Exhibit 99.1 Business Update April 5, 2022

Forward Looking Statements and Risk Factors This document contains “forward-looking statements” as defined in the Private Securities Litigation Reform Act of 1995. When Welltower uses words such as “may,” “will,” “intend,” “should,” “believe,” “expect,” “anticipate,” “project,” “pro forma,” “estimate” or similar expressions that do not relate solely to historical matters, Welltower is making forward-looking statements. Forward-looking statements, including statements related to Funds From Operations guidance, are not guarantees of future performance and involve risks and uncertainties that may cause Welltower’s actual results to differ materially from Welltower’s expectations discussed in the forward-looking statements. This may be a result of various factors, including, but not limited to: the impact of the COVID-19 pandemic; uncertainty regarding the implementation and impact of the CARES Act and future stimulus or other COVID-19 relief legislation; the status of the economy; the status of capital markets, including availability and cost of capital; issues facing the health care industry, including compliance with, and changes to, regulations and payment policies, responding to government investigations and punitive settlements and operators’/tenants’ difficulty in cost effectively obtaining and maintaining adequate liability and other insurance; changes in financing terms; competition within the health care and seniors housing industries; negative developments in the operating results or financial condition of operators/tenants, including, but not limited to, their ability to pay rent and repay loans; Welltower’s ability to transition or sell properties with profitable results; the failure to make new investments or acquisitions as and when anticipated; natural disasters and other acts of God affecting Welltower’s properties; Welltower’s ability to re-lease space at similar rates as vacancies occur; Welltower’s ability to timely reinvest sale proceeds at similar rates to assets sold; operator/tenant or joint venture partner bankruptcies or insolvencies; the cooperation of joint venture partners; government regulations affecting Medicare and Medicaid reimbursement rates and operational requirements; liability or contract claims by or against operators/tenants; unanticipated difficulties and/or expenditures relating to future investments or acquisitions; environmental laws affecting Welltower’s properties; changes in rules or practices governing Welltower’s financial reporting; the movement of U.S. and foreign currency exchange rates; Welltower’s ability to maintain its qualification as a REIT; key management personnel recruitment and retention; and other risks described in Welltower’s reports filed from time to time with the SEC. Welltower undertakes no obligation to update or revise publicly any forward-looking statements, whether because of new information, future events or otherwise, or to update the reasons why actual results could differ from those projected in any forward-looking statements. 2

Recent Highlights First Quarter 2022 Guidance Update (1) • Expect to achieve 1Q2022 net income attributable to common stockholders per diluted share within previously issued guidance range of $0.17 - $0.22 (1) • Despite delayed disbursement of HHS funds, expect 1Q2022 normalized funds from operations (FFO) per diluted share to exceed midpoint of $0.79 - $0.84 guidance range • Expect recognition of approximately $600,000 from HHS Provider Relief Fund as compared to approximately $6 million (~$0.015 per diluted share) assumed in guidance. Disbursement delays during the period resulted in significantly lower than expected recognition of funds Seniors Housing Operating (SHO) Portfolio Occupancy Gained Momentum Through First Quarter (2) • Average year-over-year occupancy growth in 1Q2022 is expected to exceed previous assumption for a 420 basis points (“bps”) increase (2) • Sequential average occupancy growth from 4Q2021 to 1Q2022 also expected to exceed previous expectation for approximately flat growth • Spot occupancy increased approximately 40bps during the quarter, with significant acceleration experienced into April • US and UK portfolio trends remain particularly favorable, with each region posting a spot occupancy gain of approximately 80bps during the quarter • Nearly all communities are accepting new residents and tour activity has increased meaningfully following the steep decline in resident and staff COVID-19 case counts since mid-January • Pricing power remains robust as evidenced by strong realized renewal rate growth Observations on Labor Trends • Through March, agency labor utilization has continued to decline following the steep fall in staff COVID-19 cases; agency labor expense is expected to moderate through 2Q2022 and to decline substantially in 2H2022 barring an additional disruptive COVID-19 surge • Staff COVID-19 cases have declined by approximately 90% since their peak in early January 2022; most communities have returned to pre-Omicron staffing levels Strong 1Q2022 Investment Activity; Pipeline Remains Robust • WELL has announced or completed approximately $1.3 billion of capital deployment, making 1Q2022 one of the most active starts to the year for investment activity in WELL’s (3) history; announced or completed approximately $7.0 billion of capital deployment since October 2020 • Announced on March 6, 2022 agreements to purchase three SH portfolios for $548 million, subject to customary closing conditions, with an expected high-single-digit unlevered IRR. The transactions are expected to be funded through the issuance of operating partnership units, assumed debt, and cash on hand • WELL’s near-term capital deployment pipeline remains robust, with opportunities across all property types and capital structure 1. See Supplemental Financial Measures at the end of this presentation for reconciliations 3 2. See 4Q2021 earnings release dated February 15, 2022 and 4Q2021 earnings conference call dated February 16, 2022 3. Includes completed and announced transactions through April 4, 2022; excludes development funding

