Table of Contents


                                 UNITED STATES                                  
                       SECURITIES AND EXCHANGE COMMISSION                       
                             Washington, D.C. 20549                             


                            SCHEDULE 14AINFORMATION                             
Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934
                                (Amendment No.)                                 


Filed by theRegistrant
Filed by a Party other than the Registrant
Check the appropriate box:


 Preliminary Proxy Statement



 Confidential, for Use of the Commission Only (as permitted by Rule
 14a-6(e)(2))                                                      



 Definitive Proxy Statement



 Definitive Additional Materials



 Soliciting Material Pursuant to (s)
 240.14a-12                         

                                 XBiotech Inc.                                  
                (Name of Registrant as Specified In Its Charter)                
Payment of Filing Fee (Check the appropriate box)


 No fee required.



 Fee paid previously with preliminary materials.



 Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a6(i)(1) and
 0-11.                                                                                        





-------------------------------------------------------------------------------

Table of Contents

                                 XBiotech Inc.                                  
                              5217 Winnebago Lane                               
                              Austin, Texas 78744                               
                    NOTICE OF ANNUAL MEETING OF SHAREHOLDERS                    
                          To Be Held on June 20, 2024                           
DearShareholder:
You are cordially invited to attend the 2024 Annual Meeting of Shareholders 
(the "Meeting") of XBiotech Inc., aBritish Colombia corporation (the 
"Company"). The meeting will be held on Thursday, June 20, 2024 at 10:00 a.m. 
central time in a virtual meeting format only, via the Internet, with no
physical in-person meeting,
for the following purposes:


 1. To elect the five (5) nominees for director named herein to serve until the
    next annual meeting andtheir successors are duly elected and qualified.    



 2. To ratify the selection by the Audit Committee of the Board of Directors of Whitley Penn LLP as              
    theindependent registered public accounting firm of the Company for its fiscal year ending December 31, 2024.



 3. To approve, on an advisory basis, the compensation of the Company's named executive officers.



 4. To conduct any other business properly brought before the meeting.

These items of business are more fully described in the Proxy Statement 
accompanying this notice.
To participate in the Annual Meeting virtually via the Internet, please visit 
www.proxydocs.com/xbit. In order to attend, you must register inadvance at 
www.proxydocs.com/xbit prior to the deadline of June 19, 2024 at 5:00 p.m. 
central time. Upon completing your registration, you will receive further 
instructions via email, including your unique links that will allow you access 
tothe meeting. You will not be able to attend the Annual Meeting in person.
Our Board unanimously recommends that you vote "For"the election of all five 
nominees for director, "For" ratification of the selection by the Audit 
Committee of the Board of Whitley Penn LLP as the independent registered 
public accounting firm of the Company for its fiscal year endingDecember 31, 
2024, and "For" approval of the compensation of the Company's executive 
officers.
The record date forthe annual meeting is April 22, 2024. Only shareholders of 
record at the close of business on that date may vote at the meeting or any 
adjournment thereof. Your vote is very important. We urge you to access and 
review the proxy materials beforevoting and vote as soon as possible, whether 
or not you plan to attend the Meeting. This Notice is not a form for voting 
and presents only an overview of the more complete proxy materials, which 
contain important information

-------------------------------------------------------------------------------

Table of Contents
and are available on the Internet or by mail. We intend to mail a Notice of 
Annual Meeting of Shareholders (the "Notice"), proxy materials and our 2023 
Annual Report (which includes our2023 Annual Report on Form
10-K),
how to vote, and how to obtain a paper copy of the proxy materials. We expect 
our 2023 Annual Report and proxy materials to be available on or about May 1, 
2024. You willneed the control number printed on your Notice, proxy card or 
voting instruction card in order to vote and you will not otherwise receive a 
paper or email copy. A list of shareholders of record will be available during 
the Meeting for inspection byshareholders for any legally valid purpose 
relating to the Meeting.

Important Notice Regarding the Availability of Proxy Materials for the 
Shareholders' Meeting to Be Held onJune 20, 2024 at 10:00 a.m. central time 
virtually at www.proxydocs.com/xbit:
This Notice, the proxystatement and annual report to shareholders are 
available at www.proxydocs.com/xbit.


                                  
                                  
By Order of the Board of Directors
                                  
John Simard                       
President, CEO and Chairman       

Austin, Texas
May 1,2024

-------------------------------------------------------------------------------

Table of Contents
                               Table of Contents                                


                                                                                           
NOTICE OF ANNUAL MEETING OF SHAREHOLDERS                                                 1 
                                                                                           
SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS ANDMANAGEMENT                            7 
                                                                                           
PROPOSAL 1                                                                               2 
                                                                                           
ELECTION OF DIRECTORS                                                                    2 
                                                                                           
PROPOSAL 2                                                                              12 
                                                                                           
RATIFICATION OF SELECTION OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM              12 
                                                                                           
PROPOSAL 3                                                                              14 
                                                                                           
ADVISORY VOTE ON THE EXECUTIVE COMPENSATION OF THE COMPANY'S NAMED EXECUTIVE OFFICERS   14 
                                                                                           
EXECUTIVE OFFICERS                                                                      16 
                                                                                           
EXECUTIVE COMPENSATION                                                                  16 
                                                                                           
Equity Compensation Plans and Other Benefits Plans                                      20 
                                                                                           
DIRECTOR COMPENSATION                                                                   29 
                                                                                           
OTHER MATTERS                                                                           32 


-------------------------------------------------------------------------------

Table of Contents
                                PROXY STATEMENT                                 
                  FOR THE 2024 ANNUAL MEETING OF SHAREHOLDERS                   
                          To be held on June 20, 2024                           
QUESTIONS AND ANSWERS ABOUT THESE PROXY MATERIALS AND VOTING
Why did I receive a notice regarding the availability of proxy materials on 
the internet, rather than a full set of proxy materials?
Pursuant to rules adopted by the Securities and Exchange Commission (the 
"SEC"), we have elected to provide access to ourproxy materials over the 
internet rather than mailing printed copies of those materials. Accordingly, 
we have sent you a Notice of Internet Availability of Proxy Materials (a 
"Notice") because the Board of Directors (sometimes referred toas the "Board") 
of XBiotech Inc. (sometimes referred to as "we," "us," the "Company" or 
"XBiotech") is soliciting your proxy to vote at our 2023 Annual Meeting of 
Shareholders, including at anyadjournments or postponements of the meeting. 
All shareholders will have the ability to access the proxy materials on the 
website referred to in the Notice or request to receive a printed set of the 
proxy materials. Instructions on how to access theproxy materials over the 
internet or to request a printed copy may be found in the Notice. The Notice 
was first mailed to our Shareholders of record entitled to vote at the annual 
meeting on or about May 8, 2024.
                      How do I attend the annual meeting?                       
The meeting will be held on Thursday, June 20, 2024 at 10:00 a.m. central time 
virtually at www.proxydocs.com/xbit. In order toattend, you must register in 
advance at www.proxydocs.com/xbit prior to the deadline of June 19, 2024 at 
5:00 p.m. central time. Upon completing your registration, you will receive 
further instructions via email, including your unique linksthat will allow you 
access to the meeting.
Who can vote at the annual meeting?
Only shareholders of record at the close of business on April 22, 2024 will be 
entitled to vote at the annual meeting. On this recorddate, there were 
30,455,031 shares of common stock outstanding and entitled to vote.
Shareholders of Record: Shares Registered in YourName
If on April 22, 2024 your shares were registered directly in your name with 
the Company's transfer agent, EquinitiTrust Company, then you are a 
shareholder of record. As a shareholder of record, you may vote virtually at 
www.proxydocs.com/xbit at the meeting or vote by proxy. Whether or not you 
plan to attend the meeting, we urge you to vote by proxy to ensureyour vote is 
counted.
Beneficial Owner: Shares Registered in the Name of a Broker or Bank
If on April 22, 2024 your shares were not held in your name, but rather in an 
account at a brokerage firm, bank, dealer or other similarorganization, then 
you are the beneficial owner of shares held in "street name" and will have 
received a Notice from that organization. The organization holding your 
account is considered to be the shareholder of record for purposes ofvoting at 
the annual meeting. As a beneficial owner, you have the right to direct your 
broker or other agent regarding how to vote the shares in your account. You 
are also invited to attend the annual meeting. However, since you are not 
theshareholder of record, you may not vote your shares through the internet at 
the meeting unless you request and obtain a valid proxy from your broker or 
other agent.

                                       1                                        

-------------------------------------------------------------------------------

Table of Contents
What am I voting on?
There are four matters scheduled for a vote:


 .  Election of the five (5) nominees for director named herein for a
    one-year                                                         
    term;                                                            



 .  Ratification of the selection by the Audit Committee of the Board of Directors of Whitley Penn LLP as            
    theindependent registered public accounting firm of the Company for its fiscal year ending December 31, 2024; and



 .  Approval, on an advisory basis, of the compensation of the Company's named executive officers for fiscalyear 2023.

What if another matter is properly brought before the meeting?
The Board of Directors knows of no other matters that will be presented for 
consideration at the annual meeting. If any other matters areproperly brought 
before the meeting, it is the intention of the persons named in the proxy to 
vote on those matters in accordance with their best judgment.
How do I vote?
For Proposal 1, you may eithervote "For" all the nominees to the Board of 
Directors or you may "Withhold" your vote for any nominee you specify. For 
each of Proposals 2 and 3, you may vote "For" or "Against" or abstain from 
voting. OurBoard unanimously recommends that you vote "For" the election of 
all five nominees for director, "For" ratification of the selection by the 
Audit Committee of the Board of Whitley Penn LLP as the independent registered 
publicaccounting firm of the Company for its fiscal year ending December 31, 
2024, and "For" approval of the compensation of the Company's executive 
officers.
The procedures for voting are fairly simple:
Shareholders of Record: Shares Registered in Your Name
If you are a shareholder of record, you may vote in person at the annual 
meeting, by proxy over the telephone, by proxy through the internet,or by 
proxy using a proxy card that you may request. Whether or not you plan to 
attend the meeting, we urge you to vote by proxy to ensure your vote is 
counted. You may still attend the meeting and vote through the internet even 
if you have alreadyvoted by proxy.


 .  To vote using a proxy card that may be delivered to you at a later time,
    simply complete, sign and date the proxycard and return it promptly     
    in the envelope provided. If you return your signed proxy card to us    
    before the annual meeting, we will vote your shares as you direct.      



 .  To vote over the                                                                                              
    telephone, dial toll-free                                                                                     
    1-866-243-5061                                                                                                
    using a touch-tone phone and follow the recorded instructions. You will be asked to provide the company number
    and control number from the Notice. Your vote must be received by the startof the meeting to be counted.      


                                       2                                        

-------------------------------------------------------------------------------

Table of Contents

 .  To vote through the internet, go to www.proxydocs.com/xbit to complete an electronic proxy card. You will beasked to
    provide the control number from the Notice. Your vote must be received by the start of the meeting to be counted.   

Beneficial Owners: Shares Registered in the Name of Broker or Bank
If you are a beneficial owner of shares registered in the name of your broker, 
bank or other agent, you should have received a Notice containing 
votinginstructions from that organization rather than from XBiotech. Simply 
follow the instructions in the Notice to ensure that your vote is counted. To 
vote during the meeting, you must submit a valid legal proxy via email to 
dsmsupport@betanxt.com withthe subject line "Legal Proxy" by 5:00 p.m., 
Central Time, on June 15, 2024, and must also register to attend the Annual 
Meeting, as described above. If you have a valid legal proxy, you may submit 
your vote via the Internet or bytelephone, as instructed by your broker, bank, 
or other agent, at any time prior to the closing of the polls during the 
Annual Meeting.
How many votes doI have?
On each matter to be voted upon, you have one vote for each share of common 
stock you own as of April 22, 2024, with noshares having cumulative voting 
rights.
What happens if I do not vote?
Shareholders of Record: Shares Registered in Your Name
If you are a shareholder of record and do not vote by completing a proxy card, 
by telephone, or through the internet at the annual meeting,your shares will 
not be voted.
Beneficial Owners: Shares Registered in the Name of Broker or Bank
If you are a beneficial owner and do not instruct your broker, bank or other 
agent how to vote your shares, the question of whether your brokeror nominee 
will still be able to vote your shares depends on whether the particular 
proposal is considered to be a routine matter under applicable rules. Brokers 
and nominees can use their discretion to vote uninstructed shares with respect 
tomatters that are considered to be routine under applicable rules, but not 
with respect to
non-routine
matters. Under applicable rules and interpretations,
non-routine
matters are matters that may substantially affect the rights or privileges of 
shareholders, such as mergers, shareholder proposals, elections of directors 
(even if not contested), executive compensation and certain corporate 
governance proposals,even if management-supported. Routine matters, on which a 
broker or other nominee is generally empowered to vote, include ratification 
of the appointment of an independent registered public accounting firm. 
Accordingly, your broker or nominee maynot vote your shares on Proposals 1 and 
3 without your instructions, but may vote your shares on Proposal 2.
What if I return a proxy card or otherwisevote but do not make specific choices?
If you return a signed and dated proxy card or otherwise vote without marking 
voting selections,your shares will be voted, as applicable, "For" the election 
of all five nominees for director, "For" ratification of the selection by the 
Audit Committee of the Board of Whitley Penn LLP as the independent registered 
publicaccounting firm of the Company for its fiscal year ending December 31, 
2024, and "For" approval on advisory basis of the compensation of the 
Company's executive officers. If any other matter is properly presented at the 
meeting,your proxyholder (one of the individuals named on your proxy card) 
will vote your shares using his or her best judgment.

                                       3                                        

-------------------------------------------------------------------------------

Table of Contents
Who is paying for this proxy solicitation?
The Company anticipates first mailing definitive copies of this proxy 
statement on or about May 8, 2024. We are asking for your proxy andwill pay 
all of the costs associated with asking for shareholders' proxies for the 2024 
Annual Meeting. In addition to the use of the mail, proxies may be solicited 
by the Directors, officers and employees of XBiotech by personal interview,telep
hone or otherwise. Directors, officers and employees will not be additionally 
compensated, but may be reimbursed for
out-of-pocket
expenses in connection withsolicitation. Arrangements also will be made with 
brokerage houses and other custodians, nominees and fiduciaries for the 
forwarding of solicitation material to beneficial owners holding our shares in 
street name, and we will reimburse custodians,nominees and fiduciaries for 
reasonable
out-of-pocket
expenses in connection with the forwarding of solicitation material.
What does it mean if I receive more than one set of proxy materials?
If you receive more than one set of proxy materials, your shares may be 
registered in more than one name or in different accounts. Pleasefollow the 
voting instructions on each of the proxy cards in the proxy materials to 
ensure that all of your shares are voted.
Can I change my vote aftersubmitting my proxy?
Yes. You can revoke your proxy at any time before the final vote at the meeting.
Shareholders of Record: Shares Registered in Your Name
If you are the record holder of your shares, you may revoke your proxy in any 
one of the following ways:


 .  You may submit a properly completed proxy card with a later date.



