UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

SCHEDULE 13G

(Amendment No. )

UNDER THE SECURITIES EXCHANGE ACT OF 1934

YUMANITY THERAPEUTICS, INC.

(Name of Issuer)

Common Stock, par value $0.001 per share

(Title of Class of Securities)

98872L 102

(CUSIP Number)

December 22, 2020

(Date of Event Which Requires Filing of This Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

o Rule 13d-1(b)

x Rule 13d-1(c)

o Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

CUSIP No. 98872L 102

1.	Name of Reporting Persons Alexandria Real Estate Equities, Inc.
2.	Check the Appropriate Box if a Member of a Group (See Instructions) (a) o (b) x
3.	SEC USE ONLY
4.	Citizenship or Place of Organization Maryland
Number of Shares Beneficially Owned by Each Reporting Person With:		5.	Sole Voting Power 0
		6.	Shared Voting Power 781,034 (1)
		7.	Sole Dispositive Power 0
		8.	Shared Dispositive Power 781,034 (1)
9.	Aggregate Amount Beneficially Owned by Each Reporting Person 781,034 (1)
10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) o
11.	Percent of Class Represented by Amount in Row (9) 7.7% (2)
12.	Type of Reporting Person (See Instructions) CO

(1) Consists of: (i) 548,895 shares of the Issuer’s common stock held by Alexandria Venture Investments, LLC (“AVI”), (ii) 7,798 shares of the Issuer’s common stock underlying immediately exercisable warrants held by AVI and (iii) 224,341 shares of the Issuer’s common stock held directly by Alexandria Equities No. 7, LLC (“AE7”). Each of AVI and AE7 are indirect, wholly-owned subsidiaries of Alexandria Real Estate Equities, Inc. (“ARE”) and, accordingly, ARE may be deemed to share voting and dispositive power with AVI and AE7 with respect to the shares reported herein.

(2) This percentage is calculated based upon 10,094,783 outstanding shares of the Issuer’s common stock, as reported in the Issuer’s Current Report on Form 8-K filed with the Securities and Exchange Commission on December 30, 2020.

CUSIP No. 98872L 102

1.	Name of Reporting Persons Alexandria Venture Investments, LLC
2.	Check the Appropriate Box if a Member of a Group (See Instructions) (a) o (b) x
3.	SEC USE ONLY
4.	Citizenship or Place of Organization Delaware
Number of Shares Beneficially Owned by Each Reporting Person With:		5.	Sole Voting Power 0
		6.	Shared Voting Power 556,693 (1)
		7.	Sole Dispositive Power 0
		8.	Shared Dispositive Power 556,693 (1)
9.	Aggregate Amount Beneficially Owned by Each Reporting Person 556,693 (1)
10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) o
11.	Percent of Class Represented by Amount in Row (9) 5.5% (2)
12.	Type of Reporting Person (See Instructions) OO

(1) These shares are held directly by AVI. Includes 7,798 shares underlying immediately exercisable warrants.

CUSIP No. 98872L 102

1.	Name of Reporting Persons Alexandria Equities No. 7, LLC
2.	Check the Appropriate Box if a Member of a Group (See Instructions) (a) o (b) x
3.	SEC USE ONLY
4.	Citizenship or Place of Organization Delaware
Number of Shares Beneficially Owned by Each Reporting Person With:		5.	Sole Voting Power 0
		6.	Shared Voting Power 224,341 (1)
		7.	Sole Dispositive Power 0
		8.	Shared Dispositive Power 224,341 (1)
9.	Aggregate Amount Beneficially Owned by Each Reporting Person 224,341 (1)
10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) o
11.	Percent of Class Represented by Amount in Row (9) 2.2% (2)
12.	Type of Reporting Person (See Instructions) OO

(1) These shares are held directly by AE7.

CUSIP No. 98872L 102

Item 1(a) Name of Issuer

Yumanity Therapeutics, Inc.

Item 1(b) Address of Issuer’s Principal Executive Offices

40 Guest Street, Suite 4410

Boston, MA 02135

Item 2(a) Name of Person Filing

This Statement on Schedule 13G has been filed on behalf of the following persons (each, a “Reporting Person” and collectively, the “Reporting Persons”):

(1) Alexandria Real Estate Equities, Inc.