Seniors Housing Update 4

(1) SHO Portfolio | COVID-19 Impact Weekly Staff COVID-19 Cases Weekly Resident COVID-19 Cases 1,400 1,000 Lower utilization of agency Strong increase in demand labor following steep decline following normalization of 1,200 in staff COVID-19 cases conditions within communities 800 1,000 90% decline 79% decline 600 since peak since peak 800 600 400 400 200 200 - - 1. All data presented as of April 1, 2022 as reported by operators 5

(1) SHO Portfolio | Additional Community Details Operations have largely normalized as impact of Omicron variant has subsided Communal Dining Visitation % of communities % of communities 100% 100% 80% 80% 60% 60% 40% 40% Indoor Visitation Outdoor Visitation Activities In-Person Tours % of communities % of communities 100% 100% 80% 80% 60% 60% 40% 40% 1. As reported by operators 6

Occupancy Continues to Outperform Seasonal Trends (1,2) SHO Portfolio Same Store Sequential Occupancy Change Pre-COVID Avg 2021 1.9% 2% 1.4% 1% 0.2% 0.4% 0.0% -1% -0.4% -0.7% -2% Since the occupancy trough in late-1Q2021, sequential average occupancy growth has meaningfully outpaced pre-COVID averages and continued through 1Q2022 -3% -3.1% -4% 1Q2021 2Q2021 3Q2021 4Q2021 1. Represents SHO same store portfolio each quarter at pro rata ownership 2. Pre-COVID average represents 2016 through 2019 7

(1) Balanced lease structure and WALT mitigates impact of inflationary pressures Shorter duration leases in SHO portfolio allow for more frequent mark-to-market of rents SHO SH Triple-Net LT/PAC MOB Health System Hospital Li Ofte her Science 15% 9% 7% 23% 3% 31% 3x increase in SHO 4Q 2011 4Q 2021 39% 14% (2) exposure over past 10 years (3) NOI NOI 5% 24% 30% (4) Approximately 2.6 year total portfolio weighted average lease term 1. WALT: Weighted Average Lease Term 2. Represents annualized NOI as reported in 4Q 2011. See 4Q 2011 Supplemental Information Report for further information 3. Represents in place NOI. See Supplemental Financial Measures at the end of this presentation for further information and reconciliation 4. Assumes 50% of SHO resident agreements reset on January 1 and 50% reset on the anniversary date (6 months). Weighted Average Lease Term/Maturity per 4Q2021 supplemental disclosure: SH NNN = 10 years, LT/PAC = 9 years, Outpatient Medical = 6 years; Health System = 12 years and based upon segment level 8 4Q2021 rental income

SHO Portfolio | Historical REVPOR Growth vs. Inflation 4Q21 SS REVPOR growth returned to pre-COVID average; further acceleration expected through 2022 (1) WELL Pre-COVID REVPOR Growth Exceeded Inflation by an Average of 2% Annually 5% 4% 3% 2% 1% 0% REVPOR decline driven by mix shift; -1% WELL SSRevPOR rate growth remained positive for CPI YoY Index individual SH segments RevPOR Growth Average 1Q15 - 1Q20 -2% 9 1. Represents quarterly year-over-year Same Store REVPOR growth percentage. See each quarters respective Supplemental Information Report for a discussion of such supplemental reporting measure as well as the applicable reconciliations

