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                                 UNITED STATES                                  
                       SECURITIES AND EXCHANGE COMMISSION                       
                             Washington, D.C. 20549                             
                            ________________________                            

                                                                                
                                      FORM                                      
                                      8-K                                       

                            ________________________                            
                                                                                
                                 CURRENT REPORT                                 
     Pursuant to Section 13 or 15(d) of TheSecurities Exchange Act of 1934      
                                                                                
               Date of Report (Date of earliest event reported):                
                                  May 11, 2023                                  

                            ________________________                            
                                                                                
                            Xenetic Biosciences,Inc.                            
               (Exact name of registrant as specified in charter)               
                                                                                

           Nevada              001-37937        45-2952962     
(State or other jurisdiction   (Commission     (IRS Employer   
     of incorporation)        File Number)  Identification No.)

                                                                                

           945 Concord Street                      
               Framingham                  01701   
                   ,                               
             Massachusetts                         
(Address of principal executive offices) (Zip Code)

                                                                                
                                     (781)                                      
                                    778-7720                                    

              (Registrant's telephone number, includingarea code)               
                                                                                
                                 Not Applicable                                 

          (Former name or former address, if changed sincelast report)          

Check the appropriate box below if theForm 8-K is intended to simultaneously 
satisfy the filing obligation of the registrant under any of the following 
provisions (
see
General Instruction A.2. below):


Written communicationspursuant to Rule 425 under the Securities Act (17 CFR 
230.425)


Soliciting materialpursuant to Rule 14a-12 under the Exchange Act (17 CFR 
240.14a-12)


Pre-commencementcommunications pursuant to Rule 14d-2(b) under the Exchange 
Act (17 CFR 240.14d-2(b))


Pre-commencementcommunications pursuant to Rule 13e-4(c) under the Exchange 
Act (17 CFR 240.13e-4(c))

           Securities registered pursuant to Section 12(b)of the Act:           
                                                                                

          Title of each class             Trading Symbol(s)  Name of each exchange on which registered
Common Stock, $0.001 par value per share        XBIO                  The Nasdaq Stock Market         
           Purchase Warrants                    XBIOW                 TheNasdaq Stock Market          


Indicate by check mark whether the registrantis an emerging growth company as 
defined in Rule 405 of the Securities Act of 1933 (17 CFR (s)230.405) or Rule 
12b-2 of the SecuritiesExchange Act of 1934 (17 CFR (s)240.12b-2).
                                                         Emerging growth company
                                                                                

If an emerging growth company, indicate by checkmark if the registrant has 
elected not to use the extended transition period for complying with any new 
or revised financial accountingstandards provided pursuant to Section 13(a) of 
the Exchange Act.





  





Item 3.03. Material Modification to Rights of Security Holders.


To the extent required by Item 3.03 of Form 8-K,the information set forth in 
Item 5.03 herein is incorporated herein by reference.


Item 5.03. Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year.


Pursuant to the approval of the Company'sBoard of Directors (the "Board") and 
the Financing Committee of the Board, on May 11, 2023, Xenetic Biosciences, 
Inc. (the"Company") filed a Certificate of Change to the Company's Articles of 
Incorporation (the "Change") withthe Secretary of State of the State of Nevada 
to effect a one-for-ten reverse stock split of its authorized, issued and 
outstanding commonstock (the "Reverse Stock Split"). Pursuant to NRS 78.207, 
no consent or approval of the stockholders is required for theReverse Stock 
Split.

The Change and the Reverse Stock Split will beeffective at 12:01 a.m., Eastern 
Time, on May 15, 2023 (the "Effective Time") pursuant to the terms of the 
Change. At theEffective Time, the total number of shares of common stock, par 
value $0.001 per share ("Common Stock"), authorized by theCompany will be 
reduced from 100,000,000 shares of Common Stock to 10,000,000 shares of Common 
Stock, and the total number of shares ofCommon Stock issued and outstanding 
will be reduced from 15,166,596 shares of Common Stock to approximately 
1,516,660 shares of CommonStock (subject to adjustment due to the effect of 
rounding fractional shares up to the nearest whole share). No fractional 
shares willbe issued as a result of the Reverse Stock Split. Any fractional 
shares that would result from the Reverse Stock Split will be roundedup to the 
nearest whole share.

All shares of the Company's Common Stocksubject to all outstanding equity 
awards and the exercise price of any such award (if applicable) and the number 
of shares remaining availablefor issuance under the Amended and Restated 
Xenetic Biosciences, Inc. Equity Incentive Plan, and all shares underlying 
outstanding preferredstock, warrants and other derivative securities of the 
Company, including exercise prices and conversion rates (if applicable) will 
beproportionately adjusted for the Reverse Stock Split.

