false
0001755237
NASDAQ
0001755237
2023-05-11
2023-05-11
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                                 UNITED STATES                                  
                       SECURITIES AND EXCHANGE COMMISSION                       
                             Washington, D.C. 20549                             

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                                      FORM                                      
                                      8-K                                       

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                                 CURRENT REPORT                                 
                        Pursuant to Section 13 or 15(d)                         
                     of the Securities Exchange Act of 1934                     
               Date of Report (Date of earliest event reported):                
                                  May 11, 2023                                  

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                          CYCLERION THERAPEUTICS, INC.                          
             (Exact name of registrant as specified in its charter)             

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                Massachusetts                         001-38787                      83-1895370             
(State or other jurisdiction of incorporation) (Commission File Number) (IRS Employer Identification Number)


                          245 First Street, 18th Floor                          
                                   Cambridge                                    
                                       ,                                        
                                 Massachusetts                                  
                                     02142                                      

          (Address of principal executive offices, including Zip Code)          
              Registrant's telephone number, including area code:               
                                       (                                        
                                      857                                       
                                       )                                        
                                    327-8778                                    

Check the appropriate box below if the Form 8-K filing is intended to 
simultaneously satisfy the filing obligation of the registrant under any of 
the following provisions:


  Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)


  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)


  Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))


  Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))


Securities registered pursuant to Section 12(b) of the Act:


Title of each class         Trading Symbol(s)  Name of each exchange on which registered
Common Stock, no par value        CYCN               The Nasdaq Capital Market LLC      


Indicate by check mark whether the registrant is an emerging growth company as 
defined in Rule 405 of the Securities Act of 1933 ((s)230.405 of this chapter) 
or Rule 12b-2 of the Securities Exchange Act of 1934 ((s)240.12b-2 of this 
chapter). Emerging growth company


If an emerging growth company, indicate by check mark if the registrant has 
elected not to use the extended transition period for complying with any new 
or revised financial accounting standards provided pursuant to Section 13(a) 
of the Exchange Act.


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Item 1.01. Entry into a Material Definitive Agreement.


The Asset Purchase Agreement

On May 11, 2023, Cyclerion Therapeutics, Inc., a Massachusetts corporation 
(the "
Company
", "
we
", "
us
" or "
our
") entered into an Asset Purchase Agreement (the "
Asset Purchase Agreement
") with JW Celtics Investment Corp., a Delaware corporation ("
Buyer Parent
") and JW Cycle Inc., a Delaware corporation ("
Buyer
" and together with Buyer Parent, "
Buyers
"), pursuant to which the Company has agreed, subject to certain conditions, 
including the authorization and approval of the Asset Purchase Agreement by 
its shareholders, to sell to Buyer specified assets relating to the Company's 
zagociguat (previously known as CY6463) and CY3018 programs (the "
Purchased Programs
", and such assets, the "
Purchased Assets
"), and Buyer has agreed to assume certain liabilities relating to the 
Purchased Programs, including, but not limited to (i) liabilities, costs and 
expenses arising after the date of the Asset Purchase Agreement relating to 
the employment of certain individuals prior to the Employee Expenses End Date 
(as defined in the Asset Purchase Agreement) ("
Employee Expenses
") and the conduct of certain preclinical and clinical trial activities prior 
to the closing of the transactions contemplated by the Asset Purchase 
Agreement ("
R&D Expenses
"), and (ii) liabilities relating to the Purchased Assets or the Purchased 
Programs to the extent relating to the period after the closing of the 
transaction, in each case, subject to the terms and conditions of the Asset 
Purchase Agreement (the "
Asset Sale Transaction
"). Cyclerion will retain the assets comprising the olinciguat, praliciguat 
and preclinical programs (the "
Retained Programs
"), which the Company intends to continue to develop and/or out-license 
following the closing of the Asset Sale Transaction.

As consideration for the Asset Sale Transaction, Buyers agreed to (a) pay the 
Company (i) $8,000,000 at the closing of the Asset Sale Transaction, plus (ii) 
the amount of any Employee Expenses and R&D Expenses for which Buyers are 
obligated to reimburse the Company pursuant to the Asset Purchase Agreement 
and which remain unpaid as of the closing of the Asset Sale Transaction; and 
(b) deliver to the Company a number of shares of common stock, par value 
$0.0001 per share, of Buyer Parent, such that following the issuance thereof, 
such shares comprise 10% of the issued and outstanding shares of Buyer Parent 
immediately following the closing of the Asset Sale Transaction, subject to 
certain protections against dilution up to a $100 million valuation of Buyer 
Parent on a fully diluted basis.

The transaction has been unanimously approved by the Company's board of 
directors (the "
Board
")
without participation of Peter M. Hecht, Ph.D., our Chief Executive Officer, 
and Terrence McGuire, due to their interests in Buyer Parent
. The affirmative vote of the holders of a majority of all shares entitled to 
vote on the proposal, in person or by proxy, is required to approve the Asset 
Sale Transaction (the "
Stockholder Approval
"). The Board has recommended that the Company's shareholders vote in favor of 
the Asset Sale Transaction.

In addition to the receipt of Stockholder Approval, the obligation of the 
Company, on the one hand, and Buyers, on the other hand, to consummate the 
Asset Sale Transaction is conditioned upon certain other customary closing 
conditions, including the accuracy of the other party's representations and 
warranties as of closing, subject, in certain instances, to certain 
materiality and other thresholds, the performance by the other party of its 
obligations and covenants under the Asset Purchase Agreement, the absence of 
any law or government order of any nature that restrains, enjoins or otherwise 
prohibits, or has the effect of restraining, enjoining or otherwise 
prohibiting, the Asset Sale Transaction from being consummated, the absence of 
a material adverse effect with respect to the Company, the Company having 
received evidence that Buyer Parent closed on the second tranche of its $81 
million financing, and the delivery of certain documentation by the other 
party, in each case, as set forth in the Asset Purchase Agreement.

The Asset Purchase Agreement also contains representations, warranties, 
covenants, indemnification and termination rights of the applicable parties 
customary for transactions similar to those contemplated by the Asset Purchase 
Agreement. Such representations and warranties are made solely for purposes of 
the Asset Purchase Agreement and, in some cases, may be subject to 
qualifications and limitations agreed to by the parties in connection with the 
negotiated terms of the Asset Purchase Agreement and may have been qualified 
by disclosures that were made in connection with the parties' entry into the 
Asset Purchase Agreement.

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The Asset Purchase Agreement requires that Cyclerion, from signing until the 
earlier of the termination of the Asset Purchase Agreement or closing of the 
Asset Sale Transaction, not initiate contact with or solicit any inquiry or 
proposal or engage in any discussions with third parties in connection with 
possible proposals regarding a sale or licensing of the Purchased Assets and 
certain other strategic transactions involving the Company. The Company has 
agreed to promptly provide notice to Buyer of any solicitation or offer made 
by any third party in connection with such alternative transaction. If Buyers 
terminate the Asset Purchase Agreement because there is a Cyclerion Adverse 
Recommendation Change (as defined in the Asset Purchase Agreement), the 
Company must pay a termination fee of $500,000 as well as reimburse 
out-of-pocket expenses of Buyers in an amount equal to $1,000,000 and 
reimbursement of Employee Expenses and R&D Expenses actually reimbursed or 
paid by Buyers.

The Asset Purchase Agreement may be terminated by either party if the 
transaction is not completed by September 11, 2023 or otherwise under certain 
specified conditions.

The foregoing description of the Asset Purchase Agreement does not purport to 
be complete and is qualified in its entirety by reference to the full text of 
such agreement filed herewith as
Exhibit 2.1
and incorporated herein by reference.

Fairness Opinion

In connection with the Asset Sale Transaction, our financial advisor, Stifel, 
Nicolaus & Company, delivered to our Board its opinion, dated May 10, 2023, 
that, as of the date thereof, the consideration to be received by the Company 
from Buyer in the Asset Sale Transaction pursuant to the Asset Purchase 
Agreement is fair to the Company, from a financial point of view.


Item 2.02. Results of Operations and Financial Condition.


The disclosure set forth in Item 7.01 of this Current Report on Form 8-K is 
incorporated herein by reference.


Item 3.02 Unregistered Sales of Equity Securities.


As previously announced, on March 31, 2023,
the Company
entered into an agreement (the "
Subscription Agreement
") with Peter M. Hecht, Ph.D., our Chief Executive Officer and a member of the 
Board, for him to make an equity investment in the Company of $5,000,000 in 
cash for common stock or nonvoting Series A convertible preferred stock of the 
Company, the purchase price, consistent with Nasdaq rules, to be at or above 
the market price at the time of signing that agreement of $0.434 per share 
(subject to appropriate adjustment for the reverse stock split anticipated to 
be implemented after our 2023 annual meeting of stockholders, if such reverse 
stock split is approved by shareholders, or any other change in our common 
stock). With the signing of the Asset Purchase Agreement, all contingencies to 
the investment have been met and the closing of the equity investment is 
scheduled to take place on May 19, 2023. Pursuant to the Subscription 
Agreement, the Board intends to solicit our shareholders to vote in favor of 
approval of the issuance of shares of common stock to Dr. Hecht upon 
conversion of such Series A convertible preferred stock.
Each share of Series A convertible preferred stock is initially convertible 
into one share of common stock, subject to customary anti-dilution protections.


The Company relied upon the exemptions from registration afforded by 
Regulation D under, and Section 4(a)(2) of, the Securities Act of 1933, as 
amended (the
"
Securities Act
"
), as transactions not involving any public offering.

Additionally, Dr. Hecht and Mr. McGuire, directly, beneficially or through 
affiliates, are equity investors in Buyer Parent, and each has committed to, 
directly, beneficially or through affiliates, purchase shares of Buyer 
Parent's preferred stock.


Item 7.01 Regulation FD Disclosure.


On May 11, 2023, the Company issued press releases regarding the execution of 
the Asset Purchase Agreement and its financial and operating results for the 
first quarter of 2023, respectively. Copies of the press releases are 
furnished as
Exhibits 99.1
and
99.2
, respectively, to this Current Report on Form 8-K. Such exhibits and the 
information set forth therein shall not be deemed to be filed for purposes of 
Section 18 of the Securities Exchange Act of 1934 (the "
Exchange Act
") or otherwise be subject to the liabilities of that section, nor shall they 
be deemed to be incorporated by reference in any filing under the Securities 
Act or the Exchange Act.

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Item 8.01 Other Events.


Voting and Support Agreements

Simultaneously with the execution of the Asset Purchase Agreement, Buyer 
Parent entered into voting and support agreements (each, a "
Voting and Support Agreement
") with each equityholder (and certain affiliates of any such equityholder) of 
Buyer Parent or any subsidiary of Buyer Parent that is also a shareholder of 
the Company, which shareholders collectively held approximately 21.3% of the 
total outstanding voting shares of the Company and include Dr. Hecht and The 
Invus Group, LLC, each of whom owns more than five percent of our total 
outstanding voting shares, as well as certain funds managed by Polaris 
Partners, an affiliate of Mr. McGuire.

Pursuant to the Voting and Support Agreements, each shareholder signatory 
thereto has agreed, with respect to all of the shares of the Company's common 
stock that such shareholder beneficially owns as of the date thereof or 
thereafter (the "
Covered Stock
"), to, among other things, (a) vote in favor of the Asset Sale Transaction; 
and (b) not transfer any such Covered Stock during the term of such Voting and 
Support Agreement. The Voting and Support Agreements will terminate upon the 
earlier of the termination of the Asset Purchase Agreement in accordance with 
its terms, the consummation of the closing of the Asset Sale Transaction, 
Buyer Parent's receipt of notice of a Cyclerion Adverse Recommendation Change, 
the mutual written consent of the parties thereto, and the entry into any 
amendment to the Asset Purchase Agreement without the prior written consent of 
the applicable shareholder that is materially adverse to such shareholder. The 
Company is an express third-party beneficiary of the Voting and Support 
Agreements.

The foregoing description of the Voting and Support Agreements does not 
purport to be
complete and is qualified in its entirety by reference to the full text of the 
form of Voting and Support Agreement, a copy of which is filed herewith as
Exhibit 10.1
and incorporated herein by reference.

Forward-Looking Statements

This Current Report on Form 8-K and the attached exhibits contain 
"forward-looking statements" within the meaning of the federal securities 
laws. These forward-looking statements include statements concerning our 
outlook for the future, as well as other statements of beliefs, future plans 
and strategies or anticipated events, and similar expressions concerning 
matters that are not historical facts. These statements can be identified by 
the use of forward-looking terminology such as "predicts," "believes," 
"potential," "continues," "estimates," "anticipates," "expects," "plans," 
"intends," "may," "could," "might," "will," "should," "positive," "projects," 
"targets," "optimistic," aims," or the negative thereof or other variations 
thereon or other comparable terminology. The forward-looking statements 
included in this Current Report on Form 8-K or the attached exhibits are based 
on management's current expectations and assumptions about future events, 
which are inherently subject to uncertainties, risks and changes in 
circumstances that are difficult to predict and could cause actual results to 
differ materially from those expressed in, or implied by, the forward-looking 
statements. These risks and uncertainties include, but are not limited to, the 
following: our shareholders failing to approve the Asset Sale Transaction; the 
failure of one or more conditions to the closing of the Asset Sale Transaction 
to be satisfied or waived by the applicable party; an increase in the 
anticipated amount of costs, fees, expenses and other charges related to the 
Asset Purchase Agreement or Asset Sale Transaction, including the expenses of 
any claims or litigation seeking to challenge the transaction or disclosures 
in connection therewith or recover any damages alleged to arise therefrom; 
expenses associated with the potential exercise of appraisal rights and any 
related adjudication of the fair value of our common stock; the occurrence of 
any event, change or other circumstances that could give rise to the 
termination of the Asset Purchase Agreement; risks arising from the diversion 
of management's attention from our ongoing business operations; risks 
associated with our ability to monetize the Retained Programs and/or to 
identify and realize business opportunities following the Asset Sale 
Transaction; fluctuations in demand for our technology; risks of losing key 
personnel, customers, distributors, or suppliers; protection of the Company's 
intellectual property and government policies and regulations, including, but 
not limited to those affecting the Company's industry; and the matters 
discussed under "Item 1A. Risk Factors" of the Company's Annual Report on Form 
10-K for the fiscal year ended December 31, 2022, as amended and updated from 
time to time in the Company's subsequent filings with the SEC. Readers are 
cautioned not to place undue reliance on forward-looking statements. Any 
forward-looking statement speaks only as of the date that it was made and the 
Company undertakes no obligation to update any forward-looking statement, 
whether as a result of new information or otherwise.

                                       4                                        
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Additional Information and Where to Find It

This Current Report on Form 8-K may be deemed to be a solicitation of proxies 
from the Company's shareholders in connection with the proposed transaction. 
In connection with the proposed transaction, the Company intends to file a 
proxy statement and relevant documents with respect to the special meeting to 
be held in connection with the proposed transaction with the U.S. Securities 
and Exchange Commission ("
SEC
"). The definitive proxy statement will be mailed to the Company's 
shareholders in advance of the special meeting. Investors and security holders 
of the Company are urged to read the proxy statement and any other relevant 
documents filed with the SEC when they become available because they will 
contain important information about the Company, Buyers and the proposed 
transaction. The proxy statement, when it becomes available, and any other 
documents filed by the Company with the SEC may be obtained free of charge at 
the SEC's website at www.sec.gov. In addition, investors and security holders 
may obtain free copies of the documents filed with the SEC by the Company by 
sending a written request to Cyclerion Therapeutics, 245 First Street, 18th 
Floor, Cambridge, Massachusetts 02142, Attention: Corporate Secretary.

Participants in the Solicitation

The Company and its directors and executive officers may, under SEC rules, be 
deemed to be participants in the solicitation of proxies from the Company's 
shareholders in connection with the proposed transaction. Information about 
the directors and executive officers, including their interests in the 
transaction, will be included in the Company's proxy statement relating to the 
transaction when it becomes available.

No Offer or Solicitation

This Current Report on Form 8-K shall not constitute an offer to sell or the 
solicitation of an offer to buy any securities, nor shall there be any sale of 
securities in any jurisdiction in which such offer, solicitation or sale would 
be unlawful prior to registration or qualification under the securities laws 
of any such jurisdiction. No offering of securities shall be made except by 
means of a prospectus meeting the requirements of Section 10 of the Securities 
Act.


Item 9.01 Financial Statements and Exhibits.


(d) Exhibits


Exhibit No.                                                                                                          Description
                                                                                                                                
2.1*        Asset Purchase Agreement, dated as of May 11, 2023, among the Company, JW Celtics Investment Corp. and JW Cycle Inc.
10.1        Form of Voting and Support Agreement                                                                                
99.1        Press Release dated May 11, 2023, announcing the Asset Sale Transaction                                             
99.2        Press Release dated May 11, 2023, announcing financial and operating results for the first quarter of 2023          
104         Cover Page Interactive Data File                                                                                    


 *Schedules have been omitted pursuant to Item 601(a)(5) of Regulation S-K. The 
 Company hereby undertakes to furnish supplemental copies of any of the omitted 
          schedules upon request by the U.S. Securities and Exchange Commission.

                                       5                                        
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                                   SIGNATURES                                   

       Pursuant to the requirements of the Securities Exchange Act of 1934, the 
       registrant has duly caused this report to be signed on its behalf by the 
                                           undersigned hereunto duly authorized.


                    Cyclerion Therapeutics, Inc.      
                                                      
Dated: May 11, 2023 By: /s/ Anjeza Gjino              
                        Name:  Anjeza Gjino           
                        Title: Chief Financial Officer



                                       6                                        
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                                                                     Exhibit 2.1

                            ASSET PURCHASE AGREEMENT                            

                                  by and among                                  

                          JW CELTICS INVESTMENT CORP.,                          

                                 JW CYCLE, INC.                                 

                                      and                                       

                          CYCLERION THERAPEUTICS, INC.                          

                            Dated as of May 11, 2023                            

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                            ASSET PURCHASE AGREEMENT                            

                               TABLE OF CONTENTS                                


                                                                                                                        Page(s)
                                                           ARTICLE I                                                           
                                                DEFINITIONS AND INTERPRETATION                                                 
Section 1.1.                                                                                                    General       1
Section 1.2.                                                                                 References; Interpretation      16
                                                          ARTICLE II                                                           
                                                  THE ASSETS AND LIABILITIES                                                   
Section 2.1.                                                                  Purchase and Sale of the Purchased Assets      16
Section 2.2.                                                                                            Excluded Assets      18
Section 2.3.                                                                                  Assumption of Liabilities      19
Section 2.4.                                                                                       Excluded Liabilities      19
Section 2.5.  Transfers not Effected at or Prior to the Closing Date; Transfers Deemed Effective as of the Closing Date      20
Section 2.6.                                                                                         Further Assurances      22
Section 2.7.                                                                                                    Closing      23
                                                          ARTICLE III                                                          
                                                      THE PURCHASE PRICE                                                       
Section 3.1.                                                                                             Purchase Price      24
Section 3.2.                                                                                          Withholding Taxes      24
                                                          ARTICLE IV                                                           
                                          REPRESENTATIONS AND WARRANTIES OF CYCLERION                                          
Section 4.1.                                                                                   Incorporation; Authority      25
Section 4.2.                                                                                       The Purchased Assets      25
Section 4.3.                                                                                        Compliance with Law      25
Section 4.4.                                                                       Consents and Approvals; No Conflicts      26
Section 4.5.                                                                                                  Contracts      26
Section 4.6.                                                                             Assigned Intellectual Property      26
Section 4.7.                                                                       Licenses, Permits and Authorizations      27
Section 4.8.                                                                                                      Taxes      27
Section 4.9.                                                                                                Broker Fees      27
Section 4.10.                                                      Representations with Respect to Consideration Shares      27
Section 4.11.                                                                                 Acknowledgement by Buyers      29
                                                           ARTICLE V                                                           
                                   REPRESENTATIONS AND WARRANTIES OF BUYER PARENT AND BUYER                                    
Section 5.1.                                                                     Incorporation; Ownership and Authority      31
Section 5.2.                                                                                             Capitalization      32
Section 5.3.                                                                                              No Operations      32
Section 5.4.                                                                      Consents and Approvals; No Violations      32


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Section 5.5.  Financing                                                               33
Section 5.6.  Broker's Fees                                                           33
                                       ARTICLE VI                                       
                        COVENANTS AND AGREEMENTS OF THE PARTIES                         
Section 6.1.  Operation of the Business                                               33
Section 6.2.  Corporate Examinations and Investigations                               34
Section 6.3.  Know-How Licenses                                                       35
Section 6.4.  Efforts                                                                 35
Section 6.5.  Employee Matters                                                        36
Section 6.6.  Use of Retained Names and Marks                                         37
Section 6.7.  Interim Period Preclinical and Clinical Trial Activities                37
Section 6.8.  Exclusivity                                                             38
Section 6.9.  Matters related to Cyclerion Stockholders Meeting                       41
Section 6.10. Buyer Parent Purchase Agreement                                         43
Section 6.11. Taxes                                                                   43
Section 6.12. FDA Letters                                                             44
Section 6.13. Post-Closing Matters                                                    45
Section 6.14. Joint Confidentiality Agreements                                        46
                                      ARTICLE VII                                       
                                 CONDITIONS TO CLOSING                                  
Section 7.1.  Conditions to the Obligations of All Parties                            46
Section 7.2.  Conditions to Buyer Parent's and Buyer's Obligations at Closing         47
Section 7.3.  Conditions to Cyclerion's Obligations at Closing                        48
                                      ARTICLE VIII                                      
                                      TERMINATION                                       
Section 8.1.  Events of Termination                                                   49
Section 8.2.  Effect of Termination                                                   51
Section 8.3.  Termination Fee                                                         51
                                       ARTICLE IX                                       
                                    INDEMNIFICATION                                     
Section 9.1.  Indemnification by Cyclerion                                            54
Section 9.2.  Indemnification by Buyers                                               54
Section 9.3.  Procedures for Indemnification                                          54
Section 9.4.  Indemnification Obligations Net of Insurance Proceeds and Other Amounts 57
Section 9.5.  Contribution                                                            58
Section 9.6.  Additional Matters; Survival of Indemnities                             58
Section 9.7.  Nonsurvival of Representations and Warranties and Pre-Closing Covenants 58
                                       ARTICLE X                                        
                         ACCESS TO INFORMATION; CONFIDENTIALITY                         
Section 10.1. Provision of Information                                                59


                                       ii                                       
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Section 10.2.  Witness Services; Cooperation     61
Section 10.3.  Reimbursement; Other Matters      61
Section 10.4.  Confidentiality                   62
Section 10.5.  Ownership of Information          63
                    ARTICLE XI                     
                DISPUTE RESOLUTION                 
Section 11.1.  Governing Law                     63
Section 11.2.  Proceedings                       64
Section 11.3.  Immunity                          64
Section 11.4.  Waiver of Jury Trial              64
                    ARTICLE XII                    
                   MISCELLANEOUS                   
Section 12.1.  Complete Agreement                64
Section 12.2.  Counterparts                      65
Section 12.3.  Survival of Agreements            65
Section 12.4.  Fees, Costs and Expenses          65
Section 12.5.  Notices                           65
Section 12.6.  Waivers                           66
Section 12.7.  Assignment                        66
Section 12.8.  Successors and Assigns            66
Section 12.9.  Payment Terms                     67
Section 12.10. Subsidiaries                      67
Section 12.11. Third Party Beneficiaries         67
Section 12.12. Bulk Sales                        67
Section 12.13. Titles and Headings               67
Section 12.14. Exhibits and Disclosure Schedules 67
Section 12.15. Severability                      68
Section 12.16. Public Announcements              68
Section 12.17. Specific Performance              69
Section 12.18. No Recourse                       69
Section 12.19. Interpretation                    69
Section 12.20. No Admission of Liability         69


                                      iii                                       
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List of Exhibits and Schedules

DISCLOSURE SCHEDULES


Exhibit A   - Form of Voting Agreement                            
Exhibit B   - Bill of Sale and Assignment and Assumption Agreement
Exhibit C   - Stockholder Agreements                              
Exhibit D   - Domain Name Assignment Agreement                    
Exhibit E   - Employee Expenses Allocation Schedule               
Exhibit F     Patent Assignment Agreement                         
Exhibit G   - Cyclerion Stockholder Letter                        
Exhibit H   - Buyer Parent Purchase Agreement                     
Exhibit I-1 - Cyclerion IND 147088 FDA Letter                     
Exhibit I-2 - Cyclerion IND 138999 FDA Letter                     
Exhibit I-3 - Cyclerion IND 155952 FDA Letter                     
Exhibit J   - Cyclerion Orphan Designation Letter                 
Exhibit K   - Transition Services Agreement                       
Exhibit L-1 - Buyer IND 147088 FDA Letter                         
Exhibit L-2 - Buyer IND 138999 FDA Letter                         
Exhibit L-3 - Buyer IND 155952 FDA Letter                         
Exhibit M   - Buyer Orphan Designation Letter                     


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                            ASSET PURCHASE AGREEMENT                            

This ASSET PURCHASE AGREEMENT (this "
Agreement
"), dated as of May 11, 2023, is entered into by and among JW Celtics 
Investment Corp. ("
Buyer Parent
"), a Delaware corporation, JW Cycle Inc. ("
Buyer
" and collectively with Buyer Parent, the "
Buyers
"), a Delaware corporation, and Cyclerion Therapeutics, Inc. ("
Cyclerion
"), a Massachusetts corporation.  "Party" or "Parties" means Buyer Parent, 
Buyer or Cyclerion, individually or collectively, as the case may be.  Each 
capitalized term used and not elsewhere defined herein has the meaning set 
forth in
Section 1.1
.

                              W I T N E S S E T H:                              

WHEREAS, Cyclerion owns certain assets comprising the Purchased Assets;

WHEREAS, Cyclerion desires to sell, transfer and assign the Purchased Assets 
and the Assumed Liabilities to Buyer and Buyer wishes to purchase, acquire and 
assume the Purchased Assets and the Assumed Liabilities on the terms and 
conditions set forth in this Agreement;

WHEREAS, concurrently herewith, each equityholder (and certain affiliates of 
any such equityholder) of a Buyer Group entity that is also an equityholder of 
Cyclerion has executed and delivered to Cyclerion, a duly signed voting 
agreement in the form attached hereto as
Exhibit A
with respect to voting at the Stockholders Meeting all shares of Cyclerion 
Common Stock that such person owns or otherwise has the right to vote in favor 
of the approval and authorization of this Agreement and the transactions 
relating hereto (each, a "
Voting Agreement
"); and

NOW, THEREFORE, in consideration of the foregoing and the mutual agreements, 
provisions and covenants contained in this Agreement, the Parties hereby agree 
as follows:

                                   ARTICLE I                                    

                         DEFINITIONS AND INTERPRETATION                         

Section 1.1.

General
.  As used in this Agreement, the following terms shall have the following 
meanings:


 (1) "                                    
     Acquisition Agreement                
     " shall have the meaning set forth in
     Section 6.8(e)                       
     .                                    



 (2) "                                                                                                              
     Acquisition Proposal                                                                                           
     " means, other than the transactions contemplated hereby, any inquiry, proposal, indication of interest or     
     offer (whether written or oral) with respect to any direct or indirect: (i) purchase or sale, in a single      
     transaction or a series of related transactions, of Cyclerion's Common Stock representing more than twenty-five
     percent (25%) of the voting power in Cyclerion, other than pursuant to that certain Stock Purchase             
     Agreement, dated March 31, 2023, by and between Cyclerion and Mr. Peter M. Hecht; (ii) merger, consolidation,  
     other business combination, reorganization, recapitalization, share exchange, dissolution, liquidation         
     or similar transaction involving Cyclerion or its Subsidiary; (iii) purchase or sale of assets, businesses,    
     securities or ownership interests (including the securities of Cyclerion's Subsidiary) representing            
     more than twenty-five percent (25%) of the net assets of Cyclerion, taken as a whole, or of Cyclerion and      
     its Subsidiary, taken as a whole, other than pursuant to this Agreement; (iv) spin-off, sale or license        
     of any assets of Cyclerion or its Subsidiary related to either of the Purchased Programs, whether specific     
     to those assets or as part of a sale of a larger set of assets, which spin-off, sale or license would          
     reasonably be expected to impede, interfere with, prevent or materially delay the transactions contemplated    
     hereby; or (v) any tender offer or exchange offer in which any Person or "group" (within the meaning           
     of Section 13(d)(3) of the Exchange Act) offers to acquire beneficial ownership, or the right to acquire       
     beneficial ownership, of twenty-five percent (25%) or more of the outstanding shares of Common Stock.          


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 (3) "                                                                            
     Action                                                                       
     " means any demand, action, audit, claim, suit, countersuit, arbitration,    
     inquiry, subpoena, case, litigation, proceeding or investigation (whether    
     civil, criminal, administrative or investigative) by or before any court or  
     grand jury, any Governmental Entity or any arbitration or mediation tribunal.



 (4) "                                                                                                                 
     Affiliate                                                                                                         
     " means, when used with respect to a specified Person and at a point in, or with respect to a period of, time, a  
     Person that directly or indirectly, through one or more intermediaries, controls, is controlled by, or is under   
     common control with, such specified Person at such point in or during such period of time.  For the purposes of   
     this definition, "control", when used with respect to any specified Person means the possession, directly or      
     indirectly, of the power to direct or cause the direction of the management and policies of such Person, whether  
     through the ownership of voting securities or other interests, by Contract or otherwise.  It is expressly agreed  
     that no Party or member of its Group shall be deemed to be an Affiliate of the other Party or a member of such    
     other Party's Group solely by reason of having common stockholders or one or more directors or officers in common.



 (5) "                                        
     Agreement                                
     " shall have the meaning set forth in the
     Preamble                                 
     .                                        



 (6) "                                                                     
     Ancillary Agreements                                                  
     " means the Stockholders Agreements, the Buyer Parent Purchase        
     Agreement, the Cyclerion Stockholder Letter, each Voting Agreement,   
     the FDA Letters, the Orphan Designation Letters, the Transition       
     Services Agreement, all Conveyancing and Assumption Instruments, the  
     Novation and Waiver Agreement and any and all other agreements entered
     into by the Parties or members of their respective Groups (but        
     as to which no Third Party is a party) in connection with this        
     Agreement or the other transactions contemplated by this Agreement.   



 (7) "                                                                                                                            
     Assets                                                                                                                       
     " means all rights, title and ownership interests in and to all rights, properties, claims, Contracts, businesses, or assets 
     (including goodwill), wherever located (including in the possession of vendors or other third parties or elsewhere), of every
     kind, character and description, whether real, personal or mixed, tangible or intangible, whether accrued, contingent or     
     otherwise, in each case, whether or not recorded or reflected on the books and records or financial statements of any Person.


                                       2                                        
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 (8) "                                                
     Assume                                           
     ," "                                             
     Assumed                                          
     " and "                                          
     Assumption                                       
     " shall have the respective meanings set forth in
     Section 2.3                                      
     .                                                



 (9) "                                    
     Assumed Contracts                    
     " shall have the meaning set forth in
     Section 2.1(b)                       
     .                                    



 (10) "                                                                                 
      Assumed Liabilities                                                               
      " means: (i) the Employee Expenses; (ii) the R&D Expenses; (iii) Liabilities under
      the Assumed Contracts to the extent relating to the period after the Closing      
      Date; (iv) any and all Liabilities relating to the PTC Grant, whether incurred    
      prior to or after the Closing; (v) 50% of any Transfer Taxes (in accordance with  
      Section 6.11(b)                                                                   
      ); and (vi) any Liabilities relating to the                                       
      Purchased Assets, Assumed Liabilities or                                          
      the Purchased Programs to the extent relating                                     
      to the period after the Closing Date.                                             



 (11) "                                    
      Assumed Names and Marks              
      " shall have the meaning set forth in
      Section 6.6                          
      .                                    



 (12) "                                                                                                 
      Backup Compound                                                                                   
      "                                                                                                 
      means any CNS-penetrant sGC Stimulator that has been declared a development candidate by Cyclerion
      .                                                                                                 



 (13) "                                                                           
      Bill of Sale and Assignment                                                 
      and Assumption Agreement                                                    
      " means that certain Bill of Sale and Assignment and Assumption Agreement by
      and between Cyclerion and Buyer in substantially the form attached hereto as
      Exhibit B                                                                   
      .                                                                           



 (14) "                                           
      Board                                       
      " means the Board of Directors of Cyclerion.



 (15) "                                                                                                      
      Board Recommendation                                                                                   
      " means the Board's recommendation that the Cyclerion stockholders authorize and approve this Agreement
      and the transactions contemplated hereby, including the consideration to be received by Cyclerion.     



 (16) "                                                                                                       
      Business Day                                                                                            
      " means any day other than Saturday or Sunday and any other day on which commercial banking institutions
      located in the Commonwealth of Massachusetts are required, or authorized by Law, to remain closed.      



 (17) "                                        
      Buyer                                    
      " shall have the meaning set forth in the
      Preamble                                 
      .                                        



 (18) "                                        
      Buyers                                   
      " shall have the meaning set forth in the
      Preamble                                 
      .                                        



 (19) "                                    
      Buyer Claim                          
      " shall have the meaning set forth in
      Section 9.1                          
      .                                    



 (20) "                                    
      Buyer Expense Reimbursement          
      " shall have the meaning set forth in
      Section 8.3(a)(i)                    
      .                                    



 (21) "                                    
      Buyer FDA Letters                    
      " shall have the meaning set forth in
      Section 7.3(a)(iv)                   
      .                                    



 (22) "                                                        
      Buyer Group                                              
      " means Buyer Parent and each Subsidiary of Buyer Parent.


                                       3                                        
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 (23) "                                    
      Buyer Hydroxy-Compound Notice        
      " shall have the meaning set forth in
      Section 6.13(c)                      
      .                                    



 (24) "                                                                        
      Buyer Indemnitees                                                        
      " means the members of the Buyer Group and their respective past, present
      and future directors, officers, employees and agents, in each case       
      in their respective capacities as such, and each of the heirs, executors,
      administrators, successors and assigns of any of the foregoing.          



 (25) "                                    
      Buyer Orphan Designation Letter      
      " shall have the meaning set forth in
      Section 7.3(a)(iv)                   
      .                                    



 (26) "                                                                                          
      Buyer Parent Purchase Agreement                                                            
      " means the Series A Preferred Stock Purchase Agreement, dated on or about the date hereof,
      by and among Buyer Parent and the investors set forth on the signature pages thereto.      



 (27) "                                    
      Buyer Parties                        
      " shall have the meaning set forth in
      Section 8.3(a)(ii)                   
      .                                    



 (28) "                                                                                                       
      Change of Control                                                                                       
      " means (i) a purchase or sale, in a single transaction or a series of related transactions, of         
      Cyclerion's Common Stock representing more than fifty percent (50%) of the voting power in Cyclerion    
      by a Third Party; (ii) a merger, consolidation, other business combination, share exchange, or similar  
      transaction involving Cyclerion or its Subsidiary in which more than fifty percent (50%) of the         
      voting power in Cyclerion is acquired by a Third Party; or (iii) the purchase or sale of assets,        
      businesses, securities or ownership interests (including the securities of Cyclerion's Subsidiary)      
      representing more than fifty percent (50%) of the net assets of Cyclerion, taken as a whole, or of      
      Cyclerion and its Subsidiary, taken as a whole, other than pursuant to this Agreement, by a Third Party.



