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2024-05-23
2024-05-23
                                                                                

                                 UNITED STATES                                  
                       SECURITIES AND EXCHANGE COMMISSION                       
                             WASHINGTON, D.C. 20549                             
                                                                                
                                      FORM                                      
                                      8-K                                       
                                                                                
                                 CURRENT REPORT                                 
     Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934     

Date of Report (Date of earliest event reported):
                  May 23, 2024                   

                                                                                

                             CRISPR THERAPEUTICS AG                             
             (Exact name of Registrant as Specified in Its Charter)             
                                                                                


               Switzerland                        001-37923           Not Applicable   
       (State or Other Jurisdiction        (Commission File Number)    (IRS Employer   
            of Incorporation)                                       Identification No.)
                                                                                       
             Baarerstrasse 14                                                          
                   6300                                               Not Applicable   
                   Zug                                                                 
                    ,                                                                  
               Switzerland                                                             
 (Address of Principal Executive Offices)                               (Zip Code)     



Registrant's Telephone Number, Including Area Code:
                     41 (0)41                      
                     561 32 77                     





         (Former Name or Former Address, if Changed Since Last Report)          
                                                                                
Check the appropriate box below if the Form 8-K filing is intended to 
simultaneously satisfy the filing obligation of the registrant under any of 
the following provisions:


 Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)                 
 Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)                
 Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
 Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))


          Securities registered pursuant to Section 12(b) of the Act:           

         Title of each class            Trading   Name of each exchange on which registered
                                       Symbol(s)                                           
Common Shares, nominal value CHF 0.03    CRSP             The Nasdaq Global Market         

Indicate by check mark whether the registrant is an emerging growth company as 
defined in Rule 405 of the Securities Act of 1933 ((s)/230.405 of this 
chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 ((s)/240.12b-2 
of this chapter).
Emerging growth company

If an emerging growth company, indicate by check mark if the registrant has 
elected not to use the extended transition period for complying with any new 
or revised financial accounting standards provided pursuant to Section 13(a) 
of the Exchange Act.





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Item 5.02. Departure of Directors or Certain Officers; Election of Directors; 
Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

Appointment of Julianne Bruno as Chief Operating Officer
On May 23, 2024, CRISPR Therapeutics AG (the "Company") announced the 
promotion of Julianne Bruno, currently the Company's Senior Vice President and 
Head of Programs & Portfolio, to be the Company's Chief Operating Officer 
effective as of May 23, 2024.
Since March 2023, Ms. Bruno, aged 38, has served as the Company's Senior Vice 
President and Head of Programs & Portfolio Management. Ms. Bruno joined the 
Company in April 2019 and has held several positions with increasing 
responsibilities, including leading the hemoglobinopathy partnership program 
with Vertex Pharmaceuticals Incorporated from the early clinical stage to the 
present day. In addition, Ms. Bruno has also been responsible for overseeing 
the Company's immuno-oncology trials and program management function, which 
spans across all of the program areas (hemoglobinopathies, immuno-oncology, 
regenerative medicine,
in vivo
) and partnerships. Before joining the Company in April 2019, Ms. Bruno worked 
at McKinsey & Company from August 2015 to March 2019 where she was a leader in 
the biotech practice and served a number of biotechnology companies on a wide 
range of commercial topics. Ms. Bruno received her M.B.A. from The Wharton 
School and also holds an A.B. from Princeton University.
Employment Agreement with Ms. Bruno
In connection with Ms. Bruno's appointment to the position of Chief Operating 
Officer, the Company's wholly owned subsidiary, CRISPR Therapeutics, Inc 
("CRISPR Inc."), entered into an Employment Agreement with Ms. Bruno (the 
"Employment Agreement"), dated May 23, 2024.
Under the Employment Agreement, Ms. Bruno will receive an annual salary of 
$460,000 and she will be eligible to participate in the Company's annual bonus 
program, with a target bonus of 45% of her annual base salary. Ms. Bruno's 
bonus for 2024 will be pro-rated to reflect the effective date of her 
promotion. Ms. Bruno will also be eligible to participate in the Company's 
2018 Stock Option and Incentive Plan, and in connection with her promotion to 
Chief Operating Officer, she will receive a one-time grant of 20,000 
restricted stock units corresponding to an equivalent number of the Company's 
common shares (the "RSU Award"). Twenty-five percent of the RSU Award will 
vest on the first, second, third and fourth anniversary of the grant date of 
such award, subject, in each case, to Ms. Bruno's continued service with 
CRISPR Inc., the Company or any other subsidiary of the Company. Ms. Bruno 
will be eligible to participate in the Company's 401(k) plan, health plans and 
other benefits on the same terms as all other Company employees.
Under the Employment Agreement, in the event CRISPR Inc. terminates her 
employment without Cause, or Ms. Bruno resigns for Good Reason (both as 
defined in the Employment Agreement), the terminating party will be required 
to give six months' notice (the "Notice Period"). During the Notice Period, 
Ms. Bruno shall continue to be entitled to all compensation under the 
Employment Agreement, and all stock options and equity-based awards shall 
continue to vest from the date notice of termination is given until the last 
day of the Notice Period. In addition, Ms. Bruno will be entitled to receive a 
pro-rated bonus for the duration of the Notice Period.
No later than 15 days following the delivery of notice by CRISPR Inc. to Ms. 
Bruno of a termination without Cause or the delivery of a notice of 
resignation by Ms. Bruno for Good Reason, Ms. Bruno will be placed on 
"administrative leave." During this period of administrative leave, Ms. Bruno 
may enter into consulting arrangements and accept board positions with other 
companies and will be allowed to engage in other employment, so long as that 
employment does not interfere with her obligations under the Employment 
Agreement. However, Ms. Bruno will continue to be entitled to all compensation 
under the Employment Agreement through the administrative leave period, which 
terminates at the end of the Notice Period.