The Company expects that upon the opening of tradingon May 15, 2023, its 
Common Stock will trade on the Nasdaq Capital Market on a split-adjusted basis 
under the current trading symbol "XBIO"and the new CUSIP number 984015 602. A 
copy of the Certificate of Change is filed as Exhibit 3.1 to this Current 
Report on Form 8-K andincorporated herein by reference.


Item 7.01. Regulation FD Disclosure.


On May 12, 2023, the Company issued a press releaseannouncing the Reverse 
Stock Split. The full text of the press release is furnished as Exhibit 99.1 
to this Current Report on Form 8-Kand hereby incorporated herein by reference. 
The information in this Item 7.01, including Exhibit 99.1 attached hereto, 
shall not be deemed"filed" for the purposes of Section 18 of the Exchange Act, 
or otherwise subject to the liabilities of that section, nor shallit be deemed 
incorporated by reference in any filing under the
Exchange Act
or the
Securities Act of 1933
,as amended, except as shall be expressly set forth by specific reference in 
such a filing.







 2 



FORWARD LOOKING STATEMENTS

This Form 8-K, including the press release, containsforward-looking statements 
that we intend to be subject to the safe harbor provisions of the Private 
Securities Litigation Reform Actof 1995. All statements contained in this Form 
8-K, including the press release, other than statements of historical facts 
may constituteforward-looking statements within the meaning of the federal 
securities laws. These statements can be identified by words such as 
"expects,""plans," "projects," "will," "may," "anticipates," "believes,""should,
" "intends," "estimates," and other words of similar meaning. Any 
forward-looking statementscontained herein are based on current expectations, 
and are subject to a number of risks and uncertainties. Many factors could 
cause ouractual activities, performance, achievements or results to differ 
materially from the activities and results anticipated in forward-lookingstateme
nts. These risks and uncertainties include those described in the "Risk 
Factors" section as detailed from time to timein the Company's reports filed 
with the Securities and Exchange Commission ("SEC"), including the Company's 
annualreport on Form 10-K, periodic quarterly reports on Form 10-Q, current 
reports on Form 8-K and other documents filed with the SEC. In addition,forward-
looking statements may also be adversely affected by general market factors, 
general economic and business conditions, includingpotential adverse effects 
of public health issues, such as the COVID-19 outbreak (including any new 
variant strains of the underlyingvirus), geopolitical events, such as the 
Russian invasion of Ukraine, and financial market instability or disruptions 
to the banking systemdue to bank failures, on economic activity, competitive 
product development, product availability, federal and state regulations and 
legislation,the regulatory process for new product candidates and indications, 
manufacturing issues that may arise, patent positions and litigation,among 
other factors. The forward-looking statements contained in this Form 8-K, 
including the press release, speak only as of the datethe statements were 
made, and the Company does not undertake any obligation to update 
forward-looking statements, except as required bylaw.




Item 9.01. Financial Statements and Exhibits.


(d) Exhibits


Exhibit No.  Description                                                                 
3.1          Certificate of Change to Articles of Incorporation                          
             .                                                                           
99.1         Press Release dated May 12, 2023.                                           
104          Cover Page Interactive Data File (embedded within the Inline XBRL document).









 3 




                                   SIGNATURES                                   

Pursuant to the requirementsof the Securities Exchange Act of 1934, the 
registrant has duly caused this report to be signed on its behalf by the 
undersigned hereuntoduly authorized.


                   XENETIC BIOSCIENCES, INC.         
                                                     
                   By:                               
                   /s/ James Parslow                 
Date: May 12, 2023 Name:   James Parslow             
                   Title:     Chief Financial Officer









 4 

Exhibit 3.1



Business Number E0450492011 - 8 Filed in the Office of Secretary of State 
State Of Nevada Filing Number 20233191096 Filed On 5/11/2023 8:58:00 AM Number 
of Pages 1

Exhibit 99.1






     Xenetic Biosciences,Inc. Announces Reverse Stock Split of Common Stock     
                                                                                
FRAMINGHAM,MA - (May 12, 2023)
-
Xenetic Biosciences, Inc. (NASDAQ: XBIO) ("Xenetic"or the "Company"), a 
biopharmaceutical company focused on advancing innovative immune-oncology 
technologies addressing hardto treat cancers,
today announced it will effect a one-for-ten reverse stock split of its 
authorized, issued and outstanding commonstock. Pursuant to the Certificate of 
Change filed with the Secretary of State of the State of Nevada, the reverse 
stock split will beeffective at 12:01 a.m., Eastern Time, on May 15, 2023. 
Xenetic expects that upon the opening of trading on May 15, 2023, its common 
stockwill trade on the Nasdaq Capital Market on a split-adjusted basis under 
the current trading symbol "XBIO" and the new CUSIPnumber 984015 602.