 (29) "                                    
      Claiming Party                       
      " shall have the meaning set forth in
      Section 9.3(b)                       
      .                                    



 (30) "                                    
      Closing                              
      " shall have the meaning set forth in
      Section 2.5                          
      .                                    



 (31) "                                    
      Closing Date                         
      " shall have the meaning set forth in
      Section 2.5                          
      .                                    



 (32) "                                                                                                                 
      Closing Payment                                                                                                   
      " means $8,000,000 plus the amount of any Employee Expenses or R&D Expenses that Buyers are obligated to reimburse
      Cyclerion for pursuant to this Agreement to the extent such amounts remain unpaid as of the Closing Date.         



 (33) "                                                                             
      CNS-penetrant sGC Stimulator                                                  
      " means an sGC stimulator with cerebral spinal fluid brain to free plasma     
      ratio of > 0.5 when dosed 1mg/kg at steady state in rat. For clarity, the  
      definition of CNS-penetrant sGC Stimulator specifically excludes the following
      compounds: praliciguat, olinciguat, and the preclinical candidate MM-500822.  



 (34) "                                                                   
      Code                                                                
      " means the United States Internal Revenue Code of 1986, as amended.


                                       4                                        
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 (35) "                                    
      Common Stock                         
      " shall have the meaning set forth in
      Section 3.1                          
      .                                    



 (36) "                                                                                                       
      Confidential Information                                                                                
      " means, with respect to a Party, all                                                                   
      confidential or proprietary                                                                             
      information to the                                                                                      
      extent concerning: (i) such Party or any                                                                
      of its Subsidiaries and (ii) the Purchased                                                              
      Assets, Assumed Liabilities, any Excluded                                                               
      Assets or any Excluded Liabilities, in                                                                  
      each case (clauses (i)-(ii)) including any                                                              
      such information furnished pursuant to                                                                  
      Article X                                                                                               
      or otherwise pursuant to this                                                                           
      Agreement or any Ancillary Agreement;                                                                   
      provided                                                                                                
      ,                                                                                                       
      however                                                                                                 
      , that "Confidential Information" shall not include any information that is (A) in the public domain or 
      known to the public through no fault of the receiving Party or any of its Subsidiaries, (B) lawfully    
      acquired after the Closing Date by the receiving Party or any of its Subsidiaries from Third Parties    
      not known to be subject to confidentiality obligations with respect to such information or (C)          
      independently developed by the receiving Party or any of its Subsidiaries after the Closing Date        
      without reference to any Confidential Information of the disclosing Party or any of its Subsidiaries.   
      Notwithstanding anything to the contrary in this Agreement, subject to the foregoing proviso, from and  
      after the Closing, all information included in the Purchased Assets and owned or Controlled by Buyer    
      as of the Closing will be the Confidential Information of Buyer, and Buyer will be considered the       
      disclosing Party and Cyclerion the receiving Party with respect thereto.  Furthermore, for the avoidance
      of doubt, subject to the foregoing proviso, any information that Buyer receives from any Third          
      Party pursuant to a Contract that is retained by Cyclerion regarding Buyer's technology, products,      
      business or objectives shall be deemed to be Confidential Information of Cyclerion.  Likewise, from     
      and after the Closing, for the avoidance of doubt, subject to the foregoing proviso, any information    
      that Cyclerion received from any Third Party pursuant to an Assumed Contract regarding Cyclerion's      
      technology, products, business or objectives shall be deemed to be Confidential Information of Buyer.   



 (37) "                                                                                  
      Consents                                                                           
      " means any consents, waivers, notices, reports or other filings to be obtained    
      from or made, including with respect to any Contract, or any registrations,        
      licenses, permits, authorizations to be obtained from, or approvals from, or       
      notification requirements to, any Third Parties, including any Governmental Entity.



 (38) "                                    
      Consideration Shares                 
      " shall have the meaning set forth in
      Section 3.1                          
      .                                    



 (39) "                                                                                       
      Contract                                                                                
      " means any agreement, contract, subcontract, obligation, binding understanding, note,  
      indenture, instrument, option, lease, promise, arrangement, release, warranty, license, 
      sublicense, insurance policy, benefit plan, purchase order or legally binding commitment
      or undertaking of any nature (whether written or oral and whether express or implied).  


                                       5                                        
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 (40) "                                                                                                               
      Control                                                                                                         
      " means, with respect to any Intellectual Property, the possession by a Party or its Affiliates (whether by     
      ownership or license, other than a license granted pursuant to this Agreement) of, (i) with respect to any      
      tangible Know-How, the legal authority or right to possession of such tangible Know-How, with the right to      
      provide such tangible Know-How to the other Party on the terms set forth herein, or (ii) with respect to Patents
      and intangible Know-How, or other Intellectual Property, the legal authority or right to grant a license,       
      sublicense, access, or right to use (as applicable) to the other Party under such Patents, intangible Know-How, 
      or other Intellectual Property on the terms set forth herein, in each case ((i) and (ii)), without breaching    
      or otherwise violating the terms of any Contract with a Third Party in existence as of the Closing Date.        



 (41) "                                                                         
      Conveyancing and Assumption Instruments                                   
      " means, collectively, the various Contracts by and between or among      
      Cyclerion, on the one hand, and any member(s) of the Buyer Group, on the  
      other hand, including the Bill of Sale, Assignment and Assumption         
      Agreement, Domain Name Assignment Agreement, Patent Assignment Agreement, 
      and other documents entered into prior to the Closing Date and to be      
      entered into, in each case to effect the transfer of Assets and the       
      Assumption of Liabilities in the manner contemplated by the Transaction   
      Agreements, in such form or forms as the applicable parties thereto agree.



 (42) "                                    
      Copyrights                           
      " shall have the meaning set forth in
      Section 1.1(80)                      
      .                                    



 (43) "                                        
      Cyclerion                                
      " shall have the meaning set forth in the
      Preamble                                 
      .                                        



 (44) "                                      
      Cyclerion Adverse Recommendation Change
      " shall have the meaning set forth in  
      Section 6.8(e)                         
      .                                      



 (45) "                                    
      Cyclerion Claim                      
      " shall have the meaning set forth in
      Section 9.2                          
      .                                    



 (46) "                                                   
      Cyclerion Common Stock                              
      " means the common stock of Cyclerion, no par value.



 (47) "C                                   
      yclerion Competing Product           
      " shall have the meaning set forth in
      Section 6.13(a)                      
      .                                    



 (48) "                                    
      Cyclerion FDA Letters                
      " shall have the meaning set forth in
      Section 7.2(a)(iii)                  
      .                                    



 (49) "                                    
      Cyclerion Hydroxy-Compound Notice    
      " shall have the meaning set forth in
      Section 6.13(c)                      
      .                                    



 (50) "                                                                    
      Cyclerion Indemnitees                                                
      " means Cyclerion, its Subsidiary, and their respective past, present
      and future directors, officers, employees and agents, in each case   
      in their respective capacities as such, each of the heirs, executors,
      administrators, successors and assigns of any of the foregoing.      



 (51) "                                    
      Cyclerion Orphan Designation Letter  
      " shall have the meaning set forth in
      Section 7.2(a)(iii)                  
      .                                    



 (52) "                                    
      Cyclerion Parties                    
      " shall have the meaning set forth in
      Section 8.3(a)(ii)                   
      .                                    


                                       6                                        
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 (53) "                                                                                                    
      Cyclerion Stockholder Letter                                                                         
      " means the letter agreement by and between Cyclerion and Buyer Parent in the form attached hereto as
      Exhibit G                                                                                            
      .                                                                                                    



 (54) "                                    
      Direct Claim                         
      " shall have the meaning set forth in
      Section 9.3(a)(ii)                   
      .                                    



 (55) "                                                                                                          
      Disclosure Schedules                                                                                       
      " means the final disclosure schedules to this Agreement that are being executed and delivered by Buyer,   
      Buyer Parent and Cyclerion, as applicable, in connection with the execution and delivery of this Agreement.



 (56) "                                                                   
      Domain Name Assignment Agreement                                    
      " means that certain Domain Name Assignment Agreement by and between
      Cyclerion and Buyer in substantially the form attached hereto as    
      Exhibit D                                                           
      .                                                                   



 (57) "                                                                                         
      Employee Expenses                                                                         
      " means any and all direct and indirect costs and expenses                                
      relating to the employment of the Employees, including, salary or                         
      other base pay and the employer portion of payroll taxes in                               
      connection with the foregoing, costs incurred in connection with                          
      providing and administering retirement benefits and health and                            
      welfare benefits, and overhead expenses (including without                                
      limitation IT, HR and payroll expenses) that are allocated to                             
      such Employees pursuant to an Allocation Schedule as set forth in                         
      Exhibit E                                                                                 
      , in each case that are incurred from                                                     
      and after the date of this Agreement                                                      
      through and including the applicable                                                      
      Employee Expenses End Date;                                                               
      provided                                                                                  
      ,                                                                                         
      however                                                                                   
      , that Employee Expenses shall exclude (i) any severance or termination costs attributable
      to any Employees or any other employees or other service providers of Cyclerion           
      who do not become Transferred Employees regardless of when such severance or termination  
      costs are incurred, (ii) any direct or indirect costs or expenses incurred or             
      accrued with respect to any Employees with respect to any time period prior to the date   
      of this Agreement and (iii) with respect to the period after the Closing Date through     
      and including the applicable Employee Expenses End Date, any amounts paid from any        
      of Cyclerion's third party disability insurance providers to any Inactive Employees.      



 (58) "                                    
      Employee Expenses End Date           
      " shall have the meaning set forth in
      Section 6.5(a)                       
      .                                    



 (59) "                                
      Employees                        
      " means the individuals listed on
      Section 1.1(59)                  
      of the Disclosure Schedules.     



 (60) "                                                                             
      Encumbrance                                                                   
      " means any charge, claim, condition, equitable interest, lien, encumbrance,  
      option, pledge, security interest, hypothecation, mortgage, right of first    
      refusal, or any restriction on use, voting, transfer, receipt of income, right
      of set-off, title retention, or exercise of any other attribute of ownership. 



 (61) "                                                                                                             
      Equity Financing                                                                                              
      " means the purchase and sale of the First Tranche Shares (as defined in the Buyer Parent Purchase Agreement) 
      and the consummation of the Second Tranche, each pursuant to the terms of the Buyer Parent Purchase Agreement.


                                       7                                        
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 (62) "                                           
      Exchange Act                                
      " means the Securities Exchange Act of 1934.



 (63) "                                    
      Excluded Assets                      
      " shall have the meaning set forth in
      Section 2.2                          
      .                                    



 (64) "                                    
      Excluded Contracts                   
      " shall have the meaning set forth in
      Section 2.2(f)                       
      .                                    



 (65) "                                    
      Excluded Liabilities                 
      " shall have the meaning set forth in
      Section 2.4                          
      .                                    



 (66) "                                                                                                                 
      Excluded Programs                                                                                                 
      " means any and all current or future programs operated by Cyclerion, other than the Purchased Programs, including
      Cyclerion's Onlinciguat program, Cyclerion's Praliciguat program, and Cyclerion's preclinical programs.           



 (67) "                                                      
      FDA                                                    
      " means the United States Food and Drug Administration.



 (68) "                                                           
      FDA Letters                                                 
      " means the Buyer FDA Letters and the Cyclerion FDA Letters.



 (69) "                                                                   
      Fully-Diluted Basis                                                 
      " shall mean, as of a specified date, the number of shares of common
      stock of Buyer Parent then-outstanding plus the number of shares    
      of common stock of Buyer Parent issuable upon exercise or conversion
      of then-outstanding shares of preferred stock of Buyer Parent.      



 (70) "                                                                                                       
      Governmental Entity                                                                                     
      " means any nation or government, any state, municipality or other political subdivision thereof and    
      any entity, body, agency, commission, department, board, bureau or court, whether domestic, foreign,    
      multinational, or supranational exercising executive, legislative, judicial, regulatory, self-regulatory
      or administrative functions of or pertaining to government and any executive official thereof.          



 (71) "                                                                       
      Group                                                                   
      " means (i) with respect to Buyer, the Buyer Group and (ii) with respect
      to Cyclerion, Cyclerion and its Subsidiary, as the context requires.    



 (72) "                                    
      Hydroxy-Compounds                    
      " shall have the meaning set forth in
      Section 6.13(c)                      
      .                                    



 (73) "                                    
      Inactive Employee                    
      " shall have the meaning set forth in
      Section 6.5(a)                       
      .                                    



 (74) "                                                                             
      IND                                                                           
      " means an Investigational New Drug application required pursuant to 21 C.F.R.
      Part 312 or any comparable filings outside of the United States required      
      to commence human clinical trials in such country or region, and all          
      supplements or amendments that may be filed with respect to the foregoing.    



 (75) "                                                                           
      Indemnifiable Losses                                                        
      " means any and all Liabilities, including damages, losses, obligations,    
      penalties, judgments, settlements, claims, payments, fines and other        
      costs and expenses (but excluding consequential, punitive, incidental and   
      similar damages except to the extent paid to a third party) of any and      
      all Actions and demands, assessments, judgments, settlements and compromises
      relating thereto and the reasonable fees and expenses of attorneys,         
      accountants, consultants and other professionals incurred in the            
      investigation or defense thereof or the enforcement of rights hereunder.    


                                       8                                        
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 (76) "                                                                                                                
      Indemnifying Party                                                                                               
      " means, with respect to any Direct Claim or Third Party Claim, the Party which is or may be required pursuant to
      Article IX                                                                                                       
      to provide indemnification pursuant to such claim.                                                               



 (77) "                                                                                                            
      Indemnitee                                                                                                   
      " means, with respect to any Direct Claim or Third Party Claim, the Buyer Indemnitee or Cyclerion Indemnitee,
      as the case may be, that may be entitled to indemnification hereunder with respect to such claim.            



 (78) "                                    
      Indemnity Payment                    
      " shall have the meaning set forth in
      Section 9.4(a)                       
      .                                    



 (79) "                                                                                                             
      Insurance Proceeds                                                                                            
      " means those monies (i) received by an insured from a Third Party insurance carrier or (ii) paid by a Third  
      Party insurance carrier on behalf of an insured, in either case net of any applicable deductible or retention.



 (80) "                                                                    
      Intellectual Property                                                
      " means all intellectual property, whether registered or unregistered
      and whether granted, pending or expired, of every kind and           
      description throughout the world, including all U.S. and non-U.S.:   
      (i) trademarks, trade dress, service marks, certification marks,     
      logos, slogans, design rights, names, corporate names, trade names,  
      internet domain names, social media accounts and addresses and       
      other similar designations of source or origin, together with the    
      goodwill symbolized by any of the foregoing (collectively, "         
      Trademarks                                                           
      "); (ii) patents and patent applications, and                        
      any and all related national or international                        
      counterparts thereto and utility models,                             
      including any provisionals, divisionals,                             
      continuations, continuations-in-part,                                
      reissues, reexaminations, substitutions and                          
      extensions thereof (including supplementary                          
      protection certificates) (collectively, "                            
      Patents                                                              
      "); (iii) copyrights and                                             
      copyrightable subject                                                
      matter, excluding Know-How (collectively, "                          
      Copyrights                                                           
      "); (iv) rights in software and computer systems;                    
      (v) all applications and registrations for                           
      the foregoing; (vi) trade secrets, and all                           
      other confidential or proprietary information,                       
      know-how, clinical data, non-clinical data,                          
      pre-clinical data, in vitro data, inventions,                        
      ideas, processes, formulae and methodologies,                        
      excluding Patents (collectively, "                                   
      Know-How                                                             
      "); and (vii) all rights and                                         
      remedies against past, present, and                                  
      future infringement, misappropriation,                               
      or other violation thereof.                                          



 (81) "                                                                         
      Intervening Event                                                         
      " means any event, fact, circumstance, development or occurrence that     
      affects the business, assets or operations of Cyclerion or its Subsidiary 
      in any material respect that is unknown to, and not reasonably            
      foreseeable by, the Board as of the date of this Agreement and becomes    
      known to the Board prior to obtaining the Stockholder Approval, except    
      that in no event shall an Acquisition Proposal or any event, fact,        
      circumstance, development or occurrence relating to the receipt, existence
      or terms of an Acquisition Proposal constitute an Intervening Event.      


                                       9                                        
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 (82) "                                                                                                             
      Joint Confidentiality Agreement                                                                               
      " means any confidentiality agreement between Cyclerion and a prospective purchaser, in each case that relates
      both to (i) all or any portion of the Purchased Assets and (ii) all or any portion of the Excluded Assets.    



 (83) "                                    
      Know-How                             
      " shall have the meaning set forth in
      Section 1.1(80)                      
      .                                    



 (84) "                                                                                                  
      Knowledge of Cyclerion                                                                             
      " means the actual knowledge of Cheryl Gault and Anjeza Gjino, in each case, following due inquiry.



 (85) "                                                                                    
      Law                                                                                  
      " means any applicable U.S. or non-U.S. federal, national, supranational, state,     
      provincial, local or similar statute, law, ordinance, regulation, rule, code, income 
      tax treaty, order, requirement or rule of law (including common law) or other binding
      directives promulgated, issued, entered into or taken by any Governmental Entity.    



 (86) "                                                                                  
      Liabilities                                                                        
      " means any and all indebtedness, liabilities, costs, expenses, Taxes, interest    
      and obligations, whether accrued or fixed, absolute or contingent, matured or      
      unmatured, known or unknown, reserved or unreserved, or determined or determinable,
      including those arising under any Law, Action, or in connection with any           
      dispute, whether asserted or unasserted, or order, writ, judgment, injunction,     
      decree, stipulation, determination or award entered by or with any Governmental    
      Entity and those arising under any Contract or any fines, damages or equitable     
      relief which may be imposed and including all costs and expenses related thereto.  


                                       10                                       
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 (87) "                                                                                       
      Material Adverse Effect                                                                 
      " means, with respect to                                                                
      Cyclerion, any change, effect,                                                          
      event, occurrence, state of                                                             
      facts or development that,                                                              
      individually or in the                                                                  
      aggregate, (x) is materially                                                            
      adverse to the assets,                                                                  
      liabilities, business, results                                                          
      of operations or the financial                                                          
      condition of such Person                                                                
      or (y) would materially                                                                 
      and adversely affect the                                                                
      ability of Cyclerion to                                                                 
      perform its obligations under                                                           
      this Agreement and the other                                                            
      Transaction Agreements;                                                                 
      provided                                                                                
      ,                                                                                       
      however                                                                                 
      , that none of the following or the results thereof, either alone or in combination,    
      shall be considered in determining whether there has been a "Material Adverse           
      Effect" or be deemed, either alone or in combination, to constitute, and none of        
      the following shall be taken into account in determining whether there would be a       
      "Material Adverse Effect": (i) any failure by Cyclerion to meet any internal or         
      published projections, forecasts, budgets or estimates relating to any period,          
      including with respect to revenue, earnings, cash flow or cash position (it being       
      understood that the underlying causes of such failure may, if they are not otherwise    
      excluded from the definition of Material Adverse Effect, be taken into account          
      in determining whether a Material Adverse Effect has occurred), (ii) any adverse        
      change, effect, event, occurrence, state of facts or development attributable to the    
      announcement, pendency or consummation of the transactions contemplated by this         
      Agreement or any of the Ancillary Agreements (including any cancellations of or         
      delays in customer orders, any reduction in sales, any termination or disruption in     
      supplier, distributor, partner or similar relationships, or any loss of employees),     
      (iii) any adverse change, effect, event, occurrence, state of facts or development      
      attributable to conditions affecting (A) the industries in which Cyclerion participates 
      (including industries from which Cyclerion obtains or purchases supplies for            
      use in their products or services) or (B) national, regional, local, international      
      or global economies (including, in each case, legal and regulatory changes), (iv)       
      any adverse change, effect, event, occurrence, state of facts or development resulting  
      from or relating to compliance with the terms of, or the taking of any action           
      pursuant to, in accordance with, or required, by or the inability to take any action    
      prohibited by, this Agreement or any of the other Transaction Agreements, (v)           
      any adverse change, effect, event, occurrence, state of facts or development arising    
      from or relating to any change in accounting requirements or principles or any          
      actual, threatened or proposed change in applicable Laws, rules or regulations or the   
      interpretation or enforcement of any of the foregoing, (vi) political conditions        
      or events or conditions, including the results of primary or general elections,         
      (vii) any adverse change, effect, event, occurrence, state of facts or development      
      arising in connection with natural disasters or acts of nature (including any           
      earthquakes, floods, hurricanes, tropical storms or fires), any national, international 
      or regional calamity, hostilities, civil unrest, acts of war, sabotage or terrorism     
      or military actions or any escalation or material worsening of any such hostilities,    
      civil unrest, acts of war, sabotage or terrorism or military actions existing or        
      underway as of the date hereof, (viii) the effect of any action taken by Buyer          
      Parent or any of its Subsidiaries with respect to the transactions contemplated         
      hereby, (ix) the effect of the coronavirus (COVID-19) pandemic (or any mutation or      
      variation of the SARS-CoV-2 virus), taking into account any "shelter-in-place" or       
      similar order, directive, or recommendation issued by a Governmental Entity or          
      Cyclerion with respect thereto, (x) any labor strike, stoppage, slowdown, lockout, labor
      dispute, or the loss, absence, illness, disability, death, quarantine, diminished       
      productivity or work schedule, termination, layoff or furlough of employees,            
      independent contractors or service providers of Cyclerion or its Subsidiary (including  
      in connection with the coronavirus (COVID-19) pandemic (or any mutation or variation    
      of the SARS-CoV-2 virus), taking into account any "shelter-in-place" or similar         
      Order, directive, or recommendation issued by a Governmental Entity), (xi) actions      
      or omissions of Cyclerion that are consented to, following disclosure of all            
      relevant facts and circumstances, or requested by Buyer Parent or any of its            
      Subsidiaries pursuant to the terms of this Agreement, (xii) any adverse change, effect, 
      event, occurrence, state of facts or development to the extent attributable to          
      changes in any financial, debt, credit, capital or banking markets or conditions        
      (including any disruption thereof), or changes in interest, currency or exchange        
      rates or the price of any commodity, security or market index, (xiii) any acts of       
      terrorism, sabotage or war (including the military conflict between Russia and Ukraine  
      and any military conflicts arising therefrom or related thereto), the outbreak or       
      escalation of hostilities, weather conditions, change in geopolitical, political or     
      social conditions, cyberattacks, disruptions in supply chains or other force majeure    
      events, in each case, including any worsening thereof, or (xiv) any items set forth     
      in the Disclosure Schedules hereto); provided that the exceptions in clauses            
      (iii), (v), (vi) and (vii), (xii) (xiii) above shall apply only to the extent such      
      change, effect, event, occurrence, state of facts or development referred to in         
      such exception does not have a materially disproportionate impact on Cyclerion          
      relative to other Persons operating in the industries in which Cyclerion operates.      


                                       11                                       
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 (88) "                                    
      Negotiation Period                   
      " shall have the meaning set forth in
      Section 6.13(c)                      
      .                                    



 (89) "                                    
      Non-Separable Information            
      " shall have the meaning set forth in
      Section 2.5(f)                       
      .                                    



 (90) "                                                                                                                            
      Novation and Waiver Agreement                                                                                                
      " means that certain Novation and Waiver Agreement, dated May 2, 2023 among Cyclerion, Buyer and the Alzheimer's Association.



 (91) "                                                                                       
      Orphan Designation Letters                                                              
      " means the Buyer Orphan Designation Letter and the Cyclerion Orphan Designation Letter.



 (92) "                                    
      Patents                              
      " shall have the meaning set forth in
      Section 1.1                          
      (80)                                 
      .                                    



 (93) "                                                               
      Patent Assignment Agreement                                     
      " means that certain Patent Assignment Agreement by and between 
      Cyclerion and Buyer in substantially the form attached hereto as
      Exhibit F                                                       
      .                                                               



 (94) "                                                                                        
      Permits                                                                                  
      " shall mean all licenses, permits, franchises, approvals, registrations, authorizations,
      consents or orders of, or filings with, or issued by any Governmental Entity.            



 (95) "                                                                                            
      Permitted Encumbrance                                                                        
      " means (i) Encumbrances for Taxes, assessments or other governmental charges or levies      
      which are not yet due and payable (and for which adequate reserves have been made on         
      Cyclerion's books and records in accordance with GAAP), (ii) statutory or common law         
      Encumbrances to secure landlords, lessors or renters under leases or rental agreements       
      confined to the premises rented, (iii) mechanics', carriers', workers', repairers' and       
      other similar Encumbrances arising or incurred in the ordinary course of business            
      relating to obligations as to which there is no default on the part of Cyclerion or the      
      validity or amount of which is being contested in good faith by appropriate proceedings,     
      or pledges, deposits or other Encumbrances securing the performance of bids, trade           
      contracts, leases or statutory obligations (including workers' compensation, unemployment    
      insurance or other social security legislation), (iv) Encumbrances on leases, subleases,     
      easements, licenses, rights of use, rights to access and rights of way arising               
      therefrom or which, individually or in the aggregate, do not or would not materially         
      impair the use or occupancy of the real property or materially detract from the value        
      of Cyclerion, (v) all covenants, conditions, restrictions, easements, charges, rights-of-way,
      other Encumbrances and other similar matters of record set forth in any state,               
      local or municipal recording or like office which, individually or in the aggregate, do      
      not materially interfere with the present use or materially detract from the value of        
      the properties or assets of Cyclerion, (vi) minor encroachments, including to foundations    
      and retaining walls, variations, if any, between tax lot lines and property lines,           
      and deviations, if any, of fences or shrubs from designated property lines, all of           
      which are insurable or which would be shown by a current accurate survey that do not         
      impair in any material respect the continue use and operation of the real property as        
      is currently used and operated, (vii) any Encumbrances reflected or identified in the        
      most recent financial statements of Cyclerion, and (viii) nonexclusive licenses of           
      Intellectual Property entered into in the ordinary course of business (A) granted to service 
      providers (such as contract research organizations, contract manufacturers, and              
      consultants) for the purpose of enabling them to perform services to Cyclerion (B) granted   
      under material transfer agreements, confidentiality agreements, or evaluation agreements     
      to enable a Third Party to evaluate Cyclerion's Intellectual Property solely for the         
      purposes of allowing the Third Party to determine whether to pursue a potential              
      transaction, in each case ((A) and (B)), entered into in the ordinary course of business.    

                                       12                                       
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 (96) "                                                                                                     
      Person                                                                                                
      " means an individual, a general or limited partnership, a corporation, a trust, a joint venture, an  
      unincorporated organization, a limited liability entity, any other entity and any Governmental Entity.



 (97) "                                    
      Pre-Closing Period                   
      " shall have the meaning set forth in
      Section 6.1                          
      .                                    



 (98) "                                                                                                                     
      Pre-Closing Tax Period                                                                                                
      " means any taxable period ending on or before the Closing Date and, with respect to any taxable period beginning     
      before and ending after the Closing Date, the portion of such taxable period ending on and including the Closing Date.



 (99) "                                        
      Preclinical and Clinical Trial Activities
      " shall have the meaning set forth in    
      Section 6.7(a)                           
      .                                        



 (100) "                                                                        
       Program Indication                                                       
       " means any neuropsychiatric, neurodegenerative and primary mitochondrial
       genetic disease or disorder, as well as stroke and stroke recovery.      



 (101) "                                    
       Proxy Statement                      
       " shall have the meaning set forth in
       Section 6.9(a)                       
       .                                    



 (102) "                                                                             
       PTC Grant                                                                     
       " means the Part the Cloud Grant dated August 15, 2021 between Cyclerion and  
       the Alzheimer's Association, as modified by the Novation and Waiver Agreement.



 (103) "                                                                                        
       Purchased Assets                                                                         
       " means all of the properties, rights, interests and other tangible and intangible assets
       of Cyclerion primarily related to the Purchased Programs, as more fully described in     
       Section 2.1                                                                              
       , but excluding any of the Excluded Assets.                                              



 (104) "                                    
       Purchased Intellectual Property      
       " shall have the meaning set forth in
       Section 2.1(a)                       
       .                                    


                                       13                                       
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 (105) "                                                         
       Purchase Price                                            
       " means the Closing Payment plus the Consideration Shares.



 (106) "                                                                                                       
       Purchased Programs                                                                                      
       " means Cyclerion's zagociguat program (also known as the CY6463 program) and Cyclerion's CY3018 program
       .                                                                                                       



 (107) "                                    
       R&D Expenses                         
       " shall have the meaning set forth in
       Section 6.7(b)                       
       .                                    



 (108) "                                                                                        
       Representatives                                                                          
       " means, with respect to any Person, any of such Person's directors, officers, employees,
       agents, consultants, advisors, accountants, attorneys or other representatives.          



 (109) "                                    
       Retained Names and Marks             
       " shall have the meaning set forth in
       Section 6.6                          
       .                                    



 (110) "                                    
       Reverse Termination Fee              
       " shall have the meaning set forth in
       Section 8.3(b)(i)                    
       .                                    



 (111) "                                                                          
       Right of First Negotiation                                                 
       " means the right, but not an obligation, of Buyer to negotiate, before any
       other Person, a license of the applicable Hydroxy-Compound from Cyclerion. 



 (112) "                                                                                       
       Second Tranche                                                                          
       " means the purchase and sale of the Second Tranche Shares (as defined in the Buyer     
       Parent Purchase Agreement) pursuant to the terms of the Buyer Parent Purchase Agreement.



 (113) "                                  
       Securities Act                     
       " means the Securities Act of 1933.



 (114) "                                    
       Specified Employees                  
       " shall have the meaning set forth in
       Section 6.5(a)                       
       .                                    



 (115) "                                                                                         
       Stockholder Agreements                                                                    
       " means the Voting Rights Agreement, Investor Rights Agreement and Right of First Refusal 
       and Co-Sale Agreement of Buyer Parent, in each case in substantially the form set forth on
       Exhibit C                                                                                 
       as well as the Cyclerion Stockholder Letter.                                              



 (116) "                                    
       Stockholder Approval                 
       " shall have the meaning set forth in
       Section 6.9(a).                      



 (117) "                                    
       Stockholders Meeting                 
       " shall have the meaning set forth in
       Section 6.9(a)                       
       .                                    



 (118) "                                                                                                      
       Straddle Period                                                                                        
       " means any taxable period beginning on or prior to the Closing Date and ending after the Closing Date.



 (119) "                                                                                                                        
       Subsidiary                                                                                                               
       " means with respect to any Person (i) a corporation, fifty percent (50%) or more of the voting or capital stock of which
       is, as of the time in question, directly or indirectly owned by such Person and (ii) any other Person in which such      
       Person, directly or indirectly, owns fifty percent (50%) or more of the equity or economic interest thereof or has the   
       power to elect or direct the election of fifty percent (50%) or more of the members of the governing body of such Person.


                                       14                                       
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 (120) "                                                                                                                     
       Superior Proposal                                                                                                     
       " means a bona fide written Acquisition                                                                               
       Proposal (with all references to                                                                                      
       "twenty-five percent (25%)" in the definition                                                                         
       thereof deemed to be "fifty percent                                                                                   
       (50%)" for the purposes of this                                                                                       
       definition) made after the date hereof by                                                                             
       any Person that (a) is not received                                                                                   
       as a result of a material breach of                                                                                   
       Section 6.8                                                                                                           
       by Cyclerion and (b) is on terms that the Board determines in good faith, after consultation with Cyclerion's         
       outside legal counsel and financial advisor, taking into account all legal, financial, regulatory and other aspects   
       of the proposal the Board determines is appropriate (including any termination or break-up fees, the conditionality,  
       the likelihood and timing of required governmental approvals, time likely to be required to consummate                
       such Acquisition Proposal, ability of the Person making the proposal to finance and pay the contemplated consideration
       and the likelihood of success of such Acquisition Proposal), such Acquisition Proposal is more favorable              
       to Cyclerion's stockholders from a financial perspective than the transactions contemplated hereby (including         
       any adjustment to the terms and conditions proposed by Buyer in response to such Acquisition Proposal).               



 (121) "                                                                       
       Tax                                                                     
       " means any United States federal, state or local, or non-United        
       States, net income, gross income, gross receipts, windfall profit,      
       severance, property, production, sales, use, license, excise, franchise,
       employment, payroll, withholding, alternative or add-on minimum, ad     
       valorem, value-added, transfer, stamp,  or environmental tax, or any    
       other tax of any kind or any charge in the nature of (or similar to)    
       taxes, together with any interest or penalty or addition to tax imposed 
       by any Governmental Entity, in each case whether disputed or not.       



 (122) "                                                                      
       Tax Return                                                             
       " means any return, declaration, report, claim for refund, information 
       return or statement or other document relating to Taxes, including     
       any schedule or attachment thereto, and including any amendment thereof
       or any related or supporting information of any of the foregoing.      



 (123) "                                    
       Termination Date                     
       " shall have the meaning set forth in
       Section 8.1(a)(ii)                   
       .                                    



 (124) "                                    
       Termination Fee                      
       " shall have the meaning set forth in
       Section 8.3(a)(i)                    
       .                                    



 (125) "                                                                                 
       Third Party                                                                       
       " means any Person other than the Parties or any of their respective Subsidiaries.



 (126) "                                    
       Third Party Claim                    
       " shall have the meaning set forth in
       Section 9.3(b)                       
       .                                    



 (127) "                                    
       Third Party Proceeds                 
       " shall have the meaning set forth in
       Section 9.4(a)                       
       .                                    



 (128) "                                    
       Trademarks                           
       " shall have the meaning set forth in
       Section 1.1                          
       (80)                                 
       .                                    



 (129) "                                                          
       Transaction Agreements                                     
       " means any of this Agreement and the Ancillary Agreements.


                                       15                                       
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 (130) "                                                                                                          
       Transfer Taxes                                                                                             
       " means any sales, use, transfer, value-added, real property transfer or gains, documentary, recordation,  
       filing, conveyance, stamp or similar Taxes incurred in connection with the consummation of the transactions
       contemplated by this Agreement (together with any interest thereon, penalties, fines, fees, additions to   
       tax or additional amounts with respect thereto), excluding, for the avoidance of doubt, any income Taxes.  



 (131) "                                    
       Transferred Employees                
       " shall have the meaning set forth in
       Section 6.5(a)                       
       .                                    



 (132) "                                    
       Transferred Records                  
       " shall have the meaning set forth in
       Section 2.1(f)                       
       .                                    



 (133) "                                    
       Transition Period                    
       " shall have the meaning set forth in
       Section 2.5(c)(ii)                   
       .                                    



 (134) "                                    
       Transition Services Agreement        
       " shall have the meaning set forth in
       Section 7.2(a)(v)                    
       .                                    



 (135) "                                        
       Voting Agreement                         
       " shall have the meaning set forth in the
       Recitals                                 


Section 1.2.

References; Interpretation
.  References in this Agreement to any gender include references to all 
genders, and references to the singular include references to the plural and 
vice versa.  Unless the context otherwise requires, the words "include", 
"includes" and "including" when used in this Agreement shall be deemed to be 
followed by the phrase "without limitation".  Unless the context otherwise 
requires, references in this Agreement to Articles, Sections, Exhibits and 
Disclosure Schedules shall be deemed references to Articles and Sections of, 
and Exhibits and Disclosure Schedules to, this Agreement.  Unless the context 
otherwise requires, the words "hereof", "hereby" and "herein" and words of 
similar meaning when used in this Agreement refer to this Agreement in its 
entirety and not to any particular Article, Section or provision of this 
Agreement.  The words "written request" when used in this Agreement shall 
include email.  Reference in this Agreement to any time shall be to Eastern 
time unless otherwise expressly provided herein.  The word "or" shall not be 
exclusive.  References to any "statute" or "regulation" are to such statute or 
regulation as amended, modified, supplemented or replaced from time to time 
(and, in the case of any statute, include any rules and regulations 
promulgated under such statute) and to any "section of any statute or 
regulation" include any successor to such section.  References to any 
Governmental Entity include any successor to such Governmental Entity, and 
references to any Affiliate include any successor to such Affiliate.  Whenever 
the last day for the exercise of any right or the discharge of any duty under 
this Agreement falls on a day other than a Business Day, the Party having such 
right or duty shall have until the next Business Day to exercise such right or 
discharge such duty.  Unless otherwise indicated, the word "day" shall be 
interpreted as a calendar day.

