Filed by Orthofix Medical Inc.
                                                                (Commission File
                                                                    No. 0-19961)
                           pursuant to Rule 425 under the Securities Act of 1933
                                               and deemed filed pursuant to Rule
                                                                          14a-12
                                       under the Securities Exchange Act of 1934
                                  Subject Company: SeaSpine Holdings Corporation
                                                                (Commission File
                                                                  No. 001-36905)


    
    

  Orthofix and SeaSpine Announce John Bostjancic to Serve as CFO for Combined   
                              Company Post Closing                              
Lewisville, Texas and Carlsbad, California -- November
18, 2022 --
Orthofix (NASDAQ: OFIX), a global medical device companywith a spine and 
orthopedics focus, and SeaSpine (NASDAQ: SPNE), a global medical technology 
company focused on surgical solutions for the treatment of spinal disorders, 
today announced that John Bostjancic will serve as Chief Financial 
Officer(CFO) for the new combined company, effective upon the completion of 
their pending merger.
Bostjancic currently serves as the CFO and Chief OperatingOfficer of SeaSpine, 
roles he has held since 2015 and 2022 respectively. Previously, Bostjancic 
served as Treasurer and Senior Vice President from 2015 through 2022, and as 
acting CFO of the SeaSpine business within Integra Life Sciences HoldingsCorpora
tion from 2014 through 2015; prior to that, he was the Senior Vice President 
of Global Supply Chain at Integra. Before joining Integra in 1999, he served 
on the accounting standards team at Merck & Co., Inc., a publicly traded 
healthcompany. Bostjancic began his career at PricewaterhouseCoopers in 1993. 
He holds a B.S. in accounting from the College of New Jersey.
"John has beena key leader of SeaSpine dating back to the successful
spin-out
of the organization in 2015. I am confident his background and experience in 
the medical device industry coupled with his cultural influence willbenefit 
the newly combined company as we continue to grow," said Keith Valentine, 
President and CEO of SeaSpine. "I believe John is well positioned to help lead 
us through the successful integration of the two companies, ensuringaccountabili
ty across all levels of the organization, as we focus on the key initiatives 
that will drive growth, scalability and shareholder value."
Doug Rice, current CFO of Orthofix will provide interim assistance 
post-closing of the expected transaction. He will assist with the integration 
and otheractivities during a transition period. Rice joined Orthofix in 2014 
and was instrumental in building talented teams and accelerating the company's 
strategic growth.
As previously announced on October 11, 2022, Orthofix and SeaSpine agreed to 
combine in an
all-stock
merger ofequals.
The transaction is expected to close in the first quarter of 2023 subject to 
Orthofix and SeaSpine shareholder approval and other customaryclosing 
conditions.
About Orthofix
Orthofix MedicalInc. is a global medical device company with a spine and 
orthopedics focus. The Company's mission is to deliver innovative, 
quality-driven solutions while partnering with health care professionals to 
improve patient mobility. Headquarteredin Lewisville, Texas, Orthofix's spine 
and orthopedics products are distributed in more than 60 countries via the 
Company's sales representatives and distributors. For more information, please 
visit
www.orthofix.com
.
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About SeaSpine
SeaSpine (
www.seaspine.com
) is a global medical technology company focused on the design, development, 
and commercialization of surgical solutions forthe treatment of patients 
suffering from spinal disorders. SeaSpine's complete procedural solutions 
feature its market-leading FLASH
TM
Navigation, a system designed to improve accuracy ofscrew placement and 
provide a cost-effective, rapid, radiation-free solution to surgical 
navigation, and a comprehensive portfolio of spinal implants and orthobiologics 
to meet the varying combinations of products that neurosurgeons and 
orthopedicspine surgeons need to facilitate spinal fusion in degenerative, 
minimally invasive surgery (MIS), and complex spinal deformity procedures on 
the lumbar, thoracic and cervical spine. With product development expertise in 
advanced optics, software,orthobiologic sciences and spinal implants, SeaSpine 
can offer its surgeon customers a complete solution to meet their patients' 
evolving clinical needs. SeaSpine currently markets its products in the United 
States and in approximately 30countries worldwide.
Forward-Looking Statements