Significant Wealth Accumulation Allows for Greater SH Affordability Backdrop to drive rate growth remains favorable (2) Home Price Appreciation | 1987 - Present S&P500 | 1981 – Present S&P/Case-Shiller U.S. National Home Price Index 5000 +13.2% average annual return over past 40 years 300 4500 A home purchased in 1987 is 4000 250 …Is now worth (3) worth over 4x more today ~$1 Million 3500 200 3000 2500 150 2000 A $10,000 investment 100 1500 made in 1981… 1000 50 (1) ~80% of seniors 75+ are homeowners 500 0 0 Seniors Housing is NOT INCOME DEPENDENT; generally funded through ASSET SALES and PERSONAL WEALTH 1. Source: U.S. Census Bureau, Current Population Survey/Housing Vacancy Survey 2. Source: Bloomberg as of 2/4/2022 10 3. Assumes reinvestment of dividends and annual compounding

Seniors Housing Backdrop Supports Sustained Revenue Acceleration in 2022+ SH Demand Remains Robust Despite Surge in COVID-19 SH Construction Continues to Recede (1) 20K (1) Seniors Housing Quarterly Unit Absorption Units Under Construction NIC MAP Primary and Secondary Markets NIC Primary and Secondary Markets 80K 8.0% Units Under Construction Construction (% Inventory) 15K UNPRECEDENTED seniors housing absorption in recent quarters 70K 7.0% Further decline in units under 10K construction expected following sharp decline in starts 60K 6.0% 5K 50K 5.0% 0K 40K 4.0% -5K 30K 3.0% -10K 20K 2.0% -15K 10K 1.0% -20K 0K 0.0% 11 1. National Investment Center for Seniors Housing & Care – latest available data

SHO Portfolio | Path to Recovery Category NOI ($M) $565 million embedded NOI growth in return to Pre- COVID levels (1) A) 4Q21 Total Portfolio - IPNOI Portfolio ex HHS 661 B) Stable Portfolio Remaining Occupancy Recovery 312 C) Development, Lease-Up, Transitions and Acquisitions 146 D) Lease-Up of COVID Class Acquisitions (4Q20-4Q21) 107 E) 4Q21 Total Portfolio - Post COVID Recovery NOI 1,226 (1) A) 4Q21 Portfolio In-Place NOI excluding HHS B) 4Q19 Stable Portfolio - Incremental NOI from return to 4Q19 NOI levels 4Q21 Total Portfolio includes $137M of Incremental NOI from: Development properties delivered subsequent to 4Q19, lease- annualized agency labor and other unusual up properties as of 4Q19, properties transitioned to new operators subsequent 4Q19, expenses incurred in 4Q21, $90M of which is from properties transitioned to SHO from SHNNN subsequent to 4Q19, properties Stable Portfolio - up from $18M in 4Q19 C) acquired subsequent to 4Q19 and prior to 4Q20. NOI stabilization assumes return to Pre-COVID NOI for acquisition properties and underwritten stabilized NOI for development properties D) Incremental NOI from stabilization of acquisitions between 4Q20 and 4Q21 Occupancy Occupancy 4Q21 portfolio post-COVID recovery NOI. Represents portfolio occupancy of 87.1% 76.5% 87.1% E) and operating margin of 30.4% Potential for ADDITIONAL UPSIDE assuming return to PEAK OCCUPANCY of 91.2% in 4Q2015 1. Represents $722 million of IPNOI in 4Q21 excluding $61 million of HHS. See Supplemental Financial Measures at the end of this presentation for reconciliation 12