 .  You may grant a subsequent proxy by telephone or through the internet.



 .  You may send a timely written notice that you are revoking your proxy
    to XBiotech's Secretary at 5217Winnebago Lane, Austin, TX 78744.     

Your most current proxy card or telephone or internet proxy is the one that 
iscounted.
Beneficial Owners: Shares Registered in the Name of Broker or Bank
If your shares are held by your broker or bank as a nominee or agent, you 
should follow the instructions provided by your broker or bank inorder to 
change your vote.
When are shareholder proposals and director nominations due for next year's 
annual meeting?
To be considered for inclusion in the Company's proxy materials for next 
year's annual meeting of shareholders, your proposal must bedelivered in 
writing by December 30, 2024, to the attention of the Secretary of XBiotech 
Inc. at 5217 Winnebago Lane, Austin, TX 78744. The deadline after which date 
the notice of a shareholder proposal submitted is considered untimely isMarch 
24, 2025. The deadline for submitting nominees for inclusion in the Company's 
proxy statement and form of proxy pursuant to

                                       4                                        

-------------------------------------------------------------------------------

Table of Contents
the Company's governing documents as they relate to the inclusion of 
shareholder director nominees in the Company's proxy materials for the 
Company's next annual meeting of theshareholders to be held in 2025 is April 
22, 2025; provided, however, that if the annual meeting is to be held on a 
date that is less than 50 days after the date on which the first public 
announcement of the date of the annual meeting was made,notice may be made not 
later than the close of business on the 10th day following such public 
announcement. If you wish to submit a solicitation of proxies in support of 
director nominees other than the Company's nominees pursuant to Rule
14a-19
for the Company's next annual meeting, notice to us must be made no later than 
March 24, 2025. Any dissenting shareholder should comply with the additional 
requirements of a proper notice under Rule
14a-19,
which includes the statement that a dissident using the universal proxy rule 
intends to solicit 67% of the outstanding voting shares entitled to vote on 
the election of directors. You are also advisedto review the Company's 
Articles, which contain additional requirements about advance notice of 
shareholder proposals and director nominations.
Howare votes counted?
Votes will be counted by the inspector of election appointed for the meeting, 
who will separately count, for theproposal to elect directors, votes "For" and 
"Withhold" ; and for the proposal to ratify the Audit Committee's selection of 
Whitley Penn LLP as our independent public accounting firm, votes 
"For""Against," broker
non-votes
and abstentions. Abstentions and broker
non-votes
will be counted towards the vote totals for Proposal 2 and will have the 
sameeffect as "Against" votes. Abstentions will have the same effect as 
"Against" on the outcome of Proposals 3. Broker
non-votes
have no effect and will not be counted towards the vote totalfor Proposals 1 
and 3.
What are "broker
non-votes"?
As discussed above, when a beneficial owner of shares held in "street name" 
does not give instructions to the broker or nomineeholding the shares as to 
how to vote on matters deemed to be
non-routine
under applicable rules, the broker or nominee may not vote the shares. These 
unvoted shares are counted as "broker
non-votes."
Proposals 1 and 3 are considered
non-routine,
so a broker or nominee holding shares may not vote those shares on those 
proposals without specific instructionsfrom the beneficial owner. Proposal 2, 
the proposal to ratify our independent public accounting firm is considered 
routine.
How many votes are needed toapprove each proposal?


 .  For Proposal 1, the election of directors, the five nominees receiving more  
    "For" votes than"Withhold" votes from the holders of shares present in person
    or represented by proxy and entitled to vote on the election of directors    
    will be elected. Only votes "For" or "Withhold" will affect the outcome.     



 .  To be approved, Proposal 2 ratifying the selection by the Audit Committee of the Board of Directors of WhitleyPenn       
    LLP as the independent registered public accounting firm of the Company for its fiscal year ending December 31, 2024     
    must receive "For" votes from the holders of a majority of shares present and entitled to vote either in personor        
    represented by proxy. If you mark your proxy to "Abstain" from voting, it will have the same effect as an "Against" vote.


                                       5                                        

-------------------------------------------------------------------------------

Table of Contents

 .  To be approved, Proposal 3, the advisory approval of the Company's executive         
    compensation must receive"For" votes from the holders of a majority of shares present
    and entitled to vote either in person or represented by proxy. If you mark your      
    proxy to "Abstain" from voting, it will have the same effect as an "Against"vote.    

What is the quorum requirement?
A quorum of shareholders is necessary to hold a valid meeting. A quorum will 
be present if shareholders holding at least
one-third
of the outstanding shares entitled to vote are present at the meeting in 
person or represented by proxy. On the record date, there were 30,455,031 
shares outstanding and entitled to vote. Thus, the holdersof 10,151,677 shares 
must be present in person or represented by proxy at the meeting to have a 
quorum.
Your shares will be countedtowards the quorum only if you submit a valid proxy 
(or one is submitted on your behalf by your broker, bank or other nominee) or 
if you vote through the internet at the meeting. Abstentions and broker
non-votes
will be counted towards the quorum requirement. If there is no quorum, the 
holders of a majority of shares present at the meeting in person or 
represented by proxy may adjourn the meeting to anotherdate.
How can I find out the results of the voting at the annual meeting?
Preliminary voting results will be announced at the annual meeting. In 
addition, final voting results will be published in a current report onForm

8-K
that we expect to file within four business days after the annual meeting. If 
final voting results are not available to us in time to file a Form
8-K
withinfour business days after the meeting, we intend to file a Form
8-K
to publish preliminary results and, within four business days after the final 
results are known to us, file an additional Form
8-K
to publish the final results.
What proxy materials are available on the internet?
The proxy statement, Form
10-K
and annual report to shareholders are available atwww.proxydocs.com/xbit.

                                       6                                        

-------------------------------------------------------------------------------

Table of Contents
Householding of Proxy Materials
The SEC has adopted rules that permit companies and intermediaries (e.g., 
brokers) to satisfy the delivery requirements forNotices of Internet 
Availability of Proxy Materials or other annual meeting materials with respect 
to two or more shareholders sharing the same address by delivering a single 
set of Notice of Internet Availability of Proxy Materials or other 
annualmeeting materials to those shareholders. This process, which is commonly 
referred to as "householding," potentially means extra convenience for 
shareholders and cost savings for companies.
This year, a number of brokers with account holders who are XBiotech Inc. 
shareholders will be "householding" theCompany's proxy materials. A single 
Notice will be delivered to multiple shareholders sharing an address unless 
contrary instructions have been received from the affected shareholders. Once 
you have received notice from your broker that theywill be "householding" 
communications to your address, "householding" will continue until you are 
notified otherwise or until you revoke your consent. If, at any time, you no 
longer wish to participate in "householding"and would prefer to receive a 
separate Notice or set of annual meeting materials, please notify your broker 
or XBiotech Inc. Direct your written request to XBiotech Inc., Attn: Corporate 
Relations, 5217 Winnebago Lane, Austin, TX 78744, or contactour Director of 
Corporate Relations at XBiotech Inc. by telephone at (512)
386-2930.
shareholders who currently receive multiple Notices at their addresses and 
would like to request "householding" oftheir communications should contact 
their brokers.
         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS ANDMANAGEMENT          
The following table sets forth certain information regarding the ownership of 
the Company's commonstock as of April 1, 2024 by (i) each of our directors; 
(ii) each of our Named Executive Officers as defined below under the heading 
"Executive Compensation"; (iii) each person known by us to beneficially own 
more than 5% ofour outstanding common stock and (iv) all of our current 
executive officers and directors as a group.
Beneficialownership is determined in accordance with the rules of the SEC and 
includes voting and investment power with respect to the securities. This 
table is based upon information supplied by officers, directors and principal 
shareholders and Schedules13D and 13G filed with the SEC. Except as indicated 
by footnote, and subject to applicable community property laws, we believe the 
persons named in the table have sole voting and investment power with respect 
to all shares of common stock shown asbeneficially owned by them. The number 
of shares of common stock used to calculate the percentage ownership of each 
listed person includes the shares of common stock underlying options held by 
such persons that are exercisable as of May 30,2024, which is 60 days after 
April 1, 2024.

                                       7                                        

-------------------------------------------------------------------------------

Table of Contents
Percentage of beneficial ownership is based on 30,450,881 shares of common 
stock outstanding as ofApril 1, 2024.


                                                                                           
Beneficial Owner                                                    Number of     Percent  
                                                                     Shares         of     
                                                                                  Total    
Name and address of Greater than 5% Shareholders                                           
Thomas Gut                                                           3,914,111       12.9 %
(1)                                                                                        
Lindenberg Family Office Ltd.                                                              
Laternengasse 5                                                                            
8001 Zurich, Switzerland                                                                   
Named Executive Officers and Directors                                                     
(2)                                                                                        
John Simard                                                          6,615,375       19.9 %
(3)                                                                                        
Jan-Paul                                                               350,243        1.1 %
Waldin                                                                                     
W. Thorpe McKenzie                                                   2,971,259        9.7 %
(4)                                                                                        
Donald MacAdam                                                         150,000          *  
Peter Libby                                                            112,500          *  
Sushma Shivaswamy                                                      495,000        1.6 %
Angela Hu                                                               70,000          *  
All named executive officers and directors as a group (7 persons)   10,764,377       33.1 %
(5)                                                                                        



* Less than one percent.


(1) Based on information set forth in a Form13/G filed with the SEC on February 7, 2024.


(2) These figures include shares of common stock underlying stock options held by 
    our Chief Executive Officer anddirectors that are immediately exercisable or  
    scheduled to become immediately exercisable within 60 days of April 1, 2024.  
    Underlying stock options include the following amounts: John Simard - 870,381;
    Jan-Paul                                                                      
    Waldin                                                                        
    - 150,000; Thorpe                                                             
    McKenzie-                                                                     
    267,500; Donald MacAdam                                                       
    -140,000;                                                                     
    Peter Libby--87,500; Sushma                                                   
    Shivaswamy--495,000 and Angela Hu--44,500.                                    


(3) Includes 1,921,828 shares of common stock issuable upon conversion 
    of a convertible loan provided byMr. Simard to the Issuer under    
    a convertible loan agreement between Mr. Simard and the Issuer     
    dated January 3, 2024 (the "Loan Agreement"). At Mr. Simard's      
    election, the balance may be converted to the common stockat any   
    time the loan balance is outstanding at a fixed conversion price   
    equal to the average Nasdaq Official Closing Price of the common   
    stock (as reflected on Nasdaq.com) for the five trading days       
    immediately preceding the signing of the LoanAgreement, which was  
    $4.048 per share, subject to a 19.9% cap limiting the number of    
    shares that could be converted under the Loan Agreement based on   
    Mr. Simard's total stock ownership in the Company at the time of   
    conversion. This amountof 1,921,828 shares is calculated based     
    on the formula to cap Mr. Simard's total stock ownership in the    
    Company not to exceed 19.9% of the Company's issued and outstanding
    common stock on the date such loan conversion is consummated.      


(4) Includes 66,748 shares held by the McKenzie Foundation, 31,864 shares held by Mr. 
    McKenzie's spouseand 7,676 shares held in a Trust for Mr. McKenzie's stepchildren.


(5) Includes 2,054,881 shares of common stock underlying stock options held by our    
    executive officers and directors(7 persons total) that are immediately exercisable
    or are scheduled to become exercisable within 60 days of April 1, 2024 and        
    1,921,828 shares of common stock issuable to Mr. Simard upon the Loan Agreement.  


                                       1                                        

-------------------------------------------------------------------------------

Table of Contents
                                   PROPOSAL 1                                   
                             ELECTION OF DIRECTORS                              
Our Board of Directors currently consists of five directors. There are five 
nominees for director, which consist of allincumbent directors. Proxies may 
not be voted for a greater number of persons than the number of nominees named 
in this proxy statement. Each director to be elected and qualified will hold 
office until the next annual meeting of shareholders anduntil his or her 
successor is elected, or, if sooner, until the director's death, resignation 
or removal. All of the nominees listed below are currently directors of the 
Company. Notwithstanding the foregoing, directors are elected by aplurality of 
the votes of the holders of shares present in person or represented by proxy 
and entitled to vote on the election of directors if the number of eligible 
nominees standing for election at any meeting of the shareholders exceeds 
thenumber of directors to be elected. The five nominees receiving the highest 
number of affirmative votes will be elected.
The Company invites and encourages all directors and nominees for director to 
attend the annual meeting of shareholders. All ofthe Company's directors at 
the time of the 2023 Annual General Meeting were in attendance either in 
person or via teleconference.
Current Board andNominees
The Nominating and Corporate Governance Committee seeks to assemble a Board 
that, as a whole, possesses the appropriate balanceof professional and 
industry knowledge, financial expertise and high-level management experience 
necessary to oversee and direct the Company's business. To that end, the 
Nominating and Corporate Governance Committee has identified and evaluatednomine
es in the broader context of the Board's overall composition, with the goal of 
recruiting members who complement and strengthen the skills of other members 
and who also exhibit integrity, collegiality, sound business judgment and 
otherqualities that the Nominating and Corporate Governance Committee views as 
critical to effective functioning of the Board. The brief biographies below 
include information, as of the date of this proxy statement, regarding the 
specific and particularexperience, qualifications, attributes or skills of 
each director or nominee that led the Nominating and Corporate Governance 
Committee to conclude that the person should serve as a director as of the 
date of this proxy statement. However, each ofthe members of the Nominating 
and Corporate Governance Committee may have a variety of reasons why he 
believes a particular person would be an appropriate nominee or director for 
the Board, and these views may differ from the views of other members.


                                                                                 
Name                 Age               Position Held With the Company            
John Simard           62   Founder, President, Chief Executive Officer & Chairman
W. Thorpe McKenzie    76   Director                                              
Jan-Paul              75   Lead Director                                         
Waldin, Esq.                                                                     
Donald H. MacAdam     77   Director                                              
Peter Libby, M.D.     77   Director                                              

John Simard,
Chairman of the Board, founded XBiotech Inc. in 2005 and has served as 
itsPresident and Chief Executive Officer and Chairman of the Board since that 
time. Prior to XBiotech, he was founder and Chief Executive Officer of CTL 
ImmunoTherapies Corp., a developer of therapeutic vaccines to treat cancer and 
chronic infectiousdisease; he also founded AlleCure Corp., of Valencia, 
California, a developer of allergy treatments and immune modulating therapies. 
In 2001, AlleCure and CTL ImmunoTherapies merged to form MannKind Corp., where 
Mr. Simard served as CorporateVice President and a board member. Mr. Simard 
holds a degree in Biochemistry from the University of Saskatchewan and 
attended graduate studies in Medical Biophysics/Immunology at the University 
of Toronto. He has over 240 issued and pendingpatents related to cancer 
therapy, therapeutic vaccines and therapeutic antibodies, as well as a 
substantial number of peer-reviewed scientific publications and the textbook 
"Immune Response Genes."

