expected cash on 
hand resulting in the
         equity at risk being considered insufficient for Adagio to finance its 
activities without
         additional subordinated financial support.    Please provide us with 
your detailed analysis
         of Adagio   s anticipated facts and circumstances at the closing of 
the business combination
         with specific reference to the authoritative literature that supports 
your position. Refer to
         ASC 810-10-25-37 and ASC 810-10-15-14 for guidance. In this regard, we 
note that prior
         to the closing of the business combination, Adagio   s October 2022 
convertible notes,
         warrants, and convertible preferred stock all convert into Adagio   s 
common stock. Lastly,
         please include in your response an accounting acquirer analysis under 
ASC 805-10-55-11
         through ASC 805-10-55-15.
23.    Please revise your tabular presentation of the pro forma shares of New 
Adagio Common
       Stock outstanding to exclude all dilutive securities and present the 
dilutive securities to be
       outstanding with the closing in a separate table or footnote disclosure 
by type and by
       holder. Also address the need to disclose the New Adagio options issued 
to Adagio option
       holders within Note 6. In this regard, we note the Sponsor Earn-Out 
Shares will be subject
       to a vesting criteria and Adagio   s options will be converted into New 
Adagio options.
       Also, separately present the shares to be acquired by the Perceptive 
PIPE Investor from
       the other PIPE Investors, as it would appear that the Perceptive PIPE 
Investor has an
FirstName LastNameAdam Stone
       existing relationship with Adagio prior to the Business Combination. 
Refer to your
Comapany    NameAja
       disclosures  on Holdco,
                       page 262,Inc.
                                  which notes CVF LLC, the Preceptive PIPE 
Investor, is a holder
       of more  than
March 12, 2024 Page 5 5%  of Adagio   s capital stock.
FirstName LastName
 Adam Stone
FirstName
Aja Holdco,LastNameAdam Stone
             Inc.
Comapany
March      NameAja Holdco, Inc.
       12, 2024
March6 12, 2024 Page 6
Page
FirstName LastName
Business of Adagio and Certain Information about Adagio, page 202

24.      Please revise this section to disclose the following:
             In regard to Adagio's product approved in the EU, please disclose 
if you are seeking
             EU approval for your other products and if not, why not.
             In regard to Adagio's aspiration to receive FDA approval in the 
USA, clearly disclose
             which of your three products you are seeking the FDA approval for.
             Clarify in what "select European markets" Adagio has commercially 
launched its
             iCLAS Cryoablation System, as referenced on page 231.
             Clarify where Adagio's 97 full-time employees are located, as 
referenced on page
             230.
             Clarify the basis for your belief that "Adagio   s future success 
is largely dependent on
             its ability to successfully develop and commercialize in the 
United States its pipeline
             products," as stated on page 32, because it appears that even 
though Adagio's product
             launched in the EU in 2020, the company only achieved combined 
sales of less than
             $0.5 million in the fiscal years 2021 and 2022.
Market Opportunity, page 202

25.      Please provide the source or basis for the valuations, growth rates 
and estimates included
         in this section or note these statements are the belief of management. 
With respect to the
         CAGRs listed on page 203, please discuss any material assumptions 
underlying these
         projections.
Current Ablation Catheter Technology Landscape, page 210

26.      Please expand on your disclosure to explain the CIRCA-DOSE randomized 
clinical trial,
         including who conducted the trial and when it was performed.
Key Benefits of ULTC, page 213

27.      We note your statement that "[w]hile still at an early stage, we 
believe our ULTC results
         could potentially demonstrate a more durable clinical outcome." Please 
clarify what you
         mean by a more durable clinical outcome. Additionally, we note that 
the data presented in
         the chart on page 213 is not based on head-to-head clinical trials. 
You may not present a
         comparison of your product candidate to other products or third party 
product candidates
         unless you have conducted head-to-head trials. You may present 
objective result of
         clinical trials, but such results should not be compared to 
alternative products unless head-
         to-head studies were conducted. Accordingly, please remove these 
comparisons from the
         prospectus.
Clinical Data, page 217

28.      Please revise this section to include a brief description of the 
October 2021 SAE that
         occurred during the US pivotal clinical study of the CE marked iCLAS   
 Cryoablation
         Catheter, the six month voluntary pause in the study, and the 
subsequent resumption of the
 Adam Stone
FirstName
Aja Holdco,LastNameAdam Stone
             Inc.
Comapany
March      NameAja Holdco, Inc.
       12, 2024
March7 12, 2024 Page 7
Page
FirstName LastName
         study following the May 2022 FSCA submission.
Adagio's Management's Discussion and Analysis of Financial Condition and 
Results of
Operations
Results of Operations, page 235

29.      Considering the significance of the research and development expense 
to your operating
         results, please expand your disclosures to include the types of 
expenses incurred during
         each period presented for each of your product candidates. If you do 
not track
         your research and development costs by project, please disclose that 
fact and explain why
         you do not maintain and evaluate research and development expenses by 
project. Also,
         provide other quantitative or qualitative disclosure that provides 
more transparency as to
         the type of research and development expenses incurred (i.e., by 
nature or type of
         expense) which should reconcile to total research and development 
expense. In this
         regard, we note your disclosures on page 216 that your product 
portfolio consists of three
         product families.
Employment Arrangements with Named Executive Officers, page 247

30.      We note your disclosure regarding the Dahldorf offer letter. Please 
file the offer letter as
         an exhibit to the registration statement or explain why you are not 
required to do so.
Beneficial Ownership of Securities, page 255

