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                        June 20, 2024

       Marvin L. White
       Chief Executive Officer
       Aptevo Therapeutics Inc.
       2401 4th Avenue, Suite 1050
       Seattle, Washington 98121

                                                        Re: Aptevo Therapeutics 
Inc.
                                                            Registration 
Statement on Form S-1
                                                            Filed June 14, 2024
                                                            File No. 333-280226

       Dear Marvin L. White:

              This is to advise you that we have not reviewed and will not 
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for 
acceleration. We remind you
       that the company and its management are responsible for the accuracy and 
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of 
action by the staff.

                                                        Please contact Jimmy 
McNamara at 202-551-7349 with any questions.



                                                                                
                        Sincerely,

                                                                                
                        Division of Corporation Finance
                                                                                
                        Office of Life Sciences
       cc:                                              Sean Donahue