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                          October 26, 2023

       Arjan Haverhals
       Chief Executive Officer
       Milestone Scientific Inc.
       425 Eagle Rock Ave, Suite 403
       Roseland, New Jersey 07068

                                                        Re: Milestone 
Scientific Inc.
                                                            Registration 
Statement on Form S-3
                                                            Filed October 19, 
2023
                                                            File No. 333-275088

       Dear Arjan Haverhals:

              This is to advise you that we have not reviewed and will not 
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for 
acceleration. We remind you
       that the company and its management are responsible for the accuracy and 
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of 
action by the staff.

                                                        Please contact Benjamin 
Richie at 202-551-7857 with any questions.



                                                                                
                          Sincerely,

                                                                                
                          Division of Corporation Finance
                                                                                
                          Office of Industrial Applications and
                                                                                
                          Services
       cc:                                              Lawrence M. Bell