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                          March 14, 2024

       James B. Breitmeyer, M.D., Ph.D.
       Chief Executive Officer
       Oncternal Therapeutics, Inc.
       12230 El Camino Real, Suite 230
       San Diego, CA 92130

                                                        Re: Oncternal 
Therapeutics, Inc.
                                                            Registration 
Statement on Form S-3
                                                            Filed March 8, 2024
                                                            File No. 333-277795

       Dear James B. Breitmeyer:

              This is to advise you that we have not reviewed and will not 
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for 
acceleration. We remind you
       that the company and its management are responsible for the accuracy and 
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of 
action by the staff.

                                                        Please contact Tyler 
Howes at 202-551-3370 with any questions.



                                                                                
                          Sincerely,

                                                                                
                          Division of Corporation Finance
                                                                                
                          Office of Life Sciences
       cc:                                              Anthony A. Gostanian, 
Esq.