                                   ARTICLE II                                   

                           THE ASSETS AND LIABILITIES                           

Section 2.1.

Purchase and Sale of the Purchased Assets
.  Subject to the terms and conditions of this Agreement, Buyer agrees to 
purchase at the Closing (as defined below) and Cyclerion agrees to and shall 
sell and cause to be sold, assigned, transferred, and conveyed to Buyer at the 
Closing, all of Cyclerion's rights, title, and interests, in and to the 
Purchased Assets, including without limitation, the following assets:

                                       16                                       
-------------------------------------------------------------------------------
(a)

Intellectual Property rights owned by Cyclerion that are primarily related to 
the research, development, manufacture, commercialization, or other 
exploitation of the Purchased Programs, including the Intellectual Property 
set forth in
Section 2.1(a)
of the Disclosure Schedules, and, except to the extent constituting an 
Excluded Asset identified on
Section 2.2(l)
of the Disclosure Schedules,  all claims and causes of action with respect to 
any of the foregoing, whether accruing before, on, or after the Closing Date, 
including all rights to and claims for damages, restitution and injunctive and 
other legal and equitable relief for past, present, and future infringement, 
misappropriation or violation thereof (the "
Purchased Intellectual Property
");

(b)

Contracts to which Cyclerion is a party to the extent primarily related to the 
research, development, manufacture or commercialization of the Purchased 
Programs, including those contracts listed in
Section 2.1(b)
of the Disclosure Schedules (the "
Assumed Contracts
");

(c)

all physical assets, wherever located, that are used or held for use primarily 
in connection with the Purchased Programs;

(d)

inventories used, held for use, or intended to be used primarily in operating 
or developing the Purchased Programs, wherever located, including inventories 
of raw materials, finished goods, drug substance, intermediates, operating 
supplies, work-in-process, products, supplies, packaging, packaging materials, 
parts and other inventories used, held for use, or intended to be used in 
operating or developing the Purchased Programs, including all: (i) of the 
foregoing listed on
Section 2.1(d)
of the Disclosure Schedules, and (ii) of the foregoing being held on 
consignment, bailment, or other arrangement;

(e)

books and records relating to the Purchased Assets, including all technical 
literature used primarily for the Purchased Programs and all rights to receive 
mail (including e-mail) and other communications related to the Purchased 
Programs (including mail (including e-mail) and communications from customers, 
suppliers, distributors, agents and others with respect to the Purchased 
Programs);

(f)

all INDs, Permits and regulatory documentation with respect to the Purchased 
Programs (including any drug designations), including those set forth on
Section 2.1(f)
of the Disclosure Schedules, all correspondence with the FDA or other 
Governmental Entity regarding the Purchased Programs, all preclinical and 
clinical study data supporting the Purchased Programs and all related 
historical safety and pharmacovigilance data, provided that Cyclerion will 
have the right to make copies of all such records and will retain the right to 
access and use any such records following the Closing (the "
Transferred Records
");

(g)

all personnel files for the Transferred Employees;

(h)

all claims, causes of action, defenses and rights of offset or counterclaim 
against Third Parties primarily related to any Purchased Asset or any Assumed 
Liability, except to the extent constituting an Excluded Asset identified on
Section 2.2(l)
of the Disclosure Schedules;

                                       17                                       
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(i)

all assets listed in Section 2.1(i) of the Disclosure Schedules; and

(j)

all goodwill primarily associated with the categories of Purchased Assets set 
forth in Section 2.1(a)-(i).

Section 2.2.

Excluded Assets
.  Notwithstanding anything contained herein to the contrary, Cyclerion shall 
retain, and Buyer shall not acquire or assume, any and all assets of Cyclerion 
not included in Purchased Assets, including the following assets, properties 
and rights (collectively, the "
Excluded Assets
"):

(a)

all cash and cash equivalents of Cyclerion, together with all rights to all 
bank accounts of Cyclerion;

(b)

all accounts receivable of Cyclerion;

(c)

all minute books, organizational documents, stock registers and such other 
books and records of Cyclerion that pertain to the ownership, organization and 
existence of Cyclerion and its Subsidiary;

(d)

all personnel files for all current and former employees of Cyclerion who do 
not become Transferred Employees;

(e)

all assets and Contracts related to, or assets held with respect to, the 
benefit plans of Cyclerion;

(f)

all rights of Cyclerion under the Transaction Agreements;

(g)

all Contracts of Cyclerion and its Subsidiary that are not Assumed Contracts, 
including those Contracts set forth in
Section 2.2(g)
of the Disclosure Schedules (the "
Excluded Contracts
");

(h)

all insurance policies and related Contracts of Cyclerion and all rights 
thereunder (including the right to make claims thereunder and to the proceeds 
thereof);

(i)

all assets, properties and rights, including all Contracts, primarily related 
to Cyclerion's business other than the Purchased Assets;

(j)

all abandoned or unclaimed property reportable under any state or local 
unclaimed property, escheat or similar Law and associated with periods prior 
to the Closing Date;

(k)

all Intellectual Property rights owned or controlled by Cyclerion that are not 
primarily related to the research, development, manufacture, commercialization 
and other exploitation of the Purchased Programs, including the Intellectual 
Property rights set forth in
Section 2.2(k)
of the Disclosure Schedules, and all the goodwill associated therewith;

                                       18                                       
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(l)

Cyclerion's or its Subsidiary's claims, causes of action, defenses and rights 
of offset or counterclaim against third parties not primarily related to any 
Purchased Asset or any Assumed Liability, as well as any claims, defenses, 
rights of offset or counterclaims made by Cyclerion or its Subsidiary against 
Third Parties related to any Purchased Assets but only to the extent in 
respect of the claims, causes of action, defenses and rights of offset or 
counterclaim against Third Parties set forth in
Section 2.2(l)
of the Disclosure Schedules;

(m)

all Joint Confidentiality Agreements, all bids and expressions of interest 
received from third parties with respect to the Purchased Assets (but 
excluding any confidentiality agreement that exclusively relates to the 
Purchased Programs);

(n)

all privileged materials, documents and records of Cyclerion or Cyclerion's 
Subsidiary that are not related to the Purchased Assets;

(o)

all Tax assets of Cyclerion or its Subsidiary, or that relate to the Purchased 
Assets for a Pre-Closing Tax Period, including (i) Tax losses, refunds, 
credits, credit carry forwards and other Tax attributes, (ii) all deposits, 
prepaid or advance payments with respect to Taxes, and (iii) any claims, 
rights, and interest in and to any Tax asset, refund, credit, deduction or 
reduction of Taxes; and

(p)

all Tax Returns, Tax information and Tax records related to Cyclerion or its 
Affiliates.

Section 2.3.

Assumption of Liabilities
. Subject to the terms and conditions of this Agreement, at the Closing, Buyer 
shall assume from Cyclerion and agree to pay, perform and discharge in 
accordance with their respective terms ("Assume"; "Assumed" and "Assumption" 
shall have the correlative meaning), all of the Assumed Liabilities regardless 
of (A) except as set forth in the definition of Assumed Liabilities, when or 
where such Liabilities arose or arise, (B) where or against whom such 
Liabilities are asserted or determined, and (C) which entity is named in any 
action associated with any Liability; provided that Buyer shall not assume 
(and the Assumed Liabilities shall not be deemed to include) Liabilities: (a) 
to the extent arising out of or relating to a breach by Cyclerion or its 
Subsidiary of an Assumed Contract or (b) to the extent relating to the period 
prior to the Closing Date.

Section 2.4.

Excluded Liabilities
.  Except for the Assumed Liabilities, Buyer shall not assume pursuant to this 
Agreement or the transactions contemplated hereby, and shall have no liability 
for, any Liabilities of Cyclerion or any of its Affiliates (the "
Excluded Liabilities
"), all of which shall be retained by and continue to be Liabilities of 
Cyclerion or its Affiliates, as applicable.  Without limiting the generality 
or effect of the foregoing, Excluded Liabilities shall include the following 
Liabilities:

(a)

all Liabilities and obligations relating to, based in whole or in part on 
events or conditions occurring or existing in connection with, or arising out 
of, Cyclerion or the Purchased Assets as operated prior to the Closing Date, 
or the ownership, possession, use, operation or sale or other disposition 
prior to the Closing Date of any of the Purchased Assets (other than the PTC 
Grant, the Employee Expenses and R&D Expenses,);

                                       19                                       
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(b)

all Liabilities based upon, arising out of or otherwise in respect of any 
employment, compensation, equity-based, incentive or other benefit plans, 
contracts, programs or agreements of Cyclerion, other than the Employee 
Expenses;

(c)

all Liabilities based upon, arising out of or otherwise in respect of any 
current or former employees, independent contractors, consultants, or other 
service providers of Cyclerion or any other member of its Group regardless of 
whenever occurring, other than (i) the Employee Expenses and (ii) solely with 
respect to the period following the Closing (or, if later, the date a 
Transferred Employee becomes employed by Buyer or its Affiliates as provided by

Section 6.5(a)
, except for the Employee Expenses related to any Inactive Employees who 
become Transferred Employees with respect to the period following the 
Closing), Liabilities related to the employment or termination of employment 
of the Transferred Employees;

(d)

except as otherwise provided in
Section 6.11(b),
all Liabilities for (i) Taxes of Cyclerion (or its Subsidiary) or (ii) Taxes 
relating to the Purchased Assets for any Pre-Closing Tax Period;

(e)

all Liabilities arising in connection with, or relating to, any real property 
owned, leased or otherwise used or occupied by Cyclerion or its Subsidiary;

(f)

all royalties or other Liabilities owed under the Excluded Contracts; and

(g)

all Liabilities relating to abandoned or unclaimed property reportable under 
any state or local unclaimed property, escheat or similar Law where the 
dormancy period elapsed on or prior to the Closing Date.

Section 2.5.

Transfers not
Effected at or Prior to the Closing Date;
Transfers Deemed Effective as of the Closing Date
.

(a)

If and to the extent that the transfer to the Buyer Group of any Purchased 
Asset or Assumption by the Buyer Group of any Assumed Liability, in each case 
contemplated hereby, would be a violation of applicable Law or require any 
Consent that has not been obtained or made by the Closing Date then, unless 
the Parties mutually shall otherwise agree, the transfer to the Buyer Group of 
such Purchased Assets or the Assumption by the Buyer Group of such Assumed 
Liabilities, as the case may be, shall be automatically deemed deferred and 
any such purported transfer or Assumption shall be null and void until such 
time as all legal impediments are removed or such Consent has been obtained or 
made.  Notwithstanding the foregoing, any such Purchased Asset or Assumed 
Liability shall continue to constitute a Purchased Asset or Assumed Liability, 
as applicable, for all other purposes of this Agreement.

(b)

With respect to Assets and Liabilities described in
Section 2.5(a)
, taking into account any applicable restrictions or considerations relating 
to the contemplated Tax treatment of the transactions contemplated hereby, 
each of Cyclerion and Buyer shall, and shall cause the members of its 
respective Group to, (i) treat for all Tax purposes (A) the deferred Assets as 
assets having been transferred to and owned by the Person entitled to such 
Assets not later than the Closing Date and (B) the deferred Liabilities as 
having been assumed by the Person intended to be subject to such Liabilities 
not later than the Closing Date and (ii) neither report nor take any Tax 
position (on a Tax Return or otherwise) inconsistent with such treatment, 
except as required by applicable Law.

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(c)

In the event that any transfer of Assets or Assumption of Liabilities intended 
to be effected hereunder has not been consummated at or prior to the Closing 
Date, whether as a result of the provisions of
Section 2.5(a)
or for any other reason:

(i)

unless the Parties shall otherwise agree, the Parties and their respective 
Group members shall cooperate and use commercially reasonable efforts to seek 
to obtain, in accordance with applicable Law, any necessary Consents for the 
transfer of all Purchased Assets and the Assumption of all Assumed Liabilities 
contemplated to be transferred or Assumed, as applicable, pursuant to this
Article II
to the fullest extent permitted by applicable Law;
provided
,
however
, that, except as otherwise agreed between Cyclerion and Buyer in writing, 
neither Cyclerion nor Buyer shall be obligated to make any payment, incur any 
Liability or offer or grant any accommodation (financial or otherwise, 
regardless of any provision to the contrary in any underlying Contract, 
including any requirements for the securing or posting of any bonds, letters 
of credit or similar instruments, or the furnishing of any guarantees) to any 
Third Party to obtain or make such Consent; and

(ii)

for the period beginning on the Closing Date and ending on the six (6)-month 
anniversary of the Closing Date (the "
Transition Period
"), (A) the Party (or the applicable member of its Group) retaining such Asset 
shall thereafter hold (or shall cause such member in its Group to hold) such 
Asset in trust for the use and benefit of the Party entitled thereto (at the 
expense of the Party entitled thereto) and (B) the Party intended to Assume 
such Liability shall, or shall cause the applicable member of its Group to, 
pay or reimburse the Party retaining such Liability for all amounts paid or 
incurred in connection with the retention of such Liability.  In addition, 
during the Transition Period, Cyclerion (or the applicable member of its 
Group) shall (or shall cause such member in its Group to) treat, insofar as 
reasonably possible and to the extent permitted by applicable Law, such 
Purchased Asset in the ordinary course of business in accordance with past 
practice and take such other actions as may be reasonably requested by Buyer 
in order to place Buyer, insofar as reasonably possible and to the extent 
permitted by applicable Law, in the same position as if such Purchased Asset 
had been transferred as contemplated hereby, and so that all the benefits and 
burdens relating to such Purchased Asset, including possession, use, risk of 
loss, potential for income and gain, and dominion, control and command over 
such Purchased Asset, are to inure from and after the Closing Date to the 
applicable member or members of the Buyer Group entitled to the receipt of 
such Purchased Asset.  In furtherance of the foregoing, the Parties agree 
that, as of the Closing Date, Buyer shall be deemed to have acquired complete 
and sole beneficial ownership over all Purchased Assets, together with all 
rights, powers and privileges incident thereto, and shall be deemed to have 
Assumed in accordance with the terms of this Agreement all Assumed 
Liabilities, and all duties, obligations and responsibilities incident 
thereto, which Buyer is entitled to acquire or required to Assume pursuant to 
the terms of the Transaction Agreements.

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(d)

If and when the Consents or conditions, the absence or non-satisfaction of 
which caused the deferral of transfer of any Asset or deferral of the 
Assumption of any Liability pursuant to
Section 2.5(a)
are obtained or satisfied, the transfer or Assumption of the applicable Asset 
or Liability shall be effected without further consideration in accordance 
with and subject to the terms of this Agreement (including
Section 2.2
and
Section 2.3
) or the applicable Ancillary Agreement, and shall, to the extent possible 
without the imposition of any undue cost on any Party, be deemed to have 
become effective as of the Closing Date.

(e)

The Party (or the applicable member of its Group) retaining any Asset or 
Liability due to the deferral of the transfer of such Asset or the deferral of 
the Assumption of such Liability pursuant to
Section 2.5(a)
or otherwise shall (i) not be obligated, in connection with the foregoing, to 
expend any money unless the necessary funds are advanced, assumed, or agreed 
in advance to be reimbursed by the Party (or the applicable member of its 
Group) entitled to such Asset or the Person intended to be subject to such 
Liability, other than reasonable attorneys' fees and recording or similar or 
other incidental fees, all of which shall be promptly reimbursed by the Party 
(or the applicable member of its Group) entitled to such Asset or the Person 
intended to be subject to such Liability and (ii) be indemnified, pursuant to 
the provisions of
Article IX
, for all Indemnifiable Losses or other Liabilities arising out of any actions 
(or omissions to act) of such retaining Party taken (or not taken) at the 
written direction of the other Party (or the applicable member of its Group) 
in connection with and relating to such retained Asset or Liability, as the 
case may be.

(f)

To the extent that any Transferred Records, in the form that Cyclerion is able 
to deliver to Buyer, is inseparable from any data or information constituting 
Excluded Assets (the "
Non-Separable Information
"), notwithstanding the fact that such Non-Separable Information may have been 
delivered to Buyer along with the Transferred Records, no right, title or 
interest shall be transferred to any member of the Buyer Group with respect to 
such Non-Separable Information. No member of the Buyer Group shall use or 
exploit in any manner such Non-Separable Information except to the extent 
expressly permitted pursuant to
Section 6.3
.

Section 2.6.

Further Assurances
.

(a)

In addition to and without limiting the actions specifically provided for 
elsewhere in this Agreement and subject to the limitations expressly set forth 
in this Agreement, including
Section 2.5
, each of the Parties shall cooperate with each other and shall use (and shall 
cause its respective Subsidiaries to use) commercially reasonable efforts, 
from and after the date of this Agreement, to take, or to cause to be taken, 
all actions, and to do, or to cause to be done, all things reasonably 
necessary on its part under applicable Law or contractual obligations to 
consummate and make effective the transactions contemplated by this Agreement 
and the Ancillary Agreements as promptly as reasonably practicable.

                                       22                                       
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(b)

Without limiting the foregoing, from and after the date of this Agreement:

(i)

each Party shall cooperate with the other Party to execute and deliver, and 
use commercially reasonable efforts to cause to be executed and delivered, all 
instruments, including instruments of transfer or title, and to make all 
filings with, and to obtain all Consents, and to take or cause to be taken all 
such other actions as such Party may reasonably be requested to take by any 
other Party from time to time, as promptly as reasonably practicable, 
consistent with the terms of this Agreement and the Ancillary Agreements, in 
order to effectuate the provisions and purposes of this Agreement and the 
Ancillary Agreements and the transfers of the applicable Assets and the 
assignment and Assumption of the applicable Liabilities and the other 
transactions contemplated hereby and thereby;

(ii)

Cyclerion will take (and cause its Subsidiary and their respective employees, 
agents, and contractors to take) such further actions reasonably requested by 
Buyer to evidence the assignment of the Purchased Intellectual Property and to 
assist Buyer in obtaining Patent rights and other Intellectual Property 
protection for inventions within the Purchased Intellectual Property, 
including executing further assignments, consents, releases, and other 
commercially reasonable documentation and providing good faith testimony by 
affidavit, declaration, in-person, or other proper means in support of any 
effort by Buyer to establish, perfect, defend, or enforce its rights in any 
Purchased Intellectual Property through prosecution of governmental filings, 
regulatory proceedings, litigation, and other means; and

(iii)

in the event that any Party (or member of such Party's Group) receives any 
Assets (including the receipt of payments made pursuant to Contracts and 
proceeds from accounts receivable with respect to such Asset) or is liable for 
any Liability that is otherwise assigned to any Person that is a member of the 
other Group pursuant to this Agreement or the Ancillary Agreements, such Party 
agrees to promptly transfer, or cause to be transferred, without further 
consideration such Asset or Liability to the other Party so entitled thereto 
(or to a member of such other Party's Group as designated by such other Party) 
and, prior to any such transfer, such Asset or Liability, as the case may be, 
shall be held in accordance with the provisions of
Section 2.5
; provided, that the provisions of this
Section 2.6(b)(iii)
are not intended to, and shall not, be deemed to constitute an authorization 
by any Party to permit the other to accept service of process on its behalf 
and no Party is or shall be deemed to be the agent of any other Party for 
service of process purposes.

(c)

From and after the date of this Agreement, with respect to any Action where 
any Party hereto is a defendant, when and if requested by such Party, the 
other Party shall use commercially reasonable efforts to petition the 
applicable court to remove the requesting Party as a defendant to the extent 
that such Action relates solely to Assets or Liabilities that the other Party 
(or any member of such other Party's Group) has been assigned pursuant to this

Article II
, and the other Party shall cooperate and assist in any required communication 
with any plaintiff or other related Third Party.

Section 2.7.

Closing
.  On the terms and subject to the conditions set forth in this Agreement, the 
closing of the transactions contemplated by this agreement (the "
Closing
") shall take place: (a) at 10:00 a.m. Eastern time, on the fifth Business Day 
after the conditions to the Closing set forth in
Section 7.1
,
Section 7.2
, and
Section 7.3
(other than those conditions that by their terms require the delivery of any 
such documents or the taking of other action at the Closing) are satisfied or 
waived; or (b) at such other time or on such other date as may be agreed upon 
by Buyer Parent and Cyclerion. The date on which the Closing is to occur is 
herein referred to as the "
Closing Date
." The Closing shall take place at the offices of Hughes Hubbard & Reed LLP, 
One Battery Park Plaza, New York, NY or at such other place as may be agreed 
upon in writing by Buyer Parent and Cyclerion.

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                                  ARTICLE III                                   

                               THE PURCHASE PRICE                               

Section 3.1.

Purchase Price
.  As payment for the Purchased Assets, Buyers shall at Closing pay and deliver:

(a)

to Cyclerion, an amount in cash equal to the Closing Payment by wire transfer 
of immediately available funds to Cyclerion to such bank account designated in 
writing by Cyclerion (such designations to be made prior to the Closing Date); 
and

(b)

a number of shares of common stock, par value 0.0001 ("
Common Stock
" and such shares of Common Stock, the "
Consideration Shares
") of Buyer Parent, such that following the issuance of the Consideration 
Shares, the Consideration Shares comprise ten percent (10%) of all of Buyer 
Parent's outstanding equity securities on a Fully-Diluted Basis immediately 
following the Closing.

(c)

The Parties intend that the cash and Consideration Shares received by 
Cyclerion with respect to the transactions contemplated by this Agreement 
shall be treated as consideration received in a taxable sale in exchange for 
the Purchased Assets pursuant to Section 1001 of the Code. This Agreement and 
the transactions contemplated hereby do not constitute a "plan of 
reorganization" within the meaning of Section 368 of the Code. Neither Party 
(nor any of their respective Representatives or Affiliates) shall take a 
position inconsistent with the tax-treatment described in this
Section 3.1(c)
absent a "determination" within the meaning of Section 1313 of the Code to the 
contrary.

Section 3.2.

Withholding Taxes
.  Buyers shall not deduct or withhold any Taxes from any amounts payable 
pursuant to this Agreement unless such deduction or withholding of Taxes is 
required under any applicable Law to be so deducted or withheld. If any 
applicable Law requires such deduction or withholding of any Tax from any such 
payments, then Buyers shall make such deduction or withholding and shall 
timely pay the full amount deducted or withheld to the relevant Governmental 
Entity in accordance with the applicable Law. Any amount so deducted and 
withheld that is timely paid to the relevant Governmental Entity in accordance 
with applicable Law shall be treated by the parties hereto for all purposes as 
having been delivered and paid to such Person in respect of which such 
deduction and withholding was made;
provided
,
however
, that Buyers shall use commercially reasonable efforts to provide such Person 
with written notice of the intent to deduct and withhold such amount at least 
five (5) Business Days prior to making the relevant payment (except in the 
case of any failure to deliver an Internal Revenue Service Form W-9 pursuant to

Section 7.2(a)(ii)
); and
provided

further
that so long as Cyclerion delivers a properly completed and executed Internal 
Revenue Service Form W-9 to Buyer pursuant to
Section 7.2(a)(ii)
, Buyers shall not deduct or withhold any Taxes under U.S. federal, U.S. state 
or U.S. local Law, from any payment to Cyclerion except to the extent 
resulting from a change in applicable Law (or guidance) on or after the date 
of this Agreement. Buyers and Cyclerion shall cooperate in good faith and take 
reasonable steps to minimize any such deduction and withholding.

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                                   ARTICLE IV                                   

                  REPRESENTATIONS AND WARRANTIES OF CYCLERION                   

Except as otherwise set forth in the Disclosure Schedules or as disclosed in 
any reports, forms, statements or other documents (including exhibits and all 
other information incorporated therein) required to be filed or furnished by 
Cyclerion with the SEC under the Exchange Act after December 31, 2022 
(excluding any disclosures in "risk factors" or otherwise relating to 
"forward-looking statements" to the extent that they are cautionary, 
predictive or forward-looking in nature), Cyclerion hereby represents and 
warrants to Buyers as follows:

Section 4.1.

Incorporation; Authority
.  Cyclerion has been duly incorporated, is validly existing as a corporation, 
and is in good standing under the laws of the State of Massachusetts and, 
except as would not individually or in the aggregate have a Material Adverse 
Effect, any other jurisdiction in which it is qualified to carry on its 
business, and, except as would not individually or in the aggregate have a 
Material Adverse Effect, has the requisite power to carry on its business as 
now conducted. Cyclerion has the requisite corporate power and authority to 
sign and deliver this Agreement and the other Transaction Agreements, and to 
perform its obligations hereunder and thereunder. This Agreement has been duly 
authorized, executed and delivered by Cyclerion and, assuming the due 
authorization, execution and delivery hereof by Buyers, constitutes a legal, 
valid and binding obligation of Cyclerion enforceable against Cyclerion in 
accordance with its terms, except as such enforcement may be limited by 
bankruptcy, insolvency or other similar laws affecting the enforcement of 
creditors' rights generally or by general principles of equity.

Section 4.2.

The Purchased Assets
.  Cyclerion is the legal and beneficial owner of all rights, title, and 
interests in and to all of the Purchased Assets and has good, valid, and 
marketable title to the Purchased Assets.  The Purchased Assets are free and 
clear of all Encumbrances other than Permitted Encumbrances. Cyclerion's 
Subsidiary does not own any right, title or interest in or to any of the 
Purchased Assets. The Purchased Assets, together with the Know-How licensed to 
Buyer pursuant to
Section 6.3
, constitutes all of the assets, tangible and intangible, owned or controlled 
by Cyclerion or its Subsidiary that are reasonably necessary for the operation 
of the Purchased Programs following the Closing
.
There are no Backup Compounds relating to the Purchased Programs.
Other than the Patents included in the Purchased Intellectual Property, 
Cyclerion and its Subsidiary do not own or Control any Patent that, absent a 
license, would be infringed by the development, manufacture, commercialization, 
or other exploitation of the Purchased Programs.

Section 4.3.

Compliance with Law
.  Except as would not individually or in the aggregate be material to 
Cyclerion, Cyclerion is not in violation of any Law, and to the Knowledge of 
Cyclerion, no event has occurred or circumstance exists that (with or without 
notice or lapse of time) would constitute or result in a violation by 
Cyclerion or its Subsidiary of, or failure on the part of Cyclerion or its 
Subsidiary to comply with, any Law that is or was applicable to the Purchased 
Programs (including research, development, manufacturing, and regulatory 
interactions). Except as would not individually or in the aggregate be 
material to Cyclerion, there is no (i) action or investigation pending or, to 
the Knowledge of Cyclerion, threatened, by any Governmental Entity or (ii) any 
legal or administrative proceeding pending or, to the Knowledge of Cyclerion, 
threatened, in each case ((i) and (ii)), against Cyclerion or its Subsidiary 
related to the Purchased Assets.

                                       25                                       
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Section 4.4.

Consents and Approvals; No Conflicts
.  Except for the Cyclerion FDA Letters and the Cyclerion Orphan Designation 
Letter, and as set forth on
Section 4.4
of the Disclosure Schedules, no filing with, and no permit, authorization, 
consent or approval of, any third party, public body or governmental authority 
is necessary for the consummation by Cyclerion of the transactions 
contemplated by this Agreement. Neither the execution and delivery of this 
Agreement by Cyclerion nor the consummation by Cyclerion of the transactions 
contemplated hereby, nor compliance by Cyclerion with any of the provisions 
hereof, will (a) conflict with or result in any breach of any provisions of 
the charter or bylaws or equivalent governing documents of Cyclerion, as may 
be amended, (b) result in a violation or breach of, or constitute (with or 
without due notice or lapse of time or both) a default (or give rise to any 
right of termination, cancellation or acceleration) under, any of the terms, 
conditions or provisions of any note, bond, mortgage, indenture, license, 
contract, agreement or other instrument or obligation to which Cyclerion is a 
party or by which Cyclerion or any of the Purchased Assets may be bound or (c) 
violate any order, writ, injunction, decree, statute, rule or regulation 
applicable to Cyclerion, or any of the Purchased Assets, except in the case of 
clauses (b) and (c) for violations, breaches or defaults which would not 
individually or in the aggregate have a Material Adverse Effect.

Section 4.5.

Contracts
.  Neither Cyclerion nor its Subsidiary is a party to any material Contract 
pursuant to which (i) Cyclerion or its Subsidiary has granted to any Third 
Party a license, covenant not to sue, option, or other right with respect to 
any Purchased Intellectual Property; and (ii) any Third Party has granted to 
Cyclerion or any of its Affiliates a license, covenant not to sue, option or 
other right with respect to any Purchased Intellectual Property.  Cyclerion 
has made available to Buyer true and complete copies of each of Assumed 
Contract (including all amendments and modifications, extensions, and renewals 
thereof and waivers thereunder).  Cyclerion has not provided to or received 
from any other party to any Assumed Contract written notice of any material 
breach or default under any Assumed Contract.  Cyclerion has not given any 
written notice of termination of any Assumed Contract to a Third Party that is 
a party thereto and has not received any written notice of termination of any 
Assumed Contract from any such Third Party that is a party thereto.

Section 4.6.

Assigned Intellectual Property
.
Section 2.1(a)
of the Disclosure Schedules sets forth a true, complete and accurate list of 
all of the Patents owned by Cyclerion or its Subsidiary that are necessary

for the research, development, manufacture, commercialization, or other 
exploitation of any Purchased Program. In addition,
Section 2.1(a)
of the Disclosure Schedules sets forth a true, complete and accurate list of 
all registered Trademarks or applications therefor, registered copyrights or 
applications therefor, and domain names owned by Cyclerion or its Subsidiary 
that, in each case, are primarily used in connection with any Purchased 
Program.

                                       26                                       
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Section 4.7.

Licenses, Permits and Authorizations
.  Cyclerion has obtained, and is in material compliance with, all of the 
Permits that are material to the development, manufacture, testing, and 
distribution of the Purchased Programs under applicable Laws.

Section 4.8.

Taxes
.

(a)

All material amounts of Taxes of Cyclerion and its Subsidiary relating to the 
Purchased Assets (whether or not shown on any Tax Return) have been timely 
paid in full. Each of Cyclerion and its Subsidiary have timely filed all 
material Tax Returns related to the Purchased Assets which are required to be 
filed by it and all such Tax Returns are true, correct and complete in all 
material respects.

(b)

No Action concerning any Taxes relating to the Purchased Assets has been 
raised or threatened by a Governmental Entity in writing, other than any such 
Action that has been fully resolved or fully withdrawn.

(c)

No written claim has ever been made by a Governmental Entity in a jurisdiction 
where Cyclerion does not pay a specific Tax or file a specific Tax Return that 
it is or may be subject to pay such Tax or file such Tax Return, in each case, 
relating to the Purchased Assets, by that jurisdiction.

(d)

Notwithstanding anything to the contrary in this Agreement, nothing in this
Section 4.8
is or shall be construed as a representation or warranty with respect to the 
proper treatment of any item by Buyer or its Affiliates after the Closing.

Section 4.9.

Broker Fees
.  Except as set forth in
Section 4.9
of the Disclosure Schedules, neither Cyclerion nor anyone on its behalf, has 
any liability to any broker, finder, investment banker or agent, or has agreed 
to pay any brokerage fees, finder's fees or commissions, or to reimburse any 
expenses of any broker, finder, investment banker or agent in connection with 
this Agreement.

Section 4.10.

Representations with Respect to Consideration Shares
.

(a)

The Consideration Shares will be issued by Buyer Parent to Cyclerion in 
reliance upon Cyclerion's representation to Buyer Parent, which by Cyclerion's 
execution of this Agreement, Cyclerion hereby confirms, that the Consideration 
Shares to be issued to Cyclerion will be acquired for investment for 
Cyclerion's own account, not as a nominee or agent, and not with a view to the 
resale or distribution of any part thereof, and that Cyclerion has no present 
intention of selling, granting any participation in, or otherwise distributing 
the same. By executing this Agreement, Cyclerion further represents that 
Cyclerion does not presently have any contract, undertaking, agreement or 
arrangement with any Person to sell, transfer or grant participations to such 
Person or to any third Person, with respect to any of the Consideration 
Shares. Cyclerion has not been formed for the specific purpose of acquiring 
the Consideration Shares.

(b)

Cyclerion has had an opportunity to discuss Buyer Parent's business, 
management, financial affairs and the terms and conditions of the issuance of 
the Consideration Shares with Buyer Parent's management and has had an 
opportunity to review Buyer Parent's facilities. The foregoing, however, does 
not limit or modify the representations and warranties of Buyer and Buyer 
Parent in
Article V
of this Agreement or the right of Cyclerion to rely thereon.

                                       27                                       
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(c)

Cyclerion understands that the Consideration Shares have not been, and will 
not be, registered under the Securities Act, by reason of a specific exemption 
from the registration provisions of the Securities Act which depends upon, 
among other things, the bona fide nature of the investment intent and the 
accuracy of Cyclerion's representations as expressed herein. Cyclerion 
understands that the Consideration Shares are "restricted securities" under 
applicable U.S. federal and state securities laws and that, pursuant to these 
laws, Cyclerion must hold the Consideration Shares indefinitely unless they 
are registered with the Securities and Exchange Commission and qualified by 
state authorities, or an exemption from such registration and qualification 
requirements is available. Cyclerion acknowledges that Buyer Parent has no 
obligation to register or qualify the Consideration Shares for resale. 
Cyclerion further acknowledges that if an exemption from registration or 
qualification is available, it may be conditioned on various requirements 
including, but not limited to, the time and manner of sale, the holding period 
for the Consideration Shares, and on requirements relating to Buyer Parent 
which are outside of Cyclerion's control, and which Buyer Parent is under no 
obligation and may not be able to satisfy.

(d)

Cyclerion understands that no public market now exists for the Consideration 
Shares, and that Buyer Parent has made no assurances that a public market will 
ever exist for the Consideration Shares.

(e)

Cyclerion understands that the Consideration Shares and any securities issued 
in respect of or exchange for the Consideration Shares, may be notated with 
one or all of the following legends:

(i)

"THE SHARES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES 
ACT OF 1933, AND HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO, OR 
IN CONNECTION WITH, THE SALE OR DISTRIBUTION THEREOF. NO SUCH TRANSFER MAY BE 
EFFECTED WITHOUT AN EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR AN 
OPINION OF COUNSEL IN A FORM SATISFACTORY TO THE COMPANY THAT SUCH 
REGISTRATION IS NOT REQUIRED UNDER THE SECURITIES ACT OF 1933."

(ii)

Any legend set forth in, or required by, the Stockholder Agreements.

(iii)

Any legend required by the securities laws of any state to the extent such 
laws are applicable to the Consideration Shares represented by the 
certificate, instrument, or book entry so legended.

(f)

Cyclerion is an accredited investor as defined in Rule 501(a) of Regulation D 
promulgated under the Securities Act.

                                       28                                       
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Section 4.11.

Acknowledgement by Buyers
.