If Ms. Bruno's employment is terminated by CRISPR Inc. without Cause or by Ms. 
Bruno for Good Reason, in each case, within 12 months following a Change in 
Control (as defined in the Employment Agreement), the Notice Period will 
become 12 months and all equity awards held by Ms. Bruno on such date that the 
notice of termination or resignation is delivered will vest, or similar other 
restrictions will expire, and such awards will become exercisable or 
nonforfeitable, subject to her execution of a release of any claims in favor 
of CRISPR Inc. However, in the event that CRISPR Inc. determines at the time 
of the Change in Control, in its sole discretion and in reliance on opinion of 
counsel, that the acceleration described in the preceding sentence is not 
permissible under applicable law, all stock options and stock-based awards 
held by Ms. Bruno as of the date of the Change in Control, shall vest and 
become exercisable or nonforfeitable as of the date of the Change in Control.

There are no transactions between Ms. Bruno and the Company subject to 
disclosure pursuant to Item 404(a) of Regulation S-K and there is no 
arrangement or understanding between Ms. Bruno and any other persons or 
entities pursuant to which Ms. Bruno was appointed as officer of the Company. 
There are no family relationships between Ms. Bruno and any of our directors 
or executive officers.


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The foregoing description of the material terms of Ms. Bruno's employment 
arrangement does not purport to be complete and is subject to, and qualified 
in its entirety by, the full text of the Employment Agreement, a copy of which 
is filed hereto as Exhibit 10.1 and is incorporated by reference herein.
Item 9.01 Financial Statements and Exhibits.
(d) Exhibits:

Exhibit                                                                                                       
  No.    Description                                                                                          
                                                                                                              
10.1*    Employment Agreement, dated May 23, 2024, by and between CRISPR Therapeutics, Inc. and Julianne Bruno
                                                                                                              
                                                                                                              
104      Cover Page Interactive Data File (embedded within the Inline XBRL document)                          


* Filed herewith.


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                                   SIGNATURES                                   
Pursuant to the requirements of the Securities Exchange Act of 1934, the 
registrant has duly caused this report to be signed on its behalf by the 
undersigned thereunto duly authorized.

                       CRISPR Therapeutics AG 
                                              
Date: May 23, 2024 By: /s/ Samarth Kulkarni   
                       Samarth Kulkarni, Ph.D.
                       Chief Executive Officer





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                                                                    Exhibit 10.1
                              EMPLOYMENT AGREEMENT                              
This Employment Agreement (
Agreement
) is made as of the 23
rd
day of May, 2024 between CRISPR Therapeutics, Inc., a Delaware corporation
(the
Company
), and Julianne Bruno (the
Executive
and, together with the Company, the
Parties
or each individually, a
Party
).
WHEREAS, this Employment Agreement shall become effective upon the later of 
the (i) full execution by both Parties; or (ii) ten (10) business days after 
the Company provided Executive with notice of this Agreement and the Exhibits 
(the
Effective Date
).
WHEREAS, the Company is a wholly owned subsidiary of CRISPR Therapeutics AG (
Parent
or
CRISPR AG
);
WHEREAS, Parent and the Company are each subject to the Swiss Ordinance act 
against excessive compensation in listed companies as a result of the of 
listing of the common shares of Parent on the Nasdaq Global Market; and
WHEREAS, the Company and the Executive are parties to that certain offer 
letter dated on or about February 11, 2019 (such agreement, as in effect, is 
referred to as the
Prior Agreement
).
NOW, THEREFORE,
in consideration of the mutual covenants and agreements herein contained and 
other good and valuable consideration, the receipt and sufficiency of which is 
hereby acknowledged, the parties agree as follows:
1.
Position and Duties
. The employment of the Executive by the Company will commence on the date 
hereof. The Executive will serve as the Chief Operating Officer of the 
Company. The Executive shall have responsibilities and duties consistent with 
such position and such other responsibilities and duties as may from time to 
time be prescribed by the Chief Executive Officer of the Company (the
CEO
) which are not inconsistent with the Executives skills and experience or 
Executives ability to discharge Executives responsibilities in the positions 
noted above. The Executive shall devote the Executives full working time and 
efforts to the business and affairs of the Company except as otherwise 
permitted under Section 3(b)(i). Notwithstanding the foregoing, the Executive 
may engage in trade association, advisory, board business, charitable or other 
community activities, as long as such services and activities are disclosed to 
the Board of Directors of Parent (the
Board
) and do not materially interfere with the Executives performance of the 
Executives duties to the Company as provided in this Agreement. During the 
period which the Executive is employed pursuant to this Agreement (the
Employment Period
), the Executives principal place of employment will be in the Greater Boston, 
Massachusetts area; however, the Company may require the Executive to travel 
temporarily to other locations in connection with the Companys business.

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2.
Compensation and Related Matters
.
(a)
Base Salary
. During the Employment Period, the Company shall pay the Executive, as 
compensation for the performance of the Executives duties and obligations 
under this Agreement, an annual base salary of $460,000 payable in a manner 
that is consistent with the Companys usual payroll practices for senior 
executives. The Executives base salary shall be reviewed annually by each of 
the Compensation Committee of the Board or any successor to such committee (the