Capital Deployment Update 13

Near-term capital deployment pipeline remains robust, exceeding $1.0 billion Notable Recent Investments (1) Transaction Segment Properties Investment Commentary Opportunistic • Portfolio comprised of eight rental and six entrance fee communities located in attractive markets across the US Investments Watermark SHO 14 $580M • Price represents a 40% discount to estimated replacement cost Executed at • Anticipated unlevered IRR in high-single-digit range Significant • Newly-developed communities in fast-growing micro markets in the Midwest with densification opportunities Discounts to New Perspective SHO 3 $119M • New Perspective to assume operations under strongly aligned RIDEA 3.0 contract Estimated • Anticipated unlevered IRR in high-single-digit range Replacement • Acquisition of 85 properties at a significant discount to estimated replacement cost, operated by Atria Senior Living Atria SHO 85 $1.6B Cost • Anticipated unlevered IRR in low-to-mid-teens range • Further expansion of relationship with StoryPoint through agreement to acquire 33 properties with median vintage of 2016. Deal expected to be funded through operating partnership units, cash, and assumed debt StoryPoint SHO 33 $548M • Price represents significant discount to replacement cost • Anticipated unlevered IRR in high-single-digit range • Acquisition of five recently developed Class A communities across the Mid-Atlantic and Southeastern US Quality Senior NNN/ SHO 5 + pipeline $172M • QSL, a best-in-class operator and developer retained to manage the properties Living • Agreed to strategic long-term exclusive development agreement Newly Established and • Class A portfolio of 100% private pay communities in highly attractive markets Growing Regency SHO 9 $450M • Cogir, an existing Welltower operator to assume operations • Anticipated unlevered IRR in high-single-digit range Relationships • Formed strategic joint venture including the acquisition of seven Class A medical office buildings and properties Aspect Health MOB 7 + pipeline $98M under construction • Ten-year exclusivity agreement on future development opportunities in NYC metro area • New long-term exclusive development agreement to build, own, and operate Class A communities Oakmont SHO 1 + pipeline $35M • Expanded relationship through purchase of an AL/MC property in a highly-desirable sub-market in SoCaL • Anticipated unlevered IRR of approximately 10% 14 1. At pro rata ownership

Capital Deployment Since 4Q20 (1) Capital Deployment Volume ✓ Initial yield of 5.9%; Stable yield of approximately 8.2% ✓ Low last-dollar exposure and innovative structure offer downside protection GROSS (1) INVESTMENTS $7.0B✓ Expected to generate high-single-digit to mid-teens unlevered IRRs to WELL Granular & Off-Market Transactions ✓ Predictive analytics and exclusive operator relationships used to execute off-market investments (1) Total Transactions ✓ Maximizing risk-adjusted return to WELL through creative investments across the capital stack 68 OM and SH Properties Acquired✓ Debt investments offer equity upside in form of warrants and/or bargain purchase options 284 ✓ Seniors housing acquisitions executed at an average investment of $20.6 million per property Seniors Housing Units Acquired 29K Significant Discount to Replacement Cost ✓ Investments made at significant discount to replacement cost offer enhanced downside protection Avg. Last Dollar Basis US transactions $184K / unit ✓ Limited recent market transactions priced above replacement cost serves to further curtail new supply Avg. Last Dollar Basis UK transactions £40K / unit StoryPoint Fort Wayne | Fort Wayne, IN Oakmont Ivy Park at Otay Ranch | Chula Vista, CA HarborChase of Vero Beach | Vero Beach, FL 15 1. Includes pro rata gross investments across acquisitions and loans since October 2020 and agreement to acquire $548 million seniors housing portfolios as disclosed on March 6, 2022; excludes development funding

Foundation for Long-Term Growth Established Opportunity to deploy in excess of $2.5 billion Annually | Economics Defined During Pandemic NEW and PROPRIETARY long-term relationships with best-in-class developers and operators with either exclusive rights or right of first offer 5 19 4 28 $25B+ Relationships Formed Newly Formed COVID Additional Relationships Total Newly Established Potential Capital Deployment Pre-COVID Relationships Growth Relationships Currently In Progress Opportunity Over Next Decade New relationships formed during depths of COVID- 19 pandemic to create visible and significant long- term capital deployment opportunities 16 Centralized Capital Allocation; Decentralized Execution

Welltower Overview 17

Welltower at a Glance S&P + % BBB Baa1 $60B 2.5 Enterprise (1) Dividend Yield 500 (1) Value 125,000+ ~22M sq. ft. Seniors Housing & Outpatient Facilities Wellness Housing Units World's largest health & wellness real estate platform 1. Bloomberg, as of April 4, 2022 18

Leadership Team SHANKH MITRA TIMOTHY G. MCHUGH JOHN F. BURKART Chief Executive Officer & Chief Financial Officer Chief Operating Officer Chief Investment Officer MATTHEW G. MCQUEEN AYESHA MENON JOSHUA T. FIEWEGER General Counsel & Senior Vice President Chief Accounting Officer Corporate Secretary Wellness Housing and Development 19

