FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Artal International S.C.A.
  2. Issuer Name and Ticker or Trading Symbol
LEXICON PHARMACEUTICALS, INC. [LXRX]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
VALLEY PARK, 44, RUE DE LA VALLEE
3. Date of Earliest Transaction (Month/Day/Year)
05/10/2024
(Street)

LUXEMBOURG, N4 L-2661
4. If Amendment, Date Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 05/10/2024   M(1)   57,546,100 A (1) 136,180,481 I See Footnotes (2) (5) (6)
Common Stock               3,516,214 I See Footnotes (3) (5) (6)
Common Stock               35,402,689 I See Footnotes (4) (5) (6)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Series A Convertible Preferred Stock (1) 05/10/2024   A(1)   1,150,922     (1)   (1) Common Stock 57,546,100 $ 108.5 (1) 1,150,922 I See Footnotes (2) (5) (6)
Series A Convertible Preferred Stock (1) 05/10/2024   M(1)     1,150,922   (1)   (1) Common Stock 57,546,100 $ 0 0 I See Footnotes (2) (5) (6)

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Artal International S.C.A.
VALLEY PARK, 44, RUE DE LA VALLEE
LUXEMBOURG, N4 L-2661
  X   X    
Wittouck Amaury
VALLEY PARK, 44, RUE DE LA VALLEE
LUXEMBOURG, N4 L-2661
  X   X    
Artal International Management S.A.
VALLEY PARK, 44, RUE DE LA VALLEE
LUXEMBOURG, N4 L-2661
  X   X    
Artal Group S.A.
VALLEY PARK, 44, RUE DE LA VALLEE
LUXEMBOURG, N4 L-2661
  X   X    
Westend S.A.
VALLEY PARK, 44, RUE DE LA VALLEE
LUXEMBOURG, N4 L-2661
  X   X    
Stichting Administratiekantoor Westend
CLAUDE DEBUSSYLAAN 46
AMSTERDAM, P7 1082 MD
  X   X    
Invus Public Equities, L.P.
750 LEXINGTON AVENUE, 30TH FLOOR
NEW YORK, NY 10022
  X   X    
Invus, L.P.
750 LEXINGTON AVENUE, 30TH FLOOR
NEW YORK, NY 10022
  X   X    
Invus Public Equities Advisors, LLC
750 LEXINGTON AVENUE, 30TH FLOOR
NEW YORK, NY 10022
  X   X    
Invus Advisors, L.L.C.
750 LEXINGTON AVENUE, 30TH FLOOR
NEW YORK, NY 10022
  X   X    

Signatures

 ARTAL INTERNATIONAL S.C.A., By: Artal International Management S.A., its managing partner, By: /s/ Pierre Claudel, Name: Pierre Claudel, Title: Managing Director   05/14/2024
**Signature of Reporting Person Date

 ARTAL INTERNATIONAL MANAGEMENT S.A., By: /s/ Pierre Claudel, Name: Pierre Claudel, Title: Managing Director   05/14/2024
**Signature of Reporting Person Date

 ARTAL GROUP S.A., By: /s/ Anne Goffard, Name: Anne Goffard, Title: Authorized Person   05/14/2024
**Signature of Reporting Person Date

 WESTEND S.A., By: /s/ Pierre Claudel, Name: Pierre Claudel, Title: Managing Director   05/14/2024
**Signature of Reporting Person Date

 STICHTING ADMINISTRATIEKANTOOR WESTEND, By: /s/ Amaury Wittouck, Name: Amaury Wittouck, Title: Sole Member of the Board   05/14/2024
**Signature of Reporting Person Date

 AMAURY WITTOUCK, By: /s/ Amaury Wittouck   05/14/2024
**Signature of Reporting Person Date

 INVUS L.P., By: Invus Advisors L.L.C., its general partner, By: /s/ Philip Bafundo, Name: Philip Bafundo, Title: Chief Financial Officer   05/14/2024
**Signature of Reporting Person Date

 Invus Public Equities, L.P., By: Invus Public Equities Advisors, LLC, its general partner, By: /s/ Philip Bafundo, Name: Philip Bafundo, Title: Chief Financial Officer   05/14/2024
**Signature of Reporting Person Date

 Invus Advisors L.L.C., By: /s/ Philip Bafundo, Name: Philip Bafundo, Title: Chief Financial Officer   05/14/2024
**Signature of Reporting Person Date

 Invus Public Equities Advisors, LLC., By: /s/ Philip Bafundo, Name: Philip Bafundo, Title: Chief Financial Officer   05/14/2024
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) On March 13, 2024, Artal International S.C.A. acquired 1,150,922 shares of Series A convertible preferred stock, $0.01 par value per share (the "Preferred Stock") of the Issuer at a price of $108.50 per share. Each share of Preferred Stock would automatically convert into 50 shares of the Issuer's common stock, par value $0.001 per share (the "Common Stock") upon receipt of shareholder approval and the satisfaction of certain other conditions (the "Conditions"); however, absent the satisfaction of such conditions, the shares were not convertible and as such, the Preferred Stock was originally reported on Table I. On May 10, 2024, all Conditions were met, and the 1,150,922 shares of Preferred Stock became derivative securities and automatically converted into 57,546,100 shares of Issuer Common Stock.
(2) These securities are directly held by Artal International S.C.A.
(3) These securities are directly held by Invus Public Equities, L.P.
(4) These securities are directly held by Invus, L.P.
(5) Invus Public Equities Advisors, LLC is the general partner of Invus Public Equities, L.P., and Invus Advisors, L.L.C. is the general partner of Invus, L.P. The Geneva branch of Artal International S.C.A. is the managing member of Invus Public Equities Advisors, LLC. Artal International S.C.A. is the managing member of Invus Advisors, L.L.C. The managing partner of Artal International S.C.A. is Artal International Management S.A. The sole stockholder of Artal International Management S.A. is Artal Group S.A. The parent company of Artal Group S.A. is Westend S.A. The majority stockholder of Westend S.A. is Stichting Administratiekantoor Westend (the "Stichting"). Mr. Amaury Wittouck is the sole member of the board of the Stichting.
(6) Each of the Reporting Persons (other than to the extent it directly holds securities reported herein) disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such Reporting Person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), each of the Reporting Persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.
 
Remarks:
Invus US Partners LLC directly holds 5,451,204 shares of Common Stock, which securities are reported on a separate Form 4. For purposes of Section 16 of the Exchange Act, the Reporting Persons may be deemed to be directors by deputization of the Issuer by virtue of Invus, L.P.'s right to designate certain members of the Issuer's board of directors pursuant to a stockholders' agreement between the Issuer and Invus, L.P.

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