(a)

Each of Buyer and Buyer Parent, on behalf of itself and its Affiliates, 
acknowledges that it has conducted, to its satisfaction, an independent 
investigation and verification of the financial condition, results of 
operations, assets, liabilities, properties and projected operations of the 
Purchased Programs, and, in making its determination to proceed with the 
transactions contemplated by this Agreement and the other Transaction 
Agreements, each of Buyer and Buyer Parent: (i) has relied solely on the 
results of its own independent investigation and verification and the 
representations and warranties of Cyclerion, and Cyclerion expressly and 
specifically sets forth in
Article IV
(each as qualified by the Disclosure Schedules), and (ii) has not relied on 
the accuracy or completeness of any other information provided to (or 
otherwise acquired by) Buyer or Buyer Parent or any of their respective 
Affiliates.  The representations and warranties of Cyclerion expressly and 
specifically set forth in this
Article IV
(each as qualified by the Disclosure Schedules) and any certificate delivered 
in connection with this Agreement are the sole and exclusive representations, 
warranties and statements (including omissions) of any kind made to Buyer or 
Buyer Parent in connection with the transactions contemplated by this 
Agreement or the other Transaction Agreements, and each of Buyer and Buyer 
Parent, on behalf of itself and each of its Affiliates, understands, 
acknowledges and agrees that all other representations, warranties or 
statements (including omissions) of any kind or nature expressed or implied 
(including any relating to the future or historical financial condition, 
results of operations, assets or liabilities of the Purchased Programs) are 
specifically disclaimed by Cyclerion.  In particular, Cyclerion disclaims any 
representation, warranty or statement (including any omission), and each of 
Buyer and Buyer Parent, on behalf of itself and each of its Affiliates, agrees 
that there shall be no liability, with respect to any information concerning 
Cyclerion not expressly represented and warranted to in this Agreement, 
including, without limitation (to the extent no representation or warranty is 
made herein with respect thereto), any information provided by Cyclerion to 
Buyer, Buyer Parent or any of their respective Affiliates, including, for the 
avoidance of doubt, with respect to the accuracy or completeness of any other 
information provided to (or otherwise acquired by) Buyer, Buyer Parent or any 
of their respective Affiliates.  None of Buyer, Buyer Parent or any of their 
respective Affiliates shall have any claim against Cyclerion or its Subsidiary 
with respect to any such disclaimed information.  To the fullest extent 
permitted by applicable Law, none of Cyclerion, its Subsidiary or their 
respective Affiliates or any of its or their respective equityholders, 
controlling Persons or Representatives shall have any liability or 
responsibility whatsoever to either of Buyer or Buyer Parent, or their 
respective Affiliates, equityholders, controlling Persons or Representatives 
on any basis (including in contract or tort, at law or in equity, under any 
Laws or otherwise) based upon any information provided or made available, or 
statements made (or any omissions therefrom), to Buyer, Buyer Parent, or their 
respective Affiliates, stockholders, controlling Persons or Representatives, 
except as and only to the extent expressly set forth in this Agreement or an 
certificate delivered in connection herewith.  Cyclerion does not make or 
provide, and each of Buyer and Buyer Parent hereby waives, any warranty or 
representation, express or implied, as to the quality, merchantability, 
fitness for a particular purpose, conformity to samples, or condition of the 
assets or any part thereof of any Purchased Assets.  BUYER AND BUYER PARENT 
SPECIFICALLY ACKNOWLEDGE AND AGREE THAT, EXCEPT FOR THE REPRESENTATIONS AND 
WARRANTIES OF CYCLERION EXPRESSLY AND SPECIFICALLY SET FORTH IN
ARTICLE IV
(AS QUALIFIED BY THE DISCLOSURE SCHEDULES) AND ANY CERTIFICATE DELIVERED IN 
CONNECTION WITH THIS AGREEMENT, (X) BUYER IS ACQUIRING THE PURCHASED ASSETS 
AND THE ASSUMED LIABILITIES ON AN "AS IS, WHERE IS" BASIS, AND (Y) NEITHER 
CYCLERION NOR ANY OTHER PERSON, WHETHER IN ANY INDIVIDUAL, CORPORATE OR ANY 
OTHER CAPACITY, IS MAKING, AND, NOTWITHSTANDING THE DELIVERY OR DISCLOSURE TO 
BUYER, BUYER PARENT OR ANY OF THEIR RESPECTIVE REPRESENTATIVES, OR ANY OTHER 
PERSON, OF ANY DOCUMENTATION OR OTHER INFORMATION BY CYCLERION OR ITS 
SUBSIDIARY OR ANY OF THEIR RESPECTIVE REPRESENTATIVES, OR ANY OTHER PERSON, 
NEITHER BUYER NOR BUYER PARENT IS RELYING ON, ANY REPRESENTATIONS OR 
WARRANTIES OF ANY KIND WHATSOEVER, WHETHER ORAL OR WRITTEN, EXPRESS OR 
IMPLIED, AT LAW OR IN EQUITY, STATUTORY OR OTHERWISE, AS TO ANY MATTER 
CONCERNING THE PURCHASED ASSETS, THE ASSUMED LIABILITIES, THE VALIDITY OF ANY 
PATENTS OR THE NON-INFRINGEMENT OF ANY INTELLECTUAL PROPERTY RIGHTS OF THIRD 
PARTIES, FUTURE REVENUE, PROFITABILITY OR SUCCESS, OR IN CONNECTION WITH THIS 
AGREEMENT OR THE OTHER TRANSACTION AGREEMENTS OR THE TRANSACTIONS CONTEMPLATED 
HEREBY OR THEREBY, OR THE ACCURACY OR COMPLETENESS OF ANY INFORMATION PROVIDED 
TO (OR OTHERWISE ACQUIRED BY) BUYER, BUYER PARENT OR ANY OF THEIR RESPECTIVE 
AFFILIATES (INCLUDING BY WAY OF ANY DOCUMENTS OR OTHERWISE), OR STATEMENT 
MADE, BY CYCLERION, ITS SUBSIDIARY OR THEIR RESPECTIVE REPRESENTATIVES IN 
CONNECTION WITH THE TRANSACTIONS CONTEMPLATED HEREBY OR PURSUANT TO THE OTHER 
TRANSACTION AGREEMENTS.

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(b)

CYCLERION HAS NOT MADE ANY REPRESENTATIONS, WARRANTIES OR STATEMENTS 
(INCLUDING BY OMISSION) OF ANY KIND OR NATURE EXPRESS OR IMPLIED (INCLUDING 
ANY RELATING TO THE FUTURE OR HISTORICAL FINANCIAL CONDITION, RESULTS OF 
OPERATIONS, PROSPECTS, ASSETS OR LIABILITIES OF THE PURCHASED PROGRAMS OR THE 
QUALITY, QUANTITY OR CONDITION OF THE PURCHASED ASSETS) TO BUYER, BUYER PARENT 
OR ANY OF THEIR RESPECTIVE AFFILIATES IN CONNECTION WITH THE TRANSACTIONS 
CONTEMPLATED BY THIS AGREEMENT AND THE OTHER TRANSACTION AGREEMENTS, EXCEPT 
FOR ANY REPRESENTATIONS AND WARRANTIES OF CYCLERION EXPRESSLY AND SPECIFICALLY 
IN
ARTICLE IV
(EACH AS QUALIFIED BY THE DISCLOSURE SCHEDULES) AND IN ANY CERTIFICATE 
DELIVERED IN CONNECTION WITH THIS AGREEMENT.

(c)

Neither Cyclerion nor its Subsidiary, whether in an individual, corporate or 
any other capacity, will have or be subject to any liability or obligation 
(indemnification or otherwise) to Buyer, Buyer Parent or any of their 
respective Affiliates resulting from (nor shall Buyer, Buyer Parent or any of 
their respective Affiliates have any claim with respect to) the distribution 
to Buyer, Buyer Parent or any of their respective Affiliates, or Buyer's, 
Buyer Parent's or any of their respective Affiliates' use of, or reliance on, 
any information, documents, projections, forecasts or other material made 
available to Buyer, Buyer Parent or any of their respective Affiliates in 
presentations (including, for the avoidance of doubt, in any Confidential 
Information presentation or other "management presentations") in expectation 
of, or in connection with, the transactions contemplated by this Agreement, 
the other Transaction Agreements or otherwise, regardless of the legal theory 
under which such liability or obligation may be sought to be imposed, whether 
sounding in contract or tort, or whether at law or in equity, or otherwise.

                                       30                                       
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(d)

In connection with the investigation by Buyers of the Purchased Assets, Buyers 
may have received certain projections, forward-looking statements and other 
forecasts and certain business plan information.  Without in any way limiting 
the generality of the foregoing, each of Buyer and Buyer Parent, on its own 
behalf and on behalf of its Affiliates, acknowledges that there are 
uncertainties inherent in attempting to make such estimates, projections and 
other forecasts and plans, that Buyer, Buyer Parent and their respective 
Affiliates are familiar with such uncertainties, that Buyer, Buyer Parent and 
their respective Affiliates are taking full responsibility for making their 
own evaluation of the adequacy and accuracy of all estimates, projections and 
other forecasts and plans so furnished to them (including the reasonableness 
of the assumptions underlying such estimates, projections, forecasts or 
plans), and that Buyer, Buyer Parent and their respective Affiliates shall 
have no claim against anyone with respect thereto.  Accordingly, each of Buyer 
and Buyer Parent, on its own behalf and on behalf of its Affiliates, 
acknowledges that neither Cyclerion nor its Subsidiary is making any 
representation or warranty with respect to, and none of Buyer, Buyer Parent or 
any of its Affiliates is relying on, such estimates, projections, forecasts or 
plans (including the reasonableness of the assumptions underlying such 
estimates, projections, forecasts or plans).

                                   ARTICLE V                                    

            REPRESENTATIONS AND WARRANTIES OF BUYER PARENT AND BUYER            

Buyer Parent and Buyer hereby jointly and severally represent and warrant to 
Cyclerion as follows:

Section 5.1.

Incorporation; Ownership and Authority
.  Each of Buyer Parent and Buyer has been duly incorporated, is validly 
existing as a corporation, and is in good standing under the laws of the State 
of Delaware, and, except as would not materially and adversely affect the 
ability of Buyer Parent or Buyer to perform its respective obligations under 
this Agreement and the other Transaction Agreements, is in good standing under 
the laws of any other jurisdiction in which it is qualified to carry on its 
business, and, except as would not materially and adversely affect the ability 
of Buyer or Buyer Parent to perform its obligations under this Agreement and 
the other Transaction Agreements, has the requisite power to carry on its 
business as now conducted. Each of Buyer Parent and Buyer has the requisite 
corporate power and authority to sign and deliver this Agreement and to 
perform its obligations hereunder. This Agreement has been duly authorized, 
executed and delivered by Buyer Parent and Buyer and, assuming the due 
authorization, execution and delivery hereof by Cyclerion, constitutes a 
legal, valid and binding obligation of Buyer Parent and Buyer enforceable 
against each of Buyer Parent and Buyer in accordance with its terms, except as 
such enforcement may be limited by bankruptcy, insolvency or other similar 
laws affecting the enforcement of creditors' rights generally or by general 
principles of equity.

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Section 5.2.

Capitalization
.

(a)

Buyer Parent's authorized capital stock as of the date of this Agreement 
consists of (i) 25,000,000 shares of common stock, of which one (1) share is 
issued and outstanding and held of record by the person identified in
Section 5.2(a)
of the Disclosure Schedules, and (ii) 17,799,974 shares of preferred stock, 
2,199,996 of which are issued and outstanding and held of record by the 
persons identified in
Section 5.2(a)
of the Disclosure Schedules. Buyer's authorized capital stock consists of 100 
shares of common stock, all of which are issued and outstanding and held by 
Buyer Parent.

(b)

Buyer Parent's authorized capital stock as of immediately after Closing (and 
after the Consideration Shares and all stock issuable in connection with the 
Buyer Parent Purchase Agreement has been issued) will consist of (i) 
25,000,000 shares of common stock, of which 1,022,222 will be issued and 
outstanding and held of record by the persons identified in
Section 5.2(b)
of the Disclosure Schedules, and (ii) 17,799,974 shares of preferred stock, 
9,199,985 of which will be issued and outstanding and held of record by the 
persons identified in
Section 5.2(b)
of the Disclosure Schedules.

(c)

When issued, the Consideration Shares will be duly authorized, validly issued, 
fully paid and non-assessable. Except as disclosed in
Section 5.2(c)
of the Disclosure Schedules or pursuant to the terms and conditions of the 
Stockholder Agreements, there are no outstanding or authorized securities 
providing for the issuance by Buyer Parent or transfer by Buyer Parent of 
additional shares of Buyer Parent's capital stock and Buyer Parent has not 
reserved any shares of its capital stock for issuance, nor are there any 
outstanding stock option rights, phantom equity or similar rights, contracts, 
arrangements or commitments to issue capital stock of Buyer Parent. Other than 
the Stockholder Agreements, there are no voting trusts, shareholder agreements 
or other agreements or understandings with respect to the voting of Buyer 
Parent's capital stock.

Section 5.3.

No Operations
.  Since the inception of each of Buyer Parent and Buyer, each of Buyer Parent 
and Buyer has not engaged in any activity, other than actions in connection 
with (i) its organization, (ii) the preparation, negotiation and execution of 
this Agreement, the Ancillary Agreements and the transactions contemplated 
hereby and thereby and (iii) the preparation, negotiation and execution of the 
Buyer Parent Purchase Agreement, the Stockholder Agreements and the 
transactions contemplated thereby. Neither Buyer nor Buyer Parent have not 
generated any revenues and has no assets or liabilities other than those 
incurred in connection with the foregoing and in associated with the 
transactions set forth in this Agreement.

Section 5.4.

Consents and Approvals; No Violations
.  Except for the consents to be obtained by the Buyers' shareholders, the 
Buyer FDA Letter, the Buyer Orphan Designation Letter and the consent of 
certain counterparties to the Assumed Contracts, no filing with, and no 
permit, authorization, consent or approval of, any third party, public body or 
governmental authority is necessary for the consummation by Buyers of the 
transactions contemplated by this Agreement. Neither the execution and 
delivery of this Agreement by Buyers nor the consummation by Buyers of the 
transactions contemplated hereby, nor compliance by Buyers with any of the 
provisions hereof, will (a) conflict with or result in any breach of any 
provisions of the charter or bylaws or equivalent governing documents of 
Buyers, as may be amended, (b) result in a violation or breach of, or 
constitute (with or without due notice or lapse of time or both) a default (or 
give rise to any right of termination, cancellation or acceleration) under, 
any of the terms, conditions or provisions of any note, bond, mortgage, 
indenture, license, contract, agreement or other instrument or obligation to 
which Buyer of Buyer Parent is a party or by which Buyer, Buyer Parent or any 
their respective properties or assets may be bound or (c) violate any order, 
writ, injunction, decree, statute, rule or regulation applicable to Buyer or 
Buyer Parent, or any of their respective properties or assets, except in the 
case of clauses (b) and (c) for violations, breaches or defaults which would 
not materially and adversely affect the ability of Buyer Parent and Buyer to 
perform their respective obligations under this Agreement and the other 
Transaction Agreements.

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Section 5.5.

Financing
.

(a)

Attached hereto as
Exhibit H
is a true and complete copy of the Buyer Parent Purchase Agreement. The Buyer 
Parent Purchase Agreement is a legal, valid and binding obligation of Buyer 
Parent and, to Buyer's knowledge, each of the other parties thereto, and is in 
full force and effect and enforceable against Buyer Parent, and to Buyer's 
knowledge, each other party thereto (except in each case as the same may be 
limited by applicable bankruptcy, insolvency, reorganization, moratorium, 
fraudulent transfer and similar laws relating to or affecting creditors' 
rights generally and general equitable principles). As of the date hereof, 
Buyer Parent is not, and to the knowledge of Buyer, none of the parties to the 
Buyer Parent Purchase Agreement are, in default or breach of the terms of the 
Buyer Parent Purchase Agreement. There are no conditions precedent or 
contingencies related to the funding of the full amount of any Equity 
Financing other than as described in the Buyer Parent Purchase Agreement. 
Buyer Parent shall have at the Closing, sufficient cash to enable it to make 
the Closing Payment and any other amounts to be paid by Buyer Parent and/or 
Buyer hereunder and in connection with the Equity Financing.

(b)

Buyers acknowledges and agrees that, notwithstanding anything to the contrary 
in this Agreement, neither the availability of financing nor the consummation 
of any financing transaction shall be a condition to the obligation of Buyers 
to consummate the transactions contemplated by this Agreement or the other 
Transaction Agreements.

Section 5.6.

Broker's Fees
.  None of Buyer Parent, Buyer nor anyone on their behalf, has any liability 
to any broker, finder, investment banker or agent, or has agreed to pay any 
brokerage fees, finder's fees or commissions, or to reimburse any expenses of 
any broker, finder, investment banker or agent in connection with this 
Agreement.

                                   ARTICLE VI                                   

                    COVENANTS AND AGREEMENTS OF THE PARTIES                     

Section 6.1.

Operation of the Business
.  Except as otherwise consented to in writing by Buyer (such consent not to 
be unreasonably withheld, conditioned or delayed), as required by applicable 
Law or as required or contemplated by this Agreement, during the period 
commencing on the date of this Agreement and ending at the Closing or the date 
on which this Agreement is earlier validly terminated pursuant to
Article VIII
(the "
Pre-Closing Period
"), Cyclerion shall not:

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(a)

sell, lease, abandon or otherwise dispose of or permit any Encumbrance (other 
than Permitted Encumbrances) on any Purchased Asset except in the ordinary 
course of business consistent with past practice;

(b)

(A) enter into, extend, modify, amend, terminate or renew under any Assumed 
Contract (or any Contract that would be an Assumed Contract if entered into 
prior to the date hereof) or (B) knowingly take, or fail to take, any action 
that would constitute a breach, violate the terms, conditions or provisions 
of, or result in a default under, or give to others any rights of termination, 
 amendment, acceleration or cancellation of any Assumed Contract;

(c)

sell, license or otherwise dispose of any Purchased Intellectual Property, and 
shall maintain in full force and effect issuances and registrations included 
in the Purchased Intellectual Property and enforce its rights in and to such 
Purchased Intellectual Property;

(d)

except as otherwise expressly permitted or required under this Agreement, 
terminate or materially modify the Purchased Programs;

(e)

terminate any Employee without cause, increase or promise to increase the 
compensation or benefits of any Employee or grant any new compensation or 
benefits to, or enter into any employment, severance, change in control, 
bonus, retention or other similar agreement or arrangement with, any Employee 
excluding the entrance into any consulting agreements with the Specified 
Employees for consulting services following the Closing as contemplated by

Section 6.5(a)
;

(f)

liquidate, dissolve, reorganize or otherwise wind up the business and 
operations of Cyclerion; or

(g)

enter into any agreement, or otherwise become obligated, to do any action 
prohibited by
Section 6.1(a)
-
(f)
.

Section 6.2.

Corporate Examinations and Investigations
.

(a)

During the Pre-Closing Period, Buyer shall be entitled, through its officers, 
employees, representatives and agents, to make such investigations and 
examinations of the books and records of Cyclerion, solely in connection with 
the Purchased Programs and the transactions contemplated by the Transaction 
Agreements. Cyclerion shall furnish to Buyer Parent, Buyer and their 
respective officers, employees, representatives or agents during such period 
with all such information concerning the affairs of Cyclerion as Buyer Parent, 
Buyer or their respective officers, employees, representatives or agents may 
reasonably request in connection with the Purchased Programs and the 
transactions contemplated by the Transaction Agreements and cause Cyclerion 
and its officers, employees, consultants, agents, accountants and attorneys to 
cooperate fully with each Party's representatives in connection with such 
review and examination and to make disclosure of the information and documents 
so requested by each other Party or its representatives. Any such 
investigations and examinations shall be conducted at reasonable times and 
under reasonable circumstances, it being agreed that any examination of 
original documents will be at Cyclerion's premises where such original 
documents are located, with copies thereof to be provided to Buyer or its 
representatives upon request.

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(b)

During the Pre-Closing Period, Cyclerion shall be entitled, through its 
officers, employees, representatives and agents, to make such investigations 
and examinations of the books, records and financial condition of Buyer Parent 
and Buyer. Buyer and Buyer Parent shall furnish to Cyclerion and its officers, 
employees, representatives or agents during such period with all such 
information concerning the affairs of Buyer Parent and Buyer as Cyclerion or 
its officers, employees, representatives or agents may reasonably request in 
connection with the transactions contemplated by the Transaction Agreements 
and the ability to fund such transactions, and cause Buyer Parent, Buyer and 
their respective officers, employees, consultants, agents, accountants and 
attorneys to cooperate fully with each Party's representatives in connection 
with such review and examination and to make disclosure of the information and 
documents so requested by each other Party or its representatives. Any such 
investigations and examinations shall be conducted at reasonable times and 
under reasonable circumstances, it being agreed that any examination of 
original documents will be at Buyer's or Buyer Parent's premises where such 
original documents are located, with copies thereof to be provided to 
Cyclerion or its representatives upon request.

Section 6.3.

Know-How Licenses
.

(a)

Buyer hereby, effective as of the Closing, grants to Cyclerion a perpetual, 
irrevocable, worldwide, non-exclusive, royalty-free license (which, for the 
avoidance of doubt, shall include the right to grant sublicenses through 
multiple tiers), to any Know-How included in the Purchased Assets and owned or 
Controlled by any member of the Buyer Group that also relates to an Excluded 
Program (including any Know-How contained in books and records included in the 
Purchased Assets to which Cyclerion has the right to keep copies of, maintain 
access to or use pursuant to
Section 2.1(e))
, in each case solely to develop, manufacture, commercialize, or otherwise 
exploit, such Excluded Program existing as of the Closing Date, but subject to 
any Assumed Contract that relates to such Know-How.  All such Know-How will be 
kept confidential by Cyclerion and treated as Buyer's trade secret information.


(b)

Cyclerion (on behalf of itself and its Subsidiary) hereby, effective as of the 
Closing Date, grants to Buyer a perpetual, irrevocable, worldwide, 
non-exclusive, royalty-free license (which, for the avoidance of doubt, shall 
include the right to grant sublicenses through multiple tiers), to any 
Know-How owned or Controlled by Cyclerion or its Subsidiary relating to an 
Excluded Asset that also relates to a Purchased Program, in each case solely 
to develop, manufacture, commercialize or otherwise exploit, the Purchased 
Programs, but subject to any existing Contract of Cyclerion with respect to 
such Excluded Assets. All such Know-How will be kept confidential by Buyer and 
treated as Cyclerion's trade secret information.

(c)

Except as expressly provided in this
Section 6.3
(
Know-How Licenses
), nothing in this Agreement will be construed as conferring by implication, 
estoppel, or otherwise any license, right, or immunity under any Patent or 
other Intellectual Property that a Party (or its successors, Affiliates or 
assigns) now owns or holds a license to, or acquires or obtains a license to 
in the future.

Section 6.4.

Efforts
.  Subject to the terms and conditions of this Agreement, each Party shall use 
commercially reasonable efforts to take, or cause to be taken, all actions and 
to do, or cause to be done, all things necessary, proper or advisable under 
this Agreement and applicable Law to satisfy the conditions to Closing set 
forth herein and consummate the transactions contemplated hereby as soon as 
practicable after the date of this Agreement and in any event no later than 
the Termination Date.

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Section 6.5.

Employee Matters
.

(a)

Promptly after the date of this Agreement (and in any case within ten (10) 
Business Days thereafter), Buyer Parent shall (or shall cause one of its 
Subsidiaries to) make a written offer of employment to each Employee, subject 
to Buyer Parent's or its Subsidiaries' standard hiring procedures, which 
offers of employment shall be effective as of and contingent on the occurrence 
of the Closing on terms and conditions set forth in this
Section 6.5(a)
; provided, however, that with respect to any Employee who is on an approved 
leave of absence as of the Closing (each such Employee, an "
Inactive Employee
"), such offer will be effective as of the date, not to exceed six (6) months 
following the Closing or such longer period to the extent required by 
applicable Law (such six month period or such longer period to the extent 
required by applicable Law), when such Employee returns to active employment 
in accordance with the terms of his or her leave.  Each Employee who accepts 
an offer of employment with Buyer Parent or its Subsidiaries and becomes an 
employee of Buyer Parent or its Subsidiaries on the Closing or upon return to 
active employment (if later) as provided for herein shall be referred to 
herein as a "
Transferred Employee
" and collectively as the "
Transferred Employees
", and the date as of which such an Employee becomes a Transferred Employee, 
shall be referred to herein as the "
Employee Expenses End Date
"); provided that, if an Inactive Employee does not become a Transferred 
Employee, Buyer shall provide Cyclerion a written invoice in respect of any 
Employee Expenses borne by Buyers with respect to such Inactive Employee 
solely with respect to the period following the Closing and Cyclerion shall 
promptly, and in any event within thirty (30) calendar days of receiving an 
invoice therefor, reimburse Buyers for such invoiced amount. Notwithstanding 
anything to the contrary contained in this
Section 6.5(a)
, Cyclerion shall, in its sole discretion, be permitted to engage the 
Employees listed on
Section 6.5(a)
of Disclosure Schedule (the "
Specified Employees
") as consultants to Cyclerion or any member of its Group following the 
Closing until the earlier to occur of the eighteen (18)-month anniversary of 
the Closing Date and such Specified Employee's termination of employment with 
Buyer or any of its Affiliates and enter into consulting agreements with such 
Specified Employees to provide consulting services to Cyclerion or any member 
of its Group for up to twenty (20) hours per month per Specified Employee, and 
Buyers agree that such Specified Employees shall be permitted to provide such 
consulting services to Cyclerion or any member of its Group, subject to 
Buyers' review and approval of the applicable consulting agreement (such 
approval not to be unreasonably withheld, conditioned or delayed), and Buyers 
will not (and will cause their Subsidiaries not to) prohibit, prevent or 
otherwise discourage any Specified Employee from providing (or agreeing to 
provide) such services; provided that the foregoing shall not effect Buyers' 
ability to enforce any then-existing confidentiality and non-use Contracts to 
which such Specified Employee is bound.

(b)

Buyers shall be responsible for all Employee Expenses and shall reimburse 
Cyclerion for any and all such Employee Expenses promptly upon (but in no 
event later than five (5) Business Days following) the presentation of 
invoices detailing such Employee Expenses to Buyer following at the end of 
each two-week period beginning on the date of this Agreement.

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(c)

Notwithstanding anything to the contrary contained herein, nothing in this
Section 6.5
shall:  (i) confer any rights, remedies or claims upon any director, officer, 
employee or independent contractor of Cyclerion or Buyer or any of their 
respective Affiliates in their capacity as such, (ii) be considered or deemed 
an amendment of any benefit plan of Cyclerion or Buyer, (iii) guarantee 
employment for any period of time or preclude the ability of Buyer or any of 
its Subsidiaries to terminate any employee or independent contractor for any 
reason at any time, or (iv) require Buyer or any of its Subsidiaries to 
continue or amend any employee compensation or benefit plans or arrangements, 
or prevent the amendment, modification or termination thereof after the 
consummation of the Closing.

Section 6.6.

Use of Retained Names and Marks
.  Buyers hereby acknowledge that Cyclerion or its Affiliates or its or their 
licensors own all right, title and interest in and to Trademarks and all other 
identifiers of source or goodwill containing, incorporating or associated with 
Trademarks, excluding Trademarks included in the Purchased Assets 
(collectively, the "
Retained Names and Marks
"), and that any and all right of Buyers to use the Retained Names and Marks 
shall terminate as of the Closing Date and shall immediately revert to 
Cyclerion or its Affiliates, along with any and all goodwill associated 
therewith.  For clarity, Buyer may nonetheless make fair use of the mark 
"Cyclerion" after the Closing Date, such as, for example, to accurately 
describe the origins and history of the Purchased Programs.

Buyers further acknowledge that they have no rights in any of the Retained 
Names and Marks, and that it is not acquiring any rights, directly or 
indirectly, to use the Retained Names and Marks, except as expressly provided 
herein.  Cyclerion hereby acknowledges that, on and after the Closing Date, 
Buyer or its Affiliates or its or their licensors own all right, title and 
interest in and to the Trademarks associated with the Purchased Assets (the "

Assumed Names and Marks
"), and that any and all right of Cyclerion to use the Assumed Names and Marks 
shall terminate as of the Closing Date.  For clarity, Cyclerion may 
nonetheless make fair use of the Assumed Names and Marks after the Closing 
Date. Cyclerion further acknowledges that, on and after the Closing Date, it 
will have no rights in any of the Assumed Names and Marks.

Section 6.7.

Interim Period Preclinical and Clinical Trial Activities
.

(a)

Following the date of this Agreement and at the times set forth in
Section 6.7
of the Disclosure Schedules, Cyclerion shall commence certain preclinical and 
clinical trial activities as set forth in
Section 6.7
of the Disclosure Schedules (such activities, the "
Preclinical and Clinical Trial Activities
").

(b)

The estimated out-of-pocket costs of Cyclerion and its Affiliates for the 
conduct in connection with the Preclinical and Clinical Trial Activities is 
set forth on
Section 6.7
of the Disclosure Schedules.  At the end of each two-week period during the 
Pre-Closing Period (and in any event no later than the fifth day following 
month end), Cyclerion or its Affiliates or Representatives shall provide Buyer 
with an invoice listing in reasonable detail all out-of-pocket costs and 
expenses related to the Preclinical and Clinical Trial Activities, including 
costs and expenses for prosecution and maintenance of Intellectual Property as 
well as an allocation of the costs of Cyclerion that relate to both the 
Purchased Programs and the Excluded Programs, as set forth on
Section 6.7
of the Disclosure Schedules (the "
R&D Expenses
").  Buyers shall as promptly as practicable (but in no event later than five 
(5) Business Days following receipt of such invoice) pay to Cyclerion by wire 
transfer of immediately available funds any such R&D Expenses set forth in 
such invoice.

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Section 6.8.

Exclusivity
.

(a)

Acquisition Proposal
. Cyclerion shall, and shall cause its Subsidiary and Representatives to, 
immediately cease and cause to be terminated all existing activities, 
discussions or negotiations with any Persons (other than Buyer) conducted 
heretofore or that may be on-going with respect to, or that would reasonably 
be expected to lead to, any Acquisition Proposal. From and after the date of 
this Agreement until the earlier of Closing or the termination of this 
Agreement in accordance with
Article VIII
, Cyclerion shall not, shall cause its Subsidiary not to, and shall use 
reasonable best efforts to cause their respective Representatives not to, 
directly or indirectly, (i) initiate, knowingly facilitate, solicit or 
knowingly encourage (including by way of furnishing non-public information), 
directly or indirectly, inquiries or the making of any proposals that 
constitute, or would reasonably be expected to lead to, any Acquisition 
Proposal, (ii) initiate, engage or participate with any third party in any 
discussions or negotiations regarding, or furnish or disclose any non-public 
information (including by providing access to its properties, assets, books 
and records or personnel) to any third party in connection with, or take any 
other action to knowingly facilitate or knowingly encourage any inquiries or 
the making of any proposal that constitutes, or would reasonably be expected 
to lead to, any Acquisition Proposal (except solely to notify such third party 
of the existence of the provisions of this
Section 6.8
) or (iii) enter into any Acquisition Agreement or, except as expressly 
permitted pursuant to
Section 6.8(e)
below, approve or resolve to approve any Acquisition Proposal, or enter into 
any agreement, arrangement or understanding that would require Cyclerion to 
abandon, terminate or fail to consummate the transactions contemplated by this 
Agreement.  Without limiting the foregoing, it is agreed that any violation of 
the foregoing restrictions by any Representative, acting on behalf of 
Cyclerion or its Subsidiary, will be deemed to be a breach of this
Section 6.8
by Cyclerion, and Cyclerion will cause its Representatives to comply with the 
terms of this
Section 6.8
.

(b)

Notwithstanding the restrictions set forth in
Section 6.8(a)
, at any time prior to obtaining Stockholder Approval, in response to an 
unsolicited bona fide written Acquisition Proposal that the Board determines 
in good faith (after consultation with outside counsel and its financial 
advisor) constitutes or would reasonably be expected to lead to a Superior 
Proposal, Cyclerion may, subject to compliance with
Section 6.8(e)
, (i) contact the Person making such Acquisition Proposal (and its 
Representatives) solely to clarify the terms and conditions thereof, (ii) 
furnish non-public information with respect to Cyclerion and its Subsidiary to 
the Person making such Acquisition Proposal (and its Representatives) pursuant 
to a customary confidentiality agreement not less restrictive of such Person 
than that certain Confidentiality Agreement, dated as of September 4, 2022, by 
and between J. Wood Capital Advisors LLC and Cyclerion;
provided
,
however
, that all such information has previously been provided to Buyer or is 
promptly made available to Buyer, and (iii) participate in discussions or 
negotiations with the Person making such Acquisition Proposal (and its 
Representatives) regarding such Acquisition Proposal.

                                       38                                       
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(c)

Notice of Acquisition Proposal
.  From and after the date of this Agreement until the earlier of Closing or 
the termination of this Agreement, Cyclerion shall promptly (and in any event 
within twenty-four (24)

hours) notify Buyer in the event that Cyclerion receives, directly or 
indirectly: (i) any Acquisition Proposal; (ii) any request for nonpublic 
information relating to Cyclerion or its Subsidiary by any Person that informs 
Cyclerion, its Subsidiary or its Representatives that such Person is 
considering making, or has made, an Acquisition Proposal; or (iii) any request 
for discussions or negotiations relating to a possible Acquisition Proposal.  
Such notice shall be made in writing and shall include (x) the identity of the 
Person or group making such Acquisition Proposal or request, and (y) the 
material terms and conditions of any Acquisition Proposal or request and, if 
written, a copy thereof.  Cyclerion will (A) keep Buyer reasonably apprised of 
any material developments, discussions and negotiations with respect to such 
Acquisition Proposal or inquiry, as well as any material modification of or 
amendment thereto and if written, provide to Buyer a copy thereof and (B) 
promptly make available to Buyer any non-public information of Cyclerion and 
its Subsidiary furnished to any third party in connection therewith that has 
not previously been provided to Buyer.

(d)

Nothing contained in this
Section 6.8
prohibits or will be construed as prohibiting Cyclerion or the Board from (i) 
complying with its disclosure obligations under federal or state Law with 
regard to an Acquisition Proposal, including taking and disclosing to 
Cyclerion stockholders a position contemplated by Rule 14d-9 or Rule 14e-2(a) 
promulgated under the Exchange Act or (ii) making any disclosure to 
Cyclerion's stockholders if, in the good faith judgment of the Board, after 
consultation with outside legal counsel, failure to make such disclosure would 
be inconsistent with its fiduciary duties under applicable Law, or otherwise 
required under applicable Law;
provided
,
however
, a Cyclerion Adverse Recommendation Change (as defined below) shall only be 
made in accordance with
Section 6.8(e)
.

(e)

Actions by Cyclerion
.  Neither the Board nor any committee thereof shall (x) approve or recommend, 
or propose publicly to approve or recommend, any Acquisition Proposal, or 
cause or permit Cyclerion or its Subsidiary to execute or enter into any 
letter of intent, memorandum of understanding, agreement in principle, merger 
agreement, acquisition agreement, joint venture agreement, partnership 
agreement or similar agreement constituting or related to, or that is intended 
to or would reasonably be expected to lead to, any Acquisition Proposal (other 
than a confidentiality agreement referred to in
Section 6.8(b)
) or requiring Cyclerion or its Subsidiary to abandon, terminate or fail to 
consummate the transactions contemplated by this Agreement (an "
Acquisition Agreement
"), or (y)(A) withdraw, amend or modify in a manner adverse to Buyer, or 
publicly propose to withdraw, amend or modify in a manner adverse to Buyer, 
the Board Recommendation or (B) recommend, authorize or approve, or propose 
publicly to recommend authorize or approve, or fail to reject, any Acquisition 
Proposal or (C) fail to include the Board Recommendation in the Proxy 
Statement (any action described in this clause (y) being referred to as a "

Cyclerion Adverse Recommendation Change
").