(1) WELL ESG Focus | Profit, Planet, People Building a Portfolio Serving our People and Good Governance for the Future our Communities is Good Business E S G • 80% Women and Minority Independent (1) Sustainability Goals & Achievements Gender parity across organization Director Leadership on the Board of Directors Targeting 10% reduction in • ESG Goals Incorporated into greenhouse gas (GHG) emissions, Management Compensation Plan (2) energy, and water use by 2025 • Separate Chairman & CEO roles Lowest G&A Burden Amongst First health care REIT to issue (3) Health Care REITs Green Bond (December 2019) 1.2% 1.0% 0.8% 0.6% >50% 0.4% 0.2% 0.0% Employee participation across 8 Employee Network Groups G&A as % of Enterprise Value 1. See Welltower 2020 Environmental, Social and Governance Report and Business Update dated June 7, 2021 for additional details and disclosures 2. See Welltower 2020 Environmental, Social and Governance Report for additional details and disclosures 20 3. Most recently disclosed trailing twelve-month G&A; Enterprise Value as of February 14, 2022

Drivers of Per Share Cash Flow Growth Post-COVID fundamental recovery sustained by strong demographic trends, SECULAR GROWTH shift to value-based health care, and social determinants of health TAILWINDS External growth strategy underpinned by value-oriented capital deployment ACCRETIVE CAPITAL philosophy and data-driven decisions in innovative structures DEPLOYMENT DIVERSIFIED PLATFORM Strongly aligned operating partners, positioned for significant growth OF OPERATORS STRONG INTERNAL Entrepreneurial – Passionate – Diverse – Aligned TALENT BASE Value-based investment philosophy and innovative structure of transactions offer RISK significant downside protection MITIGANTS Strong investment grade balance sheet and robust liquidity profile 21

New Paradigm for Growth with Lower Entity-Level Risk PAST FIVE YEARS DO NOT REFLECT OUTLOOK FOR NEXT FIVE YEARS Where we Were (2015- 2020) Where we’re Going (2021 and beyond) • Relatively flat demographic growth of key seniors housing SENIORS HOUSING • Sharply accelerating growth of 80+ age cohort DEMAND → demographic resulting from “Baby Bust” of 1928 - 1940 • Precipitous decline in starts resulting from accelerating SENIORS HOUSING • Significant multi-year increase in seniors housing supply construction costs and challenges in procuring construction SUPPLY→ financing • Substantially exited operating relationship with Genesis; • Outsized operator and post-acute concentration: Genesis PORTFOLIO immaterial post-acute care exposure following announced → Healthcare comprised nearly 20% of WELL NOI (1) sales OPERATOR • Aligned interests via RIDEA 3.0 construct with shorter term • Long-term revenue-based management contracts PLATFORM→ management contracts • Focused on improving portfolio quality through • Significant increase in net investment activity: abundant INVESTMENT dispositions opportunities to create shareholder value through capital ENVIRONMENT→ • Prohibitive seniors housing valuations resulted in deployment few net investment value creation opportunities At the cusp of multi-year period of EARNINGS • Lackluster growth resulting from elevated disposition GROWTH→ activity and impact of COVID-19 pandemic compelling per share growth 22 1. See Welltower press release and business update dated March 2, 2021

Secular Societal & Technological Trends | Impact on Real Estate Sectors Precedent for EXTENDED PERIOD OF MULTIPLE EXPANSION in Secular Growth Sectors THEME REAL ESTATE SECTOR IMPACT E-Commerce Industrial Digital Technology Data Centers Mobile Phone Usage & Wireless Technology Cellular Towers AGING OF THE POPULATION HEALTH CARE 23

Seniors Housing 24

Seniors Housing Operator Platform | Power of Diversification $$$ Monthly Rent Diversity across Acuity, Geography and Operating Model $ Low High Average Portfolio Acuity 25 25