(2) Alexandria Venture Investments, LLC

(3) Alexandria Equities No. 7, LLC

Item 2(b) Address of Principal Business Office or, if none, Residence

The address of each of the Reporting Persons is:

26 North Euclid Avenue

Pasadena, California 91101

Item 2(c) Citizenship

(1) Alexandria Real Estate Equities, Inc. is incorporated in the State of Maryland

(2) Alexandria Venture Investments, LLC is organized in the State of Delaware

(3) Alexandria Equities No. 7, LLC is organized in the State of Delaware

Item 2(d) Title of Class of Securities

Common Stock, par value $0.001 per share

Item 2(e) CUSIP Number

98872L 102

Item 3

Not applicable.

Item 4 Ownership

Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1

(a) Amount beneficially owned: See Row 9 of pages 2, 3, and 4

(b) Percent of class: See Row 11 of pages 2, 3, and 4

(i) Sole power to vote or to direct the vote: See Row 5 of pages 2, 3, and 4

(ii) Shared power to vote or to direct the vote: See Row 6 of pages 2, 3, and 4

(iii) Sole power to dispose or to direct the disposition of: See Row 7 of pages 2, 3, and 4

(iv) Shared power to dispose or to direct the disposition of: See Row 8 of pages 2, 3, and 4

CUSIP No. 98872L 102

Item 5 Ownership of Five Percent or Less of a Class

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following. o

Item 6 Ownership of More than Five Percent on Behalf of Another Person

Not applicable.

Item 7 Identification and Classification of the Subsidiary which Acquired the Security Being Reported on by the Parent Holding Company

Each of Alexandria Venture Investments, LLC and Alexandria Equities No. 7, LLC is the wholly owned subsidiary of Alexandria Real Estate Equities, Inc., which has the exclusive power to vote and dispose of shares directly owned by these subsidiaries.

Item 8 Identification and Classification of Members of the Group

The Reporting Persons are filing this Schedule 13G jointly, but not as members of a group, and each expressly disclaims membership in a group.

Item 9 Notice of Dissolution of Group

Not applicable.

Item 10 Certification

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

CUSIP No. 98872L 102

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Dated: January 4, 2021

ALEXANDRIA REAL ESTATE EQUITIES, INC.

By:	/s/ Dean A. Shigenaga
Name:	Dean A. Shigenaga
Title:	President and Chief Financial Officer


ALEXANDRIA EQUITIES NO. 7, LLC

By: ARE-Special Services, LLC, a Delaware limited liability company, managing member

	By: ALEXANDRIA REAL ESTATE EQUITIES, L.P., a Delaware limited partnership, managing member

		By: ARE-QRS CORP., a Maryland corporation, general partner

			By: Alexandria Real Estate Equities, Inc., a Maryland corporation, sole shareholder

				By:	/s/ Dean A. Shigenaga
				Name:	Dean A. Shigenaga
				Title:	President and Chief Financial Officer


ALEXANDRIA VENTURE INVESTMENTS, LLC

By:	Alexandria Real Estate Equities, Inc., a
	Maryland corporation, managing member

By:	/s/ Dean A. Shigenaga
Name:	Dean A. Shigenaga
Title:	President and Chief Financial Officer

EXHIBITS

A: Joint Filing Agreement

CUSIP No. 98872L 102

EXHIBIT A

JOINT FILING AGREEMENT

In accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, the undersigned agree to the joint filing on behalf of each of them of a statement on Schedule 13G (including amendments thereto) with respect to the Common Stock of Yumanity Therapeutics, Inc. and further agree that this agreement be included as an exhibit to such filing. Each party to the agreement expressly authorizes each other party to file on its behalf any and all amendments to such statement. Each party to this agreement agrees that this joint filing agreement may be signed in counterparts.

In evidence whereof, the undersigned have caused this Agreement to be executed on their behalf this 4th day of January, 2021.

ALEXANDRIA REAL ESTATE EQUITIES, INC.

By:	/s/ Dean A. Shigenaga
Name:	Dean A. Shigenaga
Title:	President and Chief Financial Officer


ALEXANDRIA EQUITIES NO. 7, LLC

By: ARE-Special Services, LLC, a Delaware limited liability company, managing member

	By: ALEXANDRIA REAL ESTATE EQUITIES, L.P., a Delaware limited partnership, managing member

		By: ARE-QRS CORP., a Maryland corporation, general partner

			By: Alexandria Real Estate Equities, Inc., a Maryland corporation, sole shareholder

				By:	/s/ Dean A. Shigenaga
				Name:	Dean A. Shigenaga
				Title:	President and Chief Financial Officer


ALEXANDRIA VENTURE INVESTMENTS, LLC

By:	Alexandria Real Estate Equities, Inc., a
	Maryland corporation, managing member

By:	/s/ Dean A. Shigenaga
Name:	Dean A. Shigenaga
Title:	President and Chief Financial Officer