This communication contains statements which, to the extent they are not 
statements of historical or present fact, constitute "forward-lookingstatements"
 under the securities laws. From time to time, oral or written forward-looking 
statements may also be included in other information released to the public. 
These forward-looking statements are intended to provide Orthofix's 
andSeaSpine's respective management's current expectations or plans for our 
future operating and financial performance, based on assumptions currently 
believed to be valid. Forward-looking statements can be identified by the use 
of words suchas "believe," "expect," "expectations," "plans," "strategy," 
"prospects," "estimate," "project," "target," "anticipate," "will,""should," 
"see," "guidance," "outlook," "confident," "on track" and other words of 
similar meaning. Forward-looking statements may include, among other things, 
statements relating to futuresales, earnings, cash flow, results of 
operations, uses of cash, tax rates, R&D spend, other measures of financial 
performance, potential future plans, strategies or transactions, credit 
ratings and net indebtedness, other anticipated benefitsof the proposed 
merger, including estimated synergies and cost savings resulting from the 
proposed merger, the expected timing of completion of the proposed merger, 
estimated costs associated with such transaction and other statements that are 
nothistorical facts. All forward-looking statements involve risks, 
uncertainties and other factors that may cause actual results to differ 
materially from those expressed or implied in the forward-looking statements. 
For those statements, we claim theprotection of the safe harbor for 
forward-looking statements contained in the U.S. Private Securities Litigation 
Reform Act of 1995. Such risks, uncertainties and other factors include, 
without limitation: (1) the effect of economic conditionsin the industries and 
markets in which Orthofix and SeaSpine operate in the U.S. and globally and 
any changes therein, including financial market conditions, fluctuations in 
commodity prices, interest rates and foreign currency exchange rates, andthe 
levels of market demand in the health care segments in which our products are 
purchased and utilized; (2) challenges in the development, regulatory 
approval, commercialization, reimbursement, market acceptance, performance and 
realizationof the anticipated benefits of new products of the combined 
company; (3) the scope, nature, impact or timing of the proposed merger, 
including among other things the integration of the businesses and realization 
of synergies and opportunitiesfor growth and innovation and incurrence of 
related costs and expenses; (4) future levels of indebtedness, capital 
spending and research and development spending; (5) future availability of 
credit and factors that may affect suchavailability, including credit market 
conditions and our capital structure; (6) delays and disruption in delivery of 
materials and services from suppliers; (7) cost reduction efforts and 
restructuring costs and savings; (8) newbusiness and investment opportunities; 
(9) the ability to realize the intended benefits of organizational changes; 
(10) the anticipated benefits of diversification and balance of operations 
across product lines, regions and industries;(11) the effect of changes in 
political conditions in the U.S. and other countries in which Orthofix, 
SeaSpine and the businesses of each operate, including the effect of changes 
in U.S. healthcare policies, on general market conditions in thenear term and 
beyond; (12) the effect of changes in tax, regulatory and other laws and 
regulations in the U.S. and other countries in which Orthofix, SeaSpine and 
the businesses of each operate; (13) negative effects of the announcement 
orpendency of the proposed merger on the market price of Orthofix and/or 
SeaSpine's respective common stock and/or on their respective financial 
performance; (14) the ability of the parties to receive the required 
regulatory approvals forthe proposed merger (and the risk that such approvals 
may result in the imposition of conditions that could adversely affect the 
combined company or the expected benefits of the transaction) and approvals of 
Orthofix's and SeaSpine'sshareholders and to satisfy the other conditions to 
the closing of the merger on a timely basis or at all; (15) the occurrence of 
events that may give rise to a right of one or both of the parties to 
terminate the merger agreement;(16) risks relating to the value of the 
Orthofix shares to be issued in the proposed merger, significant transaction 
costs and/or unknown liabilities; (17) the possibility that the anticipated 
benefits from the proposed merger cannot berealized in full or at all or may 
take longer to realize than expected, including risks associated with third 
party contracts containing consent and/or other provisions that may be 