Committee
) and the Board or for adjustment. Such adjustment, if any, shall be within 
the sole discretion of the Board. The annual base salary in effect at any 
given time is referred to herein as Base Salary. The Base Salary shall not be 
reduced at any time without the express written consent of the Executive.
(b)
Annual Bonus
. During the Employment Period, the Executive shall be eligible to receive an 
annual target bonus (a
Bonus
) if, as reasonably determined by the Board or, to the extent delegated by the 
Board, the Committee one or more of the performance targets annually 
determined by the Board or the Committee (
Performance Targets
) is achieved. If all of the Performance Targets are achieved, the Bonus will 
equal not less than (and may exceed) forty-five percent of the Executives Base 
Salary (the
Target Bonus
). In the event that less than all of the Performance Targets are met by 
Executive, the Bonus paid in respect of this paragraph may be less than the 
Target Bonus. Except as set forth in Sections 4 and 5(a) hereof, the Executive 
must be employed by the Company on the day any such earned Bonus is paid which 
shall be not later than 21/2 months after the end of each calendar year. The 
Executives target bonus opportunity as a percentage of Base Salary may be 
reviewed periodically and adjusted in the sole discretion of the Board. After 
any such adjustment, the term Target Bonus shall refer to the increased 
amount. The Target Bonus shall not be reduced at any time without the express 
prior written consent of the Executive.
(c)
Equity Compensation
. The Executive shall be eligible to participate in Parents equity incentive 
plan according to its terms and conditions, as defined by Parent from time to 
time in its sole discretion. Both entitlement to any equity awards and the 
amount shall be determined by Parent in its sole discretion.
(d)
Expenses
. During the Employment Period, the Executive shall be entitled to receive 
reimbursement for all reasonable expenses incurred by Executive in performing 
services hereunder, in accordance with the policies and procedures then in 
effect and established by the Company for its senior executive officers.
(e)
Other Benefits
. During the Employment Period, the Executive shall be entitled to participate 
in or receive benefits under any employee benefit plan or arrangement 
currently maintained or which may, in the future, be made available by the 
Company generally to its executives and key management employees, subject to 
and on a basis consistent with the terms, conditions and overall administration 
of such plan or arrangement. Any payments or benefits payable to the Executive 
under a plan or arrangement referred to in this Section 2(e) in respect of any 
calendar year during which the Executive is employed by the Company for less 
than the whole of such year shall, unless otherwise provided in the applicable 
plan or arrangement, be prorated in accordance with the number of days in such 
calendar year during which the Executive is so employed. Should any such 
payments or benefits accrue on a fiscal
                                                                                
                                       2                                        


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(rather than calendar) year, then the proration in the preceding sentence 
shall be on the basis of a fiscal year rather than calendar year.
(f)
Vacations
. The Executive shall be entitled to accrue up to 20 paid vacation days in 
each year, which shall be accrued ratably. In other respects, the Companys 
vacation policy as the same may then be in effect shall apply to vacations.

(g)
Approval by Shareholders Meeting and Mandatory Law
. Any compensation (including bonus, equity awards and fringe benefits) to be 
paid under this Agreement, is, to the extent required by Swiss laws and the 
Parents Article of Association, subject to approval by the general meeting of 
shareholders of Parent. In the event of a conflict between this Agreement and 
applicable mandatory Swiss law, the Company shall have the right to 
unilaterally modify the Agreement to the extent necessary to comply with 
mandatory law with immediate effect.
(h)
Indemnification and D&O Insurance
. CRISPR AG shall indemnify the Executive (including the advance of expenses) 
to the maximum extent permitted by applicable law and shall provide directors 
and officers insurance coverage on the same basis as all other directors and 
officers of CRISPR AG and its affiliates.
(i)
Non-US Taxes
. If the Executive is subject to taxes outside the United States in connection 
with any compensatory payments made to the Executive for services performed 
under this Agreement, the Company will pay on the Executives behalf the costs 
of professional tax preparation in the applicable jurisdiction by a nationally 
recognized firm experienced in preparing personal income tax returns in the 
applicable non-U.S. jurisdiction and in the United States (the
Tax Professional
) selected by the Company and acceptable to the Executive (such acceptance not 
to be unreasonably withheld, conditioned or delayed) for each year during 
which the Executive is subject to such non-U.S. taxes. The Company will 
further pay the Executive an amount sufficient to leave the Executive in a net 
after-tax position equivalent to what the Executive would experience if the 
Executive were subject only to U.S. Federal, state and local income taxes and 
had not provided the services of the Tax Professional during any such year (an

Equalization Payment
). The Company will engage the Tax Professional at the Companys cost to 
determine the amount of any Equalization Payment due to the Executive. Any 
Equalization Payment will be made as soon as reasonably promptly following 
such determination but in any event not later than the end of the year 
following the year in which the Executive pays the relevant taxes.
3.
Termination
.
(a)
General
. The Executives employment shall continue until it is terminated in 
accordance with this Agreement. Upon service of a Notice of Termination (as 
defined below), the Executive shall resign from all offices and functions 
assumed in relation to this Agreement effective upon first request of the 
Company.
(b)
Termination by the Company without Cause or by Executive for Good Reason; 
Notice Period
. In the event that the Company elects to terminate the Executives employment 
without Cause (as defined below) or the Executive elects to resign from 
Executives employment with Good Reason (as defined below) (in either case an

Involuntary Departure
),
                                                                                
                                       3                                        


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the Party electing to end the employment relationship shall provide the other 
Party with a Notice of Termination (as defined below) of the Involuntary 
Departure specifying a notice period (the
Notice Period
) of six (6) months, effective as per the end of a calendar month; provided 
that, in the case that the Notice of Termination of an Involuntary Departure 
is provided within the 12 month period following a Change in Control (the
Change in Control Period
or
CIC Period
), then the Notice Period shall be 12 months.
(i)
During the Notice Period following a Notice of Termination of an Involuntary 
Departure, the Executive shall continue to be available to provide services to 
the extent requested by the Company or the Board, provided at any time during 
the Notice Period the Company may replace the Executives position and/or 
direct the Executive to perform other or reduced work; provided further that, 
upon the 15
th
day following such Notice of Termination (or such earlier date as the Company 
shall determine in its sole discretion), the Company shall release the 
Executive from the Executives working obligations pursuant to Section 3(b)(i) 
(except to the extent the parties otherwise agree) and place the Executive on 
administrative leave for the remainder of the Notice Period (
Administrative Leave
). During such Administrative Leave, the Executive (A) may enter into 
consulting arrangements and accept board positions provided such outside 
business activities do not interfere with Executives obligations under this 
Agreement including without limitation, pursuant to Section 7 and (B) shall be 
free to engage in other employment provided that such employment does not 
interfere with Executives obligations under this Agreement including without 
limitation, pursuant to Section 7. The Company shall be prohibited during the 
Administrative Leave from reducing any compensation to which the Executive is 
entitled to receive during the remainder of the Notice Period pursuant to 
Section 3(b)(ii).
(ii)
With respect to compensation during the Notice Period following a Notice of 
Termination of an Involuntary Departure, and subject to (i) the Executive 
signing, within 30 days following the date that the Notice of Termination is 
given, a Release of Claims in a form reasonably required by the Company 
containing, among other provisions, a general release of claims in favor of 
the Company and related persons and entities (subject to customary exclusions 
including Executives rights under this Agreement, rights relating to 
outstanding equity awards granted under the various equity plans maintained by 
CRISPR AG, rights under the Companys 401(k) plan, rights to indemnification 
and D&O insurance as described in Section 2(i) above and claims that cannot be 
waived as a matter of law), confidentiality, return of property and 
non-disparagement, a reaffirmation of all of the Executives Continuing 
Obligations and, in the Companys sole discretion, a one-year post-employment 
noncompetition agreement as set forth in Section 7(c) below, and shall provide 
that if the Executive breaches any of the Executives Continuing Obligations, 
all payments under this Agreement shall immediately cease (the
Release
) and (ii) Section 6, the Executive: (A) shall continue to receive the Base 
Salary (without regard to any reduction in Base Salary that would provide a 
basis for the Executive to resign for Good Reason) and employee benefits 
consistent with the Companys then existing benefits plans and programs; (B) 
shall be entitled to receive an amount equal to the Target Bonus (without 
regard to any reduction in Target Bonus that would provide a basis for the 
Executive to resign for Good Reason) with respect to the Notice Period (i.e., 
a prorated Target Bonus based upon the number of
                                                                                