(i)

Notwithstanding anything to the contrary contained herein (including the terms 
of
Section 6.8(e)(ii)(C)
), at any time prior to obtaining Stockholder Approval, the Board may, in 
response to a Superior Proposal or an Intervening Event, make a Cyclerion 
Adverse Recommendation Change if the Board determines, in good faith, after 
consultation with its outside legal counsel and financial advisor, that the 
failure to take such action would reasonably be expected to be inconsistent 
with the directors' fiduciary duties under applicable Law.

                                       39                                       
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(ii)

Notwithstanding anything to the contrary contained in this Agreement, the 
Board shall not be entitled to make a Cyclerion Adverse Recommendation Change 
pursuant to
Section 6.8(e)(i)
, unless (x) Cyclerion shall have provided to Buyer four (4) Business Days' 
prior written notice advising Buyer that the Board intends to take such 
action, and  if relating to an Intervening Event, such notice shall contain 
the material facts and circumstances of such Intervening Event and (y) (A) 
during such four (4)-Business Day period, if requested by Buyer, Cyclerion 
shall have, and shall have used reasonable best efforts to cause its 
Representatives to have, engaged in negotiations with Buyer to enable Buyer to 
propose revisions to the terms of this Agreement or other agreements 
contemplated hereby, (B) the Board shall have considered in good faith any 
adjustments to this Agreement (including a change to the price terms hereof) 
and the other agreements contemplated hereby that may be proposed in writing 
by Buyer, (C)(1) with respect to a Superior Proposal, the Board shall have 
determined in good faith, after consultation with Cyclerion's outside legal 
counsel and financial advisor, taking into account all legal, financial, 
regulatory and other aspects of the proposal the Board determines is 
appropriate (including any termination or break-up fees, the conditionality, 
the likelihood and timing of required governmental approvals, time likely to 
be required to consummate such Acquisition Proposal, ability of the Person 
making the proposal to finance and pay the contemplated consideration and the 
likelihood of success of such Acquisition Proposal), that the Acquisition 
Proposal still constitutes a Superior Proposal after taking into account the 
adjustments to this Agreement that were offered by Buyer and that the failure 
to make a Cyclerion Adverse Recommendation Change would reasonably be expected 
to be inconsistent with the directors' fiduciary duties under applicable Law

and (2) with respect to an Intervening Event, the Board shall have determined 
in good faith that failure to make a Cyclerion Adverse Recommendation Change 
would be reasonably expected to be inconsistent with the directors' fiduciary 
duties under applicable Law, and (D) in the event of any change to (1) any of 
the terms (including the form, amount and timing of payment of consideration) 
of an Acquisition Proposal, or
(2)
the facts or circumstances relating to an Intervening Event, Cyclerion shall, 
in each case, have delivered to Buyer an additional notice consistent with 
that described in
clause (i)
above and a new notice period under
clause (i)
of this proviso shall commence (except that four (4) Business Day notice 
period referred to above shall instead be equal to two (2) Business Day) 
during which time Cyclerion shall be required to comply with the requirements 
of this
Section 6.8(e)(ii)
anew with respect to such additional notice.

(f)

Cyclerion shall not release nor permit the release of any Person from, or 
waive or permit the waiver of any provision of, and Cyclerion shall use its 
reasonable efforts to enforce or cause to be enforced, any confidentiality, 
"standstill" or similar agreement to which any of Cyclerion or its Subsidiary 
is a party, unless the Board determines in good faith (after consultation with 
outside legal counsel) that the failure to take such action would be a breach 
of its fiduciary duties under applicable Law.

(g)

Immediately following the execution of this Agreement, Cyclerion shall request 
each Person which has heretofore executed a confidentiality agreement in 
connection with such Person's consideration of acquiring Cyclerion to return 
or destroy all confidential information heretofore furnished to such Person by 
or on Cyclerion's behalf.

                                       40                                       
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Section 6.9.

Matters related to Cyclerion Stockholders Meeting
.

(a)

Except as otherwise provided in
Section 6.9(a)
of the Disclosure Schedules, as promptly as reasonably practicable following 
the date of this Agreement (and in any event no later than thirty (30) 
calendar days after the date hereof), Cyclerion shall at its own expense 
prepare (with Buyer's reasonable cooperation) and use its reasonable best 
efforts to file with the SEC in preliminary form a proxy statement (the "
Proxy Statement
") with respect to a special meeting of the stockholders of Cyclerion (the "
Stockholders Meeting
") for the purpose of obtaining the approval of the sale of the Purchased 
Assets to the Buyer contemplated by this Agreement by the holders of a 
majority of the outstanding shares of Cyclerion Common Stock (the "
Stockholder Approval
"). Cyclerion shall use reasonable best efforts to file with the SEC the 
definitive Proxy Statement and to cause the mailing of the definitive Proxy 
Statement to the stockholders of Cyclerion to occur as promptly as practicable 
following the earlier of (i) the notification of no further comments from the 
SEC and (ii) if the staff of the SEC has not informed Cyclerion that they 
intend to review the Proxy Statement, the tenth (10th) day after the date the 
preliminary Proxy Statement is filed. Cyclerion shall use reasonable best 
efforts to respond as promptly as practicable, to any comments of the SEC with 
respect to the Proxy Statement and to have the Proxy Statement cleared by the 
SEC as promptly as practicable after filing. Buyer Parent and Buyer shall 
furnish all information concerning Buyer to Cyclerion as may be reasonably 
requested in connection with the preparation, filing and distribution of the 
Proxy Statement, including furnishing and using reasonable best efforts to 
cause its accountants and other agents and service providers to furnish to 
Cyclerion all information concerning itself, its directors, officers and 
stockholders and such other matters as may be reasonably necessary or 
advisable in connection with the Proxy Statement. Cyclerion shall promptly 
notify Buyer upon the receipt of any comments from the SEC or its staff or any 
request from the SEC or its staff for amendments or supplements to the Proxy 
Statement. Notwithstanding the foregoing, prior to filing or mailing the Proxy 
Statement (or any amendment or supplement thereto) or responding to any 
comments of the SEC with respect thereto, Cyclerion shall provide Buyer a 
reasonable opportunity to review and comment on such document or response 
which comments Cyclerion will consider in good faith. If at any time prior to 
the Stockholders Meeting, any information relating to Cyclerion, Buyer or any 
of their respective affiliates, officers or directors, should be discovered by 
Cyclerion or Buyer which should be set forth in an amendment or supplement to 
the Proxy Statement, so that the Proxy Statement shall not contain any untrue 
statement of a material fact or omit to state any material fact required to be 
stated therein or necessary in order to make the statements therein, in light 
of the circumstances under which they are made, not misleading, the Party 
which discovers such information shall promptly notify the other Parties 
hereto and an appropriate amendment or supplement describing such information 
shall be filed with the SEC and, to the extent required by applicable law, 
disseminated to the stockholders of Cyclerion.

                                       41                                       
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(b)

Cyclerion agrees that the Proxy Statement will comply as to form in all 
material respects with the requirements of the Exchange Act and the rules and 
regulations promulgated thereunder and that none of the information included 
or incorporated by reference in the Proxy Statement or any amendment or 
supplement thereto will (except to the extent revised or superseded by 
amendments or supplements contemplated hereby), at the date the Proxy 
Statement is filed with the SEC or mailed to the stockholders of Cyclerion or 
at the time of the Stockholders Meeting, or at the time of any amendment or 
supplement thereof, contain any untrue statement of a material fact or omit to 
state any material fact required to be stated therein or necessary in order to 
make the statements therein, in light of the circumstances under which they 
are made, not misleading, except that no covenant is made by Cyclerion with 
respect to statements made in the Proxy Statement based on information 
supplied in writing by or on behalf of Buyer or Buyer Parent for inclusion or 
incorporation for reference therein. Buyers shall cause the information 
relating to Buyer or Buyer Parent supplied by Buyers for inclusion in the 
Proxy Statement or any amendments or supplement thereto not to, at the date 
the Proxy Statement is filed with the SEC or mailed to the stockholders of 
Cyclerion or at the time of the Stockholders Meeting, or at the time of any 
amendment or supplement thereof (except to the extent revised or superseded by 
amendments or supplements contemplated hereby), contain any untrue statement 
of a material fact or omit to state any material fact required to be stated 
therein or necessary in order to make the statements therein, in light of the 
circumstances under which they are made, not misleading.

(c)

Cyclerion shall, as promptly as practicable after the date of this Agreement, 
establish a record date (which will be as promptly as reasonably practicable 
following the date of this Agreement) for, duly call, give notice of, convene 
and hold the Stockholders Meeting for purposes of seeking the Stockholder 
Approval, which meeting Cyclerion shall cause to occur as soon as practicable 
(and in any event within twenty-five (25) Business Days) following the mailing 
of the Proxy Statement.  Cyclerion may not postpone, recess or adjourn the 
Stockholders Meeting without the prior written consent of Buyer.  
Notwithstanding the foregoing, Cyclerion shall be permitted to postpone, 
recess or adjourn the Stockholders Meeting without the prior consent of Buyer 
(and shall do so if requested by Buyer): (i) if Cyclerion is unable to obtain 
a quorum of its stockholders at the Stockholders Meeting,

(ii) such postponement, recess or adjournment is required by applicable Law or 
a request from the SEC or its staff, or (iii) in the good faith judgement of 
the Board, following consultation with outside legal counsel and Buyer Parent 
(or, in the case of a request by Buyer, in Buyer Parent's good faith 
judgement) the failure to postpone, recess or adjourn the Stockholders Meeting 
would be reasonably likely to not allow reasonably sufficient time for the 
distribution and review of any required or appropriate supplement or amendment 
to the Proxy Statement by Cyclerion's stockholders prior to the Stockholders 
Meeting as then-scheduled; provided that Cyclerion shall not be required to 
adjourn the Stockholders Meeting more than once at such request of Buyer, no 
such adjournment shall be required to be for a period exceeding five (5) 
Business Days and in no event will Cyclerion be required by this Agreement to 
change such record date. Cyclerion agrees that no matters shall be brought 
before the Stockholders' Meeting other than the approval of the transactions 
contemplated by this Agreement and any related and customary procedural 
matters (including a proposal to adjourn the meeting to allow additional 
solicitation of votes). In no event will the record date of the Company 
Stockholders' Meeting be changed without Buyer's prior written consent (which 
consent shall not be unreasonably withheld, delayed or conditioned), unless 
required by applicable Law.

(d)

Subject to
Section 6.8(e)
, Cyclerion shall (A) through the Board, recommend to the Cyclerion 
stockholders, the approval and authorization of this Agreement and the 
transactions contemplated hereby (including the consideration to be received 
by the Company), and include in the Proxy Statement such recommendation and 
(B) use its reasonable best efforts to solicit from the Cyclerion stockholders 
proxies in favor of the approval and authorization of this Agreement, and (C) 
use reasonable best efforts to take all actions reasonably necessary to secure 
the Stockholder Approval.

                                       42                                       
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(e)

Cyclerion acknowledges that its obligations pursuant to
Section 6.9(a)
,
(b)
and
(c)
, will not be affected by any Cyclerion Adverse Recommendation Change or the 
commencement, public proposal, public disclosure or communication to Cyclerion 
or the Cyclerion stockholders of any Acquisition Proposal.

(f)

The Buyers shall, and shall cause the equityholders party thereto, not amend 
the applicable Voting Agreement in any respect without Cyclerion's prior 
written consent, which may not be unreasonably withheld, conditioned or 
delayed.

Section 6.10.

Buyer Parent Purchase Agreement
.  Buyer and Buyer Parent shall use reasonable best efforts to consummate the 
closing of the Second Tranche on or prior to the Closing Date as contemplated 
in the Buyer Parent Purchase Agreement.  Buyers shall not agree to any 
amendments or modifications to, or grant any waivers of, any condition 
(including any of the financing conditions) or other provision or remedy under 
the Buyer Parent Purchase Agreement without the prior written consent of 
Cyclerion (which consent shall not be unreasonably withheld, conditioned or 
delayed) to the extent such amendments, modifications or waivers would (x) 
reduce the aggregate amount of aggregate cash proceeds available to Buyer 
Parent under the Buyer Parent Purchase Agreement, or (y) impose new or 
additional conditions precedent or otherwise expand, amend or modify any of 
the conditions or other terms therein in a manner adverse to Buyer Parent, 
Buyer or Cyclerion, including any expansion, waiver, amendment or modification 
that would be reasonably likely to (A) prevent, impair or materially delay the 
ability of Buyer Parent or Buyer to consummate the transactions contemplated 
by this Agreement or the other Transaction Agreements, (B) adversely impact 
the ability of Buyer or Buyer Parent to enforce its rights or remedies against 
the counterparties to the Buyer Parent Purchase Agreement or (C) make the 
timely funding of the Equity Financing or satisfaction of the financing 
conditions set forth in the Buyer Parent Purchase Agreement materially less 
likely to occur. Buyer Parent shall promptly (and in any event within three 
(3) Business Days) notify Cyclerion of
(1)
any amendment, waiver or modification, or agreement to do any of the foregoing 
of any term of the Buyer Parent Purchase Agreement,
(2)
the expiration or termination (or attempted or purported termination, whether 
or not valid) of the Buyer Parent Purchase Agreement, or
(3)
any refusal by any counterparty to Buyer Parent Purchase Agreement to 
consummate, or any notice in writing by any such counterparty to refuse to 
consummate, the closing contemplated under the Buyer Parent Purchase Agreement.


Section 6.11.

Taxes
.

(a)

Cyclerion and Buyers shall reasonably cooperate  with each other and make 
available or cause to be made available to each other in a timely fashion such 
data (including Tax Returns) regarding the Purchased Assets which relates to 
Taxes, Tax Returns or filings with respect thereto and other information 
reasonably requested and required for the preparation by Buyers or Cyclerion 
of any Tax Returns, elections, consents or certificates required to be 
prepared and filed by Buyers or Cyclerion and any audit or other examination 
by any Governmental Entity or administrative Action relating to liability for 
Taxes.

                                       43                                       
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(b)

The Buyer and Buyer Parent (on the one hand) and Cyclerion (on the other hand) 
shall each bear fifty percent (50%) of any Transfer Taxes. The party required 
by applicable Law to file a Tax Return relating to Transfer Taxes shall 
prepare and timely file, or shall cause to be prepared and timely filed such 
Tax Return and shall promptly after filing such Tax Return, provide evidence 
to the non-filing party that such Tax Return has been duly and timely filed 
and the relevant Transfer Taxes have been duly and timely paid. The non-filing 
party shall, promptly following receipt of the evidence of payment of such 
Transfer Taxes, reimburse the filing party in an amount equal to fifty percent 
(50%) of any Transfer Taxes due on such Tax Return. Cyclerion and Buyers agree 
to timely sign and deliver such certificates or forms as may be reasonably 
necessary or appropriate to establish any exemption from (or otherwise reduce) 
such Transfer Taxes for which  each party is eligible.  For the avoidance of 
doubt, the Purchase Price set forth in this Agreement is exclusive of Transfer 
Taxes.

(c)

For purposes of apportioning Liabilities for ad valorem and similar Taxes 
relating to the Purchased Assets, such Liabilities for Taxes payable with 
respect to a Straddle Period shall be apportioned as follows: (i) Cyclerion 
shall be apportioned an amount equal to the total amount of such Taxes for the 
entire Straddle Period multiplied by a fraction, the numerator of which is the 
number of days in the portion of the Straddle Period ending on the Closing 
Date and the denominator of which is the number of days in such Straddle 
Period, and (ii) Buyers shall be apportioned an amount equal to the excess of 
the total amount of such Taxes over the amount determined in clause (i) hereof.


(d)

Buyer shall prepare an allocation of the Purchase Price and any applicable 
Assumed Liabilities among the Purchased Assets in accordance with applicable 
Law, including Section 1060 of the Code and the Treasury Regulations 
thereunder, which allocation and any adjustments thereto shall be subject to 
the comments and approval of Cyclerion. The Buyer shall deliver a proposed 
allocation to Cyclerion within 120 days after the Closing Date.  Such 
allocation shall become final and binding twenty (20) days after Buyer 
provides it to Cyclerion, unless Cyclerion notifies Buyer in writing that 
Cyclerion objects in good faith to such allocation.  In that case, the Parties 
will resolve any disagreement in good faith and, if they are unable to do so 
within fifteen (15) days of the objection from Cyclerion, the matter shall be 
submitted to a mutually agreed upon independent accounting firm to resolve 
such dispute, which resolution will be final and binding on the parties. Buyer 
and Buyer Parent (on the one hand) and Cyclerion (on the other hand) will each 
pay 50% of any costs or fees to retain the applicable accounting firm. The 
Parties (and their respective Representatives and Affiliates) shall report, 
act and file their respective Tax Returns in accordance with such allocation, 
as finally determined pursuant to this
Section 6.11(d)
, and any adjustments thereto and shall not take any position or action 
inconsistent with such allocation and any adjustments thereto, absent a 
"determination" within the meaning of Section 1313 of the Code to the contrary.


Section 6.12.

FDA Letters
.  Promptly after Closing (but in no event later than five (5) Business Days 
following the Closing):

(a)

Cyclerion shall file, or cause to be filed, with the FDA the Cyclerion FDA 
Letters and the Cyclerion Orphan Designation Letter, and shall provide an 
as-filed copy of each such letter to Buyer.

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(b)

Buyers shall file, or cause to be filed, with the FDA the Buyer FDA Letters 
and the Buyer Orphan Designation Letter and shall provide an as-filed copy of 
each such letter to Cyclerion.

Section 6.13.

Post-Closing Matters
.

(a)

From the Closing Date until the five (5) year anniversary of the Closing Date, 
subject to
Section 6.13(b)
, Cyclerion will not (and will cause its Affiliates not to), (i) either alone 
or directly or indirectly with or through any Affiliate or Third Party, 
initiate IND-enabling preclinical development, develop, commercially 
manufacture, commercialize, or otherwise exploit any compound or product 
(including any compound or product that is part of an Excluded Program) that 
is (A) a CNS-penetrant sGC Stimulator, (B) developed for the treatment of a 
Program Indication, and (C) reasonably expected to compete with any compound 
or product in a Purchased Program for the treatment of a Program Indication 
(any such compound or product, a "
Cyclerion Competing Product
") anywhere in the world, or (ii) license, convey, grant, or otherwise 
transfer any rights to any Third Party (including any rights under any 
Intellectual Property included in the Excluded Assets) to initiate 
IND-enabling preclinical development, develop, commercially manufacture, 
commercialize, or otherwise exploit a Cyclerion Competing Product anywhere in 
the world.

(b)

If there is a Change of Control of Cyclerion, then the obligations of
Section 6.13(a)
will not apply to any program or product of an acquirer or its Affiliates 
(other than any successor entity to Cyclerion or any Affiliate of Cyclerion 
that existed prior to the closing of such Change of Control) (an "
Acquirer Program
") that becomes an Affiliate of Cyclerion as a result of such Change of 
Control; provided, that Cyclerion and such Affiliates establish and enforce 
internal processes, policies, procedures, and systems to reasonably segregate 
any Confidential Information of Buyer that Cyclerion or its Affiliates may 
have with respect to the Purchased Programs (including any Know-How licensed 
to Cyclerion pursuant to
Section 6.3
of this Agreement) from any Acquirer Program for

a product that would be a Cyclerion Competing Product if developed by 
Cyclerion or a pre-Change of Control Affiliate of Cyclerion, including 
ensuring that such Affiliates do not use or practice,

directly or indirectly, any Purchased Intellectual Property or Buyer's 
Confidential Information in such program.

(c)

From the Closing Date until the five (5) year anniversary of the Closing Date, 
if from time to time Cyclerion determines that it will abandon the prosecution 
or maintenance of any Patent covering any or all of the hydroxy-compounds set 
forth on
Section 6.13(c)
of the Disclosure Schedules (the "
Hydroxy-Compounds
") Cyclerion shall promptly thereafter deliver a written notice (the "
Cyclerion Hydroxy-Compound Notice
") to Buyer specifying such determination. To exercise its Right of First 
Negotiation, Buyer shall deliver an irrevocable written notice (the "
Buyer Hydroxy-Compound Notice
") to Cyclerion notifying Cyclerion that Buyer intends to exercise its Right 
of First Negotiation with respect to the applicable Hydroxy-Compounds within 
fifteen (15) days of receipt of the Cyclerion Hydroxy-Compound Notice.  During 
the thirty (30) day period following Cyclerion's receipt of the Buyer 
Hydroxy-Compound Notice (such period, the "
Negotiation Period
"), Cyclerion shall not negotiate the terms of a license agreement with 
respect to the applicable Hydroxy-Compounds with any Person, other than the 
Buyer, and, subject to Buyer complying with its obligations included in the 
immediately following sentence, shall not abandon the maintenance or 
prosecution of the applicable Patents).  During the Negotiation Period, Buyer 
shall be responsible for all maintenance and prosecution costs with respect to 
the applicable Patents.   Following the expiration of the Negotiation Period, 
Cyclerion may negotiate the licensing of the applicable Hydroxy-Compounds with 
any Person or may abandon the prosecution or maintenance of the applicable 
Patents, in each case as determined in its sole discretion.

                                       45                                       
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Section 6.14.

Joint Confidentiality Agreements
. Following the Closing, in the event that Cyclerion becomes aware of a breach 
or potential breach of any of the confidentiality or non-use covenants of any 
Joint Confidentiality Agreement exclusively related to any Purchased Assets, 
Cyclerion shall promptly, and in any case within five (5) Business Days, 
notify Buyer of any such breach or potential breach.  Cyclerion shall, 
promptly following receipt of a written notice from Buyer directing Cyclerion 
to take the actions contemplated by this
Section 6.14
with respect to any such breach (whether or not Cyclerion delivered notice 
thereof to Buyer), specifically enforce the confidentiality and non-use 
covenants included in the applicable Joint Confidentiality Agreement against 
the counterparty thereto. Buyers shall be responsible for any and all 
Liabilities, costs and expenses of Cyclerion or any of its Affiliates or any 
of their respective representatives to the extent arising out of or relating 
to any such enforcement action and shall promptly, and in any event within 
thirty (30) calendar days of receiving an invoice therefor, reimburse 
Cyclerion for any such Liabilities, costs or expenses.  Cyclerion shall 
promptly, and in any event within thirty (30) calendar days, pay Buyer any 
amounts recovered or received in respect of any such enforcement actions, net 
of any costs or expenses not reimbursed by Buyers in accordance with the 
immediately preceding sentence.

                                  ARTICLE VII                                   

                             CONDITIONS TO CLOSING                              

Section 7.1.

Conditions to the Obligations of All Parties
.  The obligations of the Parties to consummate the transactions contemplated 
hereby are subject to the satisfaction, on or prior to the Closing Date, of 
each of the following conditions precedent (any of which may be waived in 
whole or in part by each of the parties in its sole discretion):

(a)

Applicable Law and Approvals
.  Prior to the Closing, the following conditions precedent have been satisfied:

(i)

there will be no Law of any nature issued by a Governmental Entity of 
competent jurisdiction that restrains, enjoins or otherwise prohibits, or has 
the effect of restraining, enjoining or otherwise prohibiting, the 
transactions contemplated by any Transaction Agreement from being consummated 
as herein provided; and

(ii)

the Stockholder Approval shall have been obtained.

(b)

Novation and Waiver Agreement
. The Novation and Waiver Agreement is in full force and effect, has not been 
amended or modified in any respect (except with the express written consent of 
Cyclerion and Buyer), and there is no dispute, outstanding with respect 
thereto.

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Section 7.2.

Conditions to Buyer Parent's and Buyer's Obligations at Closing
.  The obligations of Buyer Parent and Buyer to consummate the transactions 
contemplated hereby are subject to the satisfaction, on or prior to the 
Closing Date, of each of the following conditions precedent (any one or more 
of which may be waived in whole or in part by Buyer in its sole discretion):

(a)

Closing Deliveries
. At the Closing, Cyclerion shall deliver or have caused to be delivered to 
Buyer the following:

(i)

the Stockholder Agreements, duly executed by Cyclerion;

(ii)

a properly completed and executed Internal Revenue Service Form W-9 of 
Cyclerion dated no more than ten (10) Business Days prior to the Closing Date;


(iii)

letters from Cyclerion to the FDA transferring to Buyer or any of its 
designees ownership of (i) the INDs relating to the Purchased Programs in 
substantially the form attached hereto as
Exhibit I-1
(the "
Cyclerion IND 147088 FDA Letter
"),
Exhibit I-2
(the "
Cyclerion IND 138999 FDA Letter
") and
Exhibit I-3
(the "
Cyclerion IND 155952 FDA Letter
", together with the Cyclerion IND 147088 FDA Letter and Cyclerion IND 138999 
FDA Letter, the "
Cyclerion FDA Letters
") and (ii) the orphan drug designations relating to the Purchased Programs in 
substantially the form attached hereto as
Exhibit J
(the "
Cyclerion Orphan Designation Letter
"), each duly executed by Cyclerion.

(iv)

the Conveyancing and Assumption Instruments, duly executed by Cyclerion;

(v)

a Transition Services Agreement between Cyclerion and Buyer in substantially 
the form attached hereto as
Exhibit K
(the "
Transition Services Agreement
"), duly executed by Cyclerion; and

(vi)

a certificate of the Chief Financial Officer of Cyclerion that each of the 
conditions set forth in
Section 7.2(b)
and
Section 7.2(c)
have been satisfied.

(b)

Representations and Warranties to be True
.  The representations and warranties of Cyclerion herein contained (i) that 
are qualified or limited by materiality or "Material Adverse Effect" shall be 
true and correct as of the Closing with the same effect as if made as of the 
Closing (other than such representations that are made as of a specified date, 
which shall be true and correct on and as of such date) and (ii) that are not 
so qualified or limited shall be true and correct in all material respects as 
of the Closing with the same effect as if made as of the Closing (other than 
such representations that are made as of a specified date, which shall be true 
and correct in all material respects as of such date).

(c)

Covenants
. Cyclerion shall have performed and complied in all material respects with 
all covenants and agreements required by this Agreement to be performed or 
complied with by such respective Party at or prior to the Closing.  For 
purposes of this
Section 7.2(c)
, a covenant of Cyclerion shall only be deemed to have not been performed if 
Cyclerion has materially breached such covenant and failed to cure within 
fifteen (15) calendar days after notice (or if earlier, the Termination Date); 
provided that Buyer shall not be required to consummate the Closing unless and 
until such material breach of any covenant has been cured.

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(d)

No Material Adverse Effect
.  Since the date of this Agreement, there shall not have occurred and be 
continuing a Material Adverse Effect.

Section 7.3.

Conditions to Cyclerion's Obligations at Closing
.  The obligations of Cyclerion under this Agreement shall be subject to each 
of the following conditions, unless waived by Cyclerion:

(a)

Closing Deliveries
.  On Closing, Buyers shall deliver or have caused to be delivered to 
Cyclerion the following:

(i)

the Closing Payment in accordance with this Agreement;

(ii)

evidence of issuance of the Consideration Shares;

(iii)

the Stockholder Agreements, duly executed by all of the parties thereto, other 
than Cyclerion;

(iv)

letters from Buyer to the FDA accepting ownership of (i) the INDs relating to 
the Purchased Assets in substantially the form attached hereto as
Exhibit L-1
(the "
Buyer IND 147088 FDA Letter
"),
Exhibit L-2
(the "
Buyer IND 138999 FDA Letter
") and
Exhibit L-3
(the "
Buyer IND 155952 FDA Letter
", together with the Buyer IND 147088 Letter and Buyer IND 138999 FDA Letter, 
the "
Buyer FDA Letters
") and (ii) the orphan drug designations relating to the Purchased Assets in 
substantially the form attached hereto as
Exhibit M
, each duly executed by Buyer;

(v)

the Conveyancing and Assumption Instruments, duly executed by Buyer;

(vi)

the Transition Services Agreement, duly executed by Buyer;

(vii)

evidence of the consummation of the closing of the Second Tranche as 
contemplated by the Buyer Parent Purchase Agreement; and

(viii)

a certificate of a duly authorized officer of Buyer Parent that each of the 
conditions set forth in
Section 7.3(b)
and
Section 7.3(c)
has been satisfied.

(b)

Representations and Warranties to be True
. The representations and warranties of Buyer Parent and Buyer herein 
contained (i) that are qualified or limited by materiality or "Material 
Adverse Effect" shall be true and correct as of the Closing with the same 
effect as if made as of the Closing (other than such representations that are 
made as of a specified date, which shall be true and correct on and as of such 
date) and (ii) that are not so qualified or limited shall be true and correct 
in all material respects as of the Closing with the same effect as if made as 
of the Closing (other than such representations that are made as of a 
specified date, which shall be true and correct in all material respects as of 
such date);.

                                       48                                       
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(c)

Covenants
. Buyer and Buyer Parent shall have performed and complied in all material 
respects with all covenants and agreements required by this Agreement to be 
performed or complied with by Buyer and Buyer Parent, as applicable, at or 
prior to the Closing.  For purposes of this
Section 7.3(c)
, a covenant of Buyer or Buyer Parent shall only be deemed to have not been 
performed if Buyer or Buyer Parent, as applicable, has materially breached 
such covenant and failed to cure within fifteen (15) calendar days after 
notice (or if earlier, the Termination Date); provided that Cyclerion shall 
not be required to consummate the Closing unless and until such material 
breach of any covenant has been cured.

                                  ARTICLE VIII                                  

                                  TERMINATION                                   

Section 8.1.

Events of Termination
.

(a)

This Agreement may, by notice given in the manner hereinafter provided, be 
terminated and abandoned at any time prior to completion of the Closing, as 
follows:

(i)

at any time by mutual written agreement of Buyer and Cyclerion;

(ii)

by either Party if the Closing will not have been consummated on or before 
September 11, 2023, unless such date is extended by the mutual written 
agreement of Buyer and Cyclerion (the "
Termination Date
"); provided that the right to terminate this Agreement pursuant to this
Section 8.1(a)(ii)
shall not be available to any Party whose breach of any provision of this 
Agreement has primarily caused or primarily resulted in the failure of the 
Closing to be consummated by such time;

(iii)

by Buyer, if any representation or warranty of Cyclerion set forth in this 
Agreement shall have become untrue or if a failure to perform any covenant or 
agreement on the part of Cyclerion set forth in this Agreement shall have 
occurred, in each case, such that if the breach or untruth was occurring on 
the Closing Date any of the conditions set forth in
Section 7.1
or
Section 7.2
(as applicable) would not be satisfied, and such condition is incapable of 
being satisfied by the Termination Date; provided that Buyer may not terminate 
this Agreement under this
Section 8.1(a)(iii)
unless (i) such breach has not been cured by the date which is twenty (20) 
days after Buyer notifies Cyclerion of such breach in writing and (ii) neither 
of the Buyers is then in breach of this Agreement so as to cause any of the 
conditions set forth in
Section 7.1
or
Section 7.3
not to be satisfied;

(iv)

by Cyclerion, if any representation or warranty of Buyer or Buyer Parent set 
forth in this Agreement shall have become untrue or if a failure to perform 
any covenant or agreement on the part of Buyer or Buyer Parent set forth in 
this Agreement shall have occurred, in each case, such that if the breach or 
untruth was occurring on the Closing Date any of the conditions set forth in
Section 7.1
or
Section 7.3
(as applicable) would not be satisfied, and such condition is incapable of 
being satisfied by the Termination Date; provided that Cyclerion may not 
terminate this Agreement under this
Section 8.1(a)(iv)
unless (i) such breach has not been cured by the date which is twenty (20) 
days after Cyclerion notifies Buyer or Buyer Parent, as applicable, of such 
breach in writing and (ii) Cyclerion is not then in breach of this Agreement 
so as to cause any of the conditions set forth in
Section 7.1
or
Section 7.2
not to be satisfied;

                                       49                                       
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(v)

by either Party if the Stockholders' Meeting (including any adjournment or 
postponement thereof in accordance with the terms of this Agreement) has 
concluded, the Cyclerion stockholders have voted, and the Stockholder Approval 
was not obtained;

(vi)

by either Party, if any Governmental Entity has issued any Law enjoining or 
otherwise prohibiting the transactions contemplated by this Agreement and such 
Law will have become final and nonappealable, except that the right to 
terminate this Agreement and abandon the transactions contemplated by this 
Agreement under this paragraph will not be available to any Party whose 
failure to fulfill or comply with any obligation or covenant under this 
Agreement has been the cause of, or resulted in, the issuance of such 
nonappealable Law;

(vii)

by Cyclerion if, after the sixth Business Day following the public 
announcement of the execution of this Agreement, the $5,000,000 aggregate 
purchase price payable pursuant to the Stock Purchase Agreement, dated as of 
March 31, 2023 between Cyclerion and Mr. Peter M. Hecht has not been paid;

(viii)

by Cyclerion if: (A) the conditions precedent set forth in
Section 7.1
and
Section 7.2
have been satisfied (other than those conditions that by their terms require 
the delivery of any documents or the taking of other action at the Closing, 
provided such conditions precedent would reasonably be expected to be 
satisfied at the Closing) on the date the Closing should have been consummated 
by Buyer and Buyer Parent pursuant to
Section 2.7
, (B) Cyclerion notified Buyer in writing that:
(1)
all such conditions precedent set forth in
Section 7.1
and
Section 7.2
have been satisfied or waived, and (2) Cyclerion stands ready, willing and 
able to consummate the Closing, and (C) Buyer or Buyer Parent fails to 
consummate the Closing within two (2) Business Days after the delivery of the 
notification referred to in clause (B) herein; or

(ix)

by Buyer if a Cyclerion Adverse Recommendation Change shall have been made,
provided
that Buyer may only terminate this Agreement pursuant to this
Section 8.1(a)(ix)
if it delivers notice to Cyclerion pursuant to
Section 8.1(b)
within ten (10) Business Days of such Cyclerion Adverse Recommendation Change.

(b)

If Buyer or Cyclerion terminates this Agreement pursuant to the foregoing 
provisions of this
Section 8.1
, such termination shall be effected by written notice to the other Party 
specifying the provision pursuant to which such termination is made.

                                       50                                       
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Section 8.2.

Effect of Termination
.  If this Agreement is validly terminated as permitted by
Section 8.1
, all rights and obligations of the Parties hereto under this Agreement shall 
terminate, there shall be no Liability of any Party hereto (or any of its 
Representatives or Affiliates) in connection with this Agreement or the 
transactions contemplated hereby, whether arising from or relating to any 
breaches by such party of this Agreement or otherwise;
provided
,
however
, that: (a) nothing herein is intended or shall be construed to limit the 
liability of the either Party for actual fraud or willful breach of any 
provision of this Agreement; and (b) the rights and obligations of the parties 
under
Article I
,
Section 6.5(b)
(solely with respect to the obligation of Buyers to reimburse accrued but 
unpaid Employee Expenses to Cyclerion in the event such expenses are not 
otherwise repayable to Buyer in connection with a termination of this 
Agreement),
Section 6.7(b)
(solely with respect to the obligation of Buyers to reimburse accrued but 
unpaid R&D Expenses to Cyclerion in the event such expenses are not otherwise 
repayable to Buyer in connection with a termination of this Agreement),
Section 8.2
,
Section 8.3
,
Section 10.4
, and
Article XII
will survive any termination hereof pursuant to
Section 8.1
.

Section 8.3.

Termination Fee
.

(a)

Termination Fee; Expense Reimbursement.

