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                            April 26, 2024

       Kenneth McGrath
       Chief Financial Officer
       ORASURE TECHNOLOGIES INC
       220 East First Street
       Bethlehem, Pennsylvania 18015

                                                        Re: ORASURE 
TECHNOLOGIES INC
                                                            Form 10-K filed 
March 11, 2024
                                                            Item 2.02 Form 8-K 
filed February 27, 2024
                                                            Response filed 
April 10, 2024
                                                            File No. 001-16537

       Dear Kenneth McGrath:

              We have reviewed your April 10, 2024 response to our comment 
letter and have the
       following comments.

              Please respond to this letter within ten business days by 
providing the requested
       information or advise us as soon as possible when you will respond. If 
you do not believe a
       comment applies to your facts and circumstances, please tell us why in 
your response.

              After reviewing your response to this letter, we may have 
additional comments. Unless
       we note otherwise, any references to prior comments are to comments in 
our March 20,
       2024 letter.

       Item 2.02 Form 8-K filed February 27, 2024

       Exhibit 99.1
       Orasure Technologies GAAP to Non-GAAP Reconcilation, page 10

   1.                                                   We note your response 
to prior comment 2. The underlying facts and circumstances that
                                                        lead to the inventory 
reserve adjustments, including your decision to terminate the
                                                        manufacturing of your 
Covid-19 products in Thailand, do not appear to be outside the
                                                        normal course of your 
operations. With reference to Question 100.01 of the Compliance
                                                        and Disclosure 
Interpretations for Non-GAAP Financial Measures, please confirm that
                                                        you will no longer 
exclude these inventory impairments from your non-GAAP measures.

   2.                                                   We note that you 
include an adjustment for accelerated depreciation in your determination
                                                        of non-GAAP cost of 
goods sold, gross margin, operating income, net income (loss) and
 Kenneth McGrath
ORASURE TECHNOLOGIES INC
April 26, 2024
Page 2
         earnings (loss) per share. Confirm that you will no longer exclude 
accelerated depreciation
         from your non-GAAP measures. While the useful lives of the machinery 
and equipment
         utilized for InteliSwab   production in Thailand were shortened, the 
assets continued to
         contribute to revenue generation through the end of their useful 
lives.
       Please contact Jeanne Baker at 202-551-3691 or Al Pavot at 202-551-3738 
if you have
questions regarding comments on the financial statements and related matters.



                                                              Sincerely,
FirstName LastNameKenneth McGrath
                                                              Division of 
Corporation Finance
Comapany NameORASURE TECHNOLOGIES INC
                                                              Office of 
Industrial Applications and
April 26, 2024 Page 2                                         Services
FirstName LastName