Demographic Backdrop | Rapidly Aging Population 4.5% (1) 80+ Population CAGR | Historical and Projected US Population CAGR by Age Cohort | 2020 - 2029 4.0% 5.0% 2010-2019 2020-2029 4.0% 4.5% 3.5% 4.0% 4.3% 3.0% 4.0% 3.5% 2.5% 3.0% 3.1% 2.0% 2.5% 1.4% 2.0% 2.4% 1.5% 1.5% 1.8% 1.0% 1.5% 1.0% 0.3% 0.5% 0.2% 0.5% 0.0% 0.0% US UK CAN 20-39 40-59 60-79 80+ 3.5% 5.0% UK Population CAGR by Age Cohort | 2020 - 2029 Canada Population CAGR by Age Cohort | 2020 - 2029 4.5% 3.0% 3.1% 4.0% 4.3% 2.5% 3.5% 2.0% 3.0% 1.5% 1.5% 2.5% 1.9% 2.0% 1.0% 1.5% 0.5% 1.0% -0.2% -0.2% 0.5% 0.4% 0.0% 0.5% -0.5% 0.0% 20-39 40-59 60-79 80+ 20-39 40-59 60-79 80+ 1. The Organisation for Economic Cooperation and Development (OECD). Data as of September 20, 2021 26

Seniors Housing Supply | Construction Remains Well Below Peak Levels (1) (1) Construction Starts Units Under Construction NIC Primary and Secondary Markets NIC Primary and Secondary Markets Construction Starts Construction Starts (% Inventory) Units Under Construction Construction (% Inventory) 14K 5.0% 80K 8.0% 4.5% 50%+ decline in starts 70K 7.0% Further decline in units under 12K since 4Q17 peak construction expected following 4.0% sharp decline in starts 60K 6.0% 10K 3.5% 50K 5.0% 3.0% 8K 2.5% 40K 4.0% 6K 2.0% 30K 3.0% 1.5% 4K Recent construction starts 20K 2.0% at 2012/2013 levels 1.0% 2K 10K 1.0% 0.5% 0K 0.0% 0K 0.0% 27 1. Source: NIC MAP® Data Service

Seniors Housing Supply | Surging Construction Costs Material increase in cost of development for ALL RESIDENTIAL property types including SENIORS HOUSING Lumber Cement Copper 1,800 650 11,000 1,600 600 10,000 +164% since 2017 +36% since 2017 +76% since 2017 1,400 550 9,000 1,200 500 8,000 1,000 800 450 7,000 600 400 6,000 400 350 5,000 200 0 300 4,000 Aluminum Steel 4,000 2,500 3,500 2,000 +84% since 2017 +78% since 2017 3,000 1,500 2,500 1,000 2,000 500 1,500 1,000 0 WEAKER DEVELOPMENT ECONOMICS LEADING TO SHARP DECLINE IN SENIORS HOUSING SUPPLY 28 SOURCE: Factset, as of 3/30/2022

Post-COVID Recovery | Long-Term Secular Growth Opportunity Demographic-Driven Demand Supply Deceleration Resilient Pricing Power (1) (2) (3) US 80+ Population Growth Seniors Housing Construction Starts WELL SHO Same Store REVPOR Growth 5.0% 5.0% Starts (% Inventory) Average 20M WELL’s pre-COVID pricing power remained strong despite accelerating supply and tight labor market conditions 4.5% 4.1% 19M 4.0% 4.0% 18M 3.5% 17M 3.0% 3.0% 16M 2.4% 2.5% 15M 2.0% 14M 2.0% 1.5% 13M 1.0% 12M 1.0% 0.5% 11M 0.0% 10M 0.0% Unique Opportunity to Generate Significant NOI Growth Over Multi-Year Period 1. The Organisation for Economic Cooperation and Development (OECD) 2. Source: NIC MAP® Data Service, Primary and Secondary markets 29 3. Represents quarterly year-over-year Same Store REVPOR growth percentage. See each quarters respective Supplemental Information Report for a discussion of such supplemental reporting measure as well as the applicable reconciliations