(i)

If this Agreement is validly terminated by Buyer pursuant to
Section 8.1(a)(ix)
(for the avoidance of doubt, within ten (10) Business Days of such Cyclerion 
Adverse Recommendation Change), then Cyclerion shall (A) pay to Buyer $500,000 
in cash (the "
Termination Fee
") and (B) reimburse Buyer for
(1)
Buyers' expenses in connection with this Agreement and the transactions 
contemplated hereby (excluding the Employee Expenses and R&D Expenses) in an 
amount equal to $1,000,000,
(2)
the Employee Expenses actually reimbursed or paid by Buyer or Buyer Parent, 
and (3) the R&D Expenses actually reimbursed or paid by Buyer or Buyer Parent 
(collectively, the expenses in items
(1)
,
(2)
and (3), the "
Buyer Expense Reimbursement
"), in each case, in immediately available funds within three (3) Business 
Days after such termination.  If this Agreement is validly terminated by Buyer 
pursuant to
Section 8.1(a)(iii)
, or by Cyclerion or Buyer pursuant to
Section 8.1(a)(ii)
at a time when Buyer had a right to terminate pursuant to
Section 8.1(a)(iii)
(without giving effect to any notice requirement, cure period or waiting 
period set forth therein), then Cyclerion shall pay to Buyer the Buyer Expense 
Reimbursement in immediately available funds within five (5) Business Days 
after such termination.  If this Agreement is validly terminated by either 
Party pursuant to
Section 8.1(a)(v)
, Cyclerion shall reimburse Buyer for 50% of the Employee Expenses and R&D 
Expenses actually paid or reimbursed to Cyclerion by Buyer or Buyer Parent, in 
immediately available funds within five (5) Business Days after such 
termination.  Any payment of the Termination Fee or Buyer Expense 
Reimbursement shall be deemed to be liquidated damages and not a penalty, and 
in no event shall Cyclerion be required to pay the Termination Fee or Buyer 
Expense Reimbursement on more than one occasion.

(ii)

If (A) prior to the date of the Stockholders' Meeting, an Acquisition Proposal 
shall have been publicly made or otherwise publicly communicated to Cyclerion 
and not publicly withdrawn, (B) this Agreement is validly terminated by Buyer 
pursuant to
Section 8.1(a)(iii)
or by either Party pursuant to
Section 8.1(a)(ii)
or
Section 8.1(a)(v)
, and (C) within twelve (12) months of such termination, Cyclerion enters into 
a definitive agreement with respect to, or consummates the transactions 
contemplated by such Acquisition Proposal;
provided
, that references to "twenty-five percent (25%)" in the definition of 
Acquisition Proposal shall be deemed to be references to "fifty percent 
(50%)", then, (x) in respect of termination pursuant to
Section 8.1(a)(iii)
and
Section 8.1(a)(v)
, Cyclerion shall pay to Buyer the Termination Fee within three (3) Business 
Days after the consummation of the transactions contemplated by such 
Acquisition Proposal and (y) in respect of termination pursuant to
Section 8.1(a)(ii)
, Cyclerion shall pay to Buyer the Termination Fee and the Buyer Expense 
Reimbursement within three (3) Business Days after the consummation of the 
transactions contemplated by such Acquisition Proposal.

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(iii)

Notwithstanding anything to the contrary herein or in any other Transaction 
Agreement, (i) in the event that a Termination Fee or Buyer Expense 
Reimbursement is payable under
Section 8.3(a)
, Buyer's receipt of such Termination Fee in full and/or, the aggregate amount 
of the Buyer Expense Reimbursement actually due to Buyer, as applicable, shall 
be the sole and exclusive remedy of the Buyer Group and their respective 
Affiliates and Representatives (collectively, the "
Buyer Parties
") against Cyclerion, its Subsidiary and their respective Affiliates and 
Representatives (collectively, the "
Cyclerion Parties
") for any damages suffered as a result of the failure of the Closing to be 
consummated or for a breach or failure to perform hereunder, and no Cyclerion 
Party shall have any further Liability (including with respect to any other 
Termination Fee or Buyer Expense Reimbursement) to any Person relating to or 
arising out of this Agreement or the transactions contemplated hereby, and the 
Buyer Parties shall be deemed to have waived all other remedies (including 
equitable remedies) with respect to any and all damages or Liabilities 
suffered or incurred in connection with this Agreement or the transactions 
contemplated hereby and (ii) the maximum aggregate Liability of the Cyclerion 
Parties, taken as a whole, under or in connection with this Agreement and the 
transactions contemplated hereby shall be limited to an amount equal to the 
amount of such Termination Fee plus the aggregate potential amount of the 
Buyer Expense Reimbursement, and in no event shall any of the Buyer Parties 
seek to recover, or be entitled to recover, any damages, Liabilities or other 
losses of any kind, character or description in excess of such amount 
(including to any other Termination Fee or Buyer Expense Reimbursement); 
provided that the foregoing shall not limit the ability of Buyer to recover 
reimbursement costs and expenses or indemnification pursuant to
Article IX
, and any such reimbursement, indemnification or interest shall not reduce the 
amount of such Termination Fee; and
provided
,
further
, that nothing in this
Section 8.3(a)(iii)
shall restrict Buyer's entitlement to seek and obtain specific performance as 
and to the extent permitted by
Section 12.17
.

(iv)

Cyclerion acknowledges that the agreements contained in this
Section 8.3(a)
are an integral part of the transactions contemplated by this Agreement and 
that, without these agreements, Buyer would not enter into this Agreement. 
Accordingly, if Cyclerion fails promptly to pay the Termination Fee or Buyer 
Expense Reimbursement when due pursuant to this
Section 8.3(a)
, it shall pay any reasonable and documented out-of-pocket costs and expenses 
incurred by Buyer in connection with enforcing this Agreement to obtain 
payment of such unpaid fee (including by legal action), together with interest 
on the amount of such unpaid fee at a rate per annum equal to 2% from the date 
such fee was required to be paid to (but excluding) the payment date.

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(b)

Reverse Termination Fee.

(i)

If this Agreement is validly terminated (i) by Cyclerion pursuant to
Section 8.1(a)(iv)
or
Section 8.1(a)(viii)
or (ii) by Cyclerion or the Buyer pursuant to
Section 8.1(a)(ii)
at a time when Cyclerion had a right to terminate pursuant to
Section 8.1(a)(iv)
or
Section 8.1(a)(viii)
(without giving effect to any notice requirement, cure period or waiting 
period set forth therein) then Buyers shall pay to Cyclerion an amount in cash 
equal to $1,000,000 in immediately available funds (the "Reverse Termination 
Fee") within three (3) Business Days after such termination.  Any payment of 
the Reverse Termination Fee shall be deemed to be liquidated damages and not a 
penalty, and in no event shall Buyers be required to pay the Reverse 
Termination Fee on more than one occasion.

(ii)

Notwithstanding anything to the contrary herein or in any other Transaction 
Agreement, (i) in the event that the Reverse Termination Fee is payable under

Section 8.3(a)
, Cyclerion's receipt of the Reverse Termination Fee in full shall be the sole 
and exclusive remedy of the Cyclerion Parties against the Buyer Parties for 
any damages suffered as a result of the failure of the Closing to be 
consummated or for a breach or failure to perform hereunder, and no Buyer 
Parties shall have any further Liability to any Person relating to or arising 
out of this Agreement or the transactions contemplated hereby, and the 
Cyclerion Parties shall be deemed to have waived all other remedies (including 
equitable remedies) with respect to any and all damages or Liabilities 
suffered or incurred in connection with this Agreement or the transactions 
contemplated hereby and (ii) the maximum aggregate Liability of the Buyer 
Parties, taken as a whole, under or in connection with this Agreement and the 
transactions contemplated hereby shall be limited to an amount equal to the 
amount of the Reverse Termination Fee, and in no event shall any of the 
Cyclerion Parties seek to recover, or be entitled to recover, any damages or 
other losses of any kind, character or description in excess of such amount; 
provided that the foregoing shall not limit the ability of Cyclerion to 
recover reimbursement for costs and expenses or indemnification under
Section 8.3(b)(iii)
and
Article IX
, and any such reimbursement, indemnification or interest shall not reduce the 
amount of the Termination Fee; and
provided
,
further
, that nothing in this
Section 8.3(b)(ii)
shall restrict Cyclerion's entitlement to seek and obtain specific performance 
as and to the extent permitted by
Section 12.17
.

(iii)

Each of Buyer and Buyer Parent acknowledges that the agreements contained in 
this
Section 8.3(b)(iii)
are an integral part of the transactions contemplated by this Agreement and 
that, without these agreements, Cyclerion would not enter into this Agreement. 
Accordingly, if Buyers fail promptly to pay the Reverse Termination Fee when 
due pursuant to this
Section 8.3(b)
, they shall also pay any reasonable and documented out-of-pocket costs and 
expenses incurred by Cyclerion in connection with enforcing this Agreement to 
obtain payment of such unpaid fee (including by legal action), together with 
interest on the amount of such unpaid fee at a rate per annum equal to 2% from 
the date such fee was required to be paid to (but excluding) the payment dates.


                                       53                                       
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                                   ARTICLE IX                                   

                                INDEMNIFICATION                                 

Section 9.1.

Indemnification by Cyclerion
.  Except as otherwise specifically set forth in any provision of this 
Agreement or of any Ancillary Agreement, following the Closing, Cyclerion 
shall indemnify, hold harmless and defend the Buyer Indemnitees from and 
against any and all Indemnifiable Losses of the Buyer Indemnitees to the 
extent relating to, arising out of, by reason of or otherwise in connection 
with: (i) the Excluded Liabilities, including the failure of Cyclerion or any 
other Person to pay, perform or otherwise discharge any Excluded Liability in 
accordance with its respective terms, whether arising prior to, on or after 
the Closing, (ii) Cyclerion's breach of the covenants and agreements 
applicable to it and contained in this Agreement or any Ancillary Agreement 
which require performance following the consummation of the Closing, or (iii) 
the terms of
Section 2.5(e)(ii)
(a "
Buyer Claim
").

Section 9.2.

Indemnification by Buyers
.  Except as otherwise specifically set forth in any provision of this 
Agreement, including as set forth in
Section 2.5(e)
of this Agreement, or of any Ancillary Agreement, following the Closing, Buyer 
and Buyer Parent shall jointly indemnify, and shall cause the other members of 
the Buyer Group to indemnify, hold harmless and defend the Cyclerion 
Indemnitees from and against any and all Indemnifiable Losses of the Cyclerion 
Indemnitees to the extent relating to, arising out of, by reason of or 
otherwise in connection with: (i) the Assumed Liabilities, including the 
failure of any member of the Buyer Group or any other Person to pay, perform 
or otherwise discharge any Buyer Claim in accordance with its respective 
terms, whether prior to, on or after the Closing, (ii) Buyer's or Buyer 
Parent's breach of the covenants and agreements applicable to it and contained 
in this Agreement or any Ancillary Agreement which require performance 
following the consummation of the Closing or (iii) the terms of
Section 2.5(e)(ii)
, or (iv) the matter set forth in
Section 9.2
of the Disclosure Schedules solely in respect of Third Party Claims (a "
Cyclerion Claim
").

Section 9.3.

Procedures for Indemnification
.

(a)

Direct Claims
.  Other than with respect to Third Party Claims, which shall be governed by
Section 9.3(b)
:

(i)

if a Buyer Indemnitee has made a determination that it is or may be entitled 
to indemnification in respect of any Buyer Claim, the Buyer Indemnitee shall 
so notify Cyclerion as promptly as reasonably possible after becoming aware of 
the existence of such Buyer Claim; and

(ii)

if a Cyclerion Indemnitee has made a determination that it is or may be 
entitled to indemnification in respect of any Cyclerion Claim, the Cyclerion 
Indemnitee shall so notify Buyer as promptly as reasonably possible after 
becoming aware of the existence of such Cyclerion Claim (any such claim made 
pursuant to
Section 9.3(a)(i)
or this
Section 9.3(a)(ii)
, a "
Direct Claim
").

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Each such notice shall be in writing and shall describe in reasonable detail 
the basis for the claim for indemnification hereunder and set forth, to the 
extent known, the estimated amount of Indemnifiable Losses for which 
indemnification may be sought hereunder relating to such claim (including, to 
the extent practicable, the method of computation thereof);
provided
,
however
, that the failure to provide such written notice shall not release the 
Indemnifying Party from any of its obligations except and solely to the extent 
the Indemnifying Party shall have been actually materially prejudiced as a 
result of such failure.  The Indemnifying Party will have a period of 
forty-five (45) days after receipt of any such notice under this
Section 9.3(a)
to respond to the claimant thereto.  If the Indemnifying Party fails to 
respond within such period, the claim specified in such notice from the 
Indemnitee shall be conclusively determined to be an indemnifiable claim for 
which the Indemnifying Party shall be liable to the applicable Indemnitee(s) 
hereunder.

(b)

Third Party Claims
.  If a claim or demand is made against an Indemnitee by any Third Party (a "
Third Party Claim
") as to which such Indemnitee is or may be entitled to indemnification 
pursuant to this Agreement, Cyclerion (on behalf of the Cyclerion Indemnitees) 
or Buyer (on behalf of the Buyer Indemnitees), as applicable (such claimant, 
the "
Claiming Party
"), shall notify the Indemnifying Party of the Third Party Claim in writing 
and in reasonable detail describing the basis for any claim for indemnification 
hereunder, referring to the provisions of this Agreement or any Ancillary 
Agreement in respect of which such right of indemnification is claimed by such 
Indemnitee or arises and including copies of all Third Party written notices 
and documents received by the Claiming Party (and any or all of its 
Indemnitees) relating to the Third Party Claim promptly (and in any event 
within twenty (20) days) after receipt by such Indemnitee of written notice of 
the Third Party Claim;
provided
,
however
, that the failure to provide notice of any such Third Party Claim pursuant to 
this sentence shall not release the Indemnifying Party from any of its 
obligations except and solely to the extent the Indemnifying Party shall have 
been actually materially prejudiced as a result of such failure.  Thereafter, 
the Claiming Party shall deliver to the Indemnifying Party, promptly (and in 
any event within five (5) Business Days) after the receipt thereof by the 
Claiming Party (or any of its Indemnitees), copies of any and all additional 
Third Party written notices and documents (including court papers) received by 
the Claiming Party (or any of its Indemnitees) relating to the Third Party 
Claim.

(c)

Subject to the provisions of this
Section 9.3(c)
, the Indemnifying Party has the right, exercisable by written notice to the 
Claiming Party within thirty (30) days after receipt of notice from the 
Claiming Party pursuant to
Section 9.3(b)
, to assume and conduct the defense (including, subject to the conditions of 
this
Section 9.3(c)
, settlement) of such Third Party Claim in accordance with the limits set 
forth in this Agreement with counsel selected by the Indemnifying Party and 
reasonably acceptable to the applicable Indemnitees.  If the Indemnifying 
Party does not assume the defense of a Third Party Claim in accordance with 
this
Section 9.3(c)
, the Indemnitee may defend the Third Party Claim.  If the Indemnifying Party 
has assumed the defense of a Third Party Claim as provided in this
Section 9.3(c)
, the Indemnifying Party shall not be liable for any legal expenses 
subsequently incurred by the Indemnitee in connection with the defense of the 
Third Party Claim;
provided
,
however
, that if (w) in the reasonable judgment of the Indemnitee, after consultation 
with outside counsel, there exists a conflict of interest between the 
Indemnifying Party and the applicable Indemnitee(s) in the defense of such 
Third Party Claim by the Indemnifying Party, (x) the party making such Third 
Party Claim is a Governmental Entity with regulatory or other authority over 
the Indemnitee or any of its material assets, (y) the Third Party Claim seeks 
injunctive or other nonmonetary relief that, if granted, would reasonably be 
expected to have a material and adverse effect on the Indemnitee's business or 
(z) the Indemnifying Party fails to take reasonable steps necessary to defend 
diligently such Third Party Claim, the Indemnitee may assume its own defense, 
and the Indemnifying Party shall be liable for all reasonable costs or 
expenses paid or incurred in connection with such defense.  The Indemnifying 
Party or the Indemnitee, as the case may be, has the right to participate in 
(but, subject to the prior sentence, not control), at its own expense, the 
defense of any Third Party Claim that the other Person is defending as 
provided in this Agreement.  The Indemnifying Party, if it has assumed the 
defense of any Third Party Claim as provided in this Agreement, may not, 
without the prior written consent of the Indemnitee (not to be unreasonably 
withheld, conditioned or delayed), consent to a settlement or compromise of, 
or the entry of any judgment arising from, any such Third Party Claim.  The 
Indemnitee may consent to a settlement or compromise of, or the entry of any 
judgment arising from, any Third Party Claim, the defense of which has not 
been assumed by the Indemnifying Party, only with the prior written consent of 
the Indemnifying Party, not to be unreasonably withheld, conditioned or 
delayed.

                                       55                                       
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(d)

The Claiming Party and the Indemnifying Party shall (and the Claiming Party 
shall cause the applicable Indemnitee(s) to) make reasonably available to each 
other and their respective agents and representatives all relevant records 
available to them that are necessary or appropriate for the defense of any 
Third Party Claim, subject to any
bona fide
claims of attorney-client privilege, and each of the Indemnifying Party and 
the Claiming Party shall use its reasonable efforts to assist, and to cause 
the employees and counsel of such party to assist, in the defense of such 
Third Party Claim.  If a Party asserts its right to participate in the defense 
and investigation of any Third Party Claim, the Party controlling the defense 
and investigation of such Third Party Claim shall act in good faith and 
reasonably consult and cooperate with the Indemnitee or the Indemnifying 
Party, as the case may be, in connection with any appearances, briefs, 
arguments and proposals made or submitted by or on behalf of any party in 
connection with the Third Party Claim (including considering in good faith all 
reasonable additions, deletions or changes suggested by the Indemnitee or the 
Indemnifying Party, as the case may be, in connection any filings made with 
any Governmental Entity or proposals to the Third Party claimant in connection 
therewith).  With respect to any Third Party Claim that implicates both 
Parties in any material respect due to the allocation of Liabilities, 
responsibilities for management of defense and related indemnities pursuant to 
this Agreement or any of the Ancillary Agreements, the Parties agree to use 
commercially reasonable efforts to cooperate fully and maintain a joint 
defense (in a manner that, to the extent reasonably practicable, will preserve 
for all Parties any privilege with respect thereto).  The Party that is not 
responsible for managing the defense of any such Third Party Claim shall, upon 
reasonable request, be consulted with respect to significant matters relating 
thereto and may, if necessary or helpful, retain counsel to assist in the 
defense of such claims.  Notwithstanding the foregoing, nothing in this
Section 9.3(d)
shall derogate from a Party's right to control the defense of any Action in 
accordance with
Section 9.3
.

(e)

Each of the Parties agrees that at all times from and after the Closing, if an 
Action is commenced by a Third Party naming two
(2)
or more Parties (or any member of such Parties' respective Groups) as 
defendants and with respect to which one or more named Parties (or any member 
of such Party's Group) is a nominal defendant and/or such Action is related 
solely to an Asset or Liability that the other Party has been assigned under 
this Agreement, any Ancillary Agreement or any Assumed Contract, then the 
other Party or Parties shall use commercially reasonable efforts to cause such 
nominal defendant to be removed from such Action, as soon as reasonably 
practicable.

                                       56                                       
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Section 9.4.

Indemnification Obligations Net of Insurance Proceeds and Other Amounts
.

(a)

Any recovery by any Party (including any of its Indemnitees) for any 
Indemnifiable Loss subject to indemnification pursuant to this
Article IX
shall be calculated (i) net of Insurance Proceeds actually received by such 
Party (or any of its Indemnitees) with respect to any Indemnifiable Loss, and 
(ii) net of any proceeds actually received by such Party (or any of its 
Indemnitees) from any Third Party with respect to any such Liability 
corresponding to the Indemnifiable Loss ("
Third Party Proceeds
"), in the case of (i) and (ii) net of the costs of collection thereof and any 
increase in premium attributable thereto under applicable Third Party 
policies.  Accordingly, the amount which any Indemnifying Party is required to 
pay pursuant to this
Article IX
to any Indemnitee pursuant to this
Article IX
shall be reduced by any Insurance Proceeds or Third Party Proceeds theretofore 
actually recovered by or on behalf of the Indemnitee corresponding to the 
related Indemnifiable Loss.  If an Indemnitee receives a payment required by 
this Agreement from an Indemnifying Party corresponding to any Indemnifiable 
Loss (an "
Indemnity Payment
") and subsequently receives Insurance Proceeds or Third Party Proceeds, then 
the Indemnitee shall pay to the Indemnifying Party an amount equal to the 
excess of the Indemnity Payment received over the amount of the Indemnity 
Payment that would have been due if the Insurance Proceeds, or Third Party 
Proceeds had been received, realized or recovered before the Indemnity Payment 
was made.

(b)

Insurers and Other Third Parties Not Relieved
.  The Parties hereby agree that an insurer or other Third Party that would 
otherwise be obligated to pay any amount shall not be relieved of the 
responsibility with respect thereto or have any subrogation rights with 
respect thereto by virtue of any provision contained in this Agreement or any 
Ancillary Agreement, and that no insurer or any other Third Party shall be 
entitled to a "windfall" (e.g., a benefit they would not otherwise be entitled 
to receive, or the reduction or elimination of an insurance coverage 
obligation that they would otherwise have, in the absence of the indemnification
 or release provisions) by virtue of any provision contained in this Agreement 
or any Ancillary Agreement.  Each Party shall, and shall cause its 
Subsidiaries to, use commercially reasonable efforts to collect or recover, or 
allow the Indemnifying Party to collect or recover, or cooperate with each 
other in collecting or recovering, any Insurance Proceeds that may be 
collectible or recoverable respecting the Liabilities for which indemnification 
may be available under this
Article IX
.  Notwithstanding the foregoing, an Indemnifying Party may not delay making 
any indemnification payment required under the terms of this Agreement, or 
otherwise satisfying any indemnification obligation, pending the outcome of 
any Actions to collect or recover Insurance Proceeds, and an Indemnitee need 
not attempt to collect any Insurance Proceeds prior to making a claim for 
indemnification or receiving any Indemnity Payment otherwise owed to it under 
this Agreement or any Ancillary Agreement.

                                       57                                       
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Section 9.5.

Contribution
.  If the indemnification provided for in this
Article IX
is unavailable for any reason to an Indemnitee (other than failure to provide 
notice with respect to any Third Party Claims in accordance with
Section 9.3(b)
) in respect of any Indemnifiable Loss, then the Indemnifying Party shall, in 
accordance with this
Section 9.5
, contribute to the Indemnifiable Losses incurred, paid or payable by such 
Indemnitee as a result of such Indemnifiable Loss in such proportion as is 
appropriate to reflect the relative fault of Buyer, Buyer Parent and each 
other member of the Buyer Group, on the one hand, and Cyclerion, on the other 
hand, in connection with the circumstances which resulted in such 
Indemnifiable Loss.

Section 9.6.

Additional Matters; Survival of Indemnities
.

(a)

The agreements contained in this
Article IX
shall survive the Closing.

(b)

The rights and obligations of each Party and their respective Indemnitees 
under this
Article IX
shall survive (i) the sale or other transfer by any Party or its respective 
Subsidiaries of any Assets or businesses or the assignment by it of any 
Liabilities and (ii) any merger, consolidation, business combination, sale of 
all or substantially all of the Assets, restructuring, recapitalization, 
reorganization or similar transaction involving either Party or any of its 
Subsidiaries.

(c)

The provisions of this
Article IX
shall be the sole and exclusive remedy of an Indemnitee for any monetary or 
compensatory damages or losses resulting from any breach of this Agreement or 
any Ancillary Agreement (other than the Stockholders Agreements, the Buyer 
Parent Purchase Agreement, the Voting Agreements and the Transition Services 
Agreement) and each Indemnitee expressly waives and relinquishes any and all 
rights, claims or remedies such Person may have with respect to the foregoing 
other than under this
Article IX
against any Indemnifying Party.

(d)

Notwithstanding the foregoing, to the extent the Stockholders Agreements, 
Voting Agreements or the Transition Services Agreement provide procedures for 
indemnification or contribution that differ from the provisions set forth in 
this
Article IX
, the terms of the Stockholders Agreements, the Buyer Parent Purchase 
Agreement. Voting Agreements or the Transition Services Agreement, as 
applicable, will govern.

(e)

Any amounts payable pursuant to this
Article IX
shall be paid without duplication, and in no event shall any Party receive any 
payment in respect of an Indemnifiable Loss or receive contribution under 
different provisions of any Ancillary Agreement in respect of the same 
Liabilities.

(f)

Any amount to be paid or reimbursed by an Indemnifying Party (or a member of 
such Party's Group) to an Indemnitee pursuant to this
Article IX
shall be paid in accordance with the procedures set forth in
Section 12.9
.

(g)

All indemnification payments made under this Agreement shall be treated by the 
parties as an adjustment to the Purchase Price for Tax purposes, unless 
otherwise required by Law.

Section 9.7.

Nonsurvival of Representations and Warranties and Pre-Closing Covenants
.  The Parties hereby agree that: (a) the respective representations and 
warranties of Cyclerion and Buyers and (b) the covenants and agreements which 
require performance prior to the consummation of the Closing, in each case 
contained in this Agreement or in any instrument or other document delivered 
pursuant to this Agreement shall expire with, and be terminated and 
extinguished upon, the consummation of the Closing.

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                                   ARTICLE X                                    

                     ACCESS TO INFORMATION; CONFIDENTIALITY                     

Section 10.1.

Provision of Information
.  Other than in circumstances in which indemnification is sought pursuant to
Article IX
(in which event the provisions of such
Article IX
shall govern) and subject to appropriate restrictions for Confidential 
Information:

(a)

Cyclerion Provision of Information and Systems Access
.  During the Transition Period, and subject to compliance with the terms of 
this Agreement or the Ancillary Agreements, upon the prior written reasonable 
request by, and at the expense of, Buyers for the following specific and 
identified items, Cyclerion shall provide, as soon as reasonably practicable 
following the receipt of such request, reasonable access to: (i) information 
that relates to Buyer or the Purchased Assets, as the case may be; (ii) 
information that is necessary or reasonably useful for Buyer to comply with 
the terms of, or otherwise perform under, this Agreement or any Ancillary 
Agreement to which Cyclerion and/or Buyers are parties; (iii) copies of 
Cyclerion templates and form documents used in the operation of the Purchased 
Programs; (iv) information that is otherwise required by Buyer or reasonably 
useful with regard to reasonable compliance with reporting, disclosure, filing 
or other requirements imposed on Buyer (including under applicable securities 
laws) by a Governmental Entity having jurisdiction over Buyer; or (v) 
information that is otherwise for use in any other judicial, regulatory, 
administrative or other proceeding or in order to satisfy audit, accounting, 
claims, regulatory, Action or other similar requirements, as applicable, in 
each case to the extent such information is reasonably practicable to identify 
and extract, copies of such information, templates or forms in the possession 
or control of Cyclerion or its Subsidiary, but only to the extent such items 
so relate and are not already in the possession or control of Buyer Parent or 
any of its Subsidiaries, but only to the extent such items so relate and are 
not already in the possession or control of Cyclerion.  Nothing herein shall 
require Cyclerion or its Subsidiary to: (A) permit any inspection, or to 
disclose any information, that in the reasonable judgment of Cyclerion or the 
applicable Affiliate would violate any of its obligations with respect to 
confidentiality (but solely to the extent the applicable Party did not have 
access to such information prior to the consummation of the Closing), (B) 
permit any environmental sampling or testing, including, but not limited to 
sampling of soil, groundwater, surface water, air or building materials or 
other intrusive investigations of the real property, including, for the 
avoidance of doubt, any "Phase II" or other testing, (C) take any action that 
would cause material disruption to the business of such Party or any of its 
Affiliates or cause competitive harm to such Party or its Affiliates, (D) 
disclose any information, templates or forms that Cyclerion in its sole and 
absolute discretion, determines would violate any Law or Contract between 
Cyclerion and a Third Party (as such Contract may be amended or modified from 
time to time) or waive any attorney-client privilege, rights under the work 
product doctrine or other applicable privilege contravene any applicable Law, 
fiduciary duty or binding agreement or (E) disclose any information that 
Cyclerion reasonably determines upon the advice of counsel should not be 
disclosed due to its competitively sensitive nature (but solely to the extent 
such Party did not have access to such information prior to the consummation 
of the Closing),
provided
, that in the event that the foregoing restrictions apply, Cyclerion shall 
notify Buyer of any such restrictions and the request to which they apply and 
thereafter, Cyclerion shall use commercially reasonable efforts to provide or 
cause to be provided to Buyer such access or information in a manner that 
would not be reasonably likely, in the reasonable determination of Cyclerion's 
counsel, to result in any such disruption, harm, violation or waiver.  
Notwithstanding anything to the contrary contained herein, the access provided 
under this
Section 10.1(a)
may be limited to the extent Cyclerion reasonably determines, in light of the 
coronavirus (COVID-19) pandemic or any mutation or variation of the SARS-CoV-2 
virus (taking into account any "shelter-in-place" or similar order issued by a 
Governmental Entity), that such access would jeopardize the health and safety 
of its or its Subsidiary's and their respective Affiliates' employees;
provided
,
however
, that Cyclerion, its Subsidiary and their respective Affiliates shall use 
their best reasonable efforts to allow for such access or as much of such 
access as is possible in a manner that does not jeopardize the health and 
safety of such employees.

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(b)

Buyer Provision of Information
.  From and after the Closing, and subject to compliance with the terms of 
this Agreement or the Ancillary Agreements, upon the prior written reasonable 
request by, and at the expense of, Cyclerion for the following specific and 
identified items, Buyers shall provide, as soon as reasonably practicable 
following the receipt of such request, reasonable access to: (i) information 
that relates to Cyclerion or the Excluded Assets, as the case may be; (ii) 
information that is necessary or reasonably useful for Cyclerion to comply 
with the terms of, or otherwise perform under, this Agreement or any Ancillary 
Agreement to which Cyclerion and/or Buyers are parties; (iii) information that 
is otherwise required by Cyclerion or reasonably useful with regard to 
reasonable compliance with reporting, disclosure, filing or other requirements 
imposed on Cyclerion (including under applicable securities laws) by a 
Governmental Entity having jurisdiction over Cyclerion; or (iv) information 
that is otherwise for use in any other judicial, regulatory, administrative or 
other proceeding or in order to satisfy audit, accounting, claims, regulatory, 
Action or other similar requirements, as applicable, in each case to the 
extent such information is reasonably practicable to identify and extract, 
copies of such information in the possession or control of Buyer Parent or any 
of its Subsidiaries.  Nothing herein shall require Buyer or any of its 
Subsidiaries to: (A) permit any inspection, or to disclose any information, 
that in the reasonable judgment of such Buyer Group company or the applicable 
Affiliate would violate any of its obligations with respect to confidentiality 
(but solely to the extent the applicable Party did not have access to such 
information prior to the consummation of the Closing), (B) permit any 
environmental sampling or testing, including, but not limited to sampling of 
soil, groundwater, surface water, air or building materials or other intrusive 
investigations of the real property, including, for the avoidance of doubt, 
any "Phase II" or other testing, (C) take any action that would cause material 
disruption to the business of such Party or any of its Affiliates or cause 
competitive harm to such Party or its Affiliates, (D) disclose any 
information, templates or forms that Buyer in its sole and absolute 
discretion, determines would violate any Law or Contract with a Third Party 
(as such Contract may be amended or modified from time to time) or waive any 
attorney-client privilege, rights under the work product doctrine or other 
applicable privilege contravene any applicable Law, fiduciary duty or binding 
agreement or (E) disclose any information that Buyer reasonably determines 
upon the advice of counsel should not be disclosed due to its competitively 
sensitive nature (but solely to the extent such Party did not have access to 
such information prior to the consummation of Closing,
provided
, that in the event that the foregoing restrictions apply, Buyer shall notify 
Cyclerion of any such restrictions and the request to which they apply and 
thereafter, Buyers shall use commercially reasonable efforts to provide or 
cause to be provided to Cyclerion such access or information in a manner that 
would not be reasonably likely, in the reasonable determination of Buyer's 
counsel, to result in any such disruption, harm, violation or waiver.  
Notwithstanding anything to the contrary contained herein, the access provided 
under this
Section 10.1(b)
may be limited to the extent Buyer reasonably determines, in light of the 
coronavirus (COVID-19) pandemic or any mutation or variation of the SARS-CoV-2 
virus (taking into account any "shelter-in-place" or similar order issued by a 
Governmental Entity), that such access would jeopardize the health and safety 
of its or any Buyer Group companies' and their respective Affiliates' 
employees;
provided
,
however
, that Buyer, such Buyer Group company and their respective Affiliates shall 
use their best reasonable efforts to allow for such access or as much of such 
access as is possible in a manner that does not jeopardize the health and 
safety of such employees.

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(c)

In connection with the provision of information under this
Section 10.1
, the providing Party shall be entitled to redact any portion of the 
information to the extent related to any matter other than those set forth in

Section 10.1(a)
and
(b)
, respectively.  Each of Cyclerion and Buyers agree to make their respective 
personnel available during regular business hours to discuss the information 
exchanged pursuant to this
Section 10.1
.

Section 10.2.

Witness Services; Cooperation
.  At all times from and after the Closing, each of Cyclerion, Buyer Parent 
and Buyer shall use its commercially reasonable efforts to make available to 
the other Parties, upon reasonable written request, its and its Subsidiaries' 
officers, directors, employees and agents (taking into account the business 
demands of such individuals) as witnesses to the extent that (i) such Persons 
may reasonably be required to testify in connection with the prosecution or 
defense of any Action in which the requesting Party may from time to time be 
involved (except for claims, demands or Actions in which one or more members 
of one Group is adverse to one or more members of the other Group) and (ii) 
there is no conflict in the Action between the requesting Party and the other 
Party.  Notwithstanding any provisions of
Article X
to the contrary, after the Closing, each Party shall use commercially 
reasonable efforts to assist (or cause the other members of its Group to 
assist) the other with respect to any Action or potential Action upon the 
request of such other Party, provided that any such expenses incurred in 
connection therewith shall be at such other Party's sole expense.

Section 10.3.

Reimbursement; Other Matters
.  Except to the extent otherwise contemplated by this Agreement or any 
Ancillary Agreement, a Party providing information, access to information or 
services to the other Party pursuant to this
Article X
shall be entitled to receive from the recipient, upon the presentation of 
invoices therefor, payments for such amounts, relating to supplies, 
disbursements and other out-of-pocket expenses (which shall not include the 
costs of salaries and benefits of employees of such Party or any pro rata 
portion of overhead or other costs of employing such employees which would 
have been incurred by such employees' employer regardless of the employees' 
service with respect to the foregoing), as may be reasonably incurred and 
properly paid under applicable Law in providing such information, access to 
such information or services.

                                       61                                       
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Section 10.4.

Confidentiality
.

(a)

Except as otherwise provided herein, in any Ancillary Agreement, or in any 
Contract (as such Contract may be amended or modified from time to time) 
between a Party or its Subsidiaries, on the one hand, and their respective 
employees, on the other hand, each of Cyclerion, Buyer and Buyer Parent shall 
hold, and shall cause the other members of their respective Groups and their 
respective Representatives to hold, in strict confidence, with at least the 
same degree of care that applies to Cyclerion's Confidential Information 
pursuant to policies and procedures in effect as of the Closing, and not 
disclose or release, or permit to be disclosed or released, all Confidential 
Information of the other Party that is either in the first Party's possession 
(including Confidential Information in its possession prior to the Closing) or 
furnished by the other Party or any member of its Group or their respective 
Representatives at any time pursuant to this Agreement or any Ancillary 
Agreement, and shall not use any such Confidential Information other than for 
such purposes as may be expressly permitted hereunder or under any Ancillary 
Agreement.  If any Confidential Information is disclosed to any member of the 
other Party's Group in connection with providing services to any member of 
such first Party's Group under this Agreement or any Ancillary Agreement, then 
such disclosed Confidential Information shall be used by the applicable member 
of such other Party's Group only as required to provide such services.