                                       2                                        

-------------------------------------------------------------------------------

Table of Contents
Our Board of Directors believes that Mr. Simard's qualificationsto serve as a 
director include his extensive executive leadership experience, his role as 
founder of the company, his many years of service on our Board of Directors 
and as our Chief Executive Officer, and extensive knowledge of our company 
andindustry.
Donald H. MacAdam
has served on our Board of Directors since March 2018. Mr. MacAdam is a 
technologyexecutive with extensive public and private company experience. He 
was formerly a director of Hammond Power Solutions (TSE:HPS.A), CEO of MBVax 
Bioscience, director of CTL Immunotherapies, CEO of Tm Bioscience (TSE), 
president of CRS Robotics (TSE),and CEO of L. A. Varah Ltd. (TSE). He is the 
inventor under several patents and the author of four books: Startup to IPO, 
Spontaneous Regression Cancer and the Immune System, The Resonance Model, and 
The Reinvention of Coley'sToxins.
Mr. MacAdam was selected to serve on our Board of Directors based on his 
extensive experience in thepharmaceutical industry and scientific knowledge. 
Mr. MacAdam brings to the board his core business and leadership skills as 
well as his public company director experience. Mr. MacAdam was elected to 
serve as Chairman of the CompensationCommittee.
W. Thorpe McKenzie
has served on our Board of Directors since February 2009. Mr. McKenzie served 
asManaging Director of Pointer Management Company, Chattanooga, Tennessee, 
since its inception in July 1990 until December 31, 2015, and as of January 1, 
2016, serves as its Senior Advisor. Mr. McKenzie
co-founded
Pointer Management Company in July 1990 to invest in hedge funds and similar 
types of partnerships utilizing a fund of funds approach. From August 1982 
until June 1990, he was a private investor inNew York City, and a director of 
several public and private companies. From May 1980 until July 1982, he was 
founding general partner at TIGER, a global hedge fund. From May 1971 until 
January 1980, he was a Vice President of Kidder,Peabody & Co., Inc. in New 
York. Mr. McKenzie is a graduate of the University of North Carolina in Chapel 
Hill and the Wharton Graduate division of the University of Pennsylvania in 
Philadelphia.
Mr. McKenzie was selected to serve on our Board of Directors based on his 
experience with corporate financings and hisrole as an investor in XBiotech. 
His extensive financial background qualifies him to serve as Chairman of our 
Audit Committee and as our "audit committee financial expert."
Jan-Paul
Waldin, Esq.
has served on our Board of Directors since February 2018and was appointed Lead 
Director in 2019. Mr. Waldin is a lawyer in Ontario, Canada and is a member of 
the Law Society of Upper Canada. He has been the principal of Waldin 
Barristers, a boutique civil litigation and advisory firm in Toronto,Canada, 
since January, 1981. Mr. Waldin practices trial and appellate advocacy 
principally in the area of complex corporate commercial litigation. He has 
acted as lead counsel in all levels of court in Ontario and Canada, including 
the SupremeCourt of Canada, the Federal Court of Canada, the Ontario Court of 
Appeal, the Ontario Superior Court of Justice and before Canadian federal and 
provincial administrative tribunals. Mr. Waldin's counsel and strategic advice 
is regularlysought by both publicly traded and closely held companies based in 
Canada, the European Union and the United States in connection with regulatory 
and administrative law matters, structuring shareholder relations and 
contentious corporatetransactions. He has held directorships in private and 
multinational companies, principally in the manufacturing, aviation and 
pharmaceutical industries. A graduate of the University of Toronto and Osgoode 
Hall Law School, Mr. Waldin was calledto the Ontario bar in 1976 and served 
his articles of clerkship under the late Mr. Justice Archie Campbell at the 
Policy Development Branch of the Ministry of the Attorney General for Ontario. 
He was Law Clerk to the Honourable Willard Z.Estey, then Chief Justice of the 
High Court of Justice of Ontario.

                                       3                                        

-------------------------------------------------------------------------------

Table of Contents
Mr. Waldin was selected to serve on our Board of Directors based on 
hisknowledge and experience with publicly traded companies and corporate law. 
Due to these qualifications, the Board has elected him to serve as Chairman of 
the Corporate Governance and Nominating Committee.
Peter Libby, M.D.,
has served on our Board of Directors since July 2019. Dr. Libby has been a 
cardiovascularmedicine specialist at Brigham and Women's Hospital (BWH) Since 
October 1990. He became a full professor in March 1996 and since December 1998 
has been the Mallinckrodt Professor of Medicine at Harvard Medical School 
(HMS). Dr. Libbyreceived his medical degree from the University of California, 
San Diego School of Medicine. He completed a residency in internal medicine 
and a fellowship in cardiovascular disease at Peter Bent Brigham Hospital (now 
BWH). He also completed aresearch fellowship in cellular physiology at HMS. 
Dr. Libby is board certified in internal medicine and cardiovascular disease. 
The author of over 500 original peer-reviewed publications, over 580 reviews, 
chapters and other publications,Dr. Libby also serves as an editor of the 
leading textbook of cardiovascular medicine. Dr. Libby's clinical and research 
interests include vascular biology, atherosclerosis and preventive cardiology. 
The research laboratory thatDr. Libby directs studies the messengers created 
by the body that may produce arterial plaque and blockages, as well as normal 
and abnormal function of smooth muscle and endothelial cells. Dr. Libby is 
perennially named a top cardiologist.His research has received funding from 
the American Heart Association and National Institutes of Health. Dr. Libby 
has received research recognitions on four continents including the highest 
research awards from the American Heart Associationand American College of 
Cardiology, the Gold Medal of the European Society of Cardiology, the 
Anitchkow award from the European Atherosclerosis Society, The Ernst Jung Gold 
Medal for Medicine, and the Earl Benditt award for vascular biology.
Mr. Libby was selected to serve on our Board based on his extensive knowledge 
and experience in cardiovascular medicine, afield in which he is regarded as 
one of the top key opinion leaders. He has also pioneered groundbreaking 
research, published in 2018, that demonstrates that a crucial mechanism behind 
heart attacks and stroke may involve inflammation of the typethat is targeted 
by certain of the Company's key drug discovery, development and commercializatio
n activities.
                                       T                                        
                                       HE                                       
                                       B                                        
                                      OARD                                      
                                       OF                                       
                                       D                                        
                                    IRECTORS                                    
                                       R                                        
                                   ECOMMENDS                                    
                                      A V                                       
                                      OTE                                       
                                      FOR                                       
                                       E                                        
                                      ACH                                       
                                       OF                                       
                                      THE                                       
                                      FIVE                                      
                                       N                                        
                                      AMED                                      
                                       N                                        
                                    OMINEES                                     
Independence of the Board of Directors
As required under the NASDAQ Stock Market ("NASDAQ") listing standards, a 
majority of the members of a listedcompany's Board of Directors must qualify 
as "independent," as affirmatively determined by the Board of Directors. The 
Board consults with the Company's counsel to ensure that the Board's 
determinations are consistent withrelevant securities and other laws and 
regulations regarding the definition of "independent," including those set 
forth in pertinent listing standards of NASDAQ, as in effect from time to time.


                                       4                                        

-------------------------------------------------------------------------------

Table of Contents
Consistent with these considerations, after review of all relevantidentified 
transactions or relationships between each director, or any of his family 
members, and the Company, its senior management and its independent auditors, 
the Board has affirmatively determined that the following four directors 
areindependent within the meaning of the applicable NASDAQ listing standards:

Mr. Jan-Paul
Waldin, Mr. W. Thorpe McKenzie, Mr. Donald MacAdam and Dr. Peter Libby. In 
making this determination,the Board found that none of these directors had a 
material or other disqualifying relationship with the Company.
Board Leadership Structure
Our Board of Directors is currently chaired by John Simard, our Chief 
Executive Officer.
Jan-Paul
Waldin has been appointed as the Company's independent lead director. Our 
Board of Directors believes that, given the perspective, experience, and 
expertise that Mr. Simard brings as thefounder of the Company, he is the most 
equipped individual to serve as both CEO and Chairman of the Board and his 
service in these capacities is appropriate and in the best interests of our 
Board of Directors, our company and our shareholders.
Jan-Paul
Waldin serves on our Board of Directors as lead director, is chairman of the 
corporate governance and nominating committee and a member of the audit 
committee and Compensation Committee. W. Thorpe McKenzieserves on our Board of 
Directors, is chairman of the audit committee and a member of the Compensation 
Committee and nominating and corporate governance committee. Donald MacAdam 
serves on our Board of Directors, is chairman of the CompensationCommittee and 
a member of the audit committee and corporate governance and nominating 
committee.
Role of the Board in Risk Oversight
One of the key functions of our Board of Directors is informed oversight of 
our risk management process. The Board of Directorsdoes not have a standing 
risk management committee, but rather administers this oversight function 
directly through the Board of Directors as a whole, as well as through various 
standing committees of our Board of Directors that address risksinherent in 
their respective areas of oversight. In particular, our Board of Directors is 
responsible for monitoring and assessing strategic risk exposure, and our 
Audit Committee has the responsibility to consider and discuss our major 
financialrisk exposures and the steps our management has taken to monitor and 
control these exposures, including guidelines and policies to govern the 
process by which risk assessment and management is undertaken. The Audit 
Committee also monitors compliancewith legal and regulatory requirements. Our 
Nominating and Corporate Governance Committee monitors the effectiveness of 
our corporate governance practices, including whether they are successful in 
preventing illegal or improper liability-creatingconduct. Our Compensation 
Committee assesses and monitors whether any of our compensation policies and 
programs has the potential to encourage excessive risk-taking.
Meetings of the Board of Directors
The Board of Directors met four times during 2023, the Company's last fiscal 
year. All directors who served in 2023attended all of the meetings of the 
Board and of the committees on which they served.

                                       5                                        

-------------------------------------------------------------------------------

Table of Contents
Information Regarding Committees of the Board of Directors
The Board has three standing committees: an Audit Committee, a Compensation 
Committee and a Nominating and Corporate GovernanceCommittee. The following 
table provides membership and meeting information in 2023 for each of the 
Board committees:


                                                                              
         Name            Audit     Compensation     Nominating and Corporate  
                                                          Governance          
       Jan-Paul              X                X                            X *
        Waldin                                                                
  W. Thorpe McKenzie         X *              X                            X  
  Donald H. MacAdam          X                X *                          X  
     Peter Libby                                                              
Total meetings in 2023       4                1                            1  



* Committee Chairperson

Below is a description of each committee of the Board of Directors. Each of 
the committees has authority to engage legalcounsel or other experts or 
consultants, as it deems appropriate to carry out its responsibilities.
Audit Committee
The Audit Committee of our Board of Directors was established by our Board of 
Directors in February 2015 in accordance withSection 3(a)(58)(A) of the 
Securities Exchange Act of 1934, as amended (the "Exchange Act"), to oversee 
the Company's corporate accounting and financial reporting processes and 
audits of its financial statements. For thispurpose, our Audit Committee 
performs several functions. Our Audit Committee evaluates the performance of 
and assesses the qualifications of the independent auditors; determines and 
approves the engagement of the independent auditors; determineswhether to 
retain or terminate the existing independent auditors or to appoint and engage 
new independent auditors; reviews and approves the retention of the 
independent auditors to perform any proposed permissible
non-audit
services; monitors the rotation of partners of the independent auditors on the 
Company's audit engagement team as required by law; reviews and approves or 
rejects transactions between theCompany and any related persons; confers with 
management and the independent auditors regarding the effectiveness of 
internal controls over financial reporting; establishes procedures, as 
required under applicable law, for the receipt, retention andtreatment of 
complaints received by the Company regarding accounting, internal accounting 
controls or auditing matters and the confidential and anonymous submission by 
employees of concerns regarding questionable accounting or auditing matters; 
andmeets to review the Company's annual audited financial statements and 
quarterly financial statements with management and the independent auditor.

Our Audit Committee is currently composed of three directors: Mr. W. Thorpe 
McKenzie (Chair),
Mr. Jan-Paul
Waldin and Mr. Donald H. MacAdam. Our Board of Directors has adopted a written 
charter of the Audit Committee that is available to shareholders on the 
Company's website atwww.xbiotech.com. Our Board of Directors reviews the 
NASDAQ listing standards definition of independence for Audit Committee 
members on an annual basis and has determined that all members of our Audit 
Committee are independent as defined underNASDAQ listing standards, including 
the heightened standards applicable to audit committee members.

                                       6                                        

-------------------------------------------------------------------------------

Table of Contents
Our Board of Directors has determined that W. Thorpe McKenzie qualifies asan 
"audit committee financial expert," as defined in applicable SEC rules. Our 
Board of Directors has made a qualitative assessment of Mr. McKenzie's level 
of knowledge and experience based on a number of factors, including beinga 
graduate of the Wharton Graduate division of the University of Pennsylvania, 
followed by a career in the finance industry spanning several decades, 
including extensive executive experience overseeing the preparation of 
financial statements andrelated matters. The Board also has determined that 
each Audit Committee member is sufficiently proficient in reading and 
understanding the company's financial statements to serve on the Audit 
Committee.
Report of the Audit Committee of the Board of Directors*
The Audit Committee has reviewed and discussed with management of the Company 
and the independent auditor the audited financialstatements for the fiscal 
year ended December 31, 2023. The Audit Committee has reviewed and discussed 
with the independent registered public accounting firm the matters required to 
be discussed and all communications required to be discussedby the applicable 
requirements of the Public Company Accounting Oversight Board ("PCAOB") and 
the SEC. The Audit Committee has also received the written disclosures and the 
letter from the independent registered public accounting firmrequired by 
applicable requirements of the PCAOB regarding the independent accountants' 
communications with the Audit Committee concerning independence, and has 
discussed with the independent registered public accounting firm the 
accountingfirm's independence. Based on the foregoing, the Audit Committee has 
recommended to the Board of Directors, and the Board subsequently approved the 
recommended, that the audited financial statements be included in the 
Company's AnnualReport on Form
10-K
for the fiscal year ended December 31, 2023, for filing with the SEC.
THE AUDIT COMMITTEE
Mr. W. Thorpe McKenzie (Chair)
Mr. Jan-Paul
Waldin
Mr. Donald MacAdam


 * This material is not "soliciting material," is not deemed "filed" with the SEC and is
   notto be incorporated by reference in any filing of the Company under the Exchange   
   Act or the Securities Act of 1933, as amended, whether made before or after the date 
   hereof and irrespective of any general incorporation language in any such filing.    