Supplemental Financial Measures 30

Non-GAAP Financial Measures We believe that revenues, net income and net income attributable to common stockholders ( NICS ), as defined by U.S. generally accepted accounting principles ( U.S. GAAP ), are the most appropriate earnings measurements. However, we consider Funds from Operations ( FFO ), Normalized FFO, Net Operating Income ( NOI ), In-Place NOI ( IPNOI ), Same Store NOI ( SSNOI ), REVPOR and Same Store REVPOR ( SS REVPOR ) to be useful supplemental measures of our operating performance. These supplemental measures are disclosed on our pro rata ownership basis. Pro rata amounts are derived by reducing consolidated amounts for minority partners’ noncontrolling ownership interests and adding our minority ownership share of unconsolidated amounts. We do not control unconsolidated investments. While we consider pro rata disclosures useful, they may not accurately depict the legal and economic implications of our joint venture arrangements and should be used with caution. Our supplemental reporting measures and similarly entitled financial measures are widely used by investors, equity and debt analysts and rating agencies in the valuation, comparison, rating and investment recommendations of companies. Our management uses these financial measures to facilitate internal and external comparisons to historical operating results and in making operating decisions. Additionally, these measures are utilized by the Board of Directors to evaluate management. None of the supplemental reporting measures represent net income or cash flow provided from operating activities as determined in accordance with U.S. GAAP and should not be considered as alternative measures of profitability or liquidity. Finally, the supplemental reporting measures, as defined by us, may not be comparable to similarly entitled items reported by other real estate investment trusts or other companies. Multi-period amounts may not equal the sum of the individual quarterly amounts due to rounding. 31

FFO and Normalized FFO Historical cost accounting for real estate assets in accordance with U.S. GAAP implicitly assumes that the value of real estate assets diminishes predictably over time as evidenced by the provision for depreciation. However, since real estate values have historically risen or fallen with market conditions, many industry investors and analysts have considered presentations of operating results for real estate companies that use historical cost accounting to be insufficient. In response, the National Association of Real Estate Investment Trusts ( NAREIT ) created FFO as a supplemental measure of operating performance for REITs that excludes historical cost depreciation from net income. FFO attributable to common stockholders, as defined by NAREIT, means net income attributable to common stockholders, computed in accordance with U.S. GAAP, excluding gains (or losses) from sales of real estate and impairments of depreciable assets, plus real estate depreciation and amortization, and after adjustments for unconsolidated entities and noncontrolling interests. Normalized FFO attributable to common stockholders represents FFO adjusted for certain items detailed in the reconciliations. Normalizing items include adjustments for certain non-recurring or infrequent revenues/expenses that are described in our earnings press releases for the relevant periods. We believe that Normalized FFO attributable to common stockholders is a useful supplemental measure of operating performance because investors and equity analysts may use this measure to compare our operating performance between periods or to other REITs or other companies on a consistent basis without having to account for differences caused by unanticipated and/or incalculable items. 32

Earnings Outlook Reconciliation Outlook Reconciliation: Quarter Ending March 31, 2022 (in millions, except per share data) Current Outlook Low High FFO Reconciliation: Net income attributable to common stockholders $ 78 $ 101 (1,2) Impairments and losses (gains) on real estate dispositions, net (30) (30) (1) Depreciation and amortization 309 309 NAREIT FFO and Normalized FFO attributable to common stockholders $ 357 $ 380 Diluted per share data attributable to common stockholders: Net income $ 0.17 $ 0.22 NAREIT FFO and Normalized FFO $ 0.79 $ 0.84 (1) Other items: Net straight-line rent and above/below market rent amortization $ (20) $ (20) Non-cash interest expenses 5 5 Recurring cap-ex, tenant improvements, and lease commissions (27) (27) Stock-based compensation 8 8 (1) Amounts presented net of noncontrolling interests' share and Welltower's share of unconsolidated entities. (2) Includes estimated gains on expected dispositions. 33

