As filed with the Securities and Exchange Commission on March 14, 2023

Registration No. 333-          

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM S-8

Registration Statement

Under The Securities Act of 1933

JOUNCE THERAPEUTICS, INC.

(Exact name of registrant as specified in its charter)

Delaware (State or other jurisdiction of incorporation or organization)						45‑4870634 (I.R.S. Employer Identification No.)
780 Memorial Drive Cambridge, Massachusetts (Address of principal executive offices)						02139 (Zip Code)
Jounce Therapeutics, Inc. 2017 Stock Option and Incentive Plan Jounce Therapeutics, Inc. 2017 Employee Stock Purchase Plan (Full title of the plan)

______________________________________________________________________________________________________

Richard Murray, Ph.D. Chief Executive Officer and President Jounce Therapeutics, Inc. 780 Memorial Drive Cambridge, Massachusetts 02139 (Name and address of agent for service)
(857) 259-3840 (Telephone number, including area code, for agent for service)

________________________________________________________________________________________________________

     

    Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non‑accelerated filer, smaller reporting company, or an emerging growth company. See definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b‑2 of the Exchange Act.

Large accelerated filer			¨			Accelerated filer			¨
Non‑accelerated filer			x			Smaller reporting company			x
						Emerging growth company			¨

    If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ¨  

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STATEMENT OF INCORPORATION BY REFERENCE

This Registration Statement on Form S-8 is being filed to register an additional 2,067,769 shares of Common Stock, par value $0.001 per share (the “Common Stock”), of Jounce Therapeutics, Inc. (the “Registrant”) issuable under the Registrant's 2017 Stock Option and Incentive Plan (the “2017 Option Plan”) and an additional 516,942 shares of Common Stock issuable under the Registrant's 2017 Employee Stock Purchase Plan (the “2017 ESPP”). Pursuant to General Instruction E to Form S-8, except as otherwise set forth below, this Registration Statement on Form S-8 incorporates by reference the contents of:

•the Registration Statement on Form S-8, File No. 333-215794, filed by the Registrant with the Securities and Exchange Commission on January 27, 2017 relating to the 2017 Option Plan and 2017 ESPP, except for Item 8, Exhibits;

•the Registration Statement on Form S-8, File No. 333-223519, filed by the Registrant with the Securities and Exchange Commission on March 8, 2018 relating to the 2017 Option Plan and 2017 ESPP, except for Item 8, Exhibits;

•the Registration Statement on Form S-8, File No. 333-230088, filed by the Registrant with the Securities and Exchange Commission on March 6, 2019 relating to the 2017 Option Plan and 2017 ESPP, except for Item 8, Exhibits;

•the Registration Statement on Form S-8, File No. 333-236687, filed by the Registrant with the Securities and Exchange Commission on February 27, 2020 relating to the 2017 Option Plan and 2017 ESPP, except for Item 8, Exhibits;

•the Registration Statement on Form S-8, File No. 333-253496, filed by the Registrant with the Securities and Exchange Commission on February 25, 2021 related to the 2017 Option Plan and 2017 ESPP, except for Item 8, Exhibits; and

•the Registration Statement on Form S-8, File No. 333-263215, filed by the Registrant with the Securities and Exchange Commission on March 2, 2022 related to the 2017 Option Plan, 2017 ESPP and Stock Option Inducement Award, except for Item 8, Exhibits.

PART II

INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 8. Exhibits.

