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                          March 26, 2024

       Laurent Fischer
       President and Chief Executive Officer
       Adverum Biotechnologies, Inc.
       100 Cardinal Way
       Redwood City, CA 94063

                                                        Re: Adverum 
Biotechnologies, Inc.
                                                            Registration 
Statement on Form S-3
                                                            Filed March 21, 
2024
                                                            File No. 333-278157

       Dear Laurent Fischer:

              This is to advise you that we have not reviewed and will not 
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for 
acceleration. We remind you
       that the company and its management are responsible for the accuracy and 
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of 
action by the staff.

                                                        Please contact Jason 
Drory at 202-551-8342 with any questions.



                                                                                
                          Sincerely,

                                                                                
                          Division of Corporation Finance
                                                                                
                          Office of Life Sciences
       cc:                                              Julia R. Boesch