Compensation Committee
The Compensation Committee was established by our Board of Directors in 
February 2015 and is currently composed of threedirectors: Mr. Donald MacAdam 
(Chair), Mr. W. Thorpe McKenzie and
Mr. Jan-Paul
Waldin. The Board of Directors reviews the NASDAQ listing standards definition 
of independence for CompensationCommittee members on an annual basis and has 
determined that all members of the Company's Compensation Committee are 
independent as defined under NASDAQ listing standards, including the 
heightened standards applicable to Compensation Committeemembers, and are 
"outside directors" for purposes of Section 162(m) of the Internal Revenue 
Code of 1986, as amended. The Compensation Committee has adopted a written 
charter that is available to shareholders on the Company'swebsite at 
www.xbiotech.com.

                                       7                                        

-------------------------------------------------------------------------------

Table of Contents
Compensation Committee Processes and Procedures
The Compensation Committee meets annually and with greater frequency if 
necessary. Our Compensation Committee is responsiblefor the executive 
compensation programs for our executive officers and reports to our Board of 
Directors on its discussions, decisions and other actions. Our Compensation 
Committee reviews and approves corporate goals and objectives relating to 
thecompensation of our Chief Executive Officer, evaluates the performance of 
our Chief Executive Officer in light of those goals and objectives, and 
determines and approves the compensation of our Chief Executive Officer based 
on such evaluation. OurCompensation Committee has the sole authority to 
determine our Chief Executive Officer's compensation. In addition, our 
Compensation Committee, in consultation with our Chief Executive Officer, 
reviews and approves all compensation for otherofficers.
The charter of the Compensation Committee grants the Compensation Committee 
sole authority and right, at theexpense of the Company, to retain or obtain 
the advice of legal counsel, compensation and other consultants, accountants, 
experts and advisers of its choice to assist the Committee in connection with 
its functions, including any studies orinvestigations, but only after 
conducting an independence assessment and taking into consideration all 
factors relevant to any adviser's independence from management, including 
those specified in Rule 6505(d)(3) of the Nasdaq Rules and thoseset forth in 
SEC rules. In particular, the Compensation Committee has the sole authority to 
retain compensation consultants to assist in its evaluation of executive and 
director compensation, including the authority to approve the consultant'sreason
able fees and other retention terms. During the past fiscal year, the 
Compensation Committee determined not to utilize a third party compensation 
consultant. Due to the Company's current status as a smaller reporting 
company, it does notfeel that the application of a compensation consultant is 
an efficient use of funds at the present time.
Under itscharter, the Compensation Committee may form, and delegate authority 
to, subcommittees as appropriate. In 2017, the Board determined that for the 
sake of administrative convenience, it was desirable to delegate John Simard, 
the President, CEO andChairman of the Board (the "Executive"), the authority 
to grant certain options pursuant to the terms of the Company's 2015 Equity 
Incentive Plan, as amended (the "2015 Plan"), subject to certain limitations 
including(i) without the prior written approval of the Board, Executive shall 
not in any one calendar year grant options to acquire more than 1,000,000 
Shares in the aggregate or more than 100,000 options to any one individual, 
provided that optionsgranted pursuant to any such written approval shall not 
be counted toward the foregoing thresholds; (ii) without the prior written 
approval of the Board, Executive shall not grant options to himself or to 
certain other executive officers;(iii) the exercise price for options granted 
by Executive shall be the closing price of the Shares on the date of grant and 
term of any such options shall not be greater than 10 years; and (iv) 
Executive shall make any and all optiongrants pursuant to the authority 
delegated by the Board and specify the material terms of such options and 
provide that such options will be subject to the terms and conditions of a 
stock option agreement to be prepared by the Company promptlyfollowing the 
date of grant. The purpose of this delegation of authority is to enhance the 
flexibility of option administration within the Company and to facilitate the 
timely grant of options to
non-management
employees, particularly new employees, within specified limits approved by the 
Compensation Committee.

                                       8                                        

-------------------------------------------------------------------------------

Table of Contents
The Compensation Committee will make adjustments, if any, to annualcompensation,
 bonus and equity awards and establish new performance guidelines at one or 
more meetings during 2024. Generally, the Compensation Committee's process 
comprises two related elements: the determination of compensation levels and 
theestablishment of performance objectives for the current year. For 
executives other than the Chief Executive Officer, the Compensation Committee 
solicits and considers evaluations and recommendations submitted to the 
Committee by the Chief ExecutiveOfficer. In the case of the Chief Executive 
Officer, the evaluation of his performance is conducted by the Compensation 
Committee, which determines any adjustments to his compensation as well as 
awards to be granted.
Nominating and Corporate Governance Committee
The Nominating and Corporate Governance Committee is currently composed of 
three directors:
Mr. Jan-Paul
Waldin (Chair), Mr. W. Thorpe McKenzie and Mr. Donald MacAdam. All members of 
the Nominating and Corporate Governance Committee are independent as defined 
under NASDAQ listingstandards. The Nominating and Corporate Governance 
Committee has adopted a written charter that is available to shareholders on 
the Company's website at www.xbiotech.com.
The Nominating and Corporate Governance Committee was established by the Board 
of Directors in February 2015 and is responsiblefor identifying, reviewing and 
evaluating candidates to serve as directors of the Company (consistent with 
criteria approved by the Board), reviewing and evaluating incumbent directors, 
recommending to the Board for selection candidates for electionto the Board of 
Directors, making recommendations to the Board regarding the membership of the 
committees of the Board, assessing the performance of the Board, and 
monitoring the Company's adherence to its Code of Business Conduct and Ethics.

The Nominating and Corporate Governance Committee believes that candidates for 
director, both individually andcollectively, should provide the integrity, 
experience, judgment, commitment (including having sufficient time to devote 
to the Company and level of participation), skills, diversity and expertise 
appropriate for the Company. In assessing thedirectors, both individually and 
collectively, the Nominating and Corporate Governance Committee may consider 
the current needs of the Board and the Company to maintain a balance of 
knowledge, experience and capability in various areas. However, theNominating 
and Corporate Governance Committee retains the right to modify these 
qualifications from time to time. Candidates for director nominees are 
reviewed in the context of the current composition of the Board, the operating 
requirements of theCompany and the long-term interests of shareholders. In 
conducting this assessment, the Nominating and Corporate Governance Committee 
typically considers diversity, age, skills and such other factors as it deems 
appropriate, given the current needsof the Board and the Company, to maintain 
a balance of knowledge, experience and capability on the Board. In the case of 
incumbent directors whose terms of office are set to expire, the Nominating 
and Corporate Governance Committee reviews thesedirectors' overall service to 
the Company during their terms, including the number of meetings attended, 
level of participation, quality of performance and any other relationships and 
transactions that might impair the directors'independence. In the case of new 
director candidates, the Nominating and Corporate Governance Committee also 
determines whether the nominee is independent for NASDAQ purposes, which 
determination is based upon applicable NASDAQ listing standards,applicable SEC 
rules and regulations and the advice of counsel, if necessary. The Nominating 
and Corporate Governance Committee then uses its network of contacts to 
compile a list of potential candidates, but may also engage, if it 
deemsappropriate, a professional search firm. The Nominating and Corporate 
Governance Committee will also consider candidates recommended by 
shareholders. In order to recommend a candidate for consideration, 
shareholders must follow the proceduresdescribed below under the heading 
"Advance Notice Provisions."

                                       9                                        

-------------------------------------------------------------------------------

Table of Contents
The Nominating and Corporate Governance Committee conducts any appropriateand 
necessary inquiries into the backgrounds and qualifications of possible 
candidates after considering the function and needs of the Board. The 
Nominating and Corporate Governance Committee meets to discuss and consider 
the candidates'qualifications and then selects a nominee for recommendation to 
the Board by majority vote.
Advance Notice Provisions
Our Articles contain provisions known as "Advance Notice Provisions", which 
provide that advance notice to theCompany must be made and the procedures set 
out in the Articles must be followed for persons to be eligible for election 
to the Board of Directors. Nomination of persons for election to the Board of 
Directors may only be made at an annual meeting ofshareholders or at a special 
meeting of shareholders called for any purpose, which includes the election of 
directors.
Among other things, the Advance Notice Provisions fix a deadline by which 
holders of record of common shares must submitdirector nominations to us prior 
to any annual or special meetings of shareholders and set forth the specific 
information that a shareholder must include in the written notice to the 
Company for an effective nomination to occur. No person will beeligible for 
election as a director of the Company unless nominated in accordance with the 
provisions of the Advance Notice Provisions.
In the case of an annual meeting of shareholders, notice to us must be made 
not less than 30 or more than 65 days prior to thedate of the annual meeting; 
provided, however, that if the annual meeting is to be held on a date that is 
less than 50 days after the date on which the first public announcement of the 
date of the annual meeting was made, notice may be made notlater than the 
close of business on the 10th day following such public announcement. In the 
case of a special meeting of shareholders (which is not also an annual 
meeting), notice to us must be made not later than the close of business on 
the 15thday following the day on which the first public announcement of the 
date of the special meeting was made.
The Board ofDirectors may, in its sole discretion, waive any requirement of 
the Advance Notice Provisions.
Board Diversity
The company's current Board is stable and effective. The members of our Board 
are highly qualified, outstanding individuals. TheCompany's Nominating and 
Corporate Governance Committee has a solitary objective: to identify board 
members--irrespective of gender or race--that represent the greatest value to 
our Company and shareholders. The Company'sNominating and Corporate Governance 
Committee strives to assemble a board that has diversity of thought, with each 
member offering unique insight and perspective, where individual members share 
a common ability to work productively within thecontext of the Board and 
management team.

                                       10                                       

-------------------------------------------------------------------------------

Table of Contents
                             Board Diversity Matrix                             


                                                                                                                               
                                                     As of May 1, 2024                         As of April 28, 2023            
Total Number of Directors                                    5                                           5                     
Part I: Gender Identity                   Female    Male    Non-Binary    Did Not     Female    Male    Non-Binary    Did Not  
                                                                          Disclose                                    Disclose 
                                                                          Gender                                      Gender   
               Directors                     --      --         --           5       --      --         --           5 
                                               Part II: Demographic Background                                                 
       African American or Black             --      --         --        --       --      --         --        -- 
   Alaskan Native or Native American         --      --         --        --       --      --         --        -- 
                 Asian                       --      --         --        --       --      --         --        -- 
          Hispanic or Latinx                 --      --         --        --       --      --         --        -- 
  Native Hawaiian or Pacific Islander        --      --         --                   --      --         --             
                 White                       --      --         --        --       --      --         --        -- 
   Two or More Races or Ethnicities          --      --         --        --       --      --         --        -- 
                LGBTQ+                                                                                                         
Did Not Disclose Demographic Background                                          5                                           5 

Communications With the Board of Directors
The Company's Board has adopted a formal process by which shareholders and 
other interested parties may communicate withthe Board or any of its 
directors. Shareholders and other interested parties who wish to communicate 
with the Board may do so by sending written communications addressed to the 
Secretary of XBiotech Inc. at 5217 Winnebago Lane 100 Austin, TX 78744.Each 
communication must set forth the name and address of the interested party or 
the Company shareholder on whose behalf the communication is sent and the 
number of Company shares that are owned beneficially by such shareholder as of 
the date ofthe communication. Each communication will be reviewed by the 
Company's Secretary to determine whether it is appropriate for presentation to 
the Board or relevant directors. Communications determined by the Company's 
Secretary to beappropriate for presentation to the Board or any relevant 
directors are submitted to the Board or relevant directors on a periodic basis.

Code of Ethics
The Company has adopted a Code of Business Conduct and Ethics that applies to 
all directors, officers and employees. TheCode of Business Conduct and Ethics 
is available on the Company's website at www.xbiotech.com under the Corporate 
Governance section of our Investor Relations page. If the Company makes any 
substantive amendments to the Code of Business Conductand Ethics that applies 
to our principal executive officer, principal financial officer, principal 
accounting officer, controller or persons performing similar functions, or 
grants any waiver from a provision of the Code of Business Conduct andEthics 
to any of these specified individuals that is required to be disclosed 
pursuant to SEC rules and regulations, the Company will promptly disclose the 
nature of the amendment or waiver on its website.

                                       11                                       

-------------------------------------------------------------------------------

Table of Contents
Employee, Officer and Director Hedging and Pledging
The Company has adopted an Insider Trading Policy that applies to all 
directors, officers and employees. The Insider TradingPolicy provides that the 
Company's directors, executive officers and their respective family members 
and others in their households (1) may not enter into hedging or monetization 
transactions or similar arrangements with respect to Companysecurities and (2) 
may not hold Company securities in a margin account or pledge Company 
securities as collateral for a loan. The Company does not have any practices 
or policies regarding the ability of employees other than officers to 
purchasefinancial instruments (including prepaid variable forward contracts, 
equity swaps, collars, and exchange funds), or otherwise engage in 
transactions, that hedge or offset, or are designed to hedge or offset, any 
decrease in the market value of theCompany's common stock.
Delinquent Section 16(a) Reports
Section 16(a) of the Exchange Act requires the Company's directors and 
executive officers, and persons who own morethan ten percent of a registered 
class of the Company's equity securities, to file with the SEC initial reports 
of ownership and reports of changes in ownership of common stock and other 
equity securities of the Company. Officers, directors andgreater than ten 
percent shareholders are required by SEC regulation to furnish the Company 
with copies of all Section 16(a) forms they file.
To the Company's knowledge, based solely on a review of the reports filed 
electronically with the SEC and writtenrepresentations that no other reports 
were required, during the fiscal year ended December 31, 2023, all Section 
16(a) filing requirements applicable to its officers, directors and greater 
than ten percent beneficial owners were compliedwith.
                                   PROPOSAL 2                                   
   RATIFICATION OF SELECTION OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM   
The Audit Committee has selected Whitley Penn LLP as the Company's independent 
registered public accounting firm for thefiscal year ending December 31, 2024 
and has further directed that management submit the selection of independent 
registered public accounting firm for ratification by the shareholders at the 
annual meeting. Whitley Penn has audited theCompany's financial statements for 
the fiscal year ending December 31, 2023. Representatives of Whitley Penn are 
not expected to be present at the annual meeting and will not have an 
opportunity to make a statement or to respond toquestions from the 
shareholders.
Whitley Penn is the 35th largest firm in the nation based on 2024 rankings in 
Accounting Today and oneof the fastest growing firms in the nation. They have 
an extensive team of experienced audit, tax, consulting and valuation 
professionals. For more than 20 years, Whitley Penn has been named to the 
"Best of the Best" listing by INSIDEPublic Accounting, the publication's 
report of the top 25 accounting firms in the country. INSIDE Public Accounting 
is a national monthly publication that reports on the accounting industry.
Neither the Company's Articles nor other governing documents or law require 
shareholder ratification of the selection ofWhitley Penn as the Company's 
independent registered public accounting

                                       12                                       

-------------------------------------------------------------------------------

Table of Contents
firm. However, the Audit Committee is submitting the selection of Whitley Penn 
to the shareholders for ratification as a matter of good corporate practice. 
If the shareholders fail to ratify theselection, the Audit Committee will 
reconsider whether or not to retain that firm. Even if the selection is 
ratified, the Audit Committee in its discretion may direct the appointment of 
different independent auditors at any time during the year ifthey determine 
that such a change would be in the best interests of the Company and its 
shareholders.
The affirmative vote of the holdersof a majority of the shares present in 
person or represented by proxy and entitled to vote at the annual meeting will 
be required to ratify the selection of Whitley Penn. Abstentions and broker
non-votes
willbe counted toward the tabulation of votes on proposals presented to the 
shareholders and will have the same effect as negative votes. Because this is 
a routine proposal on which brokers can vote shares in the absence of express 
instructions from thebeneficial owner, if you do not give instructions to your 
bank, brokerage firm or other agent, the bank, brokerage firm or other agent 
will nevertheless be entitled to vote your shares of common stock in its 
discretion on this routine matter and maygive or authorize the giving of a 
proxy to vote the shares of common stock in its discretion on this proposal.