Exhibit No.						Description of Exhibit
4.1						Fourth Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 of the Registrant’s Annual Report on Form 10-K (File No. 001-37998) filed March 8, 2018)
4.2						Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.2 of the Registrant’s Annual Report on Form 10-K (File No. 001-37998) filed March 8, 2018)
4.3						Specimen Common Stock Certificate (incorporated by reference to Exhibit 4.1 of the Registrant’s Registration Statement on Form S-1 (File No. 333-215372) filed December 30, 2016)
5.1						Opinion of Wilmer Cutler Pickering Hale and Dorr LLP, counsel to the Registrant
23.1						Consent of Wilmer Cutler Pickering Hale and Dorr LLP (included in Exhibit 5.1)
23.2						Consent of Ernst & Young LLP, independent registered public accounting firm
24.1						Power of Attorney (included on the signature page of this registration statement)
99.1						Jounce Therapeutics, Inc. 2017 Stock Option and Incentive Plan (incorporated by reference to Exhibit 10.1 to the Registrant’s Registration Statement on Form S-1/A (File No. 333-215372) filed January 17, 2017)
99.2						Jounce Therapeutics, Inc. 2017 Employee Stock Purchase Plan, as amended (incorporated by reference to Exhibit 10.1 to the Registrant’s Quarterly Report on Form 10-Q (File No. 001-37998) filed November 13, 2017)
107*						Filing Fee Table
*						Filed herewith

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SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Cambridge, Commonwealth of Massachusetts on this 10th day of March, 2023.

						JOUNCE THERAPEUTICS, INC.
			By:			/s/ Richard Murray
						Richard Murray, Ph.D.
						President and Chief Executive Officer

POWER OF ATTORNEY AND SIGNATURES

We, the undersigned officers and directors of Jounce Therapeutics, Inc., hereby severally constitute and appoint Richard Murray and Kim C. Drapkin and each of them singly, our true and lawful attorneys with full power to them, and each of them singly, to sign for us and in our names in the capacities indicated below, the registration statement on Form S-8 filed herewith and any and all subsequent amendments to said registration statement, and generally to do all such things in our names and on our behalf in our capacities as officers and directors to enable Jounce Therapeutics, Inc. to comply with the provisions of the Securities Act of 1933, as amended, and all requirements of the Securities and Exchange Commission, hereby ratifying and confirming our signatures as they may be signed by our said attorneys, or any of them, to said registration statement and any and all amendments thereto.

Pursuant to the requirements of the Securities Act of 1933, as amended, this registration statement has been signed by the following persons in the capacities and on the dates indicated.

Signature

Title

Date

/s/ Richard Murray

President, Chief Executive Officer and Director (Principal Executive Officer)

March 10, 2023

Richard Murray, Ph.D.

/s/ Kim C. Drapkin

Treasurer and Chief Financial Officer (Principal Financial and Accounting Officer)

March 10, 2023

Kim C. Drapkin

/s/ Jigar Raythatha

Chairman of the Board of Directors

March 10, 2023

Jigar Raythatha

/s/ Luis A. Diaz, Jr.

Director

March 10, 2023

Luis A. Diaz, Jr., M.D.

/s/ Barbara Duncan

Director

March 10, 2023

Barbara Duncan

/s/ Robert Iannone

Director

March 10, 2023

Robert Iannone, M.D., M.S.C.E.

/s/ Robert Kamen

Director

March 10, 2023

Robert Kamen, Ph.D.

/s/ Perry Karsen

Director

March 10, 2023

Perry Karsen

/s/ Luisa Salter-Cid

Director

March 10, 2023

Luisa Salter-Cid, Ph.D.

Exhibit 107

Calculation of Filing Fee Table

Form S-8

(Form Type)

Jounce Therapeutics, Inc.

(Exact Name of Registrant as Specified in its Charter)

Newly Registered Securities

Security Type

Security Class Title

Fee Calculation Rule

Amount Registered(1)

Proposed Maximum Offering Price Per Unit

Maximum Aggregate Offering Price

Fee Rate

Amount of Registration Fee

Equity

Common Stock, par value $0.001 per share

Other

2,584,711(2)

$1.016(3)

$2,626,066.38

$110.20 per $1,000,000

$289.39

Total Offering Amounts

$2,626,066.38

$289.39

Total Fee Offsets

$0.00

Net Fee Due

$289.39

(1)In accordance with Rule 416(c) under the Securities Act of 1933, as amended (the "Securities Act"), this registration statement shall be deemed to cover any additional securities that may from time to time be offered or issued to prevent dilution resulting from stock splits, stock dividends or similar transactions.