                                       4                                        


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days in the applicable Notice Period), which amount shall be payable no more 
than 60 days after the Notice of Termination (provided that if the 60-day 
period begins in one calendar year and ends in a second calendar year, such 
Target Bonus shall be paid in the second calendar year); (C) shall continue to 
vest through the last day of the Notice Period in any time-based equity awards 
outstanding as of the date the Notice of Termination is given; provided, and 
notwithstanding the foregoing, Section 5(a) may apply if the Notice of 
Termination of an Involuntary Departure occurs during a CIC Period, and (D) 
shall not continue to accrue vacation under Section 2(f).
(iii)
If during the Notice Period following a Notice of Termination of an 
Involuntary Departure, the Company terminates the Executives employment for 
Cause, then the Company shall provide a restated Notice of Termination and the 
Notice Period shall end on the earlier date set forth in the restated Notice 
of Termination.
(c)
Death
. The Executives employment hereunder shall terminate upon Executives death.
(d)
Disability
. The Company may terminate the Executives employment if the Executive is 
disabled and unable to perform the essential functions of the Executives then 
existing position or positions with or without reasonable accommodation for a 
period of 180 days (which need not be consecutive) in any 12-month period. If 
any question shall arise as to whether during any period the Executive is 
disabled so as to be unable to perform the essential functions of the 
Executives then existing position or positions with or without reasonable 
accommodation, the Executive may, and at the request of the Company shall, 
submit to the Company a certification in reasonable detail by a physician 
selected by the Company to whom the Executive or the Executives guardian shall 
have no reasonable objection as to whether the Executive is so disabled or how 
long such disability is expected to continue, and such certification shall for 
the purposes of this Agreement be conclusive of the issue. The Executive shall 
cooperate with any reasonable request of the physician in connection with such 
certification. If such question shall arise and the Executive shall fail to 
submit such certification, the Companys determination of such issue shall be 
binding on the Executive. Nothing in this Section 3(d) shall be construed to 
waive the Executives rights, if any, under existing law including, without 
limitation, the Family and Medical Leave Act of 1993, 29 U.S.C. (s)2601
et seq
. and the Americans with Disabilities Act, 42 U.S.C. (s)12101
et seq.
(e)
Termination by Company for Cause
. The Company may terminate the Executives employment hereunder for Cause.
(f)
Termination by the Executive Without Good Reason
. The Executive may terminate Executives employment hereunder at any time 
without Good Reason.
(g)
Definitions
:
(i)
Cause
. For purposes of this Agreement,
Cause
shall mean: (i) the Executives commission of any felony or commission of any 
crime involving fraud, dishonesty or moral turpitude; (ii) the Executives 
commission or attempted commission of or participation in a fraud or act of 
dishonesty against the Company; (iii) the
                                                                                
                                       5                                        


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Executives material breach of any contract or agreement between the Executive 
and the Company or the Executives material breach of any legal duty Executive 
owes to the Company; (iv) conduct by the Executive that constitutes 
insubordination, incompetence or neglect of duties; (v) the Executives failure 
to perform the duties, functions and responsibilities of the Executives 
position; or (vi) the Executives failure to cooperate with a bona fide 
internal investigation or an investigation by regulatory or law enforcement 
authorities, after being instructed by the Company to cooperate, or the 
willful destruction or failure to preserve documents or other materials known 
to be relevant to such investigation or the inducement of others to fail to 
cooperate or to produce documents or other materials in connection with such 
investigation; provided, however, the actions or conduct described in clauses 
(iv) and (v) above shall only constitute Cause if the Company provides the 
Executive with written notice thereof and the Executive has not, within 30 
days of receipt such written notice, discontinued the cited conduct or 
remedied the failure to perform and further provided that lawful actions taken 
by the Executive in the exercise of Executives rights under the United States 
Constitution shall not constitute a breach of subsection (vi) above.
(ii)
Good Reason
. For purposes of this Agreement,
Good Reason
shall mean that the Executive has complied with the
Good Reason Process
(hereinafter defined) following the occurrence of any of the following events: 
(i) a material diminution in the Executives responsibilities, authority and 
function, an adverse change to Executives job title, or a change in Executives 
reporting relationship that results in the Executive no longer reporting 
directly to the CEO; (ii) a material reduction in Base Salary except pursuant 
to a salary reduction program affecting substantially all of the employees of 
the Company, provided that it does not adversely affect the Executive to a 
greater extent than other similarly situated employees; (iii) a material 
change in the principal geographic location at which the Executive provides 
services to the Company outside of the Greater Boston, Massachusetts area; or 
(iv) the material breach of this Agreement by the Company (each a
Good Reason Condition
). Good Reason Process shall mean that (i) the Executive reasonably determines 
in good faith that a Good Reason Condition has occurred; (ii) the Executive 
notifies the Company in writing of the first occurrence of the Good Reason 
Condition within 60 days of the occurrence of such condition; (iii) the 
Executive cooperates in good faith with the Companys efforts, for a period not 
less than 30 days following such notice (the
Cure Period
), to remedy the Good Reason Condition; (iv) notwithstanding such efforts, the 
Good Reason condition continues to exist; and (v) the Executive terminates 
employment within 60 days after the end of the Cure Period. If the Company 
cures the Good Reason Condition during the Cure Period, Good Reason shall be 
deemed not to have occurred.
(iii)
Notice of Termination
. Except for termination as specified in Section 3(c), any termination of the 
Executives employment by either the Company or the Executive shall be 
communicated by written Notice of Termination to the other party hereto. For 
purposes of this Agreement, a
Notice of Termination
shall mean a notice which shall indicate the specific termination provision in 
this Agreement relied upon.
(iv)
Date of Termination
. For purposes of this Agreement, Date of Termination shall mean: (i) if the 
Executives employment is terminated by death, the
                                                                                