31.      Please disclose the natural person or persons who have voting and 
dispositive control over
         the shares held by Glazer Capital, LLC and Radcliffe Capital 
Management, L.P.
         (footnotes 9 and 10 to the beneficial ownership table).
Related Party Loans, page 259

32.      Please revise the first and second paragraph of this section to 
identify the related party and
         "an affiliate of the Sponsor," as well as the basis on which the 
person is a related
         party. Refer to Item 404(a)(1) of Regulation S-K.
Index to Financial Statements, page F-1

33.      Pursuant to Item 14(e) of the Form S-4, please provide financial 
statements of the
         registrant, Aja HoldCo, Inc. Please also include the registrant in a 
separate column in the
         pro forma financial information provided in accordance with Article 
11-02(a)(4) of
         Regulation S-X.
Adagio Medical, Inc. Financial Statements
Note 2 - Summary of Significant Accounting Policies
Inventory, page F-75

34.      We note your statement that cost for inventory is determined 
principally under standard
         cost methods. Please revise your disclosure to state the specific 
inventory costing method
 Adam Stone
FirstName
Aja Holdco,LastNameAdam Stone
             Inc.
Comapany
March      NameAja Holdco, Inc.
       12, 2024
March8 12, 2024 Page 8
Page
FirstName LastName
         utilized (e.g., LIFO, FIFO, average, specific identification, et 
cetera). Refer to ASC 330-
         10-50-1 for guidance.
Note 5 - Property and Equipment, page F-80

35.      Please either separately present the carrying value of the Consoles in 
the table or disclose
         the amount as a footnote to the table. Also, specifically disclose the 
useful life of the
         consoles.
Note 15 - Subsequent Events, page F-90

36.      Please disclose the specific date through which subsequent events were 
evaluated in
         accordance with ASC 855-10-50-1.
Annex R -- Form of Proxy Card, page R-1

37.      We note that your proxy card is seven pages long and appears to 
include entire clauses of
         the merger agreement. Please consider clarifying your proxy card in 
plain English.
Signatures, page II-7

38.      Please have the majority of your board sign the registration statement 
or advise why the
         filing is signed by two people only in their individual capacities. In 
this regard, we note
         your disclosure on page 185 where you appear to indicate that your 
board consists
         of six directors. Refer to Instruction 1 to the Signature section of 
Form S-1.
General

39.      Please disclose that ARYA has received a notice from the staff of the 
Listing
         Qualifications Department of the Nasdaq Stock Market regarding 
non-compliance with
         Nasdaq Rule IM-5101-2, as disclosed in ARYA's Form 8-K filed on 
February 28, 2024.
         Please revise your disclosure throughout the filing to briefly 
describe the Nasdaq notice
         and its potential consequences. In addition, provide an update on the 
status of this notice
         and the status of any hearing related to the notice. Finally, add risk 
factor disclosure
         related to potential delisting from the exchange.
40.      We note your disclosure on page 92 that Goldman Sachs & Co. LLC waived 
its deferred
         underwriting commission what would otherwise be due to it upon the 
closing of the
         business combination. Please address the following:
             Disclose how this waiver was obtained, why the waiver was agreed 
to, and
             clarify ARYA's current relationship with Goldman Sachs.
             Please disclose the basis for your conclusion that "no inference 
should be drawn that
             Goldman Sachs & Co LLC agrees with the disclosure regarding its 
waiver."
             Describe what relationship existed between Goldman Sachs and ARYA 
after the
             close of the IPO, including any financial or merger-related 
advisory
             services conducted by Goldman Sachs. For example, clarify whether 
Goldman Sachs
             had any role in the identification or evaluation of business 
combination targets.
 Adam Stone
Aja Holdco, Inc.
March 12, 2024
Page 9
             Disclose whether ARYA's or Adagio's boards of directors relied on 
the work
           performed by Goldman Sachs related to the merger transaction.
             Tell us whether Goldman Sachs was involved in the preparation of 
any disclosure
           that is included in this draft registration statement, including any 
analysis underlying
           disclosure in the registration statement. If so, clarify their 
involvement, whether they
           have retracted any work product associated with the transaction, and 
the risk of such
           withdrawal and reliance on their expertise. Further, if true, please 
clarify whether
           Goldman Sachs claims no role in the SPAC   s business combination 
transaction and
           has affirmatively disclaimed any responsibility for any of the 
disclosure in this
           registration statement.
41.   We note your disclosure that Annexes A through I are included in the 
filing, but we are
      unable to locate them. Please include these annexes in your next 
amendment.
42.   We note your disclosure related to the "Base Warrants" and "Pre-Funded 
Warrants."
      Please disclose the material terms and the dates of signing the Base 
Warrant Agreement
      and the Pre-Funded Warrant Agreement. Disclose the exercise price or 
formula for the
      pre-funded warrants and the warrant holders' obligation not to redeem 
their shares for a
      specified period of time. Consider adding a question and answer related 
to the pre-funded
      warrants and appropriate risk factor disclosure.
       Please contact Tracey Houser at 202-551-3736 or Li Xiao at 202-551-4391 
if you have
questions regarding comments on the financial statements and related matters. 
Please contact
Conlon Danberg at 202-551-4466 or Tonya Aldave at 202-551-3601 with any other 
questions.



                                                             Sincerely,

FirstName LastNameAdam Stone                                 Division of 
Corporation Finance
                                                             Office of 
Industrial Applications and
Comapany NameAja Holdco, Inc.
                                                             Services
March 12, 2024 Page 9
cc:       Peter Seligson, Esq.
FirstName LastName