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                          February 7, 2024

       Sean Bohen
       Chief Executive Officer
       Olema Pharmaceuticals, Inc.
       780 Brannan Street
       San Francisco, CA 94103

                                                        Re: Olema 
Pharmaceuticals, Inc.
                                                            Registration 
Statement on Form S-3
                                                            Filed January 31, 
2024
                                                            File No. 333-276787

       Dear Sean Bohen:

              This is to advise you that we have not reviewed and will not 
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for 
acceleration. We remind you
       that the company and its management are responsible for the accuracy and 
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of 
action by the staff.

                                                        Please contact Doris 
Stacey Gama at 202-551-3188 with any questions.



                                                                                
                          Sincerely,

                                                                                
                          Division of Corporation Finance
                                                                                
                          Office of Life Sciences
       cc:                                              Julia Boesch, Esq.