                                       6                                        


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date of death; (ii) if the Executives employment is terminated on account of 
disability under Section 3(d) or by the Company for Cause under Section 3(e), 
the date on which Notice of Termination is given; (iii) if the Executives 
employment terminates as a result of an Involuntary Departure under Section 
3(b), the last day of the Notice Period; (iv) if the Executives employment is 
terminated by the Executive under Section 3(f) without Good Reason, 30 days 
after the date on which a Notice of Termination is given (unless the Company 
waives all or part of the thirty (30) day period).
4.
Compensation Upon Termination
. If the Executives employment with the Company is terminated for any reason, 
the Company shall pay or provide to the Executive (or to the Executives 
authorized representative or estate) (i) any Base Salary earned through the 
Date of Termination; (ii) unpaid expense reimbursements (subject to, and in 
accordance with Section 2(d) of this Agreement); (iii) subject to Section 
3(b)(ii)(D), unused vacation that accrued through the Date of Termination; and 
(iv) any vested benefits the Executive may have under any employee benefit 
plan of the Company through the Date of Termination, which vested benefits 
shall be paid and/or provided in accordance with the terms of such employee 
benefit plans (together, the
Accrued Benefit
) on or before the time required by law but in no event more than 30 days 
after the Executives Date of Termination.
5.
Change in Control
.
(a)
Acceleration of Vesting
. In the event a Notice of Termination of an Involuntary Termination occurs 
during the CIC Period, and subject to the Executive signing, within 60 days 
following the Notice of Termination, a Release and the Release becoming 
effective and non-revocable within such 60-day period, all time based stock 
options and time based stock-based awards held by the Executive as of the date 
of the Notice of Termination, shall vest and become exercisable or 
nonforfeitable. Notwithstanding the foregoing, if, at the time of a Change in 
Control, the Company determines in its sole discretion, in reliance upon an 
opinion of counsel in form and substance satisfactory to the Company, that the 
acceleration in the prior sentence would not be permissible under applicable 
law, then in lieu of the acceleration in the prior sentence, all time based 
stock options and time based stock-based awards held by the Executive as of 
the date of such Change in Control, shall vest and become exercisable or 
nonforfeitable as of the date of such Change in Control.
(b)
Excise Tax
.
(i)
Anything in this Agreement to the contrary notwithstanding, in the event that 
any compensation, payment or distribution by the Company to or for the benefit 
of the Executive, whether paid or payable or distributed or distributable 
pursuant to the terms of this Agreement or otherwise (the
Parachute Payments
), would be subject to the excise tax imposed by Section 4999 of the Code (the
Excise Tax
), the following provisions shall apply:
(A)
If the Parachute Payments, reduced by the sum of (1) the Excise Tax and (2) 
the total of the Federal, state, and local income and employment taxes payable 
by the Executive on the amount of the Parachute Payments which are in excess 
of the Threshold Amount, are greater than or equal
                                                                                
                                       7                                        


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to the Threshold Amount, the Executive shall be entitled to the full benefits 
payable under this Agreement.
(B)
If the Threshold Amount is less than (x) the Parachute Payments, but greater 
than (y) the Parachute Payments reduced by the sum of (1) the Excise Tax and 
(2) the total of the Federal, state, and local income and employment taxes on 
the amount of the Parachute Payments which are in excess of the Threshold 
Amount, then the Parachute Payments shall be reduced (but not below zero) to 
the extent necessary so that the sum of all Parachute Payments shall not 
exceed the Threshold Amount. In such event, the Parachute Payments shall be 
reduced in the following order: (1) cash payments not subject to Section 409A 
of the Code; (2) cash payments subject to Section 409A of the Code; (3) 
equity-based payments and acceleration; and (4) non-cash forms of benefits. To 
the extent any payment is to be made over time (
e.g.
, in installments, etc.), then the payments shall be reduced in reverse 
chronological order.
(ii)
For the purposes of this Section 5(c), Threshold Amount shall mean three times 
the Executives base amount within the meaning of Section 280G(b)(3) of the 
Code and the regulations promulgated thereunder less one dollar ($1.00); and 
Excise Tax shall mean the excise tax imposed by Section 4999 of the Code, and 
any interest or penalties incurred by the Executive with respect to such 
excise tax.
(iii) All calculations and determinations under Sections 5(c)(i) and 5(c)(ii) 
shall be made by an independent accounting firm or independent tax counsel 
appointed by the Company (the

Tax Counsel

) whose determinations shall be conclusive and binding on the Company and the 
Executive for all purposes. For purposes of making the calculations and 
determinations required by Sections 5(c)(i) and 5(c)(ii), the Tax Counsel may 
rely on reasonable, good faith assumptions and approximations concerning the 
application of Section 280G and Section 4999 of the Code. The Company and the 
Executive shall furnish the Tax Counsel with such information and documents as 
the Tax Counsel may reasonably request in order to make its determinations 
under Sections 5(c)(i) and 5(c)(ii). The Company shall bear all costs the Tax 
Counsel may reasonably incur in connection with its services.
(c)
Definitions
. For purposes of this Agreement, Change in Control shall mean any of the 
following:
(i)
any person, as such term is used in Sections 13(d) and 14(d) of the Securities 
Exchange Act of 1934, as amended (the
Act
) (other than Parent, any of its subsidiaries, or any trustee, fiduciary or 
other person or entity holding securities under any employee benefit plan or 
trust of Parent or any of its subsidiaries), together with all affiliates and 
associates (as such terms are defined in Rule 12b-2 under the Act) of such 
person, shall become the beneficial owner (as such term is defined in Rule 
13d-3 under the Act), directly or indirectly, of securities of Parent 
representing 50 percent or more of the combined voting power of the Companys 
then outstanding securities having
                                                                                