(b)

Notwithstanding anything the contrary in this
Section 10.4
, each Party may disclose, or may permit disclosure of, the other Party's 
Confidential Information: (i) to its Representatives who have a need to know 
such information for non-commercial purposes and are informed of the 
obligation to hold such information confidential and in respect of whose 
failure to comply with such obligations, the first Party will be responsible 
or (ii) if any Party or any other member of its Group is required or requested 
to disclose any such Confidential Information by judicial or administrative 
process or by other requirements of Law or stock exchange rule or is advised 
by outside counsel in connection with an Action brought by a Governmental 
Entity that it is advisable to do so.  Notwithstanding the foregoing, in the 
event that any demand or request for disclosure of Confidential Information is 
made by a Third Party pursuant to clause (ii) above, each Party, as 
applicable, shall promptly notify (to the extent permissible by Law) the Party 
to whom the Confidential Information relates of the existence of such 
requirement or request and shall provide such affected Party a reasonable 
opportunity to seek an appropriate protective order or other remedy, which 
such Party will cooperate in obtaining to the extent reasonably practicable.  
In the event that such appropriate protective order or other remedy is not 
obtained, the Party which faces the disclosure requirement shall furnish only 
that portion of the Confidential Information that is required to be disclosed 
and shall take commercially reasonable steps to ensure that confidential 
treatment is accorded such Confidential Information.

(c)

Each of Cyclerion, Buyer and Buyer Parent shall inform their respective 
Representatives who have or had access to the other Party's Confidential 
Information of their obligation to hold such information confidential in 
accordance with the provisions of this Agreement.

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(d)

Without limiting the foregoing, when any Confidential Information is no longer 
needed for the purposes contemplated by this Agreement or any Ancillary 
Agreement, each Party shall, at its option and as promptly as practicable 
after receiving a written request from the other Party, either (i) return to 
such other Party all such information in a tangible form (including all copies 
thereof and all notes, extracts or summaries based thereon) or (ii) certify to 
such other Party that the first Party has destroyed such information (and such 
copies thereof and such notes, extracts or summaries based thereon);
provided
, that such first Party's Representatives may retain one
(1)
copy of such information to the extent required by applicable Law or 
professional standards, and shall not be required to destroy any such 
information located in back-up, archival electronic storage;
provided

further
, that any such information so retained shall remain subject to the 
confidentiality provisions of this Agreement or any Ancillary Agreement.


(e)

Each Party acknowledges that it and its respective Subsidiaries may presently 
have and, following the Closing, may gain access to or possession of 
confidential or proprietary information of, or personal information relating 
to, Third Parties (i) that was received under confidentiality or non-disclosure 
agreements entered into between such Third Parties, on the one hand, and the 
other Party (or another member of its Group), on the other hand, prior to the 
Closing; or (ii) that, as between the two Parties, was originally collected by 
the other Party (or another member of its Group) and that may be subject to 
and protected by privacy, data protection or other applicable Laws.  Each 
Party agrees that it shall hold, protect and use, and shall cause the other 
members of its Group and its and their respective Representatives to hold, 
protect and use, in strict confidence the confidential and proprietary 
information of, or personal information relating to, Third Parties in 
accordance with privacy, data protection or other applicable Laws and the 
terms of any agreements that were either entered into before the Closing or 
affirmative commitments or representations that were made before the Closing 
by, between or among the other Party (or other member(s) of its Group), on the 
one hand, and such Third Parties, on the other hand.

(f)

Upon the consummation of the Closing, that certain Confidentiality Agreement, 
dated as of September 4, 2022, by and between J. Wood Capital Advisors LLC and 
Cyclerion shall be terminated and be of no further force and effect.

Section 10.5.

Ownership of Information
.  Any information owned by one Party or any of its Subsidiaries that is 
provided to a requesting Party pursuant to this
Article X
shall be deemed to remain the property of the providing Party.  Unless 
expressly set forth herein, nothing contained in this Agreement shall be 
construed as granting a license or other rights to any Party with respect to 
any such information, whether by implication, estoppel or otherwise.

                                   ARTICLE XI                                   

                               DISPUTE RESOLUTION                               

Section 11.1.

Governing Law
.  This Agreement and (except to the extent, if any, expressly set forth 
therein) the other Transaction Agreements, and any disputes arising hereunder 
or (except to the extent, if any, expressly set forth therein) thereunder or 
controversies related hereto, or (except to the extent, if any, expressly set 
forth therein) thereto, shall be governed by and construed in accordance with 
the internal laws, and not the laws of conflicts, of the Commonwealth of 
Massachusetts that apply to contracts made and performed entirely within such 
state.

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Section 11.2.

Proceedings
.  Any proceeding with respect to this Agreement or (except to the extent, if 
any, expressly set forth therein) any other Transaction Agreements, any matter 
arising out of or in connection with this Agreement or (except to the extent, 
if any, expressly set forth therein) any other Transaction Agreement shall be 
brought exclusively in the state or federal courts located in the Commonwealth 
of Massachusetts.  By execution and delivery of this Agreement, each Party 
hereby accepts for herself, himself or itself and in respect of such Person's 
property, generally and unconditionally, the sole and exclusive jurisdiction 
of the aforesaid courts and appellate courts thereof.  Each Party irrevocably 
consents to service of process in any proceeding in any of the aforementioned 
courts by the mailing of copies thereof by registered or certified mail, 
postage prepaid, or by recognized overnight delivery service, to such Party at 
such Party's address referred to in
Section 12.5
.  Each Party hereto hereby irrevocably and unconditionally waives any 
objection which such Person may now or hereafter have to the laying of venue 
of any of the aforesaid actions or proceedings arising out of or in connection 
with this Agreement or (except to the extent, if any, expressly set forth 
therein) any other Transaction Agreement brought in the courts referred to 
above and hereby further irrevocably waives and agrees, to the extent 
permitted by applicable Law, not to plead or claim in any such court that any 
such proceeding brought in any such court has been brought in an inconvenient 
forum.  Final judgment in any such proceeding shall be conclusive and may be 
enforced in other jurisdictions by suit on the judgment or in any other manner 
provided by Law.  Nothing herein shall affect the right of any Party hereto to 
serve process in any other manner permitted by Law.

Section 11.3.

Immunity
.  To the extent that any Party has or hereafter may acquire any immunity from 
jurisdiction of any court or from any legal process (whether through service 
or notice, attachment prior to judgment, attachment in aid of execution, 
execution or otherwise) with respect to itself, or to such Person's property, 
each such Party hereto hereby irrevocably waives such immunity in respect of 
such Person's obligations with respect to this Agreement or (except to the 
extent expressly set forth therein) any other Transaction Agreement.

Section 11.4.

Waiver of Jury Trial
.  EACH PARTY HERETO, FOR HIMSELF, HERSELF OR ITSELF AND HIS, HER OR ITS 
AFFILIATES, HEREBY IRREVOCABLY AND UNCONDITIONALLY WAIVES TO THE FULLEST 
EXTENT PERMITTED BY APPLICABLE LAW ALL RIGHT TO TRIAL BY JURY IN ANY 
PROCEEDING (WHETHER BASED ON CONTRACT, TORT OR OTHERWISE) ARISING OUT OF OR 
RELATING TO THE ACTIONS OF THE PARTIES HERETO OR THEIR RESPECTIVE AFFILIATES 
PURSUANT TO THIS AGREEMENT OR (EXCEPT TO THE EXTENT EXPRESSLY SET FORTH 
THEREIN) ANY OTHER TRANSACTION AGREEMENT OR IN THE NEGOTIATION, ADMINISTRATION, 
PERFORMANCE OR ENFORCEMENT.

                                  ARTICLE XII                                   

                                 MISCELLANEOUS                                  

Section 12.1.

Complete Agreement
.  This Agreement, including the Exhibits and Disclosure Schedules, and the 
Ancillary Agreements shall constitute the entire agreement between the Parties 
with respect to the subject matter hereof and shall supersede all previous 
negotiations, commitments, course of dealings and writings with respect to 
such subject matter.  In the event of any inconsistency between this Agreement 
and any Disclosure Schedule hereto, the Disclosure Schedule shall prevail.  
Except as otherwise provided in this Agreement, in the event and to the extent 
that there shall be a conflict between the provisions of this Agreement and 
the provisions of any Ancillary Agreement, this Agreement shall control.

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Section 12.2.

Counterparts
.  This Agreement may be executed in one or more counterparts, all of which 
shall be considered one and the same agreement, and shall become effective 
when one or more such counterparts have been signed by each of the Parties and 
delivered to each of the Parties. The Agreement and any documents relating to 
it may be executed and transmitted to any other party by email of a PDF, which 
email or PDF shall be deemed to be, and utilized in all respects as, an 
original, wet-inked document.

Section 12.3.

Survival of Agreements
.  Except as otherwise contemplated by this Agreement or any Ancillary 
Agreement, all covenants and agreements of the Parties contained in this 
Agreement and each Ancillary Agreement shall survive the Closing and remain in 
full force and effect in accordance with their applicable terms, provided that 
the covenants and agreements which require performance prior to the 
consummation of the Closing shall expire with, and be terminated and 
extinguished upon, the consummation of the Closing.

Section 12.4.

Fees, Costs and Expenses
.  Except as otherwise agreed to in writing by the Parties or as set forth in
Section 12.4
of the Disclosure Schedules, regardless of whether the transactions provided 
for in this Agreement are consummated, each Party will pay its own costs and 
expenses incident to this Agreement and the transactions contemplated herein.


Section 12.5.

Notices
.  All notices, requests, claims, demands and other communications under this 
Agreement and, to the extent applicable and unless otherwise provided therein, 
under each of the Ancillary Agreements shall be in English, shall be in 
writing and shall be given or made (and shall be deemed to have been duly 
given or made upon receipt) by delivery in person, by overnight courier 
service, by email with receipt confirmed or by registered or certified mail 
(postage prepaid, return receipt requested) to the respective Parties at the 
following addresses (or at such other address for a Party as shall be 
specified in a notice given in accordance with this
Section 12.5
):

To Buyer:

JW Celtics Investment Corp.
c/o Ropes & Gray LLP
1211 Avenue of the Americas
New York, NY 10036-8704
Attn:  Suni Sreepada
Phone:  (212) 596-9960
Email: suni.sreepada@ropesgray.com

                                       65                                       
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To Cyclerion:

Cyclerion Therapeutics, Inc.
245 First St, Riverview II, 18
th
Floor
Cambridge, MA 02142
United States
Attn: Anjeza Gjino
Phone: 857-327-8778
Email: agjino@cyclerion.com
Fax: 617-890-6595

With a copy, which shall not constitute notice to:

Hughes Hubbard & Reed LLP
One Battery Park Plaza
New York, NY 10004
Attention: Gary Simon; Scott Naturman
Email: Gary.Simon@hugheshubbard.com; Scott.Naturman@hugheshubbard.com


Each Party may, by notice given in accordance herewith to the other Party, 
designate any further or different address to which subsequent notices, 
requests, claims, demands and other communications shall be sent.

Section 12.6.

Waivers
.  The delay or failure of either Party to exercise or enforce any of its 
rights under this Agreement will not constitute, or be deemed to be, a waiver 
of those rights, nor will any single or partial exercise of any such rights 
preclude any other or further exercise thereof or the exercise of any other 
right.  No waiver of any provision of this Agreement will be effective unless 
it is in writing and signed by the Party against which it is being enforced.

Section 12.7.

Assignment
.  No Party may assign any rights or delegate any obligations arising under 
this Agreement, in whole or in part, directly or indirectly, without the prior 
written consent of the other Party (such consent not to be unreasonably 
withheld, conditioned or delayed), and any attempt to so assign any rights or 
delegate any obligations arising under this Agreement without such consent 
shall be void.  Notwithstanding the foregoing, no such consent shall be 
required for any such assignment or delegation (i) with respect to Cyclerion, 
to a Subsidiary of Cyclerion (so long as such Subsidiary remains a Subsidiary 
of Cyclerion), (ii) with respect to Buyer Parent or Buyer, to a Subsidiary of 
Buyer Parent (so long as such Subsidiary remains a Subsidiary of Buyer Parent) 
or (iii) to a bona fide Third Party in connection with a merger, reorganization,
 consolidation or the sale of all or substantially all of the assets of a 
Party so long as the resulting, surviving or transferee entity assumes all the 
obligations of the assigning Party by operation of Law or pursuant to an 
agreement in form and substance reasonably satisfactory to the non-assigning 
Party;
provided
,
however
, that in the case of each of the preceding clauses (i) and (ii), no 
assignment permitted by this
Section 12.7
shall release the assigning Party from liability for the full performance of 
its obligations under this Agreement.

Section 12.8.

Successors and Assigns
.  The provisions of this Agreement and the obligations and rights hereunder 
shall be binding upon, inure to the benefit of and be enforceable by (and 
against) the Parties and their respective successors (whether by merger, 
acquisition of assets or otherwise) and permitted assigns.

                                       66                                       
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Section 12.9.

Payment Terms
.  All payments to be made by either Cyclerion, Buyer Parent or Buyer under 
this Agreement shall be made in U.S. dollars.  Any amount which is not 
expressed in U.S. dollars shall be converted into U.S. dollars by using the 
exchange rate published on Bloomberg at 5:00 p.m., Eastern time, on the day 
before the relevant date, or in The Wall Street Journal, Eastern Edition, on 
such date if not so published on Bloomberg.  In the event that any 
indemnification payment required to be made hereunder or under any Ancillary 
Agreement may be denominated in a currency other than U.S. dollars, the amount 
of such payment shall be converted into U.S. dollars on the date notice of the 
claim is given to the Indemnifying Party.

Section 12.10.

Subsidiaries
.  Each of the Parties shall cause to be performed, and hereby guarantees the 
performance of, all actions, agreements and obligations set forth herein to be 
performed by any Subsidiary of such Party or by any entity that becomes a 
Subsidiary of such Party at or after the date hereof, in each case to the 
extent such Subsidiary remains a Subsidiary of the applicable Party.

Section 12.11.

Third Party Beneficiaries
.  Except (i) as provided in
Article IX
relating to Indemnitees and (ii) as specifically provided in any Ancillary 
Agreement, this Agreement is solely for the benefit of the Parties and shall 
not be deemed to confer upon any Person other than the Parties any remedy, 
claim, liability, reimbursement, cause of Action or other right beyond any 
that exist without reference to this Agreement.

Section 12.12.

Bulk Sales
.  Each of the Parties hereby waive compliance by itself and each and every 
member of such Party's respective Group with the requirements and provisions 
of any "bulk-sale" or "bulk transfer" Laws of any jurisdiction that may 
otherwise be applicable with respect to the transfer or sale of any or all of 
the Purchased Assets to Buyer or any member of the Buyer Group.

Section 12.13.

Titles and Headings
.  Titles and headings to sections herein are inserted for the convenience of 
reference only and are not intended to be a part of or to affect the meaning 
or interpretation of this Agreement.

Section 12.14.

Exhibits and Disclosure
Schedules
.

(a)

The Exhibits and Disclosure Schedules shall be construed with and as an 
integral part of this Agreement to the same extent as if the same had been set 
forth verbatim herein.

                                       67                                       
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(b)

The disclosure of any matter, or reference to any Contract, in any Section of 
the Disclosure Schedules to this Agreement shall not be deemed to constitute 
an admission by Cyclerion, Buyer Parent or Buyer, or any member of such 
Party's respective Group, or to otherwise imply that any such matter or 
Contract is material for the purposes of this Agreement and shall not affect 
the interpretation of such term for the purposes of this Agreement.  In 
particular, (a) certain matters may be disclosed on the Disclosure Schedules 
that may not be required to be disclosed because of certain minimum thresholds 
or materiality standards set forth in this Agreement, (b) the disclosure of 
any such matter does not mean that it meets or surpasses any such minimum 
thresholds or materiality standards, and (c) no disclosure in the Disclosure 
Schedules relating to any possible breach or violation of any Contract or Law 
shall be construed as an admission or indication that any such breach or 
violation exists or has actually occurred.  In no event shall the listing of 
such matters in any Section of the Disclosure Schedules be deemed or 
interpreted to expand the scope of any of Cyclerion's, Buyer Parent's or 
Buyer's representations and warranties contained in this Agreement.  Each 
Section of the Disclosure Schedules is qualified in its entirety by reference 
to specific provisions of the Agreement and does not constitute, and shall not 
be construed as constituting, representations, warranties or covenants of 
Cyclerion, Buyer Parent or Buyer, or any member of such Party's respective 
Group, or their respective Affiliates, except as and to the extent provided in 
this Agreement.  Matters reflected in any Section of the Disclosure Schedule 
are not necessarily limited to matters or Contracts required by this Agreement 
to be disclosed in such Disclosure Schedules.  Regardless of the existence or 
absence of cross-references, any information disclosed in any Section of the 
Disclosure Schedules shall be deemed fully disclosed for the purposes of all 
Sections of the Disclosure Schedules and shall be deemed to qualify all 
representations and warranties of Cyclerion, Buyer Parent or Buyer to which it 
is reasonably apparent on the face of such disclosure that such disclosure is 
or can reasonably be expected to be pertinent.  The section headings in the 
Disclosure Schedules are for convenience of reference only and shall not be 
deemed to alter or affect the meaning or interpretation of any information 
disclosed herein or any provision of this Agreement.  All attachments to the 
Disclosure Schedules are incorporated by reference into the Section of the 
Disclosure Schedules in which they are directly or indirectly referenced.  The 
information contained in the Disclosure Schedules is in all events subject to
Section 10.4
and
Section 12.16
.

Section 12.15.

Severability
.  In the event any one or more of the provisions contained in this Agreement 
should be held invalid, illegal or unenforceable in any respect, the validity, 
legality and enforceability of the remaining provisions contained herein and 
therein shall not in any way be affected or impaired thereby.  The Parties 
shall endeavor in good-faith negotiations to replace the invalid, illegal or 
unenforceable provisions with valid provisions, the economic effect of which 
comes as close as possible to that of the invalid, illegal or unenforceable 
provisions.

Section 12.16.

Public Announcements
.  From and after the date hereof, Cyclerion, Buyer and Buyer Parent shall 
consult with each other before issuing, and each shall give the other the 
opportunity to review and comment upon, that portion of any press release or 
other public statement, including a public statement made to its investors, 
that relates to the transactions contemplated by this Agreement or the 
Ancillary Agreements, and shall not issue any such press release or make any 
such public statement prior to such consultation, except (a) as may be 
required by applicable Law, court process or obligations pursuant to any 
listing agreement with any national securities exchange or national securities 
quotation system; or (b) for disclosures made that are substantially identical 
to disclosure contained in any prior written public statement not made in 
violation of this
Section 12.16
.

                                       68                                       
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Section 12.17.

Specific Performance
.  The Parties hereby expressly recognize and acknowledge that irreparable 
damage would result, no adequate remedy at law would exist, and damages would 
be difficult to determine in the event that any provision of this Agreement is 
not performed in accordance with its specific terms or otherwise breached. 
Therefore, in addition to, and not in limitation of, any other remedy 
available to any Party hereto, a party under this Agreement will be entitled 
to specific performance of the terms hereof and injunctive relief, without the 
necessity of proving the inadequacy of money damages as a remedy and without 
bond or other security being required. Such remedies, and any and all other 
remedies provided for in this Agreement, will, however, be cumulative in 
nature and not exclusive and will be in addition to any other remedies 
whatsoever which any Party may otherwise have. Each of the Parties hereby 
acknowledges and agrees that it may be difficult to prove damages with 
reasonable certainty, that it may be difficult to procure suitable substitute 
performance, and that injunctive relief and/or specific performance will not 
cause an undue hardship to the Parties. Each of the Parties hereby further 
acknowledges that the existence of any other remedy contemplated by this 
Agreement does not diminish the availability of specific performance of the 
obligations hereunder or any other injunctive relief. Each Party hereby 
further agrees that in the event of any action by any other Party for specific 
performance or injunctive relief, it will not assert that a remedy at law or 
other remedy would be adequate or that specific performance or injunctive 
relief in respect of such breach or violation should not be available on the 
grounds that money damages are adequate or any other grounds.

Section 12.18.

No Recourse
.  Other than with respect to claims involving actual fraud, this Agreement 
may only be enforced against, and any Action based upon, arising out of, or 
related to this Agreement or the transactions contemplated hereby may only be 
brought against, the entities that are expressly named as parties hereto. 
Except to the extent they are a named party to this Agreement and other than 
with respect to claims involving actual fraud, no past, present or future 
director, officer, employee, incorporator, member, partner, stockholder, 
Affiliate, agent, attorney, advisor or representative or Affiliate of any of 
the foregoing shall have any Liability (whether in contract, tort, equity or 
otherwise) for any one or more of the representations, warranties, covenants, 
agreements or other obligations or liabilities of any one or more of 
Cyclerion, Buyer Parent or Buyer under this Agreement (whether for 
indemnification or otherwise) or of or for any Action based on, arising out 
of, or related to this Agreement or the transactions contemplated hereby.

Section 12.19.

Interpretation
.  The Parties have participated jointly in the negotiation and drafting of 
this Agreement.  This Agreement shall be construed without regard to any 
presumption or rule requiring construction or interpretation against the Party 
drafting or causing any instrument to be drafted.

Section 12.20.

No Admission of Liability
.  The allocation of Assets and Liabilities herein (including on the 
Disclosure Schedules hereto) is solely for the purpose of allocating such 
Assets and Liabilities between Cyclerion and Buyers and is not intended as an 
admission of liability or responsibility for any alleged Liabilities vis-a-vis 
any Third Party.

                            [Signature Page Follows]                            

                                       69                                       
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IN WITNESS WHEREOF, the Parties have caused this Agreement to be duly executed 
as of the day and year first above written.


 JW CELTICS INVESTMENT CORP.  
                              
 By:       /s/ Jason Wood     
           Name:    Jason Wood
           Title:   Director  
                              
 JW CYCLE, INC.               
                              
 By:       /s/ Jason Wood     
           Name:    Jason Wood
           Title:   Director  


                                       70                                       
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IN WITNESS WHEREOF, the Parties have caused this Agreement to be duly executed 
as of the day and year first above written.


 CYCLERION THERAPEUTICS, INC.      
                                   
 By: /s/ Cheryl Gault              
     Name:  Cheryl Gault           
     Title: Chief Operating Officer



                                       71                                       
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                                                                    Exhibit 10.1


                          VOTING AND SUPPORT AGREEMENT                          

THIS VOTING AND SUPPORT AGREEMENT, dated as of [______ __], 2023 (the "
Agreement
"), among JW Celtics Investment Corp., a Delaware corporation ("
Buyer Parent
"), and [  ], a stockholder (the "
Holder
").

                                  WITNESSETH:                                   

WHEREAS, Cyclerion Therapeutics, Inc., a Massachusetts corporation (the "
Company
"),  Buyer Parent and JW Cycle Inc., a Delaware corporation ("
Buyer
"), are entering into an Asset Purchase Agreement dated as of the date hereof 
(as the same may be amended or supplemented from time to time, the "
Asset Purchase Agreement
") providing for, among other things, Buyer's purchase of the Purchased Assets 
(as defined in the Asset Purchase Agreement) and assumption of the Assumed 
Liabilities (as defined in the Asset Purchase Agreement);

WHEREAS, the Holder is the Beneficial Owner (as defined below) of the number 
of outstanding shares of the common stock of the Company (the "
Company Common Stock
") listed on Exhibit A (such shares of Company Common Stock, the Holder's "
Existing Shares
" and, such Existing Shares, together with any additional outstanding shares 
of capital stock of the Company Beneficially Owned or acquired by the Holder 
on or after the date hereof, the "
Shares
");

WHEREAS, as a condition and an inducement to the Company and Buyer Parent 
entering into the Asset Purchase Agreement, the Holder is entering into this 
Agreement with respect to all Company Common Stock that the Holder 
Beneficially Owns and/or owns of record; and

WHEREAS, the Company and Buyer Parent desire that the Holder agree, and the 
Holder is willing to agree, subject to the limitations herein, not to Transfer 
(as defined below) any of its Shares, and to deliver a written consent with 
respect to its Shares or vote its Shares, if applicable, in a manner so as to 
facilitate consummation of the Asset Purchase Agreement and the other 
transactions contemplated by the Asset Purchase Agreement.

NOW, THEREFORE, in consideration of the mutual covenants, representations, 
warranties and agreements contained herein, and intending to be legally bound 
hereby, the parties agree as follows:

                                   ARTICLE I                                    
                                    GENERAL                                     

1.1.

Definitions
.
Capitalized terms used but not defined herein shall have the meanings set 
forth in the Asset Purchase Agreement.

"
Beneficially Own
" or "
Beneficial Ownership
" has the meaning assigned to such term in Rule 13d-3 under the Exchange Act, 
and a Person's beneficial ownership of securities shall be calculated in 
accordance with the provisions of such Rule (in each case, irrespective of 
whether or not such Rule is actually applicable in such circumstance).  For 
the avoidance of doubt, Beneficially Own and Beneficial Ownership shall also 
include record ownership of securities.

"
Beneficial Owners
" shall mean Persons who Beneficially Own the referenced securities.

-------------------------------------------------------------------------------
"
Transfer
" means (a) any direct or indirect offer, sale, lease, assignment, 
encumbrance, loan, pledge, grant of a security interest, hypothecation, 
disposition or other transfer (including by gift, tender or exchange offer, 
merger, by operation of law or otherwise), or entry into any contract, option 
or other arrangement or understanding with respect to any offer, sale, lease, 
assignment, encumbrance, loan, pledge, hypothecation, disposition or other 
transfer (including by gift, tender or exchange offer, merger, operation of 
law or otherwise), of any capital stock or interest in any capital stock (or 
any security convertible or exchangeable into such capital stock), including 
in each case through the Transfer of any Person or any interest in any Person 
or (b) in respect of any capital stock or interest in any capital stock, to 
enter into any hedge, swap, derivative instrument or any other agreement, 
transaction or series of transactions that results in an amount of Shares 
subject to
Article III
that is less than the amount of Shares subject to
Article III
immediately prior to the consummation of any such agreement, transaction or 
series of transactions.  For purposes of this Agreement, "capital stock" shall 
include interests in a partnership or limited liability company.

                                   ARTICLE II                                   
                           AGREEMENT TO RETAIN SHARES                           

2.1.

Transfer and Encumbrance of Shares
.
From the date hereof until the Termination Date (as defined below), the Holder 
shall not, with respect to the Shares, (a) Transfer any such Shares or (b) 
deposit any such Shares into a voting trust or enter into a voting agreement 
or arrangement with respect to such Shares or grant any proxy (except as 
otherwise provided herein) or power of attorney with respect thereto.  
Notwithstanding the foregoing, this
Section 2.1
shall not prohibit a Transfer of any Shares by the Holder to an affiliate of 
the Holder (in which case such transferee shall be considered the "Holder" 
hereunder)~
provided,
that a Transfer described in this sentence shall be permitted only if, as a 
precondition to such Transfer, the transferee agrees in a writing to be bound 
by the terms of this Agreement.

2.2.

Additional Purchases; Adjustments
.

(a)
The Holder agrees that any shares of Company Common Stock and any other shares 
of capital stock or other equity of the Company that the Holder purchases or 
otherwise acquires or with respect to which the Holder otherwise acquires 
voting power after the execution of this Agreement and prior to the 
Termination Date shall be subject to the terms and conditions of this 
Agreement to the same extent as if they constituted the Shares as of the date 
hereof and the Holder shall promptly notify the Company of the existence and 
number of any such after-acquired Shares.  In the event of any stock split, 
reverse stock split, stock dividend, merger, reorganization, recapitalization, 
reclassification, combination, exchange of shares or the like of the capital 
stock of the Company affecting the Shares, the terms of this Agreement shall 
apply to the resulting securities.

(b)
The Holder shall cause any of its controlled affiliates that purchases or 
otherwise acquires or otherwise acquires voting power over shares of Company 
Common Stock or any other shares of capital stock or other equity of the 
Company after execution of this Agreement and prior to the Termination Date to 
execute a voting and support agreement with Buyer Parent in the form of, and 
on terms substantially similar to, this Agreement.

                                       2                                        
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2.3.

Unpermitted Transfers; Involuntary Transfers
.
Any Transfer or attempted Transfer of any Shares or other actions taken or 
attempted to be taken in violation of this
Article II
shall, to the fullest extent permitted by Law, be null and void
ab initio.
In furtherance of the foregoing, the Holder hereby authorizes and instructs 
the Company to instruct his, her or its transfer agent to enter a stop 
transfer order with respect to all of the Shares.  If any involuntary Transfer 
of any of the Holder's Shares shall occur, the transferee (which term, as used 
herein, shall include any and all transferees and subsequent transferees of 
the initial transferee) shall take and hold such Shares subject to all of the 
restrictions, liabilities and rights under this Agreement, which shall 
continue in full force and effect until valid termination of this Agreement.


                                  ARTICLE III                                   
                         AGREEMENT TO CONSENT AND VOTE                          

3.1.

Agreement to Vote
.
Prior to the Termination Date, the Holder irrevocably and unconditionally 
agrees that it shall, at any meeting of the stockholders of the Company 
(whether annual or special and whether or not an adjourned or postponed 
meeting), however called, appear at such meeting or otherwise cause the Shares 
entitled to vote to be counted as present thereat for purpose of establishing 
a quorum and vote (or consent), or cause to be voted (in person or by proxy) 
at such meeting (or validly execute and return and cause such consent to be 
granted with respect to), all of the Shares entitled to vote:

(a)
in favor of (i) the adoption of the Asset Purchase Agreement and the approval 
of the transactions contemplated thereby, including the purchase of the 
Purchased Assets and the assumption of the Assumed Liabilities, (ii) the 
adjournment of the Stockholders Meeting if necessary to solicit proxies in 
favor of the adoption of the Asset Purchase Agreement and the consummation of 
the transactions contemplated thereby or to establish a quorum, and (iii) any 
other matter or action necessary to the consummation of the closing of the 
Asset Purchase Agreement. In furtherance of the foregoing obligations of the 
Holder, the Holder hereby agrees to deliver or deposit a proxy or voting 
instruction form, as the case may be, duly completed and executed in respect 
of all of the Shares, as directed in the Proxy Statement, as soon as 
practicable following the mailing of the Proxy Statement to the Company 
stockholders, and in any event at least 5 days prior to the Stockholders 
Meeting, voting all such Shares in accordance with the foregoing sentence. The 
Holder hereby agrees that neither he, her or it nor any person on his, her or 
its behalf will take any action to withdraw, amend or invalidate any proxy or 
voting instruction form deposited by the Holder pursuant to this Agreement 
notwithstanding any statutory or other rights or otherwise which the Holder 
might have, unless and until this Agreement is terminated in accordance with

Section 6.3
; and

(b)
against (i) any agreement, transaction or proposal that relates to an 
Acquisition Proposal or any other transaction, proposal, agreement or action 
made in opposition to adoption of the Asset Purchase Agreement or in 
competition or inconsistent with the transactions or matters contemplated by 
thereby; (ii) any action or agreement that would result in a breach of any 
covenant, representation or warranty or any other obligation or agreement of 
the Company or any of its Subsidiaries contained in the Asset Purchase 
Agreement or of the Holder contained in this Agreement; (iii) any action or 
agreement that would reasonably be expected to result in (A) any condition to 
the consummation of the Asset Purchase Agreement set forth in Article VII of 
the Asset Purchase Agreement not being fulfilled or (B) any change to the 
voting rights of any class of shares of capital stock of the Company 
(including any amendments to the Company's organizational documents); and (iv) 
any other action that would reasonably be expected to impede, interfere with, 
or frustrate the purposes of any of the transactions contemplated by the Asset 
Purchase Agreement.  Any attempt by the Holder to vote, consent or express 
dissent with respect to (or otherwise to utilize the voting power of), the 
Shares in contravention of this
Section 3.1
shall be null and void
ab initio.
If the Holder is the Beneficial Owner, but not the holder of record, of any 
Shares, the Holder agrees to take all actions necessary to cause the holder of 
record and any nominees to vote (or exercise a consent with respect to) all of 
such Shares in accordance with this
Section 3.1
.

                                       3                                        
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                                   ARTICLE IV                                   
                             ADDITIONAL AGREEMENTS                              

4.1.

Litigation
.
The Holder agrees not to commence, participate in, facilitate, assist or 
encourage, and agrees to take all actions necessary to opt out of any class in 
any class action with respect to, any claim, derivative or otherwise, against 
the Company or any of its affiliates and successors or directors (a) 
challenging the validity of, or seeking to enjoin the operation of, any 
provision of this Agreement or the Asset Purchase Agreement (including any 
claim seeking to enjoin or delay the Closing) or (b) alleging a breach of any 
fiduciary duty of the Board in connection with this Agreement, the Asset 
Purchase Agreement or the transactions contemplated hereby or thereby, and 
hereby irrevocably waives any claim or rights whatsoever with respect to any 
of the foregoing.

4.2.

Further Assurances
.
The Holder agrees that from and after the date hereof and until the 
Termination Date, the Holder shall and shall cause his, her or its 
Subsidiaries to take no action that (a) would reasonably be likely to 
adversely affect or delay the ability to obtain the Stockholder Approval or 
the approval of any other Governmental Entity required for the transactions 
contemplated by the Asset Purchase Agreement or to perform his, her or its 
respective covenants and agreements under this Agreement, (b) would make any 
representation or warranty of the Holder herein untrue or incorrect, or (c) 
would have the effect of committing or agreeing to take any of the foregoing 
actions or any other action that would reasonably be expected to make any of 
the representations or warranties contained herein untrue or incorrect or 
would have the effect of preventing or otherwise materially delaying, impeding 
or impairing the Holder from performing any of his, her or its obligations 
hereunder. The Holder shall, from time to time, execute and deliver, or cause 
to be executed and delivered, such additional or further consents, documents 
and other instruments as the Company may reasonably request for the purpose of 
effectively carrying out the transactions contemplated by this Agreement.

4.3.

Fiduciary Duties
.
The Holder is entering into this Agreement solely in his, her or its capacity 
as the record or Beneficial Owner of the Shares and nothing herein is intended 
to or shall limit or affect any actions taken by any of the Holder's designees 
serving solely in his or her capacity as a director of the Company (or a 
Subsidiary of the Company). The taking of any actions (or failures to act) by 
the Holder's designees serving as a director of the Company shall not be 
deemed to constitute a breach of this Agreement.

                                       4                                        
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                                   ARTICLE V                                    
                         REPRESENTATIONS AND WARRANTIES                         

5.1.

Holder Representations and Warranties
.
The Holder hereby represents and warrants as follows:

(a)

Ownership.
The Holder has, with respect to the Existing Shares, and at all times during 
the term of this Agreement will continue to have, Beneficial Ownership of, 
good and valid title to and full and exclusive power to deliver written 
consent, vote, issue instructions with respect to the matters set forth in 
Article III, agree to all of the matters set forth in this Agreement and to 
Transfer the Shares. The Existing Shares constitute all of the shares of 
Company Common Stock owned of record or beneficially by the Holder as of the 
date hereof.  Other than this Agreement, there are no agreements or 
arrangements of any kind, contingent or otherwise, to which the Holder is a 
party obligating the Holder to Transfer or cause to be Transferred to any 
person any of the Shares.  No Person has any contractual or other right or 
obligation to purchase or otherwise acquire any of the Shares.

(b)

Authority.
The Holder has all requisite authority (and in the case of an individual, the 
capacity) to make, enter into and carry out the terms of this Agreement and to 
perform his, her or its obligations hereunder.  This Agreement has been duly 
and validly executed and delivered by the Holder and (assuming due 
authorization, execution and delivery by Buyer Parent) constitutes a valid and 
binding agreement of the Holder, enforceable against the Holder in accordance 
with its terms (except in all cases as such enforceability may be limited by 
bankruptcy, insolvency or other similar laws affecting the enforcement of 
creditors' rights generally or by general principles of equity), and no other 
action is necessary to authorize the execution and delivery by the Holder or 
the performance of the Holder's obligations hereunder.

