United States securities and exchange commission logo




                                                                                
                           June 14, 2024

       R. Erik Holmlin, Ph.D.
       Chief Executive Officer
       Bionano Genomics, Inc.
       9540 Towne Centre Drive, Suite 100
       San Diego, California 92121

                                                        Re: Bionano Genomics, 
Inc.
                                                            Registration 
Statement on Form S-3
                                                            Filed June 10, 2024
                                                            File No. 333-280098

       Dear R. Erik Holmlin:

              This is to advise you that we have not reviewed and will not 
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for 
acceleration. We remind you
       that the company and its management are responsible for the accuracy and 
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of 
action by the staff.

                                                        Please contact Jane 
Park at 202-551-7439 with any questions.



                                                                                
                           Sincerely,

                                                                                
                           Division of Corporation Finance
                                                                                
                           Office of Industrial Applications and
                                                                                
                           Services
       cc:                                              Marc Rivera, Esq.