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                           June 28, 2023

       Terrance Coyne
       Chief Financial Officer
       Royalty Pharma plc
       110 East 59th Street
       New York, NY 10022

                                                        Re: Royalty Pharma plc
                                                            Form 10-K for the 
period ended December 31, 2022
                                                            Filed February 15, 
2023
                                                            File No. 001-39329

       Dear Terrance Coyne:

              We have limited our review of your filing to the financial 
statements and related
       disclosures and have the following comments. In some of our comments, we 
may ask you to
       provide us with information so we may better understand your disclosure.

              Please respond to these comments within ten business days by 
providing the requested
       information or advise us as soon as possible when you will respond. If 
you do not believe our
       comments apply to your facts and circumstances, please tell us why in 
your response.

                                                        After reviewing your 
response to these comments, we may have additional comments.

       Form 10-K for the period ended December 31, 2022

       Non-GAAP Financial Results, page 68

   1.                                                   In order to get a 
better understanding of your non-GAAP measures and presentation,
                                                        please address the 
following in your response and in proposed revised disclosure as
                                                        applicable:
                                                            As Total royalty 
receipts does not appear to be the most directly comparable GAAP-
                                                             basis measure for 
your non-GAAP measures, please tell us how your presentation
                                                             complies with Item 
10(e)(1)(i)(B) of Regulation S-K.
                                                            On page 53, you 
state that Adjusted EBITDA, which is derived from Adjusted Cash
                                                             Receipts, is used 
by your lenders to assess your ability to meet your financial
                                                             covenants. You 
also note on page 73 that Adjusted EBITDA is critical to the
                                                             assessment of the 
company's liquidity. In this regard in future filings,
                                                               o  relocate your 
presentations of Adjusted EBITDA to your Liquidity and Capital
                                                                  Resources 
section, and
 Terrance Coyne
Royalty Pharma plc
June 28, 2023
Page 2
                 orevise the presentation for the calculation of Adjusted 
EBITDA to more strictly
                  reflect its definition as found in the credit agreement.
         Refer to Question 102.09 of the Compliance & Disclosure 
Interpretations regarding Non-
         GAAP Financial Measures.


2.       With regards to each of your reconciliations provided on page 74, 
please address the
         following:
             Explain the apparent inconsistencies with regards to certain 
reconciling items in your
              non-GAAP measures. For example, we note that you present proceeds 
from available
              for sale debt securities as a reconciling item however you do not 
include purchases of
              available for sale debt securities in the reconciliation.
             In addition, certain adjustments to these non-GAAP liquidity 
measures appear to be
              inconsistent with Item 10(e)(1)(ii)(A) of Regulation S-K. Please 
advise.
             With regards to your non-GAAP measure, Adjusted Cash Flow, please 
more clearly
              explain what this measure represents and how you determined its 
presentation
              complies with Item 10(e)(1)(i)(C) of Regulation S-K.

       In closing, we remind you that the company and its management are 
responsible for the
accuracy and adequacy of their disclosures, notwithstanding any review, 
comments, action or
absence of action by the staff.

       You may contact Sasha Parikh at 202-551-3627 or Kevin Vaughn at 
202-551-3494 with
any questions.



FirstName LastNameTerrance Coyne                              Sincerely,
Comapany NameRoyalty Pharma plc
                                                              Division of 
Corporation Finance
June 28, 2023 Page 2                                          Office of Life 
Sciences
FirstName LastName