(c)

No Violation.
The execution, delivery and performance by the Holder of this Agreement will 
not (i) violate any provision of any Law applicable to the Holder; (ii) 
violate any order, judgment or decree applicable to the Holder; or (iii) 
conflict with, or result in a breach or default under, any agreement or 
instrument to which the Holder is a party or, if the Holder is an entity, any 
term or condition of its organizational documents, except where such conflict, 
breach or default would not reasonably be expected to, individually or in the 
aggregate, have an adverse effect on the Holder's ability to satisfy his, her 
or its obligations hereunder.

(d)

Consents and Approvals.
The execution and delivery by the Holder of this Agreement does not, and the 
performance of the Holder's obligations hereunder, require the Holder to 
obtain any consent, approval, authorization or permit of, or to make any 
filing with or notification to, any person or Governmental Entity, except such 
filings and authorizations as may be required under the Exchange Act.

(e)

Absence of Litigation.
As of the date hereof, there is no action, suit, investigation, complaint or 
other proceeding pending against the Holder or, to the knowledge of the 
Holder, any other person, or, to the knowledge of the Holder, threatened 
against the Holder or any other person that would reasonably be expected to 
restrict or prohibit (or, if successful, would restrict or prohibit) the 
performance by the Holder of his, her or its obligations under this Agreement 
or to consummate the transactions contemplated hereby or by the Asset Purchase 
Agreement on a timely basis.

                                       5                                        
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(f)

Absence of Other Voting Agreements.
None of the Shares is or will be subject to any voting trust, proxy or other 
agreement, arrangement or restriction with respect to voting, in each case, 
that is inconsistent with this Agreement.  None of the Shares is subject to 
any pledge agreement pursuant to which the Holder does not retain sole and 
exclusive voting rights with respect to the Holder's Shares subject to such 
pledge agreement at least until the occurrence of an event of default under 
the related debt instrument.

(g)

Finder's Fee.
No investment banker, broker, finder or other intermediary is entitled to a 
fee or commission from Buyer Parent in respect of this Agreement or the Asset 
Purchase Agreement based upon any arrangement or agreement made by or on 
behalf of the Holder.

5.2.

Buyer Parent Representations and Warranties
.

(a)

Organization; Authority.
Buyer Parent is a corporation duly organized, validly existing and in good 
standing under the Laws of the State of Delaware. Buyer Parent is not in 
violation of any of the provisions of its organizational documents.  Buyer 
Parent has full power and authority and is duly authorized to make, enter into 
and carry out the terms of this Agreement and to perform its obligations 
hereunder. This Agreement has been duly and validly executed and delivered by 
Buyer Parent and (assuming due authorization, execution and delivery by the 
Holder) constitutes a valid and binding agreement of Buyer Parent, enforceable 
against Buyer Parent in accordance with its terms (except in all cases as such 
enforceability may be limited by bankruptcy, insolvency or other similar laws 
affecting the enforcement of creditors' rights generally or by general 
principles of equity), and no other action is necessary to authorize the 
execution and delivery by Buyer Parent or the performance of Buyer Parent's 
obligations hereunder.

(b)

No Violation.
The execution, delivery and performance by Buyer Parent of this Agreement will 
not (i) violate any provision of any Law applicable to Buyer Parent; (ii) 
violate any order, judgment or decree applicable to Buyer Parent; or (iii) 
conflict with, or result in a breach or default under, any agreement or 
instrument to which Buyer Parent is a party or any term or condition of its 
organizational documents, except where such conflict, breach or default would 
not reasonably be expected to, individually or in the aggregate, have an 
adverse effect on Buyer Parent's ability to satisfy its obligations hereunder.


(c)

Consents and Approvals.
The execution and delivery by Buyer Parent of this Agreement, and the 
performance of Buyer Parent's obligations hereunder, does not require Buyer 
Parent to obtain any consent, approval, authorization or permit of, or to make 
any filing with or notification to, any person or Governmental Entity, except 
such filings and authorizations as may be required under the Exchange Act.

(d)

Absence of Litigation.
As of the date hereof, there is no action, suit, investigation, complaint or 
other proceeding pending against Buyer Parent or, to the knowledge of Buyer 
Parent, any other person, or, to the knowledge of Buyer Parent, threatened 
against the Company or any other person that would reasonably be expected to 
restrict or prohibit (or, if successful, would restrict or prohibit) the 
performance by Buyer Parent of its obligations under this Agreement or to 
consummate the transactions contemplated hereby or by the Asset Purchase 
Agreement on a timely basis.

                                       6                                        
-------------------------------------------------------------------------------
                                   ARTICLE VI                                   
                                 MISCELLANEOUS                                  

6.1.

No Ownership Interest.
Nothing contained in this Agreement shall be deemed to vest in Buyer Parent 
any direct or indirect ownership or incidence of ownership of or with respect 
to the Shares. All rights, ownership and economic benefits of and relating to 
the Shares shall remain vested in and belong to the Holder, and Buyer Parent 
shall not have the authority to direct the Holder in the voting or disposition 
of any Shares, except as otherwise expressly provided herein. Nothing in this 
Agreement shall be interpreted as creating or forming a "group" with any other 
Person for the purposes of Rule 13d-5(b)(l) of the Exchange Act or for any 
other similar provision of applicable Law.

6.2.

Disclosure.
The Holder hereby authorizes the Company to publish and disclose in any 
announcement or disclosure required by the SEC and in the Proxy Statement the 
Holder's identity and ownership of the Shares and the nature of the Holder's 
obligations under this Agreement.

6.3.

Termination.
This Agreement shall terminate automatically and without any further action by 
the Holders, Buyer Parent or the Company at the earlier of (a) the date the 
Asset Purchase Agreement is validly terminated in accordance with its terms, 
(b) consummation of the Closing of the Asset Purchase Agreement, (c) Buyer 
Parent's receipt of notice of an Cyclerion Adverse Recommendation Change, (d) 
the mutual written consent of the parties hereto, or (e) the entry into any 
amendment to the Asset Purchase Agreement without the prior written consent of 
the Holder (which consent may be in the form of an e-mail) that is materially 
adverse to the Holder (such date, the "
Termination Date
").  In the event of any such termination of this Agreement, this Agreement 
shall forthwith become null and void and have no effect, without any liability 
or obligation on the part of Buyer Parent or the Holder, other than liability 
for any willful and material breach of this Agreement prior to such 
termination.

6.4.

Amendment.
This Agreement may not be amended, modified or supplemented in any manner, 
whether by course of conduct or otherwise, except by an instrument in writing 
specifically designated as an amendment hereto, signed on behalf of each of 
the parties hereto and the Company at the time of the amendment.

6.5.

Extension~ Waiver.
At any time prior to the Closing, the Holder and Buyer Parent may, to the 
extent legally allowed:

(a)
extend the time for the performance of any of the obligations or acts of the 
other party hereunder;

(b)
waive any inaccuracies in the representations and warranties of the other 
party contained herein or in any document delivered pursuant hereto; or

(c)
waive compliance with any of the agreements or conditions of the other party 
contained herein.

                                       7                                        
-------------------------------------------------------------------------------
Notwithstanding the foregoing, no failure or delay by any party in exercising 
any right hereunder shall operate as a waiver thereof nor shall any single or 
partial exercise thereof preclude any other or further exercise of any other 
right hereunder.  No agreement on the part of a party to any such extension or 
waiver shall be valid unless set forth in an instrument in writing signed on 
behalf of such party.  No waiver by any of the parties hereto of any default, 
misrepresentation or breach of representation, warranty, covenant or other 
agreement hereunder, whether intentional or not, shall be deemed to extend to 
any prior or subsequent default, misrepresentation or breach or affect in any 
way any rights arising by virtue of any prior or subsequent such occurrence.

6.6.

Expenses.
Regardless of whether the transactions provided for in this Agreement are 
consummated, each party will pay its own costs and expenses incident to this 
Agreement and the transactions contemplated herein.

6.7.

Notices.
All notices, requests, claims, demands and other communications under this 
Agreement shall be in English, shall be in writing and shall be given or made 
(and shall be deemed to have been duly given or made upon receipt) by delivery 
in person, by overnight courier service, by facsimile or email with receipt 
confirmed (followed by delivery of an original via overnight courier service) 
or by registered or certified mail (postage prepaid, return receipt 
requested), to the Holder at the addresses specified on Exhibit A and for 
Buyer Parent at the following address (or at such other address for a Party as 
shall be specified in a notice given in accordance with this
Section 6.7
):

if to Buyer Parent, to:


 JW Celtics Investment Corp.                      
                                                  
 Address: 1820 Calistoga Road Santa Rosa, CA 95404
 Attn: Jason Wood                                 
 Phone: (415) 577-5305                            
 Email: jason@jwoodcapital.com                    
                                                  
 With a copy, which shall not constitute notice to
 :                                                
                                                  
 Ropes & Gray LLP                                 
 1211 Avenue of the Americas                      
 New York, NY 10036-8704                          
 Attn:  Suni Sreepada                             
 Phone:  (212) 596-9960                           
 Email: Suni.sreepada@ropesgray.com               


                                       8                                        
-------------------------------------------------------------------------------
6.8.

Interpretation.
The parties have participated jointly in the negotiation and drafting of this 
Agreement.  This Agreement shall be construed without regard to any 
presumption or rule requiring construction or interpretation against the party 
drafting or causing any instrument to be drafted. References in this Agreement 
to any gender include references to all genders, and references to the 
singular include references to the plural and vice versa.  Unless the context 
otherwise requires, the words "include", "includes" and "including" when used 
in this Agreement shall be deemed to be followed by the phrase "without 
limitation".  Unless the context otherwise requires, references in this 
Agreement to Articles and Sections shall be deemed references to Articles and 
Sections of this Agreement.  Unless the context otherwise requires, the words 
"hereof", "hereby" and "herein" and words of similar meaning when used in this 
Agreement refer to this Agreement in its entirety and not to any particular 
Article, Section or provision of this Agreement.  The words "written request" 
when used in this Agreement shall include email.  Reference in this Agreement 
to any time shall be to Eastern time unless otherwise expressly provided 
herein.  The word "or" shall not be exclusive.  References to any "statute" or 
"regulation" are to such statute or regulation as amended, modified, 
supplemented or replaced from time to time (and, in the case of any statute, 
include any rules and regulations promulgated under such statute) and to any 
"section of any statute or regulation" include any successor to such section.  
References to any Governmental Entity include any successor to such 
Governmental Entity, and references to any affiliate include any successor to 
such affiliate. Whenever the last day for the exercise of any right or the 
discharge of any duty under this Agreement falls on a day other than a 
Business Day, the party having such right or duty shall have until the next 
Business Day to exercise such right or discharge such duty.  Unless otherwise 
indicated, the word "day" shall be interpreted as a calendar day.

6.9.

Counterparts.
This Agreement may be executed in one or more counterparts, all of which shall 
be considered one and the same agreement, and shall become effective when one 
or more such counterparts have been signed by each of the parties and 
delivered to each of the parties. The Agreement and any documents relating to 
it may be executed and transmitted to any other party by email of a PDF, which 
email or PDF shall be deemed to be, and utilized in all respects as, an 
original, wet-inked document.

6.10.

Complete Agreement.
This Agreement shall constitute the entire agreement between the parties with 
respect to the subject matter hereof and shall supersede all previous 
negotiations, commitments, course of dealings and writings with respect to 
such subject matter.

6.11.

Governing Law; Venue; Waiver of Jury Trial
.

(a)

Governing Law
.
This Agreement and any disputes arising hereunder or controversies related 
hereto, shall be governed by and construed in accordance with the internal 
laws, and not the laws of conflicts, of the Commonwealth of Massachusetts that 
apply to contracts made and performed entirely within such state
.

(b)

Proceedings
.
Any proceeding with respect to this Agreement, any matter arising out of or in 
connection with this Agreement shall be brought exclusively in the state or 
federal courts located in the Commonwealth of Massachusetts.  By execution and 
delivery of this Agreement, each party hereby accepts for herself, himself or 
itself and in respect of such Person's property, generally and unconditionally, 
the sole and exclusive jurisdiction of the aforesaid courts and appellate 
courts thereof.  Each party irrevocably consents to service of process in any 
proceeding in any of the aforementioned courts by the mailing of copies 
thereof by registered or certified mail, postage prepaid, or by recognized 
overnight delivery service, to such party at such party's address referred to 
in
Section
6.7
. Each party hereto hereby irrevocably and unconditionally waives any 
objection which such Person may now or hereafter have to the laying of venue 
of any of the aforesaid actions or proceedings arising out of or in connection 
with this Agreement brought in the courts referred to above and hereby further 
irrevocably waives and agrees, to the extent permitted by applicable Law, not 
to plead or claim in any such court that any such proceeding brought in any 
such court has been brought in an inconvenient forum.  Final judgment in any 
such proceeding shall be conclusive and may be enforced in other jurisdictions 
by suit on the judgment or in any other manner provided by Law.  Nothing 
herein shall affect the right of any party hereto to serve process in any 
other manner permitted by Law
.

                                       9                                        
-------------------------------------------------------------------------------
(c)

Immunity
.  To the extent that any party has or hereafter may acquire any immunity from 
jurisdiction of any court or from any legal process (whether through service 
or notice, attachment prior to judgment, attachment in aid of execution, 
execution or otherwise) with respect to itself, or to such Person's property, 
each such party hereto hereby irrevocably waives such immunity in respect of 
such Person's obligations with respect to this Agreement
.

(d)

Waiver of Jury Trial
. EACH PARTY HERETO, FOR HIMSELF, HERSELF OR ITSELF AND HIS, HER OR ITS 
AFFILIATES, HEREBY IRREVOCABLY AND UNCONDITIONALLY WAIVES TO THE FULLEST 
EXTENT PERMITTED BY APPLICABLE LAW ALL RIGHT TO TRIAL BY JURY IN ANY 
PROCEEDING (WHETHER BASED ON CONTRACT, TORT OR OTHERWISE) ARISING OUT OF OR 
RELATING TO THE ACTIONS OF THE PARTIES HERETO OR THEIR RESPECTIVE AFFILIATES 
PURSUANT TO THIS AGREEMENT OR IN THE NEGOTIATION, ADMINISTRATION, PERFORMANCE 
OR ENFORCEMENT HEREOF.

6.12.

Assignment
.  No party may assign any rights or delegate any obligations arising under 
this Agreement, in whole or in part, directly or indirectly, without the prior 
written consent of the other party (such consent not to be unreasonably 
withheld, conditioned or delayed), and any attempt to so assign any rights or 
delegate any obligations arising under this Agreement without such consent 
shall be void.

6.13.

Specific Performance.
The parties hereby expressly recognize and acknowledge that irreparable damage 
would result, no adequate remedy at law would exist, and damages would be 
difficult to determine in the event that any provision of this Agreement is 
not performed in accordance with its specific terms or otherwise breached. 
Therefore, in addition to, and not in limitation of, any other remedy 
available to any party hereto, a party under this Agreement will be entitled 
to specific performance of the terms hereof and injunctive relief, without the 
necessity of proving the inadequacy of money damages as a remedy and without 
bond or other security being required. Such remedies, and any and all other 
remedies provided for in this Agreement, will, however, be cumulative in 
nature and not exclusive and will be in addition to any other remedies 
whatsoever which any party may otherwise have. Each of the parties hereby 
acknowledges and agrees that it may be difficult to prove damages with 
reasonable certainty, that it may be difficult to procure suitable substitute 
performance, and that injunctive relief and/or specific performance will not 
cause an undue hardship to the parties. Each of the parties hereby further 
acknowledges that the existence of any other remedy contemplated by this 
Agreement does not diminish the availability of specific performance of the 
obligations hereunder or any other injunctive relief. Each party hereby 
further agrees that in the event of any action by any other party for specific 
performance or injunctive relief, it will not assert that a remedy at law or 
other remedy would be adequate or that specific performance or injunctive 
relief in respect of such breach or violation should not be available on the 
grounds that money damages are adequate or any other grounds.

6.14.

Severability.
In the event any one or more of the provisions contained in this Agreement 
should be held invalid, illegal or unenforceable in any respect, the validity, 
legality and enforceability of the remaining provisions contained herein and 
therein shall not in any way be affected or impaired thereby.  The parties 
shall endeavor in good-faith negotiations to replace the invalid, illegal or 
unenforceable provisions with valid provisions, the economic effect of which 
comes as close as possible to that of the invalid, illegal or unenforceable 
provisions.

                                       10                                       
-------------------------------------------------------------------------------
6.15.

Third Party Beneficiaries
.  The parties hereto acknowledge and agree that the Company is an express 
third-party beneficiary of this Agreement, and as such the rights hereunder 
will inure to the benefit of and be enforceable by the Company, including but 
not limited to the right to fully enforce the Holder's obligations hereunder. 
Except for the Company, this Agreement is solely for the benefit of Buyer 
Parent and each Holder and shall not be deemed to confer upon any Person other 
than the parties hereto any remedy, claim, liability, reimbursement, cause of 
Action or other right beyond any that exist without reference to this 
Agreement.

6.16.

No Recourse.
This Agreement may only be enforced against, and any claims or causes of 
action that may be based upon, arise out of or relate to this Agreement, or 
the negotiation, execution or performance of this Agreement may only be made 
against the Holder and no former, current or future equity holders, 
controlling persons, directors, officers, employees, agents or affiliates of 
any party hereto or any former, current or future stockholder, controlling 
person, director, officer, employee, general or limited partner, member, 
manager, agent or affiliate (other than the Holder) of any of the foregoing, 
including the Company (each, unless a permitted transferee contemplated by 
Section 2.1, a "
Non-Recourse Party
") shall have any liability for any obligations or liabilities of the parties 
to this Agreement or for any claim (whether in tort, contract or otherwise) 
based on, in respect of, or by reason of, the transactions contemplated hereby 
or in respect of any representations made or alleged to be made in connection 
herewith. Without limiting the rights of any party against the other parties 
hereto, in no event shall any party or any of its affiliates seek to enforce 
this Agreement against, make any claims for breach of this Agreement against, 
or seek to recover monetary damages from, any Non-Recourse Party.  For the 
avoidance of doubt, nothing in this
Section 6.16
shall be deemed to limit, restrict or otherwise affect in any way any rights 
or remedies available under the Asset Purchase Agreement.

                            [Signature Page Follows]                            

                                       11                                       
-------------------------------------------------------------------------------
IN WITNESS WHEREOF, the parties hereto, intending to be legally bound hereby, 
have executed or caused this Agreement to be executed in counterparts, all as 
of the day and year first above written.


 BUYER PARENT:                
                              
 JW CELTICS INVESTMENT CORP.  
                              
 By:                          
 Name:     Jason Wood         
 Title:    Director           


                [Signature page to Voting and Support Agreement]                

-------------------------------------------------------------------------------

 HOLDERS:                      
                               
 [If Holder is an entity]      
                               
 [Entity Name]                 
                               
 By:                           
 Name:                         
 Title:                        
                               
 [If Holder is an Individual]  
                               
 Name:                         


                [Signature page to Voting and Support Agreement]                

-------------------------------------------------------------------------------
                                   Exhibit A                                    


Holder Existing Shares Notice Address
                                     



                                      A-1                                       
-------------------------------------------------------------------------------
-------------------------------------------------------------------------------
                                                                    Exhibit 99.1

       Cyclerion Announces Definitive Agreement for Zagociguat and CY3018       

 Certain Cyclerion shareholders and new investors have agreed to invest $81M to 
      launch a new company targeting diseases of mitochondrial dysfunction      

 Cyclerion to receive $8M in cash and 10% equity in the new company in exchange 
                      for its zagociguat and CY3018 assets                      

     Definitive agreement signing triggers previously announced $5M equity      
                            investment in Cyclerion                             

CAMBRIDGE, Mass., May 11, 2023
- Cyclerion Therapeutics, Inc. (Nasdaq: CYCN) announced today that it has 
signed a definitive agreement with a new private company ("NewCo") to sell two 
of its sGC stimulator assets in exchange for cash and equity ownership. 
Investors in NewCo have agreed to invest $81M to develop zagociguat 
(previously CY6463) to treat MELAS* and other diseases associated with 
mitochondrial dysfunction and advance CY3018.

Under the terms of the asset purchase agreement, Cyclerion will receive an $8M 
cash payment at closing, reimbursement for all expenses related to zagociguat 
and CY3018 for the period between the signing and closing of the transaction, 
and 10% equity ownership in NewCo that is subject to anti-dilution protection 
through $100M in post-money valuation.  Cyclerion will also have additional 
future equity purchase rights in NewCo. Current Cyclerion shareholders 
including Invus and CEO Peter Hecht are participating in the capitalization of 
NewCo. They are joined in the NewCo investor syndicate by Venrock, J Wood 
Capital and Sanofi Ventures.  The transaction is subject to approval by 
Cyclerion shareholders. Each of the current Cyclerion investors who are 
participating in the NewCo capitalization have agreed to vote their Cyclerion 
shares in favor of the transaction.  Following the closing, NewCo will be 
solely responsible for all activities and expenses related to developing and 
commercializing zagociguat and CY3018.
-------------------------------------------------------------------------------
Signing of the definitive agreement triggered the previously announced $5M 
equity investment by CEO Peter Hecht. This investment will take place on May 
19, 2023, and Hecht will receive a mix of common stock and nonvoting 
convertible preferred stock of Cyclerion at a minimum purchase price of $0.434 
per share, subject to adjustment for any reverse stock split or similar event.

"We are pleased to see our zagociguat and CY3018 assets attracting the capital 
and capabilities they will need to continue their development in mitochondrial 
and CNS diseases.  Over the past 12 months, our board, management and advisors 
have carried out an exhaustive and thorough process to evaluate all available 
opportunities to maximize the value of our assets for our shareholders in this 
exceptionally challenging capital market while advancing potentially 
life-changing medicines to patients," said Errol De Souza, Chair of the Board 
at Cyclerion "With this transaction, we believe these compounds will receive 
the focus they deserve, and Cyclerion shareholders will be able to benefit 
from future value creation via Cyclerion's equity position in the new company 
without any go-forward operational or financial obligations for these 
programs."

Stifel is acting as financial advisor to Cyclerion; Hughes Hubbard & Reed LLP 
is serving as legal counsel to the Board and the Company.

About Cyclerion Therapeutics

Cyclerion Therapeutics is a clinical-stage biopharmaceutical company on a 
mission to develop treatments for serious diseases. Cyclerion's portfolio 
includes novel sGC stimulators that modulate a key node in a fundamental 
signaling network in both the CNS and the periphery. The multidimensional 
pharmacology elicited by the stimulation of sGC has the potential to impact a 
broad range of diseases. Zagociguat is a CNS-penetrant sGC stimulator that has 
shown rapid improvements across a range of endpoints reflecting multiple 
domains of disease activity, including mitochondrial disease-associated 
biomarkers. CY3018 is a CNS-targeted sGC stimulator in preclinical development 
that preferentially localizes to the brain and has a pharmacology profile that 
suggests its potential for the treatment of neuropsychiatric diseases and 
disorders. Praliciguat is a systemic sGC stimulator that is licensed to Akebia 
and being advanced in rare kidney disease. Olinciguat is a vascular sGC 
stimulator that the Company intends to out-license for cardiovascular 
diseases. For more information about Cyclerion, please visit

https://www.cyclerion.com/

and follow us on Twitter

(
@Cyclerion
)

and LinkedIn

(
www.linkedin.com/company/cyclerion
).
-------------------------------------------------------------------------------
Forward Looking Statement

Certain matters discussed in this press release are "forward-looking 
statements". We may, in some cases, use terms such as "predicts," "believes," 
"potential," "continue," "estimates," "anticipates," "expects," "plans," 
"intends," "may," "could," "might," "will," "should", "positive" or other 
words that convey uncertainty of future events or outcomes to identify these 
forward-looking statements. In particular, the Company's statements regarding 
the potential of zagociguat and CY3018 for the treatment of mitochondrial and 
CNS diseases, the potential for any successful development of zagociguat or 
CY3018, any future value creation to the Company from the sale, all of which 
depend on the successful development, commercialization and/or sales relating 
to zagociguat and CY3018 (which cannot be assured and is not in the Company's 
control), and other trends and potential future results are examples of such 
forward-looking statements. The forward-looking statements include risks and 
uncertainties, including, but not limited to, the risks that the Company may 
never successfully close the referenced transactions, that if completed, the 
referenced transactions may not be successful in generating future value for 
Cyclerion shareholders,

that zagociguat and CY3018 may not demonstrate the desired safety and efficacy 
in ongoing and future clinical trials, the ability of the new company to 
successfully develop and/or commercialize zagociguat and CY3018, and the 
receipt of regulatory approvals. The factors discussed herein could cause 
actual results and developments to be materially different from those 
expressed in or implied by such statements. The forward-looking statements are 
made only as of the date of this press release and the Company undertakes no 
obligation to publicly update such forward-looking statements to reflect 
subsequent events or circumstance.

* MELAS (Mitochondrial
Encephalopathy
, Lactic Acidosis, and Stroke-like episodes syndrome)

Investors and Media Inquiries

Cyclerion Investor Relations
Phone: 857-327-8778
Email: IR@cyclerion.com

                                      ###                                       
-------------------------------------------------------------------------------
-------------------------------------------------------------------------------
                                                                    Exhibit 99.2


      Cyclerion Announces Corporate Updates and Q1 2023 Financial Results       

 Definitive agreement reached with new company ("NewCo") established by certain 
                    Cyclerion shareholders and new investors                    

 Cyclerion to receive $8M in cash and 10% equity in NewCo in exchange for its   
                          zagociguat and CY3018 assets                          

     Definitive agreement signing triggers previously announced $5M equity      
                            investment in Cyclerion                             

 Cyclerion CEO Peter Hecht Ph.D. to lead NewCo while continuing to serve on the 
          Cyclerion board as one of the company's largest shareholders          

Biopharma executive Errol De Souza Ph.D. elected as chair of the Cyclerion board

CAMBRIDGE, Mass., May 11, 2023
- Cyclerion Therapeutics, Inc. (Nasdaq: CYCN) today announced corporate 
updates and first quarter 2023 financial results.

Definitive Agreement Signed

On May 11, 2023 Cyclerion entered into a definitive agreement to sell two of 
its sGC* stimulator assets, zagociguat (formerly CY6463) and CY3018, to a new 
private company ("NewCo") formed by certain current Cyclerion shareholders and 
new investors who have agreed to invest $81M to advance these assets. Under 
the terms of the agreement, Cyclerion will receive an $8M cash payment at 
closing, reimbursement for all expenses related to zagociguat and CY3018 for 
the period between signing and closing of the transaction, and 10% equity 
ownership in NewCo that is subject to anti-dilution protection through $100M 
in post-money valuation.  Cyclerion will also have additional future equity 
purchase rights in NewCo.  The transaction is subject to approval by Cyclerion 
shareholders and, once completed, will enable the assets to be developed in 
NewCo with the capital and capabilities to advance them while giving Cyclerion 
shareholders the opportunity to participate in future value creation without 
having the obligation to make direct investments and take on the risk of these 
early-stage programs.

Go Forward Strategy

Previously, Cyclerion out-licensed the peripherally active sGC stimulator 
praliciguat to Akebia Therapeutics, Inc. ("Akebia"), a leading biopharmaceutical
 company focused on kidney disease. Under the terms of that agreement, the 
Company is eligible to receive up to $585M in development, regulatory, and 
commercialization milestones, as well as sales-based royalties. Cyclerion 
retains full rights to olinciguat, an oral, once-daily, peripheral sGC 
stimulator, that has shown a favorable safety and tolerability profile, drug 
characteristics, and dose-dependent pharmacological activity in several 
placebo controlled clinical studies.  Olinciguat has a strong patent estate 
with intellectual property exclusivity to the late 2030s.  sGC stimulators are 
now approved for PAH** and HFrEF*** (both multibillion dollar opportunities).  
In similar fashion to today's transaction and the Akebia license, Cyclerion 
intends to identify a partner with deep cardiovascular experience to maximize 
olinciguat's value while minimizing distraction and operating expense.
-------------------------------------------------------------------------------
These external development deals make up a growing diverse portfolio of upside 
value for our shareholders and the potential for non-dilutive funds from 
upfront and milestone payments and/or monetization of equity positions and 
royalties. The externalization of the initial sGC assets means that Cyclerion 
now has the opportunity to bring in new assets to develop using its highly 
efficient and externalized model. The Company will initially target assets in 
the CNS therapeutic area that are at a later stage of development and can be 
advanced to approval more quickly.

Upon approval of the current transaction by Cyclerion shareholders, Peter 
Hecht will transition out of his Cyclerion CEO role and join NewCo as its CEO. 
Dr. Hecht, a major Cyclerion shareholder, will continue to serve as a 
Cyclerion Director.  Cyclerion has initiated a search to bring in a new leader 
to drive the company's strategy going forward.

Board of Directors

Current independent board member Errol De Souza has been elected to serve as 
the chair of the Cyclerion Board effective immediately. Dr. De Souza is a 
seasoned R&D and business leader with broad experience - from large pharma to 
start ups - in the discovery and development of therapeutics for the treatment 
of CNS disorders.

"I am excited to have a unique platform from which to exercise my passion for 
finding underappreciated and undervalued neuro assets.  I've been fortunate to 
have had multiple successful opportunities to uncover important neuro 
therapies through approval that are having profound impacts on patients' 
lives, and I've done so in a variety of circumstances, including small 
biotechs" said Errol De Souza, Chair of the Cyclerion Board of Directors. "I 
am looking forward to the opportunity to take learnings from each of those and 
apply them to Cyclerion alongside a group of supportive, long-term, core 
investors."

ADv Study Results

Cyclerion recently completed the analysis of its signal-seeking clinical study 
of zagociguat for the potential treatment of Alzheimer's disease with vascular 
pathology (ADv) (NCT04798989). This exploratory, randomized, placebo-controlled,
 study of oral once-daily zagociguat was designed to evaluate safety, 
tolerability, and pharmacokinetics as well as explore the impact on biomarkers 
and cognitive performance over a twelve-week dosing period. The total number 
of participants in the study was capped at 12 participants due to challenges 
associated with enrollment. Data from this study show that the safety and 
tolerability profile of once-daily zagociguat was consistent with prior 
studies. Given the small number of participants Cyclerion is unable to draw 
any conclusions from the data generated in the study.

Equity Investment

Signing of the definitive agreement today triggered the previously announced 
$5M equity investment by CEO Peter Hecht. This investment will take place on 
May 19, 2023 and Hecht will receive a mix of common stock and nonvoting 
convertible preferred stock of Cyclerion at a minimum purchase price of $0.434 
per share, subject to adjustment for any reverse stock split or similar event. 
 The proceeds from this investment and the $8M upfront from the sale of 
zagociguat and CY3018 are expected to support ongoing operations for at least 
12 months post-closing of the transaction.
-------------------------------------------------------------------------------
Financial Position


 . Cash, cash equivalents, and restricted cash balance on March 31, 2023 was approximately
   $7.2 million, as compared to approximately $13.4 million on December 31, 2022.         



 . Research and development expenses were approximately $3.8 million for Q1 2023, as compared to approximately          
   $9.7 million for Q1 2022. The decrease of approximately $6.0 million was primarily driven by decreases of $3.1       
   million in external research and development costs related to zagociguat and CY3018, $1.6 million in employee-related
   expenses, $0.6 million in non-cash stock-based compensation, and $0.6 million in professional services.              



 . General and administrative expenses were approximately $3.3 million for Q1 2023, as compared to approximately $4.0 million for
   Q1 2022. The decrease of approximately $0.7 million was primarily driven by a decrease in non-cash stock-based compensation.  



 . Net Loss: Net loss was approximately $7.0 million for Q1 2023, as compared to approximately $13.0 million for Q1 2022.


About Cyclerion Therapeutics

Cyclerion Therapeutics is a clinical-stage biopharmaceutical company on a 
mission to develop treatments for serious diseases. Cyclerion's portfolio 
includes novel sGC stimulators that modulate a key node in a fundamental 
signaling network in both the CNS and the periphery. The multidimensional 
pharmacology elicited by the stimulation of sGC has the potential to impact a 
broad range of diseases. Zagociguat is a CNS-penetrant sGC stimulator that has 
shown rapid improvements across a range of endpoints reflecting multiple 
domains of disease activity, including mitochondrial disease-associated 
biomarkers. CY3018 is a CNS-targeted sGC stimulator in preclinical development 
that preferentially localizes to the brain and has a pharmacology profile that 
suggests its potential for the treatment of neuropsychiatric diseases and 
disorders. Praliciguat is a systemic sGC stimulator that is licensed to Akebia 
and being advanced in rare kidney disease. Olinciguat is a vascular sGC 
stimulator that the Company intends to out-license for cardiovascular 
diseases. For more information about Cyclerion, please visit
https://www.cyclerion.com/
and follow us on Twitter (
@Cyclerion
) and LinkedIn (
www.linkedin.com/company/cyclerion
).
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Forward Looking Statement

Certain matters discussed in this press release are "forward-looking 
statements". We may, in some cases, use terms such as "predicts," "believes," 
"potential," "continue," "estimates," "anticipates," "expects," "plans," 
"intends," "may," "could," "might," "will," "should", "positive" or other 
words that convey uncertainty of future events or outcomes to identify these 
forward-looking statements. In particular, the Company's statements regarding 
the assessment of the best combination of capital, capabilities, and 
transactions  available to it resulting in the Company pursuing a transaction 
or that any transaction, if pursued, will be completed on attractive terms, 
the success of any such potential transactions in delivering any future value 
to the Company, the sufficiency of any expected revenues to provide liquidity 
and capital resources to pursue any of our go-forward business plans regarding 
any product candidate, the potential for zagociguat in the treatment of 
mitochondrial diseases, the potential for CY3018 in the treatment of CNS 
diseases, the potential for olinciguat in the treatment of cardiovascular and 
cardiopulmonary diseases, the potential for any successful development of any 
of our assets, and other trends and potential future results are examples of 
such forward-looking statements. The forward-looking statements include risks 
and uncertainties, including, but not limited to, the success of any 
transactions in delivering any future value to the company, our ability to 
succeed with any go-forward business, the sufficiency of any expected proceeds 
to provide liquidity and capital resources to pursue any of our go-forward 
business plans regarding any product candidate (including without limitation 
our ability to fund additional clinical trials); any ability to successfully 
demonstrate the efficacy, safety and therapeutic effectiveness of any product 
candidate; any results of clinical studies not necessarily being indicative of 
or supported by the final results of subsequent clinical trials; the timing of 
and ability to pursue, obtain and maintain U.S. Food and Drug Administration 
("FDA") or other regulatory authority approval of, or other action with 
respect to, product candidates; the Company's ability to successfully defend 
its intellectual property or obtain necessary licenses at a cost acceptable to 
the Company, if at all; the successful implementation of the Company's 
research and development programs and collaborations; the success of the 
Company's license agreements; the acceptance by the market of the product 
candidates, if approved; and other factors, including general economic 
conditions and regulatory developments, not within the Company's control. The 
factors discussed herein could cause actual results and developments to be 
materially different from those expressed in or implied by such statements. 
The forward-looking statements are made only as of the date of this press 
release and the Company undertakes no obligation to publicly update such 
forward-looking statements to reflect subsequent events or circumstance.

* sGC (Soluble guanylate cyclase)

** PAH (Pulmonary arterial hypertension)

***

HFrEF (Heart failure with reduced ejection fraction)

Investors and Media Inquiries

Cyclerion Investor Relations
Phone: 857-327-8778
Email: IR@cyclerion.com

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