UNITED STATES
                                        SECURITIES AND EXCHANGE COMMISSION
                                              Washington, D.C. 20549
                                              NOTICE OF EFFECTIVENESS


          Effective Date:     2024-05-17  4:30 P.M.
          Form:               S-3
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          CIK:                     0001357459
          Company Name:            PALISADE BIO, INC.
          File Number:             333-279222