(2)Consists of 2,067,769 shares of Common Stock authorized for issuance under the Jounce Therapeutics, Inc. 2017 Stock Option and Incentive Plan and 516,942 shares of Common Stock authorized for issuance under the Jounce Therapeutics, Inc. 2017 Employee Stock Purchase Plan, as amended.

(3)Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and 457(h) of the Securities Act and based upon the average of the high and low prices of the Registrant’s Common Stock as reported on the Nasdaq Global Select Market on March 8, 2023.

Exhibit 5.1

March 10, 2023

Jounce Therapeutics, Inc.

780 Memorial Drive

Cambridge, MA 02139

Re: Registration Statement on Form S-8; 2017 Stock Option and Incentive Plan; 2017 Employee Stock Purchase Plan

Ladies and Gentlemen:

We have assisted in the preparation of a Registration Statement on Form S-8 (the “Registration Statement”) to be filed with the Securities and Exchange Commission (the “Commission”) under the Securities Act of 1933, as amended (the “Securities Act”), relating to (i) an aggregate of 2,067,769 shares (the “Plan Shares”) of common stock, $0.001 par value per share (the “Common Stock”), of Jounce Therapeutics, Inc., a Delaware corporation (the “Company”), issuable under the Company’s 2017 Stock Option and Incentive Plan (the “2017 Plan”) and (ii) an aggregate of 516,942 shares (the “ESPP Shares,” and together with the Plan Shares, the “Shares”) of Common Stock of the Company pursuant to the Company’s 2017 Employee Stock Purchase Plan (together with the 2017 Plan, the “Plans”).

We have examined the Certificate of Incorporation and By-Laws of the Company, each as amended and restated to date, and originals, or copies certified to our satisfaction, of all pertinent records of the meetings of the directors and stockholders of the Company, the Registration Statement and such other documents relating to the Company as we have deemed material for the purposes of this opinion.

In our examination of the foregoing documents, we have assumed the genuineness of all signatures, the authenticity of all documents submitted to us as originals, the conformity to original documents of all documents submitted to us as certified, photostatic or other copies, the authenticity of the originals of any such documents and the legal competence of all signatories to such documents.

We assume that the appropriate action will be taken, prior to the offer and sale of the Shares in accordance with the Plans, to register and qualify the Shares for sale under all applicable state securities or “blue sky” laws.

We express no opinion herein as to the laws of any state or jurisdiction other than the state laws of the Commonwealth of Massachusetts, the General Corporation Law of the State of Delaware and the federal laws of the United States of America.

It is understood that this opinion is to be used only in connection with the offer and sale of the Shares while the Registration Statement is in effect.

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Jounce Therapeutics, Inc.

March 10, 2023

Page 2

Please note that we are opining only as to the matters expressly set forth herein, and no opinion should be inferred as to any other matters.

Based on the foregoing, we are of the opinion that the Shares have been duly authorized for issuance and, when the Shares are issued and paid for in accordance with the terms and conditions of the Plans, the Shares will be validly issued, fully paid and nonassessable.

We hereby consent to the filing of this opinion with the Commission in connection with the Registration Statement in accordance with the requirements of Item 601(b)(5) of Regulation S-K under the Securities Act. In giving such consent, we do not hereby admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations of the Commission.

Very truly yours,

    

    

/s/ WILMER CUTLER PICKERING HALE AND DORR LLP        

WILMER CUTLER PICKERING HALE AND DORR LLP    

Exhibit 23.2

Consent of Independent Registered Public Accounting Firm

We consent to the incorporation by reference in the Registration Statement (Form S-8) pertaining to the Jounce Therapeutics, Inc. 2017 Stock Option and Incentive Plan and the Jounce Therapeutics, Inc. 2017 Employee Stock Purchase Plan of our report dated March 10, 2023, with respect to the consolidated financial statements of Jounce Therapeutics, Inc. included in its Annual Report (Form 10-K) for the year ended December 31, 2022, filed with the Securities and Exchange Commission.

/s/ Ernst & Young LLP                                                    

Boston, Massachusetts

March 10, 2023