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the right to vote in an election of the Board (
Voting Securities
) (in such case other than as a result of an acquisition of securities 
directly from Parent); or
(ii)
the date a majority of the members of the Board is replaced during any 
12-month period by directors whose appointment or election is not endorsed by 
a majority of the members of the Board before the date of the appointment or 
election; or
(iii)
the consummation of (A) any consolidation or merger of Parent where the 
stockholders of Parent, immediately prior to the consolidation or merger, 
would not, immediately after the consolidation or merger, beneficially own (as 
such term is defined in Rule 13d-3 under the Act), directly or indirectly, 
shares representing in the aggregate more than 50 percent of the voting shares 
of the company issuing cash or securities in the consolidation or merger (or 
of its ultimate parent corporation, if any), or (B) any sale or other transfer 
(in one transaction or a series of transactions contemplated or arranged by 
any party as a single plan) of all or substantially all of the assets of 
Parent.
Notwithstanding the foregoing, a Change in Control shall not be deemed to have 
occurred for purposes of the foregoing clause (i) solely as the result of an 
acquisition of securities by Parent which, by reducing the number of shares of 
Voting Securities outstanding, increases the proportionate number of Voting 
Securities beneficially owned by any person to 50 percent or more of the 
combined voting power of all of the then outstanding Voting Securities; 
provided, however, that if any person referred to in this sentence shall 
thereafter become the beneficial owner of any additional shares of Voting 
Securities (other than pursuant to a stock split, stock dividend, or similar 
transaction or as a result of an acquisition of securities directly from 
Parent) and immediately thereafter beneficially owns 50 percent or more of the 
combined voting power of all of the then outstanding Voting Securities, then a 
Change in Control shall be deemed to have occurred for purposes of the 
foregoing clause (i). For the avoidance of doubt, a migratory merger of Parent 
for the principal purpose of redomiciling Parent shall not constitute a Change 
in Control.
6.
Section 409A
.
(a)
Anything in this Agreement to the contrary notwithstanding, if at the time of 
the Executives separation from service within the meaning of Section 409A of 
the Code, the Company determines that the Executive is a specified employee 
within the meaning of Section 409A(a)(2)(B)(i) of the Code, then to the extent 
any payment or benefit that the Executive becomes entitled to under this 
Agreement on account of the Executives separation from service would be 
considered deferred compensation subject to the 20 percent additional tax 
imposed pursuant to Section 409A(a) of the Code as a result of the application 
of Section 409A(a)(2)(B)(i) of the Code, such payment shall not be payable and 
such benefit shall not be provided until the date that is the earlier of (A) 
six months and one day after the Executives separation from service, or (B) 
the Executives death. If any such delayed cash payment is otherwise payable on 
an installment basis, the first payment shall include a catch-up payment 
covering amounts that would otherwise have been paid during the six-month 
period but for the application of this provision, and the balance of the 
installments shall be payable in accordance with their original schedule. 
Solely for purposes of Section 409A of the Code, each installment payment 
under this Agreement is considered a separate payment.
                                                                                
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(b)
All in-kind benefits provided and expenses eligible for reimbursement under 
this Agreement shall be provided by the Company or incurred by the Executive 
during the time periods set forth in this Agreement. All reimbursements shall 
be paid as soon as administratively practicable, but in no event shall any 
reimbursement be paid after the last day of the taxable year following the 
taxable year in which the expense was incurred. The amount of in-kind benefits 
provided or reimbursable expenses incurred in one taxable year shall not 
affect the in-kind benefits to be provided or the expenses eligible for 
reimbursement in any other taxable year. Such right to reimbursement or 
in-kind benefits is not subject to liquidation or exchange for another benefit.

(c)
To the extent that any payment or benefit described in this Agreement 
constitutes non-qualified deferred compensation under Section 409A of the 
Code, and to the extent that such payment or benefit is payable upon the 
Executives termination of employment, then such payments or benefits shall be 
payable only upon the Executives separation from service. The determination of 
whether and when a separation from service has occurred shall be made in 
accordance with the presumptions set forth in Treasury Regulation Section 
1.409A1(h).
(d)
The parties intend that this Agreement will be administered in accordance with 
Section 409A of the Code. To the extent that any provision of this Agreement 
is ambiguous as to its compliance with Section 409A of the Code, the provision 
shall be read in such a manner so that all payments hereunder comply with 
Section 409A of the Code. The parties agree that this Agreement may be 
amended, as reasonably requested by either party, and as may be necessary to 
fully comply with Section 409A of the Code and all related rules and 
regulations in order to preserve the payments and benefits provided hereunder 
without additional cost to either party.
(e)
The Company makes no representation or warranty and shall have no liability to 
the Executive or any other person if any provisions of this Agreement are 
determined to constitute deferred compensation subject to Section 409A of the 
Code but do not satisfy an exemption from, or the conditions of, such Section.

