FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
HEATH JAMES R
  2. Issuer Name and Ticker or Trading Symbol
IsoPlexis Corp [ISO] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
C/O ISOPLEXIS CORPORATION, 35 NE INDUSTRIAL ROAD		 3. Date of Earliest Transaction (Month/Day/Year)
03/10/2023
(Street)

BRANFORD, CT 06405		 4. If Amendment, Date Original Filed (Month/Day/Year)
 6. Individual or Joint/Group Filing (Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3) 		2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8) 		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4) 		6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4) 		7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 03/10/2023   M   81,888 A $ 0.1275 81,888 D  
Common Stock 03/10/2023   M   32,000 A $ 0.2788 113,888 D  
Common Stock 03/10/2023   M   40,000 A $ 0.44 153,888 D  
Common Stock 03/10/2023   M   48,000 A $ 0.7263 201,888 D  

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3) 		2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8) 		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5) 		6. Date Exercisable and Expiration Date
(Month/Day/Year) 		7. Title and Amount of Underlying Securities
(Instr. 3 and 4) 		8. Price of Derivative Security
(Instr. 5) 		9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4) 		10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4) 		11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option $ 0.1275 03/10/2023   M     81,888   (1) 03/21/2025 Common Stock 81,888 $ 0 0 D  
Stock Option $ 0.2788 03/10/2023   M     32,000   (2) 11/25/2025 Common Stock 32,000 $ 0 0 D  
Stock Option $ 0.44 03/10/2023   M     40,000   (3) 08/17/2026 Common Stock 40,000 $ 0 0 D  
Stock Option $ 0.7263 03/10/2023   M     48,000   (4) 09/30/2027 Common Stock 48,000 $ 0 0 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
HEATH JAMES R
C/O ISOPLEXIS CORPORATION
35 NE INDUSTRIAL ROAD
BRANFORD, CT 06405		   X      

Signatures

 /s/James R. Heath   03/10/2023
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) (1) 25% vested March 22, 2016 and the reminder vested in 36 monthly installments thereafter.
(2) (2) 25% vested November 26, 2016 and the reminder vested in 36 monthly installments thereafter.
(3) (3) 25% vested August 18, 2017 and the reminder vested in 36 monthly installments thereafter.
(4) (4) 25% vested October 1, 2018 and the reminder vested in 36 monthly installments thereafter.

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