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                          December 14, 2023

       Julie Eastland
       President and Chief Executive Officer
       Harpoon Therapeutics, Inc.
       611 Gateway Boulevard, Suite 400
       South San Francisco, California 94080

                                                        Re: Harpoon 
Therapeutics, Inc.
                                                            Registration 
Statement on Form S-3
                                                            Filed December 8, 
2023
                                                            File No. 333-275958

       Dear Julie Eastland:

              This is to advise you that we have not reviewed and will not 
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for 
acceleration. We remind you
       that the company and its management are responsible for the accuracy and 
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of 
action by the staff.

                                                        Please contact Alan 
Campbell at 202-551-4224 with any questions.



                                                                                
                          Sincerely,

                                                                                
                          Division of Corporation Finance
                                                                                
                          Office of Life Sciences
       cc:                                              Marina Remennik