7.
Proprietary Information, Noncompetition and Cooperation
.
(a)
Confidentiality and Assignment Agreement.
The Executive has entered into the Proprietary Information and Inventions 
Agreement (the
Confidentiality and Assignment Agreement
), attached hereto as
Exhibit A
, the terms of which are incorporated by reference as material terms of this 
Agreement. For purposes of this Agreement, the obligations in this Section 7 
and those that arise in the Confidentiality and Assignment Agreement, and any 
other agreement relating to confidentiality, assignment of inventions, or 
other restrictive covenants shall collectively be referred to as the 
Continuing Obligations.
(b)
Non-Solicitation
.
In order to protect the Companys proprietary information and good will, during 
the Executives employment with the Company and for a period of twelve (12) 
months following the (i) the delivery of a Notice of Termination, in the case 
of an Involuntary Departure or (ii) the termination of the Executives 
employment for any other reason (the
Restricted Period
,) the Executive will not, directly or indirectly, in any
                                                                                
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manner, other than for the benefit of the Company (i) divert or take away 
customers of the Company or any of its suppliers; and/or (ii) solicit, entice, 
attempt to persuade any other employee or consultant of the Company to leave 
the Company for any reason (other than the termination of subordinate 
employees undertaken in the course of the Executives employment with the 
Company). The Executive acknowledges and agrees that if the Executive violates 
any of the provisions of this paragraph 7(b), the running of the Restricted 
Period will be extended by the time during which the Executive engages in such 
violation(s).
(c)
Noncompetition
. The Executive acknowledges and agrees that in consideration and as a 
condition of the Executives promotion by the Company and in exchange for, 
among other things, the benefits contained in this Agreement, including 
without limitation the opportunity to receive enhanced post-employment 
severance benefits, which the Executive acknowledges and agrees is fair and 
reasonable consideration that is independent from the continuation of the 
Executives employment, during the Restricted Period the Executive will not 
directly or indirectly, whether as owner, partner, shareholder, director, 
manager, consultant, agent, employee, co-venturer or otherwise, engage, 
participate or invest in any Competing Business anywhere in the world. For 
purposes hereof, the term
Competing Business
shall mean any entity engaged in the discovery, development or commercialization
 of gene editing technology for human therapeutics. Notwithstanding anything 
to the contrary in this Agreement, nothing contained hereinabove or 
hereinbelow shall be deemed to prohibit the Executive from (i) acquiring, 
solely as an investment, shares of capital stock (or other interests) of any 
corporation (or other entity) not exceeding 2% of such corporations (or other 
entitys) then outstanding shares of capital stock (or equity interest), or 
(ii) working for a line of business, division or unit of a larger entity that 
competes with the Company as long as the Executives activities for such line 
of business, division or unit do not involve work by the Executive on matters 
that are directly competitive with the Companys business. Notwithstanding the 
foregoing, this Section 7(c) shall not be enforceable during the post-employment
 portion of the Restricted Period if the Executive is terminated by the 
Company without Cause, is laid off from employment or if the Company elects to 
waive the restrictions set forth in this Section 7(c). If Section 7(c) is 
enforced during the post-employment portion of the Restricted Period, the 
Company shall pay the Executive at the rate of 50% of the highest annualized 
base salary paid to the Executive within the two year period preceding the 
last day of Executives employment (the Garden Leave Pay) during the 
post-employment portion of the Restricted Period. During the Restricted Period 
Executive will promptly (and immediately upon request) notify the Company of 
any change in address and each subsequent employer or business activity 
including the name and address of employer or other post-Company plans and the 
nature of Executives activities. The Companys election not to provide 
post-employment Garden Leave Pay shall be deemed a waiver of Executives 
post-employment noncompetition obligations under this Section 7(c). In no 
event will Garden Leave Pay be duplicative of other pay and the Executive 
agrees that any Garden Leave Pay received pursuant to this Section 7(c) shall 
reduce (and shall not be in addition to) any other pay that the Executive may 
be entitled to receive during the post-employment portion of the Restricted 
Period. The Executive acknowledges having been advised by the Company of the 
right to consult with counsel regarding the noncompetition restrictions 
contained in this Section 7(c) prior to executing this Agreement.
(d)
Litigation and Regulatory Cooperation
. During and after the Executives employment, the Executive shall use 
reasonable efforts to cooperate with the Company in the
                                                                                
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defense or prosecution of any claims or actions now in existence or that may 
be brought in the future against or on behalf of the Company that relate to 
events or occurrences that transpired while the Executive was employed by the 
Company. The Executives cooperation in connection with such claims or actions 
shall include, but not be limited to, being available to meet with counsel to 
prepare for discovery or trial and to act as a witness on behalf of the 
Company at mutually convenient times. During and after the Executives 
employment, the Executive shall use reasonable efforts to cooperate with the 
Company in connection with any investigation or review of any federal, state 
or local regulatory authority as any such investiga
tion or review relates to events or occurrences that transpired while the 
Executive was employed by the Company. The Company shall reimburse the 
Executive for any reasonable outofpocket expenses incurred in connection with 
the Executives performance of obligations pursuant to this Section 7(d) and 
pay the Executive an hourly rate based on the Executives annual base salary 
rate in effect immediately prior to the Executives last day of employment with 
the Company. In no event shall the services under this Section exceed five (5) 
hours per month or 20 hours in any year and in no event shall the Executive be 
required to provide such services beyond the second anniversary of Executives 
last day of employment with the Company.
(e)
Injunction
. The Executive agrees that it would be difficult to measure any damages 
caused to the Company that might result from any breach by the Executive of 
the promises set forth in this Section 7 and the Confidentiality and 
Assignment Agreement, and that in any event money damages would be an 
inadequate remedy for any such breach. Accordingly, subject to Section 8 of 
this Agreement, the Executive agrees that if the Executive breaches, or 
proposes to breach, any portion of this Agreement and the Confidentiality and 
Assignment Agreement, the Company shall be entitled, in addition to all other 
remedies that it may have, to an injunction or other appropriate equitable 
relief to restrain any such breach without showing or proving any actual 
damage to the Company.
(f)
Protected Reporting; Defend Trade Secrets Act Immunity
. Nothing in this Agreement or the Confidentiality and Assignment Agreement, 
and nothing in any policy or procedure, in any other confidentiality, 
employment, separation agreement or in any other document or communication 
from the Company limits the Executives ability to file a charge or complaint 
with any government agency concerning any acts or omissions that the Executive 
may believe constitute a possible violation of federal or state law or making 
other disclosures that are protected under the whistleblower provisions of 
applicable federal or state law regulation or affects the Executives ability 
to communicate with any government agency or otherwise participate in any 
investigation or proceeding that may be conducted by a government agency, 
including by providing documents or other information, without notice to the 
Company. In addition, for the avoidance of doubt, pursuant to the federal 
Defend Trade Secrets Act of 2016, the Executive shall not be held criminally 
or civilly liable under any federal or state trade secret law for the 
disclosure of a trade secret that (i) is made (A) in confidence to a federal, 
state, or local government official, either directly or indirectly, or to an 
attorney; and (B) solely for the purpose of reporting or investigating a 
suspected violation of law; or (ii) is made in a complaint or other document 
filed in a lawsuit or other proceeding, if such filing is made under seal.
8.
Arbitration of Disputes
. Any controversy or claim arising out of or relating to this Agreement or the 
breach thereof or otherwise arising out of the Executives employment or the 
termination of that employment (including, without limitation, any claims of 
unlawful
                                                                                