Principal Accountant Fees and Services
The following table represents aggregate fees billed to the Company during the 
fiscal years ended December 31, 2023 andDecember 31, 2022, by Whitley Penn, 
the Company's principal accountant. All fees described below were
pre-approved
by the Audit Committee.


                                           
                      Fiscal Year Ended    
                     2023           2022   
                        (in thousands)     
Audit Fees           $ 290           $ 307 
(1)                                        
Audit-Related Fees     --             -- 
(2)                                      
Tax Fees               --             -- 
(3)                                      
All Other Fees         --               5 
(4)                                       
Total Fees           $ 290           $ 312 



(1) Audit fees consist of fees billed for professional services by Whitley Penn for audit and quarterly review ofour financial    
    statements and related services that are normally provided in connection with statutory and regulatory filings or engagements.


(2) Audit-related fees consist of fees billed for assurance and related services that are reasonably related to            
    theperformance of the audit or review of our consolidated financial statements and are not reported under "Audit Fees."


(3) Tax fees consist of fees billed for tax consultation services for professional
    services relating to taxcompliance, tax planning, and tax advice.             


(4) All other fees consist of fees billed for publications provided by Whitley Penn.


                                       13                                       

-------------------------------------------------------------------------------

Table of Contents
In connection with the audit of the 2023 and 2022 financial statements, the 
Company enteredinto an engagement agreement with Whitley Penn which sets forth 
the terms by which Whitley Penn will perform audit services for the Company. 
Such agreements are subject to alternative dispute resolution procedures.
During the fiscal years ended December 31, 2023 and December 31, 2022, none of 
the total hours expended on the Company'sfinancial audit by Whitley Penn was 
provided by persons other than the full-time permanent employees.
None of Whitley Penn's reportson the Company's financial statements for the 
fiscal year ended December 31, 2023 and December 31, 2022 contained an adverse 
opinion or a disclaimer of opinion, or was qualified or modified as to 
uncertainty, audit scope or accountingprinciples. During the fiscal year ended 
December 31, 2023 and December 31, 2022, there were (i) no disagreements 
between the Company and Whitley Penn on any matter of accounting principles or 
practices, financial statement disclosure orauditing scope or procedure, which 
disagreement, if not resolved to the satisfaction of Whitley Penn, would have 
caused Whitley Penn to make reference to the subject matter of the 
disagreement in their reports on the Company's consolidatedfinancial 
statements for such years, and (ii) no "reportable events" as that term is 
defined in Item 304(a)(1)(v) of Regulation
S-K.
Pre-Approval
Policies And Procedures
The Audit Committee's policy is to
pre-approve
the scope of all audit and
non-audit
services rendered by the Company's independent registered public accounting 
firm. Audit services and permitted
non-audit
services must be
pre-approved
by the full Audit Committee.
                                       T                                        
                                       HE                                       
                                       B                                        
                                      OARD                                      
                                       OF                                       
                                       D                                        
                                    IRECTORS                                    
                                       R                                        
                                   ECOMMENDS                                    
                                       A                                        
                                      VOTE                                      
                                      FOR                                       
                                       P                                        
                                    ROPOSAL                                     
                                       2                                        
                                   PROPOSAL 3                                   
                  ADVISORY VOTE ON THE EXECUTIVE COMPENSATION                   
                   OF THE COMPANY'S NAMED EXECUTIVE OFFICERS                    
This proposal provides our shareholders with the opportunity to cast an 
advisory vote on the Company's executive compensation program(commonly known as

"say-on-pay")
of our named executive officers as disclosed in this Proxy Statement pursuant 
to Item 402 of Regulation
S-K
and in accordance with the SEC's rules. This proposal, which may be referred 
to as a
"say-on-pay"
proposal, isrequired by Section 14A of the Exchange Act, which was put in 
place by the Dodd-Frank Wall Street Reform and Consumer Protection Act of 
2010. We must provide this opportunity to our shareholders at least once every 
three years.
As described in this proxy statement under the heading "Executive 
Compensation," our executive compensation program is designed toenable us to 
attract and retain key executives who are critical to the Company's future 
success and creation of shareholder value. Our executive compensation program 
seeks enhance shareholder value by aligning the financial interests of 
ourexecutive officers with those of our shareholders. We have also designed 
our compensation program to motivate and reward

                                       14                                       

-------------------------------------------------------------------------------

Table of Contents
executives whose knowledge, skills and performance are critical to our 
success. We believe that both short-term and long-term incentive compensation 
opportunities provided to our named executiveofficers are directly aligned 
with our performance, and that our compensation program is structured to 
ensure that a significant portion of executives' compensation opportunities is 
directly related to achievement of financial and operationalgoals and other 
factors that impact shareholder value.
We are asking our shareholders to indicate their support for the compensation 
ofour named executive officers, as described in this proxy statement. This 
proposal, commonly known as a
"say-on-pay"
proposal, gives our shareholders theopportunity to express their views on the 
compensation of our named executive officers. This vote is not intended to 
address any specific item of compensation, but rather the overall compensation 
of our named executive officers and the philosophy,policies and practices 
described in this proxy statement. Accordingly, we are asking our shareholders 
to vote "FOR" the following resolution at the annual meeting:
"RESOLVED, that the Company's shareholders approve, on an advisory basis, the 
compensation paid to the Company's namedexecutive officers, as disclosed 
pursuant to the compensation disclosure rules of the Securities and Exchange 
Commission, including the compensation tables and narrative discussion 
included in the section of the proxy statement entitled ExecutiveCompensation."

While the vote does not bind the Board of Directors to any particular action, 
the Board of Directors values the inputof the shareholders, and will take into 
account the outcome of this vote in considering future compensation decisions.
                                       T                                        
                                       HE                                       
                                       B                                        
                                      OARD                                      
                                       OF                                       
                                       D                                        
                                    IRECTORS                                    
                                       R                                        
                                   ECOMMENDS                                    
                                       A                                        
                                      VOTE                                      
                                      FOR                                       
                                       P                                        
                                    ROPOSAL                                     
                                       3                                        

                                       15                                       

-------------------------------------------------------------------------------

Table of Contents
                               EXECUTIVE OFFICERS                               
The following table sets forth our named executive officers for the fiscal 
year ended December 31, 2023, their ages, andthe positions held by each such 
person with the Company:


                                                                                       
Name                          Age             Position Held With the Company           
John Simard                    62  Founder, President, Chief Executive Officer Chairman
Dr. Sushma Shivaswamy, Ph.D.   46  Chief Scientific Officer                            
Angela Hu                      41  Director of Finance                                 

John Simard's biographical information is set forth above under Proposal 1.
Sushma Shivaswamy, Ph.D.
was appointed as the Company's Chief Scientific Officer in November 2017. As 
CSO Dr. Shivaswamy overseesall scientific and technical operations with 
respect to research and development and Good Manufacturing Practice production 
of antibody. Dr. Shivaswamy has been with the Company since 2009 also holding 
positions of Director of Research &Development (2011-2015) and Senior 
Scientist (2009-2011). Prior to joining XBiotech, Dr. Shivaswamy was a 
postdoctoral researcher at the Center for Systems and Synthetic Biology at the 
University of Texas at Austin. She has a Ph.D. degree inMolecular Biology from 
the Center for Cellular and Molecular Biology, India. Dr.
Angela Hu
joined XBiotech in April 2015,initially serving as the Financial Controller 
before transitioning to the position of Director of Finance in February 2023. 
Ms. Hu holds a Bachelor degree in finance and has previous experience as a 
senior accountant at National Instruments andHoneywell prior to joining 
XBiotech.
                             EXECUTIVE COMPENSATION                             
For the year ended December 31, 2023, our principal executive officer and our 
two other executive officers (the "Named ExecutiveOfficers") were as follows:


 .  John Simard, Founder, President, Chief Executive Officer & Chairman;



 .  Sushma Shivaswamy, Ph.D., Chief Scientific Officer; and



 .  Angela Hu, Director of Finance

Processes and Procedures for Compensation Decisions
Our Compensation Committee has the sole authority to determine our Chief 
Executive Officer's compensation and, in its discretion, mayaward cash bonus 
payments in addition to the incentive cash payments set forth in the Chief 
Executive Officer's employment agreement. In determining the Chief Executive 
Officer's compensation, our Compensation Committee has discretion toconsider 
any factors it deems important, including but not limited to our Chief 
Executive Officer's performance and the performance of the Company. In 
addition, our Compensation Committee, in consultation with our Chief Executive 
Officer,reviews and approves all compensation for other officers.
In addition, our Compensation Committee, in consultation with our 
ChiefExecutive Officer, reviews and approves all compensation for other 
officers, including the directors. The Compensation Committee is authorized to 
retain the services of one or more executive compensation and benefits 
consultants or other outsideexperts or advisors as it sees fit, in connection 
with the establishment of our compensation programs and related policies.

                                       16                                       

-------------------------------------------------------------------------------

Table of Contents
Summary Compensation Table
The following table shows for the fiscal years ended December 31, 2023 and 
December 31, 2022, compensation awardedto, paid to, or earned by, the Named 
Executive Officers.
           Summary Compensation Table for Fiscal Years 2023 and 2022            


                                                                                                                               
Name and Principal Position                         Year    Salary ($)    Option     Bonus($)       All Other        Total ($) 
                                                                          Awards       (2)        Compensation($)              
                                                                           ($)                         (3)                     
                                                                           (1)                                                 
John Simard, President & Chief Executive Officer    2023     1,065,440    --    4,480,000             11,041    5,556,481 
                                                    2022       881,440    --    3,780,000              9,494    4,670,934 
Sushma Shivaswamy, Ph.D. Chief Scientific Officer   2023       445,190    270,509    --              4,800      720,499 
                                                    2022       376,440    --    --              4,800      381,240 
Angela Hu, Director of Finance                      2023       193,333     81,153    --              4,800      279,286 



(1) In accordance with SEC rules, this column reflects the aggregate grant date fair value of the option        
    awardsgranted during 2023 and 2022, as applicable, computed in accordance with Financial Accounting Standard
    Board ASC Topic 718 for stock-based compensation transactions, or ASC 718. Assumptions used in the          
    calculation of these amounts are included inNote 2 to the Financial Statements in our Annual Report on Form 
    10-K                                                                                                        
    for the year ended December 31, 2023. These amounts do not reflect the                                      
    actual economic value that will be realized by the NamedExecutive Officer                                   
    upon the vesting of the stock options, the exercise of the stock                                            
    options, or the sale of the common stock underlying such stock options.                                     


(2) Amounts shown represent performance bonuses earned for 2023 and 2022. Mr. Simard was granted a cash bonusof    
    $4,480,000 in 2023 and $3,780,000 in 2022, which was paid in the second quarter of 2023 and 2022, respectively.


(3) Amounts shown represent premiums for health and life insurance as well as short and long-term disabilityinsurance
    paid by us on behalf of the Named Executive Officers. All of these benefits are provided to the Named Executive  
    Officers on the same terms as provided to all of our regular full-time employees in the United States. For more  
    informationregarding these benefits, see below under "Perquisites, Health, Welfare and Retirement Benefits."     

Compensation CommitteeInterlocks and Insider Participation
As indicated above, the Compensation Committee currently consists of Donald 
MacAdam (Chair), W.Thorpe McKenzie, and
Jan-Paul
Waldin. No member of the Compensation Committee has ever been an officer or 
employee of ours and no member is party to a related party transaction with 
us. None of our executiveofficers currently serves, or has served during the 
last completed fiscal year, on the Compensation Committee or Board of 
Directors of any other entity that has one or more executive officers serving 
as a member of our Board of Directors orCompensation Committee.

                                       17                                       

-------------------------------------------------------------------------------

Table of Contents
Outstanding Equity Awards at Fiscal Year End
The following table shows for the fiscal year ended December 31, 2023, certain 
information regarding outstanding equity awards at fiscal
year-end
for the Named Executive Officers.
                 Outstanding Equity Awards at December 31, 2023                 
                                 Option Awards                                  


                                                                                                   
Name                Grant Date        Number of       Number of        Option          Option      
                                      Securities      Securities      Exercise     Expiration Date 
                                      Underlying      Underlying      Price ($)                    
                                      Unexercised    Unexercised                                   
                                      Options (#)    Options (#)                                   
                                      Exercisable    Unexercisable                                 
John Simard         03/31/2014 (1)        500,000                       $ 10.00          3/31/2024 
                                                                                                   
                    03/31/2016 (2)         48,125                       $  9.45          3/30/2026 
                                                                                                   
                    06/19/2017 (3)         61,516                       $  4.24          6/19/2027 
                                                                                                   
                    06/19/2018 (4)        110,740                       $  4.44          6/18/2028 
                                                                                                   
                    06/27/2019 (5)        150,000                       $  7.45          6/26/2029 
                                                                                                   
                    12/06/2019 (6)        500,000                       $ 11.12          12/5/2029 
                                                                                                   
Sushma Shivaswamy   11/05/2014 (7)         30,000                       $ 15.00         11/05/2024 
                                                                                                   
                     6/19/2017 (8)         50,000                       $  4.24         06/19/2027 
                                                                                                   
                    11/20/2017 (9)        150,000                       $  4.13         11/19/2027 
                                                                                                   
                    01/04/2019 (10)        15,000                       $  5.26         01/03/2029 
                                                                                                   
                    11/06/2019 (11)       100,000                       $ 10.36         11/05/2029 
                                                                                                   
                    11/19/2021 (12)       100,000                       $ 12.67         11/18/2031 
                                                                                                   
                    02/10/2023 (13)        25,000           75,000      $  3.84         02/09/2033 
                                                                                                   
Angela Hu           04/01/2015 (14)         4,500                       $ 19.00         04/01/2025 
                                                                                                   
                    01/04/2019 (15)         5,000                       $  5.26         01/03/2029 
                                                                                                   
                    11/06/2019 (16)        10,000                       $ 10.36         11/05/2029 
                                                                                                   
                    11/19/2021 (17)        10,000                       $ 12.64         11/18/2031 
                                                                                                   
                    02/10/2023 (18)         7,500           22,500      $  3.84         02/09/2033 
                                                                                                   



(1) Fully vested as of July 31, 2016. Expired in accordance to its terms as of March 31, 2024.