No fractional shares will be issued as a resultof the reverse stock split. Any 
fractional shares that would result from the reverse stock split will be 
rounded up to the nearest wholeshare.

Stockholders of record are not required to sendin their current stock 
certificates or evidence of book-entry or other electronic positions for 
exchange. Following the effectivenessof the reverse stock split, each stock 
certificate and book-entry or other electronic position representing issued 
and outstanding sharesof Xenetic's common stock will be automatically 
adjusted. Those stockholders holding common stock in "street name" will 
receiveinstructions from their brokers if they need to take any action in 
connection with the reverse stock split. Stockholders should directany 
questions concerning the reverse stock split to their broker or Xenetic's 
transfer agent and registrar, Empire Stock Transfer, Inc.,at info@empirestock.co
m.

About Xenetic Biosciences

Xenetic Biosciences, Inc. is a biopharmaceuticalcompany focused on advancing 
innovative immune-oncology technologies addressing hard to treat cancers. The 
Company's DNase platform isdesigned to improve outcomes of existing 
treatments, including immunotherapies, by targeting neutrophil extracellular 
traps (NETs), whichhave been implicated in cancer progression and resistance 
to cancer treatments. Xenetic is currently focused on advancing its 
systemicDNase program into the clinic as an adjunctive therapy for pancreatic 
carcinoma and locally advanced or metastatic solid tumors.

For more information, please visit the Company's website at
www.xeneticbio.com andconnect on Twitter, LinkedIn, and Facebook.

















 1 







Forward-Looking Statements

This press release contains forward-looking statementsthat we intend to be 
subject to the safe harbor provisions of the Private Securities Litigation 
Reform Act of 1995. All statements containedin this press release other than 
statements of historical facts may constitute forward-looking statements 
within the meaning of the federalsecurities laws. These statements can be 
identified by words such as "expects," "plans," "projects," "will,""may," 
"anticipates," "believes," "should," "intends," "estimates," and otherwords of 
similar meaning, including, but not limited to, statements regarding: our 
expectation that upon the opening of trading on May15, 2023, our common stock 
will trade on the Nasdaq Capital Market on a split-adjusted basis; all 
statements regarding expectations forour DNase-base oncology platform, 
including the DNase platform improving outcomes of existing treatments, 
including immunotherapies, bytargeting neutrophil extracellular traps (NETs), 
which have been implicated in cancer progression and resistance to cancer 
treatments,and our focus on advancing our systemic DNase program into the 
clinic as an adjunctive therapy for pancreatic carcinoma and locally 
advancedor metastatic solid tumors. Any forward-looking statements contained 
herein are based on current expectations, and are subject to a numberof risks 
and uncertainties. Many factors could cause our actual activities, 
performance, achievements, or results to differ materiallyfrom the activities 
and results anticipated in forward-looking statements. Important factors that 
could cause actual activities, performance,achievements, or results to differ 
materially from such plans, estimates or expectations include, among others, 
(1) unexpected costs,charges or expenses resulting from our manufacturing and 
collaboration agreements; (2) unexpected costs, charges or expenses 
resultingfrom the licensing of the DNase platform; (3) uncertainty of the 
expected financial performance of the Company following the licensingof the 
DNase platform; (4) failure to realize the anticipated potential of the DNase, 
XCART or PolyXen technologies; (5) the ability ofthe Company to implement its 
business strategy; and (6) other risk factors as detailed from time to time in 
the Company's reports filedwith the SEC, including its annual report on Form 
10-K, periodic quarterly reports on Form 10-Q, current reports on Form 8-K and 
otherdocuments filed with the SEC. The foregoing list of important factors is 
not exclusive. In addition, forward-looking statements may alsobe adversely 
affected by general market factors, general economic and business conditions, 
including potential adverse effects of publichealth issues, such as the 
COVID-19 outbreak, and geopolitical events, such as the Russian invasion of 
Ukraine, on economic activity,competitive product development, product 
availability, federal and state regulations and legislation, the regulatory 
process for new productcandidates and indications, manufacturing issues that 
may arise, patent positions and litigation, among other factors. The 
forward-lookingstatements contained in this press release speak only as of the 
date the statements were made, and the Company does not undertake 
anyobligation to update forward-looking statements, except as required by law.



Contact
:

JTC Team, LLC
Jenene Thomas
(833) 475-8247
xbio@jtcir.com






 2 





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