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employment discrimination whether based on age or otherwise) shall, to the 
fullest extent permitted by law, be settled by arbitration in any forum and 
form agreed upon by the parties or, in the absence of such an agreement, under 
the auspices of the American Arbitration Association (
AAA
) in Boston, Massachusetts in accordance with the Employment Arbitration Rules 
of the AAA, including, but not limited to, the rules and procedures applicable 
to the selection of arbitrators. In the event that any person or entity other 
than the Executive or the Company may be a party with regard to any such 
controversy or claim, such controversy or claim shall be submitted to 
arbitration subject to such other person or entitys agreement. Judgment upon 
the award rendered by the arbitrator may be entered in any court having 
jurisdiction thereof. This Section 8 shall be specifically enforceable. 
Notwithstanding the foregoing, this Section 8 shall not preclude either party 
from pursuing a court action for the sole purpose of obtaining a temporary 
restraining order or a preliminary injunction in circumstances in which such 
relief is appropriate; provided that any other relief shall be pursued through 
an arbitration proceeding pursuant to this Section 8.
9.
Consent to Jurisdiction
. To the extent that any court action is permitted consistent with or to 
enforce Section 8 of this Agreement, the parties hereby agree that the 
Middlesex County Superior Court of The Commonwealth of Massachusetts shall 
have exclusive jurisdiction of such dispute, provided that the Company and the 
Executive agree that all civil actions related to Section 7(c) of this 
Agreement shall be brought in the county of Suffolk, Massachusetts and that 
the superior court or the business litigation session of the superior court 
shall have exclusive jurisdiction. Accordingly, with respect to any such court 
action, the Executive submits to the personal jurisdiction of such courts.
10.
Integration
. This Agreement and the Confidentiality and Assignment Agreement constitutes 
the entire agreement between the parties with respect to the subject matter 
hereof and supersedes all prior agreements, including the Prior Agreement, 
between the Parties concerning such subject matter.
11.
Withholding
. All payments made by the Company to the Executive under this Agreement shall 
be net of any tax or other amounts required to be withheld by the Company 
under applicable law.
12.
Successor to the Executive
. This Agreement shall inure to the benefit of and be enforceable by the 
Executives personal representatives, executors, administrators, heirs, 
distributees, devisees and legatees. In the event of the Executives death 
after Executives termination of employment but prior to the completion by the 
Company of all payments due Executive under this Agreement, the Company shall 
continue such payments to the Executives beneficiary designated in writing to 
the Company prior to Executives death (or to Executives estate, if the 
Executive fails to make such designation).
13.
Enforceability
. If any portion or provision of this Agreement (including, without 
limitation, any portion or provision of any section of this Agreement) shall 
to any extent be declared illegal or unenforceable by a court of competent 
jurisdiction, then the remainder of this Agreement, or the application of such 
portion or provision in circumstances other than those as to which it is so 
declared illegal or unenforceable, shall not be affected thereby, and each 
portion
                                                                                
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and provision of this Agreement shall be valid and enforceable to the fullest 
extent permitted by law.
14.
Survival
. The provisions of this Agreement and the Confidentiality and Assignment 
Agreement shall survive the termination of this Agreement and/or the 
termination of the Executives employment to the extent necessary to effectuate 
the terms contained herein.
15.
Waiver
. Except as otherwise provided in Section 7(c), no waiver of any provision 
hereof shall be effective unless made in writing and signed by the waiving 
party. The failure of any party to require the performance of any term or 
obligation of this Agreement, or the waiver by any party of any breach of this 
Agreement, shall not prevent any subsequent enforcement of such term or 
obligation or be deemed a waiver of any subsequent breach.
16.
Notices
. Any notices, requests, demands and other communications provided for by this 
Agreement shall be sufficient if in writing and delivered in person or sent by 
a nationally recognized overnight courier service or by registered or 
certified mail, postage prepaid, return receipt requested, to the Executive at 
the last address the Executive has filed in writing with the Company or, in 
the case of the Company, at its main offices, attention of the CEO and a copy 
of such notice shall be sent to CRISPR AG, Attention: General Counsel, at the 
main offices of CRISPR AG.
17.
Amendment
. This Agreement may be amended or modified only by a written instrument 
signed by the Executive and by a duly authorized representative of the Company.

18.
Governing Law
. This is a Massachusetts contract and shall be construed under and be 
governed in all respects by the laws of the Commonwealth of Massachusetts, 
without giving effect to the conflict of laws principles of such Commonwealth. 
With respect to any disputes concerning federal law, such disputes shall be 
determined in accordance with the law as it would be interpreted and applied 
by the United States Court of Appeals for the First Circuit.
19.
Counterparts
. This Agreement may be executed in any number of counterparts, each of which 
when so executed and delivered shall be taken to be an original; but such 
counterparts shall together constitute one and the same document.
20.
Assignment and Transfer by the Company
. The Company will have the right to assign and/or transfer this Agreement to 
its affiliates, successors and assigns. The Executive expressly consents to be 
bound by the provisions of this Agreement for the benefit of the Company or 
any parent, subsidiary or affiliate to whose employ the Executive may be 
transferred without the necessity that this Agreement be re-signed at the time 
of such transfer.
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IN WITNESS WHEREOF, the parties have executed this Agreement effective on the 
date and year first above written.
CRISPR THERAPEUTICS, INC.
By:
/s/ Megan Menner
Megan Menner
Head of Human Resources

EXECUTIVE
/s/ Julianne Bruno
                                 Julianne Bruno                                 
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
                                                                                
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                                   EXHIBIT A                                    
                                                                                
                    Confidentiality and Assignment Agreement                    
                                                                                


                                                                                
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