                                       18                                       

-------------------------------------------------------------------------------

Table of Contents

(2) Fully vested as of March 31, 2019.


(3) Fully vested as of June 19, 2020.


(4) Fully vested as of June 19, 2021.


(5) Fully vested as of June 27, 2022.


(6) Fully vested as of December 6, 2020.


(7) Fully vested as of November 5, 2016.


(8) Fully vested as of June 19, 2020.


(9) Fully vested as of November 20, 2020.


(10) Fully vested as of January 4, 2021.


(11) Fully vested as of November 6, 2022.


(12) Fully vested as of November 19, 2023.


(13) The options vest at the rate of                                                                                     
     one-fourth                                                                                                          
     of the total number ofshares subject to the option over two years with the initial vesting event on August 10, 2023.


(14) Fully vested as of April 1, 2019.


(15) Fully vested as of January 4, 2021.


(16) Fully vested as of November 06, 2022.


(17) Fully vested as of November 19, 2023.


(18) The options vest at the rate of                                                                                     
     one-fourth                                                                                                          
     of the total number ofshares subject to the option over two years with the initial vesting event on August 10, 2023.

Employment Agreements with NamedExecutive Officers
All of our Named Executive Officers have or had employment agreements and/or 
offer letters with us that provide thattheir employment is at will and may be 
terminated at any time by the executive or by us with or without cause and 
without notice. The employment agreements provide for certain base salary, 
target bonus and severance payments to our Named ExecutiveOfficers as follows:

Employment Agreement with John Simard.
We entered into an employment agreement and change of control agreementwith 
John Simard, our Chief Executive Officer and President on March 22, 2005. The 
employment agreement is for an indefinite term. Mr. Simard's current annual 
base salary is $960,000 per year, and he is eligible for an annualincentive 
cash payment of up to 35% of his base salary, subject to the achievement of 
short-term and long-term business performance objectives as well as personal 
performance objectives, as established from time to time by the board or 
CompensationCommittee. The employment agreement contains customary
non-competition
and
non-solicitation
provisions which apply for a period of six months afterMr. Simard's employment 
is terminated for any reason. In addition, Mr. Simard agrees that all 
intellectual property developed by him during the term of his employment 
agreement shall be our property. If Mr. Simard is terminatedwithout cause, if 
he resigns for good reason or if there is a change in control, he is entitled 
to certain severance benefits. Mr. Simard may voluntarily resign for any 
reason by providing us with three months prior notice. We may elect towaive 
all or a portion of such notice by paying to Mr. Simard his base salary that 
he would have earned if he had remained employed by us for the full duration 
of such notice period. If Mr. Simard terminates his employment within 12 
monthsafter a "change of control" for "good reason" or if he is terminated 
without cause, we will make a lump sum payment to him equal to twelve month of 
his base salary, plus other sum owed to him for arrears of salary, vacation 
payand, if awarded, his performance bonus, subject to his prior resignation as 
a director. Additionally, if Mr. Simard terminates his

                                       19                                       

-------------------------------------------------------------------------------

Table of Contents
employment within 12 months after a change of control or for good reason, all 
unvested stock options held by him will immediately vest on such termination 
and will survive and be exercisable byMr. Simard, along with his vested 
options, in accordance with the terms of the option agreements. To the extent 
permitted by applicable law, we will provide health, medical, dental and other 
insurance benefits to Mr. Simard for a period ofone year after his termination 
date.
Offer Letters with Other Named Executive Officers
. There are no employment agreements forDr. Shivaswamy or Ms. Hu. We entered 
into an offer letter with Dr. Shivaswamy upon her hiring, which originally 
provided that she was paid an annual base salary of $70,000 per year as well 
as granted stock options.Dr. Shivaswamy's current base salary is $450,000 and 
from time to time she receives option grants as approved by the Board of 
Directors or Compensation Committee. We entered into a written employment 
arrangement with Ms. Hu, pursuantto which she received a base salary of 
USD$200,000 and from time to time she receives option grants as approved by 
the Board of Directors or Compensation Committee.
None of the Named Executive Officers' employment agreements or offer letters 
provide for the gross up of any excise taxes imposed bySection 4999 of the 
Internal Revenue Code of 1986, as amended (the "Code"). If any of the payments 
under the employment agreements or offer letters would constitute a "parachute 
payment" within the meaning ofSection 280G of the Code, subject to the excise 
tax imposed by Section 4999 of the Code, the employment agreements and offer 
letters provide for a best-after tax analysis with respect to such payments, 
under which the executive willreceive whichever of the following two 
alternative forms of payment would result in the executive officer's receipt, 
on an
after-tax
basis, of the greater amount of the transaction payment notwithstandingthat 
all or some portion of the transaction payment may be subject to the excise 
tax: (i) payment in full of the entire amount of the transaction payment, or 
(ii) payment of only a part of the transaction payment so that the 
executivereceives the largest payment possible without the imposition of the 
excise tax.
               EQUITY COMPENSATION PLANS ANDOTHER BENEFITS PLANS                
2005 Incentive Stock Option Plan.
Our Board of Directors adopted and our shareholders approved the 2005 Plan on 
November 11, 2005 for eligible employees, directors andconsultants. Our Board 
of Directors administers the 2005 Plan including, without limitation, the 
selection of recipients of stock options under the 2005 Plan, the grant of 
stock options, the determination of the terms and conditions of any 
suchoptions, the interpretation of the 2005 Plan and any other action they 
deem appropriate in connection with the administration of the 2005 Plan. The 
exercise price of the incentive stock options must equal at least 100% of the 
fair market value ofour common stock on the date of grant, as determined by 
the Board of Directors, in its sole discretion, provided that such price may 
not be less than the lowest price permitted under the applicable rules and 
regulations of all regulatory authoritiesto which XBiotech is subject, 
including the stock exchange on which XBiotech's shares are listed. The term 
of the options is at the discretion of the Board of Directors, but may not 
exceed ten years from the grant date. The options expire onthe earlier of the 
expiration date or the date three months following the day on which the 
participant ceases to be a director, officer or employee of, or consultant to, 
XBiotech, or in the event of the termination of the participant with cause, 
thedate of such termination, and in all cases, is subject to extension at the 
discretion of the Board of Directors. All options are nontransferable and may 
be exercised only by the participant, or in the event of the death of the 
participant, a legalrepresentative

                                       20                                       

-------------------------------------------------------------------------------

Table of Contents
until the earlier of the options' expiry date of the first anniversary of the 
participants' death or such other date as may be specified by the Board of 
Directors. Pursuant to the termsof the 2005 Plan, the 2005 Plan automatically 
terminated on the tenth anniversary of its effective date, namely, November 
11, 2015. Following this expiry, no additional awards have been or will be 
granted under the 2005 Plan. However, all stockoptions granted under the 2005 
Plan prior to the initial public offering continue to be governed by the terms 
of the 2005 Plan.
2015 EquityIncentive Plan.
The 2015 Plan was adopted by the Board of Directors on April 1, 2015, and 
approved by the Company'sshareholders on March 13, 2015. The 2015 Plan is not 
subject to the provisions of the Employee Retirement Income Security Act of 
1974 because it is not an "employee benefit plan" as defined in that Act. The 
2015 Plan is not a pension,profit-sharing or stock bonus plan within the 
meaning of Section 401(a) of the Internal Revenue Code of 1986, as amended 
(the "Code"). The purpose of the 2015 Plan is to promote the interests of the 
Company by (i) providingdirectors, officers, employees and consultants of the 
Company or any of its subsidiaries or other persons as the Board may approve 
("Eligible Persons") with greater incentive to further develop and promote the 
business and financialsuccess of the Company; (ii) aligning the interests of 
participants with those of Company shareholders and (iii) assisting the 
Company in attracting, retaining and motivating its directors, officers and 
employees. The 2015 Plan becameeffective March 13, 2015 and will continue in 
effect for a term of ten years from the date adopted by the Board, unless 
terminated earlier by the Board. Upon adoption, the 2015 Plan initially had 
1,000,000 common shares of the Company availablefor issuance under the 2015 
Plan. On May 13, 2016, the Board adopted an amendment to the 2015 Plan that 
increased the number of shares reserved for issuance thereunder to 4,000,000, 
which amendment was approved by the shareholders onJune 20, 2016. On December 
18, 2019, the Board of Directors adopted a second amendment to the 2015 Plan 
to increase the number of common shares that may be awarded under the plan by 
an additional 2,500,000 shares, which amendment wasapproved by the 
shareholders on June 26, 2020. On April 27, 2020, the Board of Directors 
adopted a third amendment to the 2015 Plan to increase the number of common 
shares that may be awarded under the plan by an additional 1,500,000shares, 
which amendment was approved by the shareholders on June 26, 2020. If any 
award (or portion thereof) expires or terminates without having been exercised 
in full or is forfeited to or repurchased by the Company, the number of 
CommonShares subject to such award will again be available for issuance under 
the 2015 Plan. Common Shares used to pay the exercise price of an award or to 
satisfy the tax withholding obligations related to an award will become 
available for future grantunder the 2015 Plan. To the extent an award under 
the 2015 Plan is paid out in cash rather than Common Shares, such cash payment 
will not result in a reduction in the number of Common Shares available for 
issuance under the 2015 Plan.
Adjustments.
In the event that any dividend or other distribution (whether in the form of 
cash, Common Shares, other securities, orother property), recapitalization, 
stock split, reverse stock split, reorganization, merger, consolidation,
split-up,
spin-off,
combination, repurchase, or exchange ofCommon Shares or other securities of 
the Company, or other change in the corporate structure of the Company 
affecting the Common Shares occurs, the Board, in order to prevent diminution 
or enlargement of the benefits or potential benefits intendedto be made 
available under the 2015 Plan, will adjust the number and class of Common 
Shares that may be delivered under the 2015 Plan and/or the number, class, and 
price of Common Shares covered by each outstanding award.

                                       21                                       

-------------------------------------------------------------------------------

Table of Contents
Administration.
The 2015 Plan is administered by the Board, which pursuant to theterms of such 
Plan has delegated certain of its administrative authority and functions to 
the Company's Compensation Committee. The Board has also delegated the 
authority to grant options (subject to certain limitations) to the 
Company'schief executive officer, who is deemed to constitute a committee 
under the terms of the 2015 Plan. The Board has retained the authority to 
concurrently administer the 2015 Plan with any committee and may, at any time, 
reassume some or all of thepowers previously delegated. The Board of Directors 
has the authority to determine all questions arising out of the 2015 Plan and 
any award granted pursuant to the 2015 Plan, which interpretations and 
determinations will be conclusive and binding onthe Company and all other 
affected persons.
To the extent that the Board determines it to be desirable to qualify awards 
grantedhereunder as "performance-based compensation" within the meaning of 
Section 162(m) of the Code, the 2015 Plan will be administered by a Committee 
of two or more "outside directors" within the meaning of Section 162(m)of the 
Code.
Recoupment.
All awards granted under the 2015 Plan shall be subject to recoupment in 
accordance with any clawbackpolicy that the Company is required to adopt 
pursuant to the listing standards of any stock exchange on which the Company's 
securities are listed or as is otherwise required by other applicable law. In 
addition, an Award Agreement may containsuch other clawback, recovery or 
recoupment provisions as the Board determines necessary or appropriate, 
including but not limited to a reacquisition right in respect of previously 
acquired Common Shares.
Limitations on Transfer.
Unless the Board expressly provides otherwise in the Award Agreement, an award 
may not be sold, pledged,assigned, hypothecated, transferred, or disposed of 
in any manner other than by will or by the laws of descent or distribution and 
may be exercised, during the lifetime of the participant, only by the 
participant.
Merger or Change in Control
. In the event of a merger or change of control, as defined in the 2015 Plan, 
an outstanding award may, atthe determination of the Board (i) be assumed or 
substantially equivalent award substituted by the acquiring or succeeding 
corporation; (ii) be terminated upon or immediately prior to the merger or 
change of control (with or withoutpayment or receipt of any consideration); 
(iii) vest and become exercisable, realizable or payable, or applicable 
restrictions lapse prior to or upon consummation of the merger or change of 
control; or (iv) any combination of the foregoing. Ifa successor corporation 
does not assume or provide a substitute for an outstanding award, such award 
shall fully vest and the participant shall have the right to exercise all of 
his or her outstanding Options and SARs and all restrictions onRestricted 
Share Awards and RSU Awards will lapse, and, with respect to awards subject to 
performance-based vesting, all performance goals or other vesting criteria 
will be deemed achieved at 100% of target levels and all other terms and 
conditionsmet.
Suspension, Termination or Amendment.
Subject to any limitations imposed by the 2015 Plan, the Board has the right 
at anytime and from time to time to suspend, amend or terminate the 2015 Plan 
in any manner without consent or approval from participants or shareholders. 
No such suspension, amendment or termination shall materially prejudice the 
rights of anyparticipant under any outstanding award without the participant's 
consent. The full powers of the Board as provided for in the 2015 Plan will 
survive the termination of the 2015 Plan until all awards have been exercised 
or settled in full orhave otherwise expired.

                                       22                                       

-------------------------------------------------------------------------------

Table of Contents
Stock Options.
Options under the 2015 Plan can take the form of both incentivestock options 
("ISOs"), under which favorable tax treatment will be afforded the holder if 
certain conditions are met, and options not intended to qualify as ISOs 
("NQSOs"). The exercise price under both ISOs and NQSOs shall beat least 100% 
(or 110% in the case of an ISO granted to a participant who owns 10% or more 
of the total voting power of all classes of the Company's shares) of the fair 
market value of the Common Share on the date of grant. An option does 
notconvey any rights of a shareholder to the participant until the underlying 
shares have been issued. Only Eligible Persons who are employees of the 
Company or its parent or subsidiaries may be granted ISOs.
The Board may impose such limitations or conditions on the exercise or vesting 
of any option as it deems appropriate. Each Award Agreementwill provide that 
the Option granted thereunder may be exercised by notice signed by the 
participant and accompanied by full payment for the Common Shares being 
purchased or by other means, including without limitation electronic means via

on-line
arrangements, as the Board may from time to time approve and allow. Acceptable 
form of consideration for payment of the exercise price may include: (i) cash 
or check (ii) tendering to the CompanyCommon Shares already owned by the 
participant, and registered in his or her name, having a fair market value 
equal to the option price, (iii) a broker-assisted cashless exercise 
arrangement; (iv) net exercise; (v) such otherconsideration and method of 
payment permissible under applicable law; or (vi) by any combination of any of 
the foregoing payment methods.
Except as otherwise specified in the Award Agreement, (i) an option will 
remain exercisable for 90 days after the date the participantceases to be an 
Eligible Person due to his or her termination without cause or resignation (or 
180 days in the case of the participant's retirement); (ii) if a participant 
ceases to be an Eligible Person due a termination of employment orservice on 
account of disability, the option may be exercised by the participant or a 
representative within 365 days after such termination; (iii) in the event of 
death of the participant while an Eligible Person or within 90 days after 
ceasingto be an Eligible Person, the option shall be exercisable within 365 
days after the date of the participant's death; and (iv) an option shall 
immediately terminate and cease to be exercisable upon a participant's 
termination forcause. However, in no event may an option be exercised more 
than ten years (five years in the case of a participant who owns Common Shares 
possessing more than 10% of the total combined voting power of class of shares 
of the Company) after the grantdate or after the expiration of the option.
Stock Appreciation Rights.
Awards under the 2015 Plan may also be in the formof stock appreciation rights 
("SARs"), which are generally intended to give a participant the right to 
receive the difference between the fair market value per Common Share on the 
date of exercise over the exercise price, subject to theterms, conditions and 
vesting requirements imposed by the Board and set forth in the Award Agreement 
evidencing the SAR award. The exercise under each SAR will be determined by 
the Board by reference to the fair market price(s) of the Common Shareson the 
primary Stock Exchange for which most trading of the Common Shares occurs, 
generally by reference to the closing market price of the Common Shares, 
provided that such price may not be less than 100% of the Fair Market Value 
Price per CommonShare on the date of grant. To exercise a SAR, the participant 
must provide written notice of exercise to the Company in compliance with the 
provisions of the Award Agreement. No SAR shall be exercisable after the 
expiration of ten years from thedate of its grant or such shorter period 
specified in the Award Agreement. The appreciation distribution in respect of 
a SAR shall be paid in Common Shares, in cash, in any combination of the two 
or in any other form of consideration, as determinedby the Board and set forth 
in the Award Agreement.

