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                     January 31, 2024

       Shoshana Shendelman
       President and Chief Executive Officer
       Applied Therapeutics Inc.
       545 Fifth Avenue, Suite 1400
       New York, NY 10017

                                                        Re: Applied 
Therapeutics Inc.
                                                            Form 10-K for the 
Fiscal Year Ended December 31, 2022
                                                            Filed March 23, 
2023
                                                            File number 
001-38898

       Dear Shoshana Shendelman:

              We have completed our review of your filing. We remind you that 
the company and its
       management are responsible for the accuracy and adequacy of their 
disclosures, notwithstanding
       any review, comments, action or absence of action by the staff.



                                                                                
                     Sincerely,

                                                                                
                     Division of Corporation Finance
                                                                                
                     Office of Life Sciences