NOI, IPNOI, SSNOI, REVPOR & SS REVPOR We define NOI as total revenues, including tenant reimbursements, less property operating expenses. Property operating expenses represent costs associated with managing, maintaining and servicing tenants for our properties. These expenses include, but are not limited to, property-related payroll and benefits, property management fees paid to operators, marketing, housekeeping, food service, maintenance, utilities, property taxes and insurance. General and administrative expenses represent costs unrelated to property operations and transaction costs. These expenses include, but are not limited to, payroll and benefits, professional services, office expenses and depreciation of corporate fixed assets. IPNOI represents NOI excluding interest income, other income and non-IPNOI and adjusted for timing of current quarter portfolio changes such as acquisitions, development conversions, segment transitions, dispositions and investments held for sale. SSNOI is used to evaluate the operating performance of our properties using a consistent population which controls for changes in the composition of our portfolio. As used herein, same store is generally defined as those revenue-generating properties in the portfolio for the relevant year-over-year reporting periods. Land parcels, loans and sub- leases as well as any properties acquired, developed/redeveloped (including major refurbishments where 20% or more of units are simultaneously taken out of commission for 30 days or more), sold or classified as held for sale during that period are excluded from the same store amounts. Properties undergoing operator and/or segment transitions (except Seniors Housing Triple-net to Seniors Housing Operating with the same operator) are also excluded from same store amounts. Normalizers include adjustments that in management’s opinion are appropriate in considering SSNOI, a supplemental, non-GAAP performance measure. None of these adjustments, which may increase or decrease SSNOI, are reflected in our financial statements prepared in accordance with U.S. GAAP. Significant normalizers (defined as any that individually exceed 0.50% of SSNOI growth per property type) are separately disclosed and explained in the relevant supplemental reporting package. No reconciliation of the forecasted range for SSNOI on a combined basis or by property type is included in this release because we are unable to quantify certain amounts that would be required to be included in the comparable GAAP financial measure without unreasonable efforts, as we believe such reconciliation would imply a degree of precision that could be confusing or misleading to investors. REVPOR represents the average revenues generated per occupied room per month at our seniors housing operating properties. It is calculated as our pro rata version of total resident fees and services revenues from the income statement divided by average monthly occupied room days. SS REVPOR is used to evaluate the REVPOR performance of our properties under a consistent population which eliminates changes in the composition of our portfolio. It is based on the same pool of properties used for SSNOI and includes any revenue normalizations used for SSNOI. We use REVPOR and SS REVPOR to evaluate the revenue-generating capacity and profit potential of its seniors housing operating portfolio independent of fluctuating occupancy rates. They are also used in comparison against industry and competitor statistics, if known, to evaluate the quality of our seniors housing operating portfolio. We believe NOI, IPNOI, SSNOI, REVPOR and SS REVPOR provide investors relevant and useful information because they measure the operating performance of our properties at the property level on an unleveraged basis. We use these metrics to make decisions about resource allocations and to assess the property level performance of our properties. 34

In-Place NOI Reconciliations (dollars in thousands) 4Q21 In-Place NOI by property type 4Q21 % of Total Net income (loss) $ 66,194 Seniors Housing Operating $ 721,684 39 % Loss (gain) on real estate dispositions, net (11,673) Seniors Housing Triple-Net 430,476 24 % Loss (income) from unconsolidated entities 12,174 Outpatient Medical 425,592 23 % Income tax expense (benefit) 2,051 Health System 162,104 9 % Other expenses 15,483 Long-Term/Post-Acute Care 94,808 5 % Impairment of assets 2,357 Total In-Place NOI $ 1,834,664 100 % Provision for loan losses, net (39) Loss (gain) on extinguishment of debt, net (1,090) Loss (gain) on derivatives and financial instruments, net (830) General and administrative expenses 33,109 Depreciation and amortization 284,501 Interest expense 121,848 Consolidated net operating income 524,085 (1) NOI attributable to unconsolidated investments 20,287 (2) NOI attributable to noncontrolling interests (27,889) Pro rata net operating income (NOI) 516,483 Adjust: Interest income (39,672) (3) Other income (11,898) Sold / held for sale (3,770) (4) Non operational 2,040 (5) Non In-Place NOI (16,395) (6) Timing adjustments 11,878 In-Place NOI 458,666 Annualized In-Place NOI $ 1,834,664 (1) Represents Welltower's interest in joint ventures where Welltower is the minority partner. (2) Represents minority partner's interest in joint ventures where Welltower is the majority partner and includes an adjustment to remove NOI related to a leasehold portfolio interest for 26 properties assumed by a wholly-owned affiliate in conjunction with the Holiday Retirement transaction. Subsequent to the initial transaction, we purchased eight of the leased properties and one of the properties was sold by the landlord and removed from the lease. No rent will be paid in excess of net cash flows relating to the leasehold properties. (3) Excludes amounts recognized in other income related to the Health and Human Services Provider Relief Fund in the US and similar programs in the UK and Canada. (4) Primarily includes development properties and land parcels. (5) Primarily represents non-cash NOI. (6) Represents timing adjustments for current quarter acquisitions, construction conversions and segment or operator transitions. 35

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