triggered by the proposed transaction; (18) risks associatedwith transaction-rel
ated litigation; (19) the possibility that costs or difficulties related to 
the integration
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of Orthofix's and SeaSpine's operations will be greater than expected; (20) 
the ability of the combined company to retain and hire key personnel; (21) the 
intendedqualification of the merger as a
tax-free
reorganization to Orthofix and SeaSpine shareholders for U.S. federal income 
tax purposes; and (22) the impact of the proposed merger on the respective 
businessesof Orthofix and SeaSpine. There can be no assurance that the 
proposed merger will in fact be consummated in the manner described or at all. 
For additional information on identifying factors that may cause actual 
results to vary materially from thosestated in forward-looking statements, see 
the reports of Orthofix and SeaSpine on Forms
10-K,
10-Q
and
8-K
filed with orfurnished to the Securities and Exchange Commission (the "SEC") 
from time to time. Any forward-looking statement speaks only as of the date on 
which it is made, and Orthofix and SeaSpine assume no obligation to update or 
revise suchstatement, whether as a result of new information, future events or 
otherwise, except as required by applicable law.
Additional Information about theProposed Transaction and Where to Find It
In connection with the proposed transaction, Orthofix has filed with the SEC a 
registration statement onForm
S-4,
which includes a preliminary prospectus of Orthofix and a preliminary joint 
proxy statement of Orthofix and SeaSpine (the "joint proxy statement/prospectus"
). Each party also plans to fileother relevant documents with the SEC 
regarding the proposed transaction. INVESTORS AND SECURITY HOLDERS ARE URGED 
TO READ THE JOINT PROXY STATEMENT/PROSPECTUS AND OTHER RELEVANT DOCUMENTS 
FILED WITH THE SEC WHEN THEY BECOME AVAILABLE, BECAUSE THEYWILL CONTAIN 
IMPORTANT INFORMATION ABOUT THE PROPOSED TRANSACTION. A definitive joint proxy 
statement/prospectus will be sent to Orthofix's shareholders and SeaSpine's 
shareholders. Investors and securityholders may obtain a free copy ofthe joint 
proxy statement/prospectus (if and when it becomes available) and other 
relevant documents filed by Orthofix and SeaSpine with the SEC at the SEC's 
website at www.sec.gov. Copies of the documents filed by Orthofix with the SEC 
will beavailable free of charge on Orthofix's website at http://ir.orthofix.com/
 or by contacting Orthofix's Investor Relations at (214)
937-3190.
Copies of the documents filed by SeaSpine with the SEC willbe available free 
of charge on SeaSpine's website at http://investor.seaspine.com/ or by 
contacting SeaSpine's Investor Relations at (415)
937-5402.
Orthofix and SeaSpine and their respective directors, executive officers and 
other members of management and employees may be deemed to be participants in 
thesolicitation of proxies in respect of the proposed transaction. Information 
about directors and executive officers of Orthofix is available in the 
Orthofix proxy statement for its 2022 Annual Meeting, which was filed with the 
SEC on April 27,2022. Information about directors and executive officers of 
SeaSpine is available in the SeaSpine proxy statement for its 2022 Annual 
Meeting, which was filed with the SEC on April 22, 2022. Other information 
regarding the participants in theproxy solicitation and a description of their 
direct and indirect interests, by security holdings or otherwise, will be 
contained in the joint proxy statement/prospectus and other relevant materials 
filed with the SEC regarding the proposedtransaction when they become 
available. Investors should read the joint proxy statement/prospectus 
carefully when it becomes available before making any voting or investment 
decisions. Investors may obtain free copies of these documents fromOrthofix 
and SeaSpine as indicated above.
This communication and the information contained herein shall not constitute 
an offer to sell or thesolicitation of an offer to buy any securities, nor 
shall there be any sale of securities in any jurisdiction in which such offer, 
solicitation or sale would be unlawful prior to registration or qualification 
under the securities laws of any suchjurisdiction. No offering of securities 
shall be made except by means of a prospectus meeting the requirements of 
Section 10 of the Securities Act of 1933, as amended.
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Orthofix Contact    SeaSpine Contact  
                                      
Alexa Huerta        John Bostjancic,  
Investor Relations  Investor Relations
Tel 214 937 3190    760 216 5111      
                                      
Denise Landry       LeAnn Burton      
Media Relations     Media Relations   
Tel 214 937 2529    760 607 9703      

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