                                       23                                       

-------------------------------------------------------------------------------

Table of Contents
Restricted Share Awards.
The Board may grant Common Shares which are subjectto restrictions on 
transferability as established by the Board and set forth in the Award 
Agreement evidencing such Restricted Share Award. A Restricted Share Award may 
be awarded in consideration for (i) cash, check, bank draft or money 
orderpayable to the Company; (ii) past services actually rendered to the 
Company or an Affiliate; or (iii) any other form of legal consideration that 
may be acceptable to the Board, in its sole discretion, and permissible under 
applicable law.Common Shares subject to a Restricted Share Award may be 
subject to forfeiture to or repurchase by the Company in accordance with a 
vesting schedule or other restrictions to be determined by the Board as 
specified in the Award Agreement. The Board,in its discretion, may accelerate 
the time at which any vesting conditions or other restrictions will lapse or 
be removed. Except as otherwise provided in the Award Agreement, a participant 
holding a Restricted Share Award may exercise full votingrights and be 
entitled to receive all dividends and distributions paid with respect to such 
Common Shares prior to the vesting of the award. If any such dividends or 
distributions are paid in Common Shares, the Common Shares will be subject to 
thesame restrictions on transferability and forfeitability as the Common 
Shares subject to the Restricted Share Award with respect to which they were 
paid. Except as otherwise provided in the 2015 Plan, Common Shares subject to 
the Restricted ShareAward will be held in escrow and released after such 
Common Shares vest or the restrictions lapse or at such other time as 
determined by the Board.
Restricted Share Unit Awards
.
Awards under the 2015 Plan may be in the form of a Restricted Share Unit (RSU) 
Award, whichrepresent the right to receive Common Shares (or its cash 
equivalent or combination thereof) at a designated time in the future, subject 
to participant's satisfaction of the restrictions and conditions to vesting 
established by the Board andset forth in the Award Agreement evidencing the 
RSU Award. At the time of grant of a RSU Award, the Board will determine the 
consideration, if any, to be paid by the participant upon delivery of each 
Common Share subject to the RSU Award. Theconsideration to be paid (if any) by 
the participant for each Common Share subject to a Restricted Share Unit Award 
may be paid in any form of legal consideration that may be acceptable to the 
Board of Directors in its sole discretion andpermissible under applicable law. 
A participant may be credited with dividend equivalents, which at the 
discretion of the Board, may be converted into additional common shares 
covered by the RSU Award. Since RSUs are not actual ownership interestsin the 
underlying Common Shares, a participant holding an RSU Award is not entitled 
to voting, dividend or other shareholder rights unless or until the RSUs vest 
and the Common Shares thereunder are transferred to the participant. Except 
asotherwise provided in the Award Agreement, the RSU Award (or vested portion 
thereof) shall be settled upon the participant's satisfaction of the 
applicable vesting criteria.
Performance Share Awards
.
The Board shall determine the terms and conditions applicable to a Performance 
Share Award, includingthe performance period, the performance objectives or 
other vesting provisions (including, without limitation, continued status as 
an Eligible Person). Performance objectives may be based upon the achievement 
of Company-wide, divisional, businessunit or individual goals. After the 
applicable performance period has ended, a participant will be entitled to 
receive a payout of the number of Common Shares subject to the Performance 
Share Award earned over the performance period, to bedetermined as a function 
of the extent to which the corresponding performance objectives or other 
vesting provisions have been achieved. The Board, in its sole discretion, may 
reduce or waive any performance objectives or other vesting provisionsfor such 
Common Shares subject to the Performance Share Award. A vested Performance 
Share Award may be settled in Common Shares, its cash equivalent, or in any 
combination thereof, as determined by the Board and contained in the Award 
Agreement.

                                       24                                       

-------------------------------------------------------------------------------

Table of Contents
401(k) Plan
All of our full-time employees in the United States, including our Named 
Executive Officers, are eligible to participate in our 401(k) plan,which is a 
retirement savings defined contribution plan established in accordance with 
Section 401(a) of the Code. Pursuant to our 401(k) plan, employees may elect 
to defer their eligible compensation into the plan on a
pre-tax
basis, up to the statutorily prescribed annual limit of $22,500 in 2023 
(additional salary deferrals not to exceed $7,500 are available to those 
employees 50 years of age or older) and to have the amount ofthis reduction 
contributed to our 401(k) plan. In general, eligible compensation for purposes 
of the 401(k) plan includes an employee's wages, salaries, fees for 
professional services and other amounts received for personal services 
actuallyrendered in the course of employment with us to the extent the amounts 
are includible in gross income, and subject to certain adjustments and 
exclusions required under the Code. The 401(k) plan currently does not offer 
the ability to invest in oursecurities.
Potential Payments Upon Termination or Change in Control
Pursuant to his employment agreement, Mr. Simard is eligible to receive 
severance and change in control benefits under the terms of hisemployment 
agreement described above under "--Employment Agreements with Named Executive 
Officers." Additionally, stock options granted to our Named Executive Officers 
are subject to the change in control provisions set forth in the2005 Plan and 
the 2015 Plan, as applicable, and as further described above under "--Equity 
Compensation Plans and Other Benefit Plans."
Compensation Committee Report*
TheCompensation Committee has reviewed and discussed the section titled 
"Executive Compensation" with management. Based on such review and discussion, 
the Compensation Committee has recommended to the Board of Directors that the 
sectiontitled "Executive Compensation" be included in this proxy statement.
Respectfully submitted by the members of the CompensationCommittee of the 
Board of Directors:
Donald MacAdam (Chair)
W. Thorpe McKenzie
Jan-Paul
Waldin


* This material is not "soliciting material," is not deemed "filed" with the SEC and is
  notto be incorporated by reference in any filing of the Company under the Exchange   
  Act or the Securities Act of 1933, as amended, whether made before or after the date 
  hereof and irrespective of any general incorporation language in any such filing.    

Equity Compensation Plan Information
The following table provides information as of December 31, 2023, with respect 
to shares of our common stock that may be issued under ourexisting equity 
compensation plans:

                                       25                                       

-------------------------------------------------------------------------------

Table of Contents

                                                                                              
Plan Category                      (a)                  (b)                   (c)             
                                Number of         Weighted-average    Number of securities    
                                securities           exercise              remaining          
                                  to be              price of            available for        
                                issued upon         outstanding         future issuance       
                                exercise of          options,            under equity         
                                outstanding          warrants            compensation         
                                 options,           and rights               plans            
                                 warrants                             (excludingsecurities    
                                and rights                               reflected in         
                                                                          column (a))         
Equity compensation plans                                                                     
approved by shareholders:                                                                     
2005 Incentive                      821,333 (1)         $    11.93              -- (2)
Stock Option Plan                                                                     
2015 Equity                       4,218,185 (1)         $     8.98               2,120,801    
Incentive Plan                                                                                
Equity compensation plans not                                                                 
approved by shareholders:                                                                     
None                                                                                          



(1) All shares issuable upon exercise of options.


(2) The 2005 Incentive Stock Option Plan expired in November 2015.

                           CEO PAY RATIO PERFORMANCE                            
Item 402(u) of the SEC's Regulation
S-K
requires disclosure of the ratio of the annual totalcompensation of the 
Company's CEO to the Company's median employee's annual total compensation. 
The ratio disclosed below is a reasonable estimate calculated in a manner 
consistent with Item 402(u).
Methodology and Determined Ratio
The payratio disclosure rule permits companies to identify the median employee 
only once every three years, provided that there has not been a change in 
employee population or employee compensation arrangements that would 
significantly change the pay ratiodisclosure. However, the total compensation 
amounts for both the median employee and the CEO to calculate the CEO pay 
ratio are required to be updated and disclosed on an annual basis.
In 2023, we determined the median employee by analyzing base salary and wages 
(including overtime, stock option, etc.) for all activeemployees (annualized 
based on full-time or part-time hourly or salaried status for 2020 if employed 
for less than the full year) in and outside the United States as of December 
31, 2023. We calculated the median employee's totalcompensation for 2023 in 
accordance with the rules applicable to disclosure of compensation in the 
summary compensation table. The total compensation of the median employee 
based on this methodology and criteria for 2023 was $100,548.
Mr. Simard's total compensation for 2023, as reported in the Summary 
Compensation Table, was $5,556,481. Therefore, the annual CEOtotal 
compensation was approximately 55 times that of the median annual total 
compensation of all other employees in 2023.

                                       26                                       

-------------------------------------------------------------------------------

Table of Contents
                             PAY VERSUS PERFORMANCE                             
As required by Section 953(a) of the Dodd-Frank Wall Street Reform and 
Consumer Protection Act and Item 402(v) of Regulation
S-K,
we are providing the following information about the relationship between 
executive compensation actually paid and certain financial performance of our 
company.


                                                                                                                   
Year      Summary          Compensation          Average             Average           Value of        Net Income  
        Compensation      Actually Paid to       Summary          Compensation       Initial Fixed      (Loss)     
       Table Total for          PEO            Compensation      Actually Paid to        $100          (millions)  
         Principal                            Table Total for        Non-PEO          Investment          (5)      
         Executive                               Non-PEO              NEOs             Based On                    
          Officer                                 Named                (3)              Total                      
          ("PEO")                               Executive                            Shareholder                   
            (1)                                  Officers                               Return                     
                                                 ("NEOs")                              ("TSR")                     
                                                   (2)                                   (4)                       
(a)         (b)                 (c)                (d)                 (e)               (f)              (g)      
2023         5,556,481           5,556,481            499,893             324,062            13.96         (24.56 )
2022         4,670,934           4,670,934            356,748             356,748           (68.64 )       (32.90 )
2021         7,785,554           7,785,554          1,119,996             529,317           (12.91 )       (17.41 )



(1) The dollar amounts reported in column (b) are the amounts of total        
    compensation reported forMr. Simard (our Chief Executive Officer) for each
    corresponding year in the "Total" column of the Summary Compensation      
    Table. Refer to "Executive Compensation--Summary Compensation Table."     


(2) The dollar amounts reported in column (d) represent the average of the amounts reported for ourcompany's named executive       
    officers as a group (excluding Mr. Simard) in the "Total" column of the Summary Compensation Table in each applicable year. The
    names of each of the named executive officers (excluding Mr. Simard)included for purposes of calculating the average amounts   
    in each applicable year are as follows: for 2023 Dr. Shivaswamy and Ms. Hu and for 2022, Dr. Shivaswamy and Ms. Queena Han.    


(3) The dollar amounts reported in column (e) represent the average amount of "compensation actuallypaid" to the named            
    executive officers as a group (excluding Mr. Simard), as computed in accordance with Item 402(v) of Regulation                
    S-K.                                                                                                                          
    The dollar amounts do not reflect the actual average amount ofcompensation earned by or paid to the named executive officers  
    as a group (excluding Mr. Simard) during the applicable year. In accordance with the requirements of Item 402(v) of Regulation
    S-K,                                                                                                                          
    thefollowing adjustments were made to average total compensation for the named executive officers                             
    as a group (excluding Mr. Simard) for each year to determine the compensation actually paid:                                  



                                                                        
Year   Average Reported      Average Reported     Average Compensation  
            Summary          Value of Equity      Actually Paid to Non- 
       Compensation Table      Awards ($)             PEO NEOs ($)      
           Total for                                                    
            Non-PEO                                                     
           NEOs ($)                                                     
2023              499,893            (175,831 )                 324,062 
2022              356,748            --                   356,748 
2021            1,119,996            (590,679 )                 529,317 


                                       27                                       

-------------------------------------------------------------------------------

Table of Contents

(4) Cumulative TSR is calculated by dividing the sum of the cumulative amount of dividends
    for the measurementperiod, assuming dividend reinvestment, and the difference         
    between our company's share price at the end and the beginning of the measurement     
    period by our company's share price at the beginning of the measurement period.       


(5) The dollar amounts reported represent the amount of net income (loss) reflected
    in our consolidated auditedfinancial statements for the applicable year.       

Analysis of the Information Presented in the Pay Versus Performance Table
We generally seek to incentivize long-term performance, and therefore do not 
specifically align our performance measures with"compensation actually paid" 
(as computed in accordance with Item 402(v) of Regulation
S-K)
for a particular year. In accordance with Item 402(v) of Regulation
S-K,
we are providing the following descriptions of the relationships between 
information presented in the Pay Versus Performance table.
Compensation Actually Paid and Net Income (Loss)
Our business model includes discovery and development of drug candidates for 
potential sale prior to marketing authorization. Revenues are thusperiodic 
(However, during the current reporting there was ongoing revenue associated 
with Janssen agreement related to our sale of bermekimab in 2019.). Our 
company has historically looked to value creation of is pipeline of assets 
rather than tonet income (loss) as a performance measure for our executive 
compensation program. In 2023 and 2022, our net loss increased due to 
declining revenues from the winding down of manufacturing commitments with the 
Janssen agreement. Compensation paidfor both our principal executive officer 
and
non-PEO
named executive officers increased between 2023 and 2022.
Compensation Actually Paid and Cumulative TSR
The compensation actually paid to Mr. Simard and the average amount of 
compensation actually paid to our named executive officers as agroup 
(excluding Mr. Simard) during the periods presented are related to performance 
measures with respect to the potential transactional value and market 
potential with our pipeline of drug candidates. To align executive 
compensation withperformance, we employ several measures, but they are 
generally not financial performance measures, such as TSR. For compensation we 
consider both stock options and cash awards as an essential part of our 
executive incentive andretention program. Stock options only generate value if 
the market price of our common stock increases and the executive officer 
remains employed with us during the vesting period and align our executive 
officers' interests with those ofour shareholders. Cash bonus provides strong 
incentive and retention value and is generally less costly to the Company in 
the long term than stock based compensation.

