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                          March 22, 2024

       Todd Harris, Ph.D.
       Chief Executive Officer
       Tyra Biosciences, Inc.
       2656 State Street
       Carlsbad, CA 92008

                                                        Re: Tyra Biosciences, 
Inc.
                                                            Registration 
Statement on Form S-3
                                                            Filed March 19, 
2024
                                                            File No. 333-278068

       Dear Todd Harris:

              This is to advise you that we have not reviewed and will not 
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for 
acceleration. We remind you
       that the company and its management are responsible for the accuracy and 
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of 
action by the staff.

                                                        Please contact Jason 
Drory at 202-551-8342 with any questions.



                                                                                
                          Sincerely,

                                                                                
                          Division of Corporation Finance
                                                                                
                          Office of Life Sciences
       cc:                                              Cheston Larson