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                         November 22, 2023

       Kamal Adawi
       Chief Financial Officer
       Exagen Inc.
       1261 Liberty Way
       Vista, California 92081

                                                        Re: Exagen Inc.
                                                            Registration 
Statement on Form S-3
                                                            Filed November 17, 
2023
                                                            File No. 333-275362

       Dear Kamal Adawi:

              This is to advise you that we have not reviewed and will not 
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for 
acceleration. We remind you
       that the company and its management are responsible for the accuracy and 
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of 
action by the staff.

                                                        Please contact Abby 
Adams at 202-551-6902 with any questions.



                                                                                
                         Sincerely,

                                                                                
                         Division of Corporation Finance
                                                                                
                         Office of Industrial Applications and
                                                                                
                         Services