                                       28                                       

-------------------------------------------------------------------------------

Table of Contents
                             DIRECTOR COMPENSATION                              
We compensate
non-employee
members of the Board of Directors through both cash fees and annual 
equitygrants under our 2015 Plan, which grants are made at the fair market 
value of our common stock at the time of grant. Directors who are also 
employees do not receive cash or equity compensation in addition to 
compensation they receive for theirservice as our employees. Both
non-employee
and employee members of the Board of Directors are reimbursed as necessary for 
travel, lodging and other reasonable expenses incurred while attending Board 
ofDirectors or committee meetings.
The following table shows for the fiscal year ended December 31, 2023 certain 
information withrespect to the compensation of all
non-employee
directors of the Company. Because John Simard serves as Chief Executive 
Officer of XBiotech Inc., he does not receive compensation for his services as 
Chairmanof the Board.
                   Director Compensation for Fiscal Year 2023                   


                                                                                              
Name                 Fees Earned or      Option Awards    All Other Compensation    Total ($) 
                     Paid in Cash ($)    ($)(1)(2)(3)              ($)                        
W. Thorpe McKenzie             87,000          103,938               --      190,938 
Jan-Paul                       93,000          103,938               --      196,938 
Waldin                                                                               
Peter Libby                    60,000          103,938               --      163,938 
Donald H. MacAdam              84,000          103,938               --      187,938 



(1) Amounts listed represent the aggregate grant date fair value amount computed                                       
    as of the grant date of eachoption awarded during 2023 in accordance                                               
    with ASC 718. Assumptions used in the calculation of these amounts are                                             
    included in Note 2 to the Financial Statements in our Annual Report on Form                                        
    10-K                                                                                                               
    for the yearended December 31, 2023. As required by SEC rules, the amounts shown exclude the impact of estimated   
    forfeitures related to service-based vesting conditions. Our directors will only realize compensation to the extent
    the trading price of ourcommon stock is greater than the exercise price of such stock options. As required by SEC  
    rules, the amounts shown exclude the impact of estimated forfeitures related to service-based vesting conditions.  


(2) Pursuant to the terms of their Board Member Agreements or other agreements with the Company. McKenzie, MacAdam,Waldin, and
    Libby were each granted 25,000 nonstatutory stock options under the Company's 2015 Equity Incentive Plan, which options   
    were granted at the closing sales price per share of the Company's Common Stock on the date of issuance.All such options  
    vest in two equal portions at six months and one year from the Grant Date and expire ten years from the Grant Date.       


                                       29                                       

-------------------------------------------------------------------------------

Table of Contents

(3) The aggregate number of outstanding options held by McKenzie, MacAdam, Waldin, and  
    Libby as ofDecember 31, 2023 was 267,500, 140,000, 150,000 and 87,500, respectively.

Transactions with Related Parties
Policies and Procedures for Related Party Transactions
. As set forth in our audit committee charter, our audit committee is 
responsiblefor reviewing and approving, in accordance with the Company's 
Related Party Transaction Policy, any proposed transaction between the Company 
and any related party as defined by applicable law, the SEC rules and the 
Nasdaq Rules, which consistof all transactions and series of similar 
transactions to which we were a party or will be a party and in which any of 
our directors, executive officers and holders of more than 5% of our voting 
securities and their respective affiliates has adirect or indirect material 
interest. As used in this section, the terms "related person" and 
"transaction" have the meanings set forth in Item 404(a) of Regulation

S-K
under the SecuritiesAct. In the course of its review and approval of 
transactions with related persons, the audit committee considers:


 .  the nature of the related person's interest in the transaction;



 .  the material terms of the transaction, including the amount involved and the type of the transaction;



 .  the importance of the transaction to the related person and to XBiotech;



 .  whether the transaction would impair the judgment of a director or executive     
    officer to act in our best interestand the best interest of our shareholders; and



 .  any other matters the audit committee deems appropriate.

Any member of the audit committee who is a related person with respect to a 
transaction under review will not be able to participate in thediscussions or 
vote on the approval or ratification of the transaction, other than to provide 
all material information regarding the transaction, including information 
regarding the extent of the member's interest in the transaction, to theaudit 
committee. However, such a director may be counted in determining the presence 
of a quorum at a meeting of the committee that considers the transaction. Any 
material changes to the terms of, or any renewal of, any of these transactions 
willalso require the same approval. If a related party transaction will be 
ongoing, the audit committee may establish guidelines or other parameters or 
conditions relating to our participation in the transaction. The audit 
committee may from time totime
pre-approve
types or categories of transactions by related persons but we have no such
pre-approved
types or categories of transactions at this time.
Related Transactions.
During the last two completed fiscal years, we have not been a party to any 
transaction or series of transactionsin which the amount involved exceeds 
$120,000, in which any of our directors, executive officers, or holders of 
more than 5% of our shares, or an affiliate or immediate family member 
thereof, had or will have a direct or indirect material interest,other than 
compensation arrangements which are described under the sections of this proxy 
captioned "Director Compensation" and "Executive Compensation" and the 
previously disclosed Convertible Loan Agreement (the"Loan") dated January 3, 
2024 between the Company and Mr. Simard, our Chief Executive Officer and 
chairman of the Board of Directors. The Loan provides $10 million in funding 
for the construction of a new,
state-of-the-art
research and development facility at 5217 Winnebago Lane in Austin, Texas. The 
Loan is secured by the real estate andcash holdings of the Company, with 
interest to accrue at a simple rate equal to eight percent per year and 
interest-only payments to be made at
six-month
intervals after the

                                       30                                       

-------------------------------------------------------------------------------

Table of Contents
Loan is funded. The largest amount of principal outstanding under the Loan was 
$10 million on January 4, 2024. The current amount of principal outstanding, 
as of April 24, 2024, is$10 million. We have paid approximately $0 in 
principal and $0 in interest under the Loan. At Mr. Simard's election, the 
balance may be converted to XBiotech stock at any time the Loan balance is 
outstanding at a fixed conversionprice equal to the average Nasdaq Official 
Closing Price of the common stock (as reflected on Nasdaq.com) for the five 
trading days immediately preceding the signing of this Loan, which is $4.048 
per share. The conversion feature is subject to a caplimiting the number of 
shares that could be converted under the Loan based on Mr. Simard's total 
stock ownership in the Company at the time of conversion. The Loan also allows 
Mr. Simard to obtain immediate cash repayment of the Loanbalance at his 
election one year after the Loan is funded or upon certain other conditions 
set forth in the Loan.
Related PersonTransaction Policy.
We adopted a formal, written policy, which became effective as of February 
2015, that our executive officers, directors (including director nominees), 
holders of more than 5% of any class of our voting securities, and anymember 
of the immediate family of or any entities affiliated with any of the 
foregoing persons, are not permitted to enter into a related party transaction 
with us without the prior approval or, in the case of pending or ongoing 
related partytransactions, ratification of our audit committee. For purposes 
of our policy, a related party transaction is a transaction, arrangement or 
relationship where we were, are or will be involved and in which a related 
party had, has or will have adirect or indirect material interest, other than 
transactions available to all of our employees.
Indemnification Agreements.
Wehave entered into indemnification agreements with our directors in addition 
to the indemnification provided for under the British Columbia Business 
Corporations Act (the "BCBCA") and in our Articles. These agreements, among 
other things,require us to indemnify our directors for certain expenses, 
including attorneys' fees, judgments, fines and settlement amounts incurred by 
a director in any action or proceeding arising out of their services as one of 
our directors or any othercompany or enterprise to which the person provides 
services at our request. We believe that these indemnification agreements are 
necessary to attract and retain qualified persons as directors.
Requirements under the British Columbia Business Corporations Act.
Pursuant to the BCBCA, directors and officers are required to acthonestly and 
in good faith with a view to the best interests of the company. Under the 
BCBCA, subject to certain limited exceptions, a director who holds a 
disclosable interest in a material contract or transaction is not entitled to 
vote on anydirector's resolution approving such contract or transaction. A 
director or senior officer, with certain exceptions, has a disclosable 
interest in a contract or transaction if:
(a) the contract or transaction is material to the company;
(b) the company has entered, or proposes to enter, into the contract or 
transaction;
(c) either of the following applies to the director or senior officer:
(i) the director or senior officer has a material interest in the contract or 
transaction;
(ii) the director or senior officer is a director or senior officer of, or has 
a material interest in, a person who has a material interest inthe contract or 
transaction.

                                       31                                       

-------------------------------------------------------------------------------

Table of Contents
                                 OTHER MATTERS                                  
The Board of Directors knows of no other matters that will be presented for 
consideration at the annual meeting. If any other matters areproperly brought 
before the meeting, it is the intention of the persons named in the proxy to 
vote on such matters in accordance with their best judgment.


                                  
By Order of the Board of Directors
                                  
                                  
John Simard                       
President & CEO                   

May 1, 2024
A copyof the Company's Annual Report to the Securities and Exchange Commission 
on Form
10-K
for the fiscal year ended December 31, 2023 is available without charge upon 
written request to: CorporateSecretary, XBiotech Inc., 5217 Winnebago Lane 
Austin, TX 78744. This Annual Report is enclosed herewith. This report does 
not form any part of the material for solicitation of proxies.

                                       32                                       

-------------------------------------------------------------------------------

Table of Contents

Biotech Biotech YOUR YOUR VOTE VOTE IS IS IMPORT IMPORTANT! ANTI PLEASE PLEASE 
VOTE VOTE BY: BY: 10:00 10:00 AM, AM, Cen Central tralTime, Time, June June 
20, 20, 2024. 2024. This proxy is being solicited on behalfof the Board of 
Directors The The undersigned undersigned hereby hereby appoints appoints John 
John Simard Simard a and nd! Angela Angela Hu Hu (the (the"'Named "Named 
Proxies1. Proxies"), and and each each Of or either eitherof o f them. them, 
as as the the tue true and and lawful lawful att:lmeys atiomeys of of the the 
unders-igned. undersigned, v. with ith full full powerpower of of substilution 
substitution and and revocation, rewocation, and and authorizes authorizes 
them. them, and and each each o of f them. them, t1 tp vote wote all all the 
the s shares hares of of capital capital stick stock of XBioledl ofXBiotech 
lnc. Inc. w which hich the the undersigned undersigned is is entitJed entitled 
to to vote vote at at said said meeting meeting a and nd anyadjourrment any 
adjoumment or or poslponement postponement thereof thereof upon upon the the 
mattersmatters specified specified a and nd upon upon s such uch other other 
matlersas matters as may may be be property properly brought brought before 
before the the meeting meeting or or a any rryadjourrmento adjournment orr 
postponement postponementthereof, thereof. oonferring conferring a authority 
uthority upon upon s such uch t true ue and and lawfut lawful a attorneys 
tlorneys t1 to vote vote in in their their discretion discretion on on s such 
udl o other ther matters matters as asmaypropertyc:orre may properly come 
before before the the meeting meeting and and revolting revoking any any proxy 
proxy heretofore heretofore giwn. given. THE THE SHARES SHARES REPRESENTED 
REPRESENTED BY BY THIS THIS PROXY PROXY W WILL IU BE BEVOTED VOTED AS AS 
DIRECTED DIRECTED OR. OR, IF IF NO NO DIRECTION DIRECTION IS IS GIVEN. GIVEN, 
SHARES SHARES WILL WILL BE BE VOTED VOTED IDENTICAL IDENTICAL TO TO THE THE 
BOARD BOARD OF OF DIRECTORS DIRECTORS R8COMMENDATION. RECOMMENDATION. ThisThis 
proxy, proxy, when when property properly executed. executed, will will be be 
voted voted in in the the rrenner manner directed directed herein. herein. In 
In their their disctetion, discretion, the the Named Named Proxies Proxies are 
areauthorized authorized rto to vote vote upon upon such such other other 
matters matters that that maypropertycome may properly come before before the 
the meeting meeting or or a any ny adjournment adjoumment o orr postponement 
postponement thereof.thereof. You You are are encouraged encouraged to to 
specify specifyyour your choice choice by by marking marking the the a 
appropriate ppropriate box box (SEE (SEE REVERSE REVERSE SIDE) SIDE) but but 
you you need need not not maril. mark a any rrybox box ifif you you w wish 
is-h to to \Ole vote in in aocorda:r. accordance oa witt with the the Board 
Board of of Oiroot:. Directors' rs' t&OOI'NMI'Idation. recommendation. The The 
Na!Md Named ProxiM Proxies eenr.cannototvote vote your your shares shares 
unless unless you you sign sign (on (on tte the l'G\Ietse reverse side) side) 
Md and retum return this this card. card. PLEASE PLEASE BE BE SURE SURE TO TO 
SIGN SIGN AND AND DATE DATE THIS THIS PROXYPROXY CARD CARD AND AND MARK MARK 
ON ON THE THE REVERSE REVERSE SIDE SIDE Copyright~ Copyright (c) 2024 2024 
B:etaNXT. BetaNxtT, In<. Inc. o orr its its affiliates. affiliates. All All 
Rights Rights Reserved Reserved

-------------------------------------------------------------------------------

Table of Contents

Please make your marks like this: THE BOARD OF DIRECTORS RECOMMENDS A VOTE: 
FOR ON PROPOSALS 1, 2 AND 3 PROPOSAL YOUR VOTE 1. To electthe five (5) 
nominees for director named herein to serve until the next annual meeting and 
their successorsare duly elected and qualified. 1.01 FOR = WITHHOLD John 
Simard 1.02 W. Thome McKenzie O O 1.03 Jan-Paul Wakdin, Esq. 1.04 Donald H. 
MacAdam OO 1.05 Peter Libby, M.D. FOR AGAINST ABSTAIN 2. To ratify the 
selection by the Audit Committee of the Board of Directors of Whitey Penn LLP 
as the independent registered public accounting firm of the Companyfor its 
fiscal year ending December 31,2024. 3. To approve, on an advisory basis, the 
compensation of the Company's named executive officers. ([] oO oO To conduct 
any other business properly brought before the meeting. You must register to 
attend the meeting online and/orparticipate at www.proxyd ocs.com/XBIT 
Authorized Signatures - Must be completed for your instructions to be 
executed. Please sign exactly as your name{s) appears on your account. If held 
in joint tenancy, all persons should sign. Trustees,administrators, etc., 
should indude title and authority. Corporations should provide full name of 
corporation and title of authorized officer signing the Proxy/Vote Form. 
Signature (and Title if applicable) Date Signature (if held jointly) Date

{graphic omitted}
{graphic omitted}
{graphic omitted}
{graphic omitted}