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                         April 8, 2024

       A. Earnest Toth, Jr.
       Chief Financial Officer
       Aquestive Therapeutics, Inc.
       30 Technology Drive
       Warren, NJ 07059

                                                        Re: Aquestive 
Therapeutics, Inc.
                                                            Registration 
Statement on Form S-3
                                                            File No. 333-278498
                                                            Filed April 3, 2024

       Dear A. Earnest Toth:

              This is to advise you that we have not reviewed and will not 
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for 
acceleration. We remind you
       that the company and its management are responsible for the accuracy and 
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of 
action by the staff.

                                                        Please contact Tamika 
Sheppard at 202-551-8346 with any questions.



                                                                                
                         Sincerely,

                                                                                
                         Division of Corporation Finance
                                                                                
                         Office of Life Sciences
       